iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088810

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AAQR03153147

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000014645.2	ENSOGAT00000014657.2	ENSOGAP00000013129.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.40e-131	438.7	13	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ ++ +++F++++ ++gk++A++a+e+l+eln dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNHVSGEDAGNNFFLQRNSIGKNRAQAAMEFLQELNNDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           ++++ees+++l ++++ Ff++f++Vv+++ ++++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++Pf+
   Q: 102  GSFVEESPENLLDNDPsFFCRFTIVVATQLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHFQsydldrmekKDHSHTPWIVIIAKYLAQWYSETNGRTPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALNTT 279
           *****99999999998***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk++++fw+                                                              
   Q: 280  QIPSsIEDIFNDDRCINITKQTPSFWIlaralkefvskegqgylpvrgtipdmiadsskyiklqnvyrekakkdvaavgnhvskllqsi 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +csn++ l+v             +v+kde+++++++p     lyl+lra++rf+k++gr+pg +++++++d+  +
   Q: 369  gkapesisekelkLLCSNSAFLRVVrcrslaeeyglNTVNKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGISNYQVEEDIgkL 457
           *************99********777777777788899999999999999999999*****************************8888 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++  ++    +++g++ +++dd+i+e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  KSCLSGFL----QEYGLSVMVKDDYIHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           88888888....********************************************************9776 PP

Organism

Otolemur garnettii

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNHVSGEDA GNNFFLQRNS IGKNRAQAAM EFLQELNNDV SGSFVEESPE NLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCGCTTG CGCGCATGTG GAGCCTGTGG CGGCGCTCGG TAGGGGCTCT GGTGTTCTCC 60
GCGCGGCCGG CGCAGCCATG GCGCAGCCGG GGAAGCTGCT TAAGGAGCAG AAGTATGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.72	4.00e-126	444.00
IUUC-Aml-002333	Ailuropoda melanoleuca	96.27	0.00e+00	1078.00
IUUC-Atr-002644	Amborella trichopoda	41.73	1.00e-115	410.00
IUUC-Apl-003446	Anas platyrhynchos	83.62	0.00e+00	917.00
IUUC-Aca-004450	Anolis carolinensis	79.92	0.00e+00	915.00
IUUC-Aly-006187	Arabidopsis lyrata	40.19	8.00e-126	443.00
IUUC-Ath-007600	Arabidopsis thaliana	40.75	5.00e-127	447.00
IUUC-Ago-007900	Ashbya gossypii	26.42	3.00e-40	159.00
IUUC-Acl-008333	Aspergillus clavatus	34.53	1.00e-82	300.00
IUUC-Afl-008529	Aspergillus flavus	36.15	6.00e-88	318.00
IUUC-Afu-009071	Aspergillus fumigatus	33.51	8.00e-82	297.00
IUUC-Ani-009443	Aspergillus nidulans	33.39	2.00e-79	289.00
IUUC-Ang-009669	Aspergillus niger	33.51	2.00e-83	302.00
IUUC-Aor-009914	Aspergillus oryzae	35.47	9.00e-85	307.00
IUUC-Ate-010450	Aspergillus terreus	34.76	4.00e-85	308.00
IUUC-Ame-011183	Astyanax mexicanus	71.64	0.00e+00	827.00
IUUC-Bgr-012111	Blumeria graminis	33.64	2.00e-67	249.00
IUUC-Bta-012583	Bos taurus	96.07	0.00e+00	1078.00
IUUC-Bci-013892	Botrytis cinerea	32.97	6.00e-67	248.00
IUUC-Bdi-014592	Brachypodium distachyon	43.13	4.00e-128	451.00
IUUC-Bol-016399	Brassica oleracea	40.65	1.00e-124	439.00
IUUC-Bra-017506	Brassica rapa	38.99	1.00e-120	426.00
IUUC-Cel-018456	Caenorhabditis elegans	35.79	5.00e-94	338.00
IUUC-Cja-020007	Callithrix jacchus	95.53	0.00e+00	1075.00
IUUC-Cfa-020324	Canis familiaris	97.19	0.00e+00	1089.00
IUUC-Cpo-022248	Cavia porcellus	65.30	0.00e+00	635.00
IUUC-Csa-023149	Chlorocebus sabaeus	92.83	0.00e+00	917.00
IUUC-Cho-024537	Choloepus hoffmanni	84.16	0.00e+00	798.00
IUUC-Cin-025763	Ciona intestinalis	49.15	6.00e-156	543.00
IUUC-Csv-026113	Ciona savignyi	46.11	2.00e-147	516.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.58	4.00e-65	242.00
IUUC-Cne-026884	Cryptococcus neoformans	30.07	2.00e-72	266.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.11	6.00e-19	89.40
IUUC-Dre-028140	Danio rerio	72.66	0.00e+00	845.00
IUUC-Dno-030033	Dasypus novemcinctus	95.98	0.00e+00	951.00
IUUC-Dor-030513	Dipodomys ordii	67.09	2.00e-112	399.00
IUUC-Dse-031536	Dothistroma septosporum	34.94	8.00e-86	311.00
IUUC-Dme-031683	Drosophila melanogaster	44.51	1.00e-127	449.00
IUUC-Ete-032420	Echinops telfairi	81.59	0.00e+00	875.00
IUUC-Eca-033992	Equus caballus	96.40	0.00e+00	904.00
IUUC-Eeu-034713	Erinaceus europaeus	77.95	4.00e-115	408.00
IUUC-Fca-036548	Felis catus	95.32	0.00e+00	1069.00
IUUC-Fal-037600	Ficedula albicollis	80.27	0.00e+00	885.00
IUUC-Fox-038037	Fusarium oxysporum	33.88	7.00e-77	281.00
IUUC-Fso-038387	Fusarium solani	35.34	3.00e-79	288.00
IUUC-Gmo-038562	Gadus morhua	71.78	0.00e+00	826.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.59	7.00e-75	274.00
IUUC-Gga-041129	Gallus gallus	84.11	0.00e+00	943.00
IUUC-Gac-042558	Gasterosteus aculeatus	73.07	0.00e+00	836.00
IUUC-Gma-043610	Glycine max	41.34	3.00e-121	428.00
IUUC-Ggo-045611	Gorilla gorilla	95.53	0.00e+00	1071.00
IUUC-Hsa-046563	Homo sapiens	96.07	0.00e+00	1077.00
IUUC-Hvu-047790	Hordeum vulgare	38.11	3.00e-76	278.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	95.88	0.00e+00	1076.00
IUUC-Kpa-049309	Komagataella pastoris	35.86	2.00e-84	306.00
IUUC-Lch-050038	Latimeria chalumnae	75.47	0.00e+00	846.00
IUUC-Lpe-051535	Leersia perrieri	41.65	9.00e-112	397.00
IUUC-Loc-051917	Lepisosteus oculatus	69.37	0.00e+00	792.00
IUUC-Lma-053112	Leptosphaeria maculans	34.76	2.00e-88	319.00
IUUC-Laf-053690	Loxodonta africana	94.94	0.00e+00	1071.00
IUUC-Mcc-055117	Macaca mulatta	94.42	0.00e+00	1060.00
IUUC-Meu-056761	Macropus eugenii	74.95	0.00e+00	813.00
IUUC-Mor-057230	Magnaporthe oryzae	34.30	5.00e-79	288.00
IUUC-Mpo-057514	Magnaporthe poae	34.18	1.00e-72	267.00
IUUC-Mtr-058551	Medicago truncatula	40.14	1.00e-117	416.00
IUUC-Mla-059183	Melampsora laricipopulina	37.16	3.00e-97	348.00
IUUC-Mga-060144	Meleagris gallopavo	82.39	0.00e+00	913.00
IUUC-Mvi-060221	Microbotryum violaceum	36.18	2.00e-84	306.00
IUUC-Mmr-061325	Microcebus murinus	93.30	0.00e+00	1050.00
IUUC-Mdo-062532	Monodelphis domestica	89.49	0.00e+00	1009.00
IUUC-Mmu-063956	Mus musculus	95.69	0.00e+00	1073.00
IUUC-Mac-064521	Musa acuminata	40.93	1.00e-123	436.00
IUUC-Mpu-066716	Mustela putorius furo	95.82	0.00e+00	1015.00
IUUC-Mlu-067459	Myotis lucifugus	94.40	0.00e+00	1054.00
IUUC-Nfi-068245	Neosartorya fischeri	34.05	1.00e-82	300.00
IUUC-Ncr-068910	Neurospora crassa	34.18	6.00e-77	281.00
IUUC-Nle-070034	Nomascus leucogenys	93.33	0.00e+00	1026.00
IUUC-Opr-070552	Ochotona princeps	85.23	0.00e+00	870.00
IUUC-Ont-071426	Oreochromis niloticus	73.53	0.00e+00	853.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.82	0.00e+00	776.00
IUUC-Ocu-074911	Oryctolagus cuniculus	94.94	0.00e+00	1070.00
IUUC-Oba-075437	Oryza barthii	43.13	9.00e-119	420.00
IUUC-Obr-076684	Oryza brachyantha	43.13	4.00e-114	405.00
IUUC-Ogl-077170	Oryza glaberrima	43.13	9.00e-119	420.00
IUUC-Ogu-078844	Oryza glumaepatula	43.91	4.00e-112	398.00
IUUC-Oin-079105	Oryza indica	43.13	3.00e-118	418.00
IUUC-Olo-080943	Oryza longistaminata	40.64	1.00e-106	380.00
IUUC-Oni-082891	Oryza nivara	40.27	4.00e-112	398.00
IUUC-Opu-083457	Oryza punctata	43.13	4.00e-118	418.00
IUUC-Oru-084960	Oryza rufipogon	40.64	1.00e-106	379.00
IUUC-Osa-085358	Oryza sativa	43.32	8.00e-119	420.00
IUUC-Ola-086420	Oryzias latipes	71.31	1.00e-167	582.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.06	4.00e-62	232.00
IUUC-Oar-089196	Ovis aries	95.90	0.00e+00	1075.00
IUUC-Ptr-090617	Pan troglodytes	96.25	0.00e+00	1078.00
IUUC-Pan-092761	Papio anubis	96.25	0.00e+00	1082.00
IUUC-Psi-093191	Pelodiscus sinensis	86.07	0.00e+00	956.00
IUUC-Pma-094380	Petromyzon marinus	61.05	0.00e+00	662.00
IUUC-Pno-095084	Phaeosphaeria nodorum	33.03	1.00e-75	278.00
IUUC-Ppa-095875	Physcomitrella patens	39.81	2.00e-119	422.00
IUUC-Pfo-096467	Poecilia formosa	72.78	0.00e+00	833.00
IUUC-Pab-098255	Pongo abelii	95.95	0.00e+00	897.00
IUUC-Pop-099722	Populus trichocarpa	40.93	5.00e-125	441.00
IUUC-Pca-100807	Procavia capensis	78.49	4.00e-118	417.00
IUUC-Ppe-101280	Prunus persica	40.60	3.00e-124	438.00
IUUC-Pva-102333	Pteropus vampyrus	91.25	0.00e+00	1013.00
IUUC-Pgr-103401	Puccinia graminis	31.79	9.00e-81	294.00
IUUC-Ptt-103889	Puccinia triticina	27.85	3.00e-58	219.00
IUUC-Pte-104355	Pyrenophora teres	35.59	2.00e-91	330.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	36.36	2.00e-92	333.00
IUUC-Rno-105810	Rattus norvegicus	95.32	0.00e+00	1068.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.02	2.00e-37	150.00
IUUC-Sha-106770	Sarcophilus harrisii	89.05	3.00e-153	533.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.27	1.00e-78	287.00
IUUC-Spo-108276	Schizosaccharomyces pombe	35.27	2.00e-86	312.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.96	1.00e-68	253.00
IUUC-Smo-109296	Selaginella moellendorffii	42.61	7.00e-125	440.00
IUUC-Sit-110157	Setaria italica	44.78	7.00e-136	477.00
IUUC-Sly-111105	Solanum lycopersicum	39.75	7.00e-122	431.00
IUUC-Stu-112469	Solanum tuberosum	39.75	5.00e-124	437.00
IUUC-Sar-113083	Sorex araneus	72.48	0.00e+00	744.00
IUUC-Sbi-113813	Sorghum bicolor	44.40	8.00e-135	473.00
IUUC-Sre-115058	Sporisorium reilianum	38.89	2.00e-85	310.00
IUUC-Tgu-116772	Taeniopygia guttata	80.08	0.00e+00	887.00
IUUC-Tru-118686	Takifugu rubripes	71.64	0.00e+00	833.00
IUUC-Tsy-119111	Tarsius syrichta	89.05	5.00e-149	521.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.42	0.00e+00	752.00
IUUC-Tca-121491	Theobroma cacao	40.60	2.00e-117	416.00
IUUC-Tre-122103	Trichoderma reesei	36.40	6.00e-82	298.00
IUUC-Tvi-122672	Trichoderma virens	37.20	2.00e-76	280.00
IUUC-Tae-125316	Triticum aestivum	43.32	4.00e-128	451.00
IUUC-Tur-126487	Triticum urartu	41.98	9.00e-122	430.00
IUUC-Tme-127097	Tuber melanosporum	38.43	3.00e-95	342.00
IUUC-Ttr-128465	Tursiops truncatus	89.20	0.00e+00	990.00
IUUC-Uma-129645	Ustilago maydis	37.61	8.00e-85	307.00
IUUC-Vda-129989	Verticillium dahliae	30.91	4.00e-57	215.00
IUUC-Vpa-130529	Vicugna pacos	91.62	0.00e+00	1022.00
IUUC-Vvi-131059	Vitis vinifera	41.34	8.00e-123	434.00
IUUC-Xtr-132002	Xenopus tropicalis	79.13	0.00e+00	904.00
IUUC-Xma-133930	Xiphophorus maculatus	73.38	0.00e+00	839.00
IUUC-Yli-134505	Yarrowia lipolytica	34.67	1.00e-85	310.00
IUUC-Zma-135895	Zea mays	45.04	2.00e-134	472.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence