iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034012

UUCD1 version

UUC-EqC-01028

Ensembl Protein ID

ENSECAP00000016951.1

UniProt Accession

F6UHT1; F6UHT1_HORSE

Protein Name

Uncharacterized protein

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000018624.1	ENSECAT00000020640.1	ENSECAP00000016951.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-113	380.0	302	922
ULD/UDP/UBQ/UBQ_Other	3.60e-18	65.4	143	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++ +v+pr+++++++++a++fsgy+
   Q: 302  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQ 390
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 391  QQDSQELLAFLLDGLHEDLNRVKKKPYLELKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
           ******************************8888..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 478  TLPLPLKKDRVMEvflvpadprcrptqyrvivplmgavsdlcealsrlsgiaaenmvvtdvynhrfhkifqmdeglnhimprddifvye 566
           ********99999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 567  tcstssdssecvtlpvyfrerksrtsstssgavlygqpllisvprhkltfeslyeavcerisryikqplpdesgglplepgacngsrgs 655
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 656  cegddeeemehqeegkehlsetegsgedelgsehsettqkikgqpcpkrlftfslvnsygtadinslaadgkllklnsrstlaidwdse 744
           ***************************************************************************************** PP
   S: 186  ...............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeq 243
                                           l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++ 
   Q: 745  trslyydeqeseayekhvsmlqpqkkkkmavALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY- 832
           ***********************************************************************************99885. PP
   S: 244  ksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkne.kgkWllfdDskVtevkeeevleetgsta 330
             r k+++ vefp + L++s+f+++ +    +++ Y+Liav +H+G ++ GHY+ay+kn+ +gkW++fdDs+V+  +ee++++   + a
   Q: 833  -WRDKLDTVVEFPVRgLNMSEFVCDLSA---RPYVYDLIAVSNHYGAMGVGHYTAYAKNKlNGKWYYFDDSNVSLASEEQIVT---KAA 914
           .567******************999443...49**************************52666*******************...*** PP
   S: 331  YvlfYkrr 338
           YvlfY+rr
   Q: 915  YVLFYQRR 922
           ******96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 221
           78999999**************************888*****9999977444.46********************99986 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MAEGGGCCER PDAETQKSEL GALMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 60
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLLNWYGC VEGQQPIVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAG GCGGAGGCTG CTGTGAGCGA CCGGATGCAG AGACCCAGAA ATCCGAGCTC 60
GGGGCCTTGA TGAGGACCAC GCTCCAACGA GGGGCGCAGT GGTGAGCGCC GAGCCCGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ecb:100053443

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	94.19	0.00e+00	1685.00
IUUC-Atr-002991	Amborella trichopoda	35.12	2.00e-142	499.00
IUUC-Apl-004068	Anas platyrhynchos	71.27	0.00e+00	1214.00
IUUC-Aca-004459	Anolis carolinensis	69.00	0.00e+00	1236.00
IUUC-Ath-007343	Arabidopsis thaliana	36.38	9.00e-151	527.00
IUUC-Ago-007911	Ashbya gossypii	38.66	7.00e-63	236.00
IUUC-Ang-009562	Aspergillus niger	43.82	2.00e-54	208.00
IUUC-Bta-012929	Bos taurus	94.40	0.00e+00	1743.00
IUUC-Bdi-014013	Brachypodium distachyon	36.65	1.00e-151	530.00
IUUC-Bol-016335	Brassica oleracea	34.98	1.00e-133	470.00
IUUC-Bra-016930	Brassica rapa	35.09	3.00e-131	462.00
IUUC-Cel-018203	Caenorhabditis elegans	56.22	7.00e-70	258.00
IUUC-Cja-018798	Callithrix jacchus	93.26	0.00e+00	1662.00
IUUC-Cfa-020599	Canis familiaris	95.54	0.00e+00	1724.00
IUUC-Cpo-022144	Cavia porcellus	90.11	0.00e+00	1638.00
IUUC-Csa-023770	Chlorocebus sabaeus	94.39	0.00e+00	1592.00
IUUC-Cho-024595	Choloepus hoffmanni	84.97	0.00e+00	1093.00
IUUC-Cin-025292	Ciona intestinalis	43.78	0.00e+00	741.00
IUUC-Cne-026852	Cryptococcus neoformans	40.22	2.00e-72	268.00
IUUC-Dre-027869	Danio rerio	71.52	0.00e+00	894.00
IUUC-Dno-029316	Dasypus novemcinctus	92.53	0.00e+00	1716.00
IUUC-Dor-031038	Dipodomys ordii	86.84	0.00e+00	861.00
IUUC-Ete-032970	Echinops telfairi	82.63	0.00e+00	1055.00
IUUC-Fca-035373	Felis catus	91.18	0.00e+00	1685.00
IUUC-Fal-037634	Ficedula albicollis	75.30	0.00e+00	1308.00
IUUC-Fox-037986	Fusarium oxysporum	44.49	1.00e-63	238.00
IUUC-Gmo-038866	Gadus morhua	64.43	0.00e+00	1159.00
IUUC-Ggr-039740	Gaeumannomyces graminis	43.96	8.00e-62	233.00
IUUC-Gga-040729	Gallus gallus	68.87	0.00e+00	1261.00
IUUC-Gac-042631	Gasterosteus aculeatus	66.95	0.00e+00	1248.00
IUUC-Ggo-045337	Gorilla gorilla	93.32	0.00e+00	1534.00
IUUC-Hsa-045669	Homo sapiens	95.02	0.00e+00	1716.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	95.12	0.00e+00	1747.00
IUUC-Lch-050533	Latimeria chalumnae	69.10	0.00e+00	1190.00
IUUC-Lpe-051424	Leersia perrieri	36.41	5.00e-150	525.00
IUUC-Laf-053803	Loxodonta africana	92.42	0.00e+00	1737.00
IUUC-Mcc-055556	Macaca mulatta	90.77	0.00e+00	1604.00
IUUC-Meu-056742	Macropus eugenii	72.29	0.00e+00	1331.00
IUUC-Mor-056985	Magnaporthe oryzae	42.86	4.00e-61	230.00
IUUC-Mpo-057486	Magnaporthe poae	44.69	6.00e-62	233.00
IUUC-Mtr-058138	Medicago truncatula	43.60	2.00e-136	479.00
IUUC-Mga-059300	Meleagris gallopavo	71.57	0.00e+00	1227.00
IUUC-Mdo-061848	Monodelphis domestica	84.02	0.00e+00	1570.00
IUUC-Mmu-063960	Mus musculus	90.13	0.00e+00	1659.00
IUUC-Mac-065239	Musa acuminata	33.97	4.00e-132	465.00
IUUC-Mpu-066920	Mustela putorius furo	95.64	0.00e+00	1731.00
IUUC-Mlu-068088	Myotis lucifugus	92.95	0.00e+00	1718.00
IUUC-Ncr-068879	Neurospora crassa	30.90	3.00e-66	247.00
IUUC-Nle-070010	Nomascus leucogenys	95.12	0.00e+00	1723.00
IUUC-Opr-070740	Ochotona princeps	90.98	0.00e+00	1214.00
IUUC-Ont-072573	Oreochromis niloticus	64.61	0.00e+00	1264.00
IUUC-Oan-073363	Ornithorhynchus anatinus	77.32	0.00e+00	1422.00
IUUC-Ocu-074242	Oryctolagus cuniculus	89.18	0.00e+00	1603.00
IUUC-Obr-076902	Oryza brachyantha	36.55	1.00e-147	517.00
IUUC-Ola-086553	Oryzias latipes	67.95	0.00e+00	1276.00
IUUC-Olu-087717	Ostreococcus lucimarinus	40.40	4.00e-123	435.00
IUUC-Oga-088562	Otolemur garnettii	86.83	0.00e+00	1484.00
IUUC-Oar-090439	Ovis aries	93.88	0.00e+00	1706.00
IUUC-Ptr-090801	Pan troglodytes	95.22	0.00e+00	1724.00
IUUC-Pan-092717	Papio anubis	89.64	0.00e+00	1574.00
IUUC-Psi-093942	Pelodiscus sinensis	74.30	0.00e+00	1303.00
IUUC-Pab-098522	Pongo abelii	93.48	0.00e+00	1240.00
IUUC-Pop-099313	Populus trichocarpa	36.50	3.00e-151	529.00
IUUC-Pca-100161	Procavia capensis	83.61	0.00e+00	1490.00
IUUC-Rno-106081	Rattus norvegicus	89.72	0.00e+00	1671.00
IUUC-Sha-106937	Sarcophilus harrisii	83.66	0.00e+00	1530.00
IUUC-Sit-109948	Setaria italica	36.10	7.00e-139	488.00
IUUC-Sly-111746	Solanum lycopersicum	37.77	1.00e-151	530.00
IUUC-Sar-113542	Sorex araneus	89.82	0.00e+00	1623.00
IUUC-Ssc-115637	Sus scrofa	95.12	0.00e+00	1720.00
IUUC-Tgu-117267	Taeniopygia guttata	72.42	0.00e+00	1302.00
IUUC-Tca-121001	Theobroma cacao	35.95	1.00e-153	536.00
IUUC-Tae-125295	Triticum aestivum	35.51	8.00e-149	521.00
IUUC-Tbe-127669	Tupaia belangeri	75.85	0.00e+00	914.00
IUUC-Ttr-128778	Tursiops truncatus	94.09	0.00e+00	1716.00
IUUC-Vda-129781	Verticillium dahliae	30.24	1.00e-69	258.00
IUUC-Vpa-130571	Vicugna pacos	96.62	0.00e+00	1137.00
IUUC-Vvi-131010	Vitis vinifera	36.88	4.00e-151	528.00
IUUC-Xtr-132305	Xenopus tropicalis	69.14	0.00e+00	1280.00
IUUC-Yli-134392	Yarrowia lipolytica	43.37	4.00e-62	233.00
IUUC-Zma-135699	Zea mays	35.91	8.00e-142	498.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence