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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063848
Ensembl Protein ID ENSMUSP00000044535.7
UniProt Accession Q8K400; E9QLY8; Q80TM5; Q8K401; Q9D2F3; STXB5_MOUSE
Genbank Protein ID AAM61881.1; AAM61882.1; BAB31853.1; BAC65699.1
Protein Name Syntaxin-binding protein 5; Lethal(2) giant larvae protein homolog 3; Tomosyn-1
Genbank Nucleotide ID AF516607; AF516608; AK019788; AC122390
Gene Name Stxbp5; Kiaa4253; Llgl3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000019790.16 ENSMUST00000038213.13 ENSMUSP00000044535.7
ENSMUSG00000019790.16 ENSMUST00000141722.7 ENSMUSP00000123253.1
ENSMUSG00000019790.16 ENSMUST00000125200.7 ENSMUSP00000121507.1
ENSMUSG00000019790.16 ENSMUST00000136324.1 ENSMUSP00000123355.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.50e-13 51.4 240 270
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf.sd.tllvsGsdDgtikvWDlrtg 33
            ++++a+ ++ + ++++  Dgt+ +W++r+ 
   Q: 240  AIHSVAWhHEgKQFICSHSDGTLTIWNVRSP 270
           69*****977799***************986 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release (By similarity). Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane.
 Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release (By similarity). Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane.
Protein Sequence
(Fasta)
MRKFNIRKVL DGLTAGSSSA SQQQQQQQHP PGNREPEIQE TLQSEHFQLC KTVRHGFPYQ 60
PSALAFDPVQ KILAVGTQTG ALRLFGRPGV ECYCQHDSGA AVIQLQFLIN EGALVSALAD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063848|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGCGCGGA GACCGGCCCC GGGTGCCCGG GCCATGCGGG CCGGGCGGCT GCGCTGAACG 60
GAGGCCGAGC CCGGGACCTG CCGGGGGACT GCCGGGCTGC GGGCCATGGA TGCGGCGGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063848|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0268--Exocytosis
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR000664--Lethal2_giant
IPR013905--Lgl_C_dom
IPR013577--LLGL2
IPR001388--Synaptobrevin
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50892--V_SNARE
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08596--Lgl_C
PF08366--LLGL
PF00400--WD40
PRINTS

PR00962--LETHAL2GIANT
SMART

SM00320--WD40
Gene Ontology

GO:0005892--C:acetylcholine-gated channel complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030141--C:secretory granule
GO:0005096--F:GTPase activator activity
GO:0017137--F:Rab GTPase binding
GO:0019905--F:syntaxin binding
GO:0017075--F:syntaxin-1 binding
GO:0007409--P:axonogenesis
GO:0006887--P:exocytosis
GO:0045921--P:positive regulation of exocytosis
GO:0015031--P:protein transport
GO:0030193--P:regulation of blood coagulation
GO:0017157--P:regulation of exocytosis
GO:0010468--P:regulation of gene expression
GO:0050708--P:regulation of protein secretion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000919 Aegilops tauschii 21.44 1.00e-19 92.40
IUUC-Aml-001923 Ailuropoda melanoleuca 95.92 0.00e+00 2113.00
IUUC-Aca-004796 Anolis carolinensis 88.74 0.00e+00 1996.00
IUUC-Aly-005770 Arabidopsis lyrata 23.38 7.00e-22 100.00
IUUC-Ago-007756 Ashbya gossypii 23.76 1.00e-19 92.00
IUUC-Ame-010663 Astyanax mexicanus 78.55 0.00e+00 1748.00
IUUC-Bta-013413 Bos taurus 95.92 0.00e+00 2141.00
IUUC-Bci-013698 Botrytis cinerea 21.20 9.00e-14 72.80
IUUC-Cel-018519 Caenorhabditis elegans 38.57 2.00e-136 481.00
IUUC-Cja-018984 Callithrix jacchus 96.27 0.00e+00 2111.00
IUUC-Cfa-021212 Canis familiaris 96.01 0.00e+00 2108.00
IUUC-Cpo-021336 Cavia porcellus 91.67 0.00e+00 1865.00
IUUC-Csa-023249 Chlorocebus sabaeus 93.92 0.00e+00 2023.00
IUUC-Cin-025731 Ciona intestinalis 57.32 1.00e-87 315.00
IUUC-Csv-026036 Ciona savignyi 39.47 0.00e+00 712.00
IUUC-Cgl-026432 Colletotrichum gloeosporioides 23.47 6.00e-12 66.60
IUUC-Dre-027886 Danio rerio 78.87 0.00e+00 1744.00
IUUC-Dno-029866 Dasypus novemcinctus 88.29 0.00e+00 1940.00
IUUC-Dor-031024 Dipodomys ordii 89.55 0.00e+00 1874.00
IUUC-Dme-031607 Drosophila melanogaster 47.97 0.00e+00 659.00
IUUC-Ete-032893 Echinops telfairi 95.65 0.00e+00 1541.00
IUUC-Eeu-034491 Erinaceus europaeus 80.78 0.00e+00 1109.00
IUUC-Fca-036249 Felis catus 95.64 0.00e+00 2075.00
IUUC-Fal-036761 Ficedula albicollis 91.58 0.00e+00 2030.00
IUUC-Fox-037853 Fusarium oxysporum 22.92 3.00e-17 84.70
IUUC-Fso-038327 Fusarium solani 23.28 7.00e-16 79.70
IUUC-Gmo-039272 Gadus morhua 73.64 0.00e+00 1697.00
IUUC-Ggr-039723 Gaeumannomyces graminis 22.04 1.00e-15 79.00
IUUC-Gga-040415 Gallus gallus 89.58 0.00e+00 1972.00
IUUC-Gac-041699 Gasterosteus aculeatus 76.36 0.00e+00 1702.00
IUUC-Ggo-045391 Gorilla gorilla 96.96 0.00e+00 2092.00
IUUC-Hsa-045903 Homo sapiens 96.88 0.00e+00 2087.00
IUUC-Itr-048722 Ictidomys tridecemlineatus 85.74 0.00e+00 1734.00
IUUC-Loc-052677 Lepisosteus oculatus 78.48 0.00e+00 1820.00
IUUC-Mcc-055526 Macaca mulatta 96.88 0.00e+00 2086.00
IUUC-Mor-057129 Magnaporthe oryzae 21.90 4.00e-15 77.40
IUUC-Mpo-057585 Magnaporthe poae 22.97 2.00e-15 78.20
IUUC-Mtr-057936 Medicago truncatula 24.24 4.00e-19 90.50
IUUC-Mla-058927 Melampsora laricipopulina 21.31 2.00e-06 48.50
IUUC-Mga-059965 Meleagris gallopavo 91.39 0.00e+00 1895.00
IUUC-Mvi-060348 Microbotryum violaceum 22.83 1.00e-10 63.20
IUUC-Mmr-061246 Microcebus murinus 96.44 0.00e+00 2077.00
IUUC-Mdo-062626 Monodelphis domestica 93.86 0.00e+00 2068.00
IUUC-Mpu-066690 Mustela putorius furo 92.88 0.00e+00 1747.00
IUUC-Mlu-067504 Myotis lucifugus 88.34 0.00e+00 1961.00
IUUC-Ncr-068624 Neurospora crassa 22.27 2.00e-17 84.70
IUUC-Nle-069640 Nomascus leucogenys 96.53 0.00e+00 2079.00
IUUC-Opr-070681 Ochotona princeps 80.90 0.00e+00 1040.00
IUUC-Ont-071645 Oreochromis niloticus 77.08 0.00e+00 1717.00
IUUC-Oan-073020 Ornithorhynchus anatinus 91.24 0.00e+00 1683.00
IUUC-Ocu-074803 Oryctolagus cuniculus 96.40 0.00e+00 2088.00
IUUC-Oba-075180 Oryza barthii 21.48 8.00e-20 93.20
IUUC-Obr-076139 Oryza brachyantha 21.81 8.00e-18 86.70
IUUC-Ogl-077142 Oryza glaberrima 21.48 7.00e-20 93.20
IUUC-Ogu-079037 Oryza glumaepatula 21.43 2.00e-18 89.00
IUUC-Oin-079192 Oryza indica 21.42 3.00e-18 87.80
IUUC-Olo-080693 Oryza longistaminata 22.30 5.00e-16 80.10
IUUC-Ome-081753 Oryza meridionalis 25.70 1.00e-08 55.80
IUUC-Oni-082885 Oryza nivara 21.59 2.00e-19 91.30
IUUC-Osa-085916 Oryza sativa 21.42 2.00e-18 88.20
IUUC-Ola-087197 Oryzias latipes 72.76 0.00e+00 1514.00
IUUC-Oga-088333 Otolemur garnettii 92.08 0.00e+00 1995.00
IUUC-Oar-090222 Ovis aries 95.42 0.00e+00 2105.00
IUUC-Ptr-091012 Pan troglodytes 96.96 0.00e+00 2092.00
IUUC-Pan-091748 Papio anubis 95.84 0.00e+00 2073.00
IUUC-Psi-093405 Pelodiscus sinensis 89.37 0.00e+00 2011.00
IUUC-Pno-095147 Phaeosphaeria nodorum 22.96 4.00e-10 60.50
IUUC-Pfo-096143 Poecilia formosa 77.75 0.00e+00 1760.00
IUUC-Pab-098201 Pongo abelii 93.32 0.00e+00 1980.00
IUUC-Pop-099380 Populus trichocarpa 27.14 6.00e-17 83.60
IUUC-Pca-100605 Procavia capensis 90.12 0.00e+00 1543.00
IUUC-Ppe-101373 Prunus persica 27.38 5.00e-21 97.10
IUUC-Pva-102580 Pteropus vampyrus 90.62 0.00e+00 1941.00
IUUC-Rno-106102 Rattus norvegicus 98.26 0.00e+00 2151.00
IUUC-Sce-106140 Saccharomyces cerevisiae 23.44 3.00e-11 64.30
IUUC-Sit-110386 Setaria italica 22.77 6.00e-20 93.60
IUUC-Sar-113111 Sorex araneus 87.56 0.00e+00 1786.00
IUUC-Sbi-114175 Sorghum bicolor 22.24 2.00e-19 92.00
IUUC-Sre-115050 Sporisorium reilianum 22.18 8.00e-13 70.10
IUUC-Ssc-115307 Sus scrofa 93.14 0.00e+00 2051.00
IUUC-Tgu-116507 Taeniopygia guttata 91.58 0.00e+00 2036.00
IUUC-Tru-118038 Takifugu rubripes 72.32 0.00e+00 1630.00
IUUC-Tsy-119133 Tarsius syrichta 90.01 0.00e+00 1927.00
IUUC-Tni-120014 Tetraodon nigroviridis 75.84 0.00e+00 1711.00
IUUC-Tvi-122424 Trichoderma virens 23.91 1.00e-17 85.50
IUUC-Tae-125643 Triticum aestivum 21.40 1.00e-20 95.90
IUUC-Tbe-127510 Tupaia belangeri 91.49 0.00e+00 1319.00
IUUC-Ttr-128804 Tursiops truncatus 84.65 0.00e+00 1828.00
IUUC-Uma-129388 Ustilago maydis 21.48 2.00e-12 68.60
IUUC-Vda-129843 Verticillium dahliae 20.04 2.00e-13 72.00
IUUC-Vpa-130694 Vicugna pacos 87.41 0.00e+00 1863.00
IUUC-Vvi-131379 Vitis vinifera 23.58 7.00e-20 93.20
IUUC-Xtr-132160 Xenopus tropicalis 87.55 0.00e+00 1813.00
IUUC-Xma-133008 Xiphophorus maculatus 77.70 0.00e+00 1758.00
IUUC-Yli-134491 Yarrowia lipolytica 22.74 5.00e-16 80.50
Created Date 25-Jun-2017

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