iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-060144

UUCD1 version

UUC-MeG-00803

Ensembl Protein ID

ENSMGAP00000006350.2

UniProt Accession

G1N3N7; G1N3N7_MELGA

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000006278.2	ENSMGAT00000007098.2	ENSMGAP00000006350.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.50e-119	398.4	15	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 3    RQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnve 91
           R  rlwG+++qe+l+sa+v++++a+++G+E+lKnLvl G+gs+t+vD+++v+ ++++++F+++++++g+s+A++a e l+eln+dv++ 
   Q: 15   REYRLWGDHGQEALESAHVCVINATATGTEILKNLVLPGIGSFTIVDGNRVSGEDVGNNFFLQKSHIGQSRAQSATELLQELNSDVSGN 103
           5679************************************************************************************* PP
   S: 92   aheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctl 176
           ++ees+++l ++++ Ff++f++Vv+++ ++++ +++++l++n ++pl++++t+Gl+G++rviik++++ +s++d   +++++++Pf++l
   Q: 104  FVEESPENLLDNDPsFFNRFNLVVATQLSESTVLRLAELLWNFNIPLLICRTYGLVGYMRVIIKEHPVVESHPDnalEDLRLDKPFPEL 192
           ***************************************************************************************** PP
   S: 177  ketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafaktti 250
            e+++         +++++++w+v+++k+l ++  e++ + +++++eke++++++++++ +      edeenfeeai+++++a+++t i
   Q: 193  TEHIQsydldhmdkKDHSHTPWIVIVAKYLTKWFNEKSDQLPKSYKEKEAFRQLIRQGILKnengtpEDEENFEEAIKNVNTALNTTKI 281
           ***99999999999***********************************************9*************************** PP
   S: 251  ns.ikqllksfecdivtkskspfwv................................................................ 274
           +  i+++++++ c ++t+++++fw+                                                                
   Q: 282  PRcIEEIFNDDCCINLTEQSPSFWIlvravkefvanegqgclpvrgtipdmiadsskfiklqnvyrekakrdiaavgshaakllqslgk 370
           ***************************************************************************************** PP
   S: 275  ...........sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avd 334
                      s+csn++ l+v             + +kde+++ +++p     lyl+lra++rf k++gr+pg+ +++++dd+  + +
   Q: 371  apesiserelkSLCSNSAFLRVVrcrslseeyglNTFNKDEIISNMDNPdsevvLYLMLRAVDRFYKQHGRYPGVYNYQVEDDIgkLKS 459
           *********************777777777777766777777766666666777*****************************999999 PP
   S: 335  lvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           ++t+++    +++g++ +++dd+++e++++++++ + ++a+ gG+aaqE+iKv++g+f+ ++n++++ ++
   Q: 460  CLTSFL----QEHGLSVVVKDDYVHEFCRYGAAEPHAIAAFMGGAAAQEIIKVITGQFVIFNNTYIYSGM 525
           ***999....********************************************************9776 PP

Organism

Meleagris gallopavo

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

VVRSTLILHG KDFVREYRLW GDHGQEALES AHVCVINATA TGTEILKNLV LPGIGSFTIV 60
DGNRVSGEDV GNNFFLQKSH IGQSRAQSAT ELLQELNSDV SGNFVEESPE NLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGTAAGAT CTACACTGAT CTTACATGGA AAAGATTTTG TAAGAGAAGT ACATAGAGAG 60
AGGTACACAG TACAGCAGGT TTGGGGTTTT ACTGTCCGCA TATTGATAAG CAATGACTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	41.86	4.00e-120	424.00
IUUC-Aml-002333	Ailuropoda melanoleuca	82.26	0.00e+00	932.00
IUUC-Atr-002644	Amborella trichopoda	39.58	1.00e-108	386.00
IUUC-Apl-003446	Anas platyrhynchos	95.40	0.00e+00	1025.00
IUUC-Aca-004450	Anolis carolinensis	80.27	0.00e+00	903.00
IUUC-Aly-006187	Arabidopsis lyrata	39.28	2.00e-119	422.00
IUUC-Ath-007600	Arabidopsis thaliana	39.16	3.00e-120	425.00
IUUC-Ago-007900	Ashbya gossypii	25.09	1.00e-34	140.00
IUUC-Acl-008333	Aspergillus clavatus	33.63	2.00e-76	279.00
IUUC-Afl-008529	Aspergillus flavus	33.64	4.00e-80	291.00
IUUC-Afu-009071	Aspergillus fumigatus	33.21	1.00e-76	280.00
IUUC-Ani-009443	Aspergillus nidulans	33.33	3.00e-74	272.00
IUUC-Ang-009669	Aspergillus niger	32.55	2.00e-78	286.00
IUUC-Aor-009914	Aspergillus oryzae	32.97	9.00e-77	280.00
IUUC-Ate-010450	Aspergillus terreus	32.73	8.00e-79	287.00
IUUC-Ame-011183	Astyanax mexicanus	71.65	0.00e+00	809.00
IUUC-Bgr-012111	Blumeria graminis	31.05	1.00e-59	223.00
IUUC-Bta-012583	Bos taurus	83.52	0.00e+00	944.00
IUUC-Bci-013892	Botrytis cinerea	31.90	6.00e-62	231.00
IUUC-Bdi-014592	Brachypodium distachyon	42.45	5.00e-121	427.00
IUUC-Bol-016399	Brassica oleracea	40.15	4.00e-121	427.00
IUUC-Bra-017506	Brassica rapa	38.12	1.00e-114	406.00
IUUC-Cel-018456	Caenorhabditis elegans	35.75	2.00e-89	322.00
IUUC-Cja-020007	Callithrix jacchus	82.67	0.00e+00	936.00
IUUC-Cfa-020324	Canis familiaris	83.33	0.00e+00	943.00
IUUC-Cpo-022248	Cavia porcellus	56.47	7.00e-154	536.00
IUUC-Csa-023149	Chlorocebus sabaeus	80.89	0.00e+00	809.00
IUUC-Cho-024537	Choloepus hoffmanni	73.75	0.00e+00	707.00
IUUC-Cin-025763	Ciona intestinalis	51.33	5.00e-157	546.00
IUUC-Csv-026113	Ciona savignyi	47.48	1.00e-143	502.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.17	2.00e-62	233.00
IUUC-Cne-026884	Cryptococcus neoformans	29.24	2.00e-66	246.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.80	2.00e-19	90.50
IUUC-Dre-028140	Danio rerio	73.09	0.00e+00	830.00
IUUC-Dno-030033	Dasypus novemcinctus	82.72	0.00e+00	818.00
IUUC-Dor-030513	Dipodomys ordii	59.74	1.00e-102	366.00
IUUC-Dse-031536	Dothistroma septosporum	32.20	1.00e-77	283.00
IUUC-Dme-031683	Drosophila melanogaster	43.13	3.00e-123	434.00
IUUC-Ete-032420	Echinops telfairi	72.87	0.00e+00	792.00
IUUC-Eca-033992	Equus caballus	83.78	0.00e+00	798.00
IUUC-Eeu-034713	Erinaceus europaeus	69.69	2.00e-104	372.00
IUUC-Fca-036548	Felis catus	82.01	0.00e+00	927.00
IUUC-Fal-037600	Ficedula albicollis	90.04	0.00e+00	967.00
IUUC-Fox-038037	Fusarium oxysporum	31.71	8.00e-69	254.00
IUUC-Fso-038387	Fusarium solani	33.16	1.00e-73	270.00
IUUC-Gmo-038562	Gadus morhua	69.96	0.00e+00	811.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.71	5.00e-69	254.00
IUUC-Gga-041129	Gallus gallus	96.96	0.00e+00	1041.00
IUUC-Gac-042558	Gasterosteus aculeatus	70.34	0.00e+00	805.00
IUUC-Gma-043610	Glycine max	39.58	7.00e-116	410.00
IUUC-Ggo-045611	Gorilla gorilla	82.67	0.00e+00	936.00
IUUC-Hsa-046563	Homo sapiens	82.95	0.00e+00	938.00
IUUC-Hvu-047790	Hordeum vulgare	38.62	2.00e-75	275.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	82.77	0.00e+00	935.00
IUUC-Kpa-049309	Komagataella pastoris	34.03	3.00e-77	282.00
IUUC-Lch-050038	Latimeria chalumnae	75.63	0.00e+00	828.00
IUUC-Lpe-051535	Leersia perrieri	39.68	4.00e-105	374.00
IUUC-Loc-051917	Lepisosteus oculatus	69.32	0.00e+00	768.00
IUUC-Lma-053112	Leptosphaeria maculans	35.32	9.00e-86	310.00
IUUC-Laf-053690	Loxodonta africana	83.40	0.00e+00	941.00
IUUC-Mcc-055117	Macaca mulatta	81.20	0.00e+00	918.00
IUUC-Meu-056761	Macropus eugenii	70.21	0.00e+00	748.00
IUUC-Mor-057230	Magnaporthe oryzae	32.55	1.00e-72	266.00
IUUC-Mpo-057514	Magnaporthe poae	31.93	1.00e-66	246.00
IUUC-Mtr-058551	Medicago truncatula	39.29	1.00e-113	403.00
IUUC-Mla-059183	Melampsora laricipopulina	35.77	3.00e-95	342.00
IUUC-Mvi-060221	Microbotryum violaceum	34.75	1.00e-78	286.00
IUUC-Mmr-061325	Microcebus murinus	82.49	0.00e+00	931.00
IUUC-Mdo-062532	Monodelphis domestica	83.78	0.00e+00	942.00
IUUC-Mmu-063956	Mus musculus	83.90	0.00e+00	946.00
IUUC-Mac-064521	Musa acuminata	39.35	9.00e-116	410.00
IUUC-Mpu-066716	Mustela putorius furo	81.65	0.00e+00	874.00
IUUC-Mlu-067459	Myotis lucifugus	82.10	0.00e+00	924.00
IUUC-Nfi-068245	Neosartorya fischeri	33.39	1.00e-77	283.00
IUUC-Ncr-068910	Neurospora crassa	31.10	8.00e-69	254.00
IUUC-Nle-070034	Nomascus leucogenys	83.43	0.00e+00	924.00
IUUC-Opr-070552	Ochotona princeps	75.56	0.00e+00	769.00
IUUC-Ont-071426	Oreochromis niloticus	70.99	0.00e+00	817.00
IUUC-Oan-073389	Ornithorhynchus anatinus	80.86	0.00e+00	750.00
IUUC-Ocu-074911	Oryctolagus cuniculus	82.58	0.00e+00	937.00
IUUC-Oba-075437	Oryza barthii	41.07	5.00e-111	394.00
IUUC-Obr-076684	Oryza brachyantha	40.88	3.00e-106	378.00
IUUC-Ogl-077170	Oryza glaberrima	41.07	5.00e-111	394.00
IUUC-Ogu-078844	Oryza glumaepatula	41.97	6.00e-105	374.00
IUUC-Oin-079105	Oryza indica	41.07	2.00e-110	392.00
IUUC-Olo-080943	Oryza longistaminata	38.46	2.00e-99	355.00
IUUC-Oni-082891	Oryza nivara	38.00	5.00e-104	370.00
IUUC-Opu-083457	Oryza punctata	41.07	2.00e-110	392.00
IUUC-Oru-084960	Oryza rufipogon	38.46	2.00e-99	355.00
IUUC-Osa-085358	Oryza sativa	41.27	4.00e-111	394.00
IUUC-Ola-086420	Oryzias latipes	71.31	9.00e-168	582.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.66	5.00e-60	224.00
IUUC-Oga-088810	Otolemur garnettii	82.39	0.00e+00	937.00
IUUC-Oar-089196	Ovis aries	82.86	0.00e+00	937.00
IUUC-Ptr-090617	Pan troglodytes	83.14	0.00e+00	939.00
IUUC-Pan-092761	Papio anubis	82.95	0.00e+00	939.00
IUUC-Psi-093191	Pelodiscus sinensis	88.01	0.00e+00	969.00
IUUC-Pma-094380	Petromyzon marinus	61.10	0.00e+00	645.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.18	8.00e-68	252.00
IUUC-Ppa-095875	Physcomitrella patens	40.08	1.00e-116	412.00
IUUC-Pfo-096467	Poecilia formosa	70.21	0.00e+00	798.00
IUUC-Pab-098255	Pongo abelii	81.51	0.00e+00	767.00
IUUC-Pop-099871	Populus trichocarpa	39.81	2.00e-119	422.00
IUUC-Pca-100807	Procavia capensis	70.57	3.00e-106	378.00
IUUC-Ppe-101280	Prunus persica	38.62	3.00e-116	411.00
IUUC-Pva-102333	Pteropus vampyrus	79.47	0.00e+00	883.00
IUUC-Pgr-103401	Puccinia graminis	30.97	3.00e-79	288.00
IUUC-Ptt-103889	Puccinia triticina	27.67	3.00e-59	222.00
IUUC-Pte-104355	Pyrenophora teres	34.53	6.00e-85	307.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	34.77	8.00e-86	310.00
IUUC-Rno-105810	Rattus norvegicus	83.52	0.00e+00	941.00
IUUC-Sce-106397	Saccharomyces cerevisiae	24.73	2.00e-31	129.00
IUUC-Sha-106770	Sarcophilus harrisii	82.66	2.00e-137	480.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.40	5.00e-72	265.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.35	2.00e-79	289.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.04	6.00e-64	238.00
IUUC-Smo-109296	Selaginella moellendorffii	41.57	9.00e-120	423.00
IUUC-Sit-110157	Setaria italica	42.99	3.00e-127	448.00
IUUC-Sly-111105	Solanum lycopersicum	39.07	8.00e-119	420.00
IUUC-Stu-112469	Solanum tuberosum	39.25	1.00e-119	423.00
IUUC-Sar-113083	Sorex araneus	63.37	0.00e+00	666.00
IUUC-Sbi-113813	Sorghum bicolor	42.42	7.00e-125	440.00
IUUC-Sre-115058	Sporisorium reilianum	38.05	7.00e-82	297.00
IUUC-Tgu-116772	Taeniopygia guttata	86.42	0.00e+00	930.00
IUUC-Tru-118686	Takifugu rubripes	70.42	0.00e+00	813.00
IUUC-Tsy-119111	Tarsius syrichta	75.81	8.00e-124	436.00
IUUC-Tni-120231	Tetraodon nigroviridis	69.09	0.00e+00	737.00
IUUC-Tca-121491	Theobroma cacao	38.81	3.00e-112	398.00
IUUC-Tre-122103	Trichoderma reesei	34.07	3.00e-75	275.00
IUUC-Tvi-122672	Trichoderma virens	34.57	1.00e-71	263.00
IUUC-Tae-125679	Triticum aestivum	42.45	3.00e-122	431.00
IUUC-Tur-126487	Triticum urartu	41.79	9.00e-119	420.00
IUUC-Tme-127097	Tuber melanosporum	35.24	1.00e-84	306.00
IUUC-Ttr-128465	Tursiops truncatus	77.59	0.00e+00	867.00
IUUC-Uma-129645	Ustilago maydis	33.67	5.00e-89	321.00
IUUC-Vda-129989	Verticillium dahliae	29.26	1.00e-51	196.00
IUUC-Vpa-130529	Vicugna pacos	79.28	0.00e+00	891.00
IUUC-Vvi-131059	Vitis vinifera	39.77	4.00e-117	414.00
IUUC-Xtr-132002	Xenopus tropicalis	74.81	0.00e+00	849.00
IUUC-Xma-133930	Xiphophorus maculatus	70.80	0.00e+00	805.00
IUUC-Yli-134505	Yarrowia lipolytica	33.14	1.00e-80	293.00
IUUC-Zma-135895	Zea mays	42.03	9.00e-124	436.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence