iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071426

Ensembl Protein ID

ENSONIP00000003837.1

UniProt Accession

I3J4P7; I3J4P7_ORENI

Genbank Protein ID

ENSONIP00000003837

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AERX01013865

Gene Name

nae1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000003065.1	ENSONIT00000003838.1	ENSONIP00000003837.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	7.90e-120	401.2	12	524

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe l++a+v+l++a+++G+E+lKnLvl G+g +t+vD++tv+ ++ +++F+++++++gk++A++a e+l+eln+dv+
   Q: 12   YDRQLRLWGDHGQETLENAHVCLINATATGTEILKNLVLPGIGAFTIVDGHTVTGEDAGNNFFLSKDSIGKNRAQAATEHLQELNSDVS 100
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           + ++ee +++l +++  Ff +f++V+  + ++++ +++ +++++a+vp++ ++t+Gl+G++r +++++t+++s++d   +++++++P  
   Q: 101  GNFVEEGPDKLLDNDSeFFHRFTIVIGVQLPESTCLRLGSVLWSASVPFLVCKTYGLIGYMRLVVQEHTVIESHPDnalEDLRLDQPYA 189
           **************999************************************************************************ PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           ++++++          +++++++w+ +++k+le++ +e++++++++++eke++++++++++++      edeenfeeai+++++a+++t
   Q: 190  EFQNHIKsydldsmekKDHSHTPWIIIVAKYLEKWLSEHNGQPPKNYKEKEAFRQLIREGIRKnengvpEDEENFEEAIKNVNTALNPT 278
           *****77777777777************************************************************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
            i+s +++l++s +c+++t +++ fwv                                                              
   Q: 279  KIPSaVEDLFNSEQCKNITAQSPCFWVmlravkefvhnegngslpvrgtipdmiadsqkfinlqnvyrekamqdaaavskhvesllqsv 367
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavd 334
                         fc+na+ l+v            ++v+kde+++ +++p     +yl+lra++rf ++++r+pg+ ++++++d + +
   Q: 368  gkpaesipekdikLFCKNASFLRVVrcrslaeeysvDTVNKDEITSCMDSPdsemvFYLMLRAVDRFYQQHSRYPGVYNYQVEED-ISK 455
           ***********************6666666666666999999999999999999*******************************.888 PP
   S: 335  lvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           l++ + +l  ++++++ +++dd+i+e++++++++ +t++a++gG aaqE+iK++s++f+p++n+f+++a+
   Q: 456  LKACVNSLL-QEYSLNVNIKDDYIHEFCRYGAAEPHTVSAFLGGSAAQEAIKIISHQFVPFNNTFIYNAM 524
           888777777.*********************************************************997 PP

Organism

Oreochromis niloticus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MASTKASKEQ KYDRQLRLWG DHGQETLENA HVCLINATAT GTEILKNLVL PGIGAFTIVD 60
GHTVTGEDAG NNFFLSKDSI GKNRAQAATE HLQELNSDVS GNFVEEGPDK LLDNDSEFFH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTACATCTAA ACAGACAAAT AAATTAAAAT CCCTAAAAAC TACCCGAAAT CAAATGAAAA 60
AAAAAATACA GAAAATAGTG AGAAGAAAAA GATAAAAGAC GGTCTGCTGA ATATGCACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	41.24	6.00e-123	434.00
IUUC-Aml-002333	Ailuropoda melanoleuca	73.45	0.00e+00	852.00
IUUC-Atr-002644	Amborella trichopoda	39.36	4.00e-111	395.00
IUUC-Apl-003446	Anas platyrhynchos	72.25	0.00e+00	806.00
IUUC-Aca-004450	Anolis carolinensis	71.48	0.00e+00	823.00
IUUC-Aly-006187	Arabidopsis lyrata	40.64	2.00e-126	445.00
IUUC-Ath-006692	Arabidopsis thaliana	40.60	8.00e-127	447.00
IUUC-Ago-007900	Ashbya gossypii	26.74	5.00e-42	165.00
IUUC-Acl-008333	Aspergillus clavatus	35.50	3.00e-85	309.00
IUUC-Afl-008529	Aspergillus flavus	36.23	1.00e-88	320.00
IUUC-Afu-009071	Aspergillus fumigatus	35.24	1.00e-85	310.00
IUUC-Ani-009443	Aspergillus nidulans	34.48	1.00e-79	291.00
IUUC-Ang-009669	Aspergillus niger	33.69	6.00e-84	305.00
IUUC-Aor-009914	Aspergillus oryzae	36.38	2.00e-87	317.00
IUUC-Ate-010450	Aspergillus terreus	34.41	3.00e-86	312.00
IUUC-Ame-011183	Astyanax mexicanus	82.55	0.00e+00	957.00
IUUC-Bgr-012111	Blumeria graminis	30.84	1.00e-61	231.00
IUUC-Bta-012583	Bos taurus	73.91	0.00e+00	855.00
IUUC-Bci-013892	Botrytis cinerea	33.27	3.00e-66	246.00
IUUC-Bdi-014592	Brachypodium distachyon	42.02	1.00e-126	446.00
IUUC-Bol-016399	Brassica oleracea	40.84	5.00e-126	444.00
IUUC-Bra-017506	Brassica rapa	39.85	3.00e-121	429.00
IUUC-Cel-018456	Caenorhabditis elegans	35.42	4.00e-95	342.00
IUUC-Cja-020007	Callithrix jacchus	72.93	0.00e+00	846.00
IUUC-Cfa-020324	Canis familiaris	73.53	0.00e+00	853.00
IUUC-Cpo-022248	Cavia porcellus	50.19	2.00e-137	482.00
IUUC-Csa-023149	Chlorocebus sabaeus	71.68	0.00e+00	714.00
IUUC-Cho-024537	Choloepus hoffmanni	61.82	1.00e-175	609.00
IUUC-Cin-025763	Ciona intestinalis	48.21	1.00e-154	539.00
IUUC-Csv-026113	Ciona savignyi	45.02	6.00e-144	504.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	33.04	5.00e-71	261.00
IUUC-Cne-026884	Cryptococcus neoformans	29.37	1.00e-72	267.00
IUUC-Cme-027210	Cyanidioschyzon merolae	24.89	4.00e-18	86.70
IUUC-Dre-028140	Danio rerio	83.68	0.00e+00	959.00
IUUC-Dno-030033	Dasypus novemcinctus	73.02	0.00e+00	744.00
IUUC-Dor-030513	Dipodomys ordii	51.75	1.00e-86	313.00
IUUC-Dse-031536	Dothistroma septosporum	32.21	2.00e-80	293.00
IUUC-Dme-031683	Drosophila melanogaster	42.62	2.00e-125	442.00
IUUC-Ete-032420	Echinops telfairi	62.60	0.00e+00	687.00
IUUC-Eca-033992	Equus caballus	71.85	0.00e+00	699.00
IUUC-Eeu-034713	Erinaceus europaeus	59.06	3.00e-89	322.00
IUUC-Fca-036548	Felis catus	72.40	0.00e+00	839.00
IUUC-Fal-037600	Ficedula albicollis	70.69	0.00e+00	788.00
IUUC-Fox-038037	Fusarium oxysporum	32.54	4.00e-72	265.00
IUUC-Fso-038387	Fusarium solani	34.12	3.00e-74	272.00
IUUC-Gmo-038562	Gadus morhua	83.74	0.00e+00	956.00
IUUC-Ggr-040005	Gaeumannomyces graminis	35.12	1.00e-74	273.00
IUUC-Gga-041129	Gallus gallus	72.05	0.00e+00	815.00
IUUC-Gac-042558	Gasterosteus aculeatus	88.60	0.00e+00	993.00
IUUC-Gma-043610	Glycine max	38.79	1.00e-116	413.00
IUUC-Ggo-045611	Gorilla gorilla	72.93	0.00e+00	848.00
IUUC-Hsa-046563	Homo sapiens	73.16	0.00e+00	851.00
IUUC-Hvu-047790	Hordeum vulgare	38.29	6.00e-80	291.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	73.35	0.00e+00	845.00
IUUC-Kpa-049309	Komagataella pastoris	33.21	1.00e-78	287.00
IUUC-Lch-050038	Latimeria chalumnae	73.78	0.00e+00	848.00
IUUC-Lpe-051535	Leersia perrieri	40.44	3.00e-109	388.00
IUUC-Loc-051917	Lepisosteus oculatus	77.08	0.00e+00	862.00
IUUC-Lma-053112	Leptosphaeria maculans	34.77	8.00e-87	314.00
IUUC-Laf-053690	Loxodonta africana	73.35	0.00e+00	853.00
IUUC-Mcc-055117	Macaca mulatta	71.67	0.00e+00	832.00
IUUC-Meu-056761	Macropus eugenii	61.28	0.00e+00	676.00
IUUC-Mor-057230	Magnaporthe oryzae	34.55	1.00e-78	287.00
IUUC-Mpo-057514	Magnaporthe poae	34.62	9.00e-74	271.00
IUUC-Mtr-058551	Medicago truncatula	38.39	5.00e-116	411.00
IUUC-Mla-059183	Melampsora laricipopulina	35.20	5.00e-100	358.00
IUUC-Mga-060144	Meleagris gallopavo	70.99	0.00e+00	797.00
IUUC-Mvi-060221	Microbotryum violaceum	33.21	2.00e-79	290.00
IUUC-Mmr-061325	Microcebus murinus	71.24	0.00e+00	826.00
IUUC-Mdo-062532	Monodelphis domestica	75.05	0.00e+00	863.00
IUUC-Mmu-063956	Mus musculus	73.91	0.00e+00	854.00
IUUC-Mac-064521	Musa acuminata	39.11	8.00e-119	421.00
IUUC-Mpu-066716	Mustela putorius furo	72.84	0.00e+00	799.00
IUUC-Mlu-067459	Myotis lucifugus	72.59	0.00e+00	842.00
IUUC-Nfi-068245	Neosartorya fischeri	35.06	2.00e-85	310.00
IUUC-Ncr-068910	Neurospora crassa	33.52	2.00e-73	270.00
IUUC-Nle-070034	Nomascus leucogenys	70.86	0.00e+00	815.00
IUUC-Opr-070552	Ochotona princeps	68.55	0.00e+00	704.00
IUUC-Oan-073389	Ornithorhynchus anatinus	70.50	0.00e+00	662.00
IUUC-Ocu-074911	Oryctolagus cuniculus	73.35	0.00e+00	850.00
IUUC-Oba-075437	Oryza barthii	41.22	6.00e-116	411.00
IUUC-Obr-076684	Oryza brachyantha	41.60	7.00e-111	394.00
IUUC-Ogl-077170	Oryza glaberrima	41.22	6.00e-116	411.00
IUUC-Ogu-078844	Oryza glumaepatula	41.43	8.00e-108	384.00
IUUC-Oin-079105	Oryza indica	41.22	2.00e-115	409.00
IUUC-Olo-080943	Oryza longistaminata	38.68	5.00e-103	368.00
IUUC-Oni-082891	Oryza nivara	38.36	3.00e-109	389.00
IUUC-Opu-083457	Oryza punctata	41.22	7.00e-115	407.00
IUUC-Oru-084960	Oryza rufipogon	38.51	3.00e-104	372.00
IUUC-Osa-085358	Oryza sativa	41.41	4.00e-116	411.00
IUUC-Ola-086420	Oryzias latipes	90.08	0.00e+00	703.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.40	2.00e-66	246.00
IUUC-Oga-088810	Otolemur garnettii	73.53	0.00e+00	853.00
IUUC-Oar-089196	Ovis aries	73.68	0.00e+00	850.00
IUUC-Ptr-090617	Pan troglodytes	73.35	0.00e+00	853.00
IUUC-Pan-092761	Papio anubis	73.35	0.00e+00	852.00
IUUC-Psi-093191	Pelodiscus sinensis	72.34	0.00e+00	828.00
IUUC-Pma-094380	Petromyzon marinus	62.68	0.00e+00	670.00
IUUC-Pno-095084	Phaeosphaeria nodorum	34.36	3.00e-76	280.00
IUUC-Ppa-095875	Physcomitrella patens	40.45	5.00e-121	427.00
IUUC-Pfo-096467	Poecilia formosa	90.49	0.00e+00	1015.00
IUUC-Pab-098255	Pongo abelii	72.89	0.00e+00	707.00
IUUC-Pop-099722	Populus trichocarpa	40.45	2.00e-123	436.00
IUUC-Pca-100807	Procavia capensis	61.89	3.00e-94	338.00
IUUC-Ppe-101280	Prunus persica	39.36	1.00e-121	430.00
IUUC-Pva-102333	Pteropus vampyrus	71.05	0.00e+00	806.00
IUUC-Pgr-103401	Puccinia graminis	30.18	2.00e-78	286.00
IUUC-Ptt-103889	Puccinia triticina	26.13	2.00e-56	213.00
IUUC-Pte-104355	Pyrenophora teres	35.55	6.00e-87	315.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.19	1.00e-87	317.00
IUUC-Rno-105810	Rattus norvegicus	73.53	0.00e+00	843.00
IUUC-Sce-106397	Saccharomyces cerevisiae	25.51	7.00e-35	141.00
IUUC-Sha-106770	Sarcophilus harrisii	76.62	8.00e-131	459.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	34.17	1.00e-79	290.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.90	5.00e-82	298.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	34.13	3.00e-70	259.00
IUUC-Smo-109296	Selaginella moellendorffii	41.02	2.00e-119	422.00
IUUC-Sit-110157	Setaria italica	42.40	3.00e-130	458.00
IUUC-Sly-111105	Solanum lycopersicum	38.67	1.00e-119	423.00
IUUC-Stu-112469	Solanum tuberosum	38.86	2.00e-120	426.00
IUUC-Sar-113083	Sorex araneus	55.23	2.00e-171	595.00
IUUC-Sbi-113813	Sorghum bicolor	42.16	3.00e-128	452.00
IUUC-Sre-115058	Sporisorium reilianum	36.67	4.00e-78	286.00
IUUC-Tgu-116772	Taeniopygia guttata	70.59	0.00e+00	794.00
IUUC-Tru-118686	Takifugu rubripes	88.56	0.00e+00	1006.00
IUUC-Tsy-119111	Tarsius syrichta	70.14	7.00e-116	410.00
IUUC-Tni-120231	Tetraodon nigroviridis	80.78	0.00e+00	900.00
IUUC-Tca-121491	Theobroma cacao	39.17	5.00e-116	411.00
IUUC-Tre-122103	Trichoderma reesei	34.57	2.00e-79	290.00
IUUC-Tvi-122672	Trichoderma virens	34.32	3.00e-74	272.00
IUUC-Tae-125950	Triticum aestivum	42.21	2.00e-125	442.00
IUUC-Tur-126487	Triticum urartu	40.49	1.00e-118	420.00
IUUC-Tme-127097	Tuber melanosporum	37.32	1.00e-94	340.00
IUUC-Ttr-128465	Tursiops truncatus	68.80	0.00e+00	785.00
IUUC-Uma-129645	Ustilago maydis	32.61	3.00e-85	309.00
IUUC-Vda-129989	Verticillium dahliae	30.26	2.00e-55	209.00
IUUC-Vpa-130529	Vicugna pacos	70.30	0.00e+00	803.00
IUUC-Vvi-131059	Vitis vinifera	39.74	2.00e-120	426.00
IUUC-Xtr-132002	Xenopus tropicalis	71.48	0.00e+00	829.00
IUUC-Xma-133930	Xiphophorus maculatus	91.37	0.00e+00	1023.00
IUUC-Yli-134505	Yarrowia lipolytica	32.26	1.00e-83	303.00
IUUC-Zma-135895	Zea mays	42.21	9.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence