iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090439

Ensembl Protein ID

ENSOARP00000014984.1

UniProt Accession

W5PX00; W5PX00_SHEEP

Genbank Protein ID

ENSOARP00000014984

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01045653

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000013960.1	ENSOART00000015204.1	ENSOARP00000014984.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.50e-114	381.0	302	923
ULD/UDP/UBQ/UBQ_Other	6.80e-18	64.5	143	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++ +v+pr+++++++++a++fsgy+
   Q: 302  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQ 390
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 391  QQDSQELLAFLLDGLHEDLNRVKKKPYLELKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
           ******************************8888..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 478  TLPLPLKKDRVMEiflvpadprcrptqyrvvvplmgavsdlcealsklsgiaaenmvvtdvynhrfhkifqmdeglnhimprddifvye 566
           ********99999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 567  vrstspdgsecvtlpvyfrerksrpsststgavlygqpllvsvpkhkltleslyqavcerisryikqplpdesgssplelgacngsrsg 655
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 656  cagedeeemehqeegreqlsetegsgddepgsdhgeatqkkskgrpcprrlftfslvnsygtadinslatdgkllkltsrstlaidwds 744
           ***************************************************************************************** PP
   S: 186  ................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfsee 242
                                            l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++
   Q: 745  etrsryyneqesetyekhvsmlqpqkkkktavALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY 833
           ************************************************************************************99885 PP
   S: 243  qksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkne.kgkWllfdDskVtevkeeevleetgst 329
              r k+++ vefp + L++s+f+++p+     ++ Y+Liav +H+G ++ GHY+ay+kn+ +gkW++fdDs+V+   e+++++   + 
   Q: 834  --WRDKLDTVVEFPVRgLNMSEFVCDPSAR---PYVYDLIAVSNHYGAMGVGHYTAYAKNKlNGKWYYFDDSNVSLACEDQIVT---KA 914
           ..567*********************8866...9**************************52666*******************...** PP
   S: 330  aYvlfYkrr 338
           aYvlfY+rr
   Q: 915  AYVLFYQRR 923
           *******96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 221
           78999999**************************888*****9999977444.46********************99986 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MAEGGEYRER PDAETQKSEL GALMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 60
EHNLYPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPAEA WNKLLNWYGC VEGQQPIVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAG GTGGAGAGTA CCGTGAGCGA CCGGATGCGG AGACCCAGAA ATCCGAGCTC 60
GGGGCCTTGA TGAGGACCAC GCTCCAGCGA GGGGCGCAGT GGTGAGCGCC GGGCGCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

oas:101105032

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	93.67	0.00e+00	1691.00
IUUC-Atr-002991	Amborella trichopoda	35.40	1.00e-143	504.00
IUUC-Apl-004068	Anas platyrhynchos	70.42	0.00e+00	1209.00
IUUC-Aca-004459	Anolis carolinensis	69.65	0.00e+00	1255.00
IUUC-Ago-007911	Ashbya gossypii	38.26	2.00e-63	238.00
IUUC-Ani-009479	Aspergillus nidulans	43.01	2.00e-51	198.00
IUUC-Ang-009562	Aspergillus niger	45.52	6.00e-56	213.00
IUUC-Ame-011064	Astyanax mexicanus	64.65	0.00e+00	897.00
IUUC-Bta-012929	Bos taurus	99.27	0.00e+00	1856.00
IUUC-Bdi-014013	Brachypodium distachyon	36.67	2.00e-151	530.00
IUUC-Bra-017029	Brassica rapa	35.94	2.00e-139	489.00
IUUC-Cel-018257	Caenorhabditis elegans	33.19	2.00e-93	337.00
IUUC-Cja-018798	Callithrix jacchus	92.00	0.00e+00	1664.00
IUUC-Cfa-020599	Canis familiaris	94.61	0.00e+00	1729.00
IUUC-Cpo-022144	Cavia porcellus	89.25	0.00e+00	1629.00
IUUC-Csa-023770	Chlorocebus sabaeus	93.28	0.00e+00	1589.00
IUUC-Cho-024595	Choloepus hoffmanni	84.02	0.00e+00	1102.00
IUUC-Cin-025292	Ciona intestinalis	43.28	0.00e+00	746.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	42.29	2.00e-60	228.00
IUUC-Cne-026852	Cryptococcus neoformans	40.77	8.00e-74	272.00
IUUC-Dre-027869	Danio rerio	64.55	0.00e+00	1221.00
IUUC-Dno-029316	Dasypus novemcinctus	91.29	0.00e+00	1711.00
IUUC-Ete-032970	Echinops telfairi	81.81	0.00e+00	1064.00
IUUC-Eca-034012	Equus caballus	93.88	0.00e+00	1709.00
IUUC-Eeu-035158	Erinaceus europaeus	78.64	0.00e+00	804.00
IUUC-Fca-035373	Felis catus	90.04	0.00e+00	1674.00
IUUC-Fal-037634	Ficedula albicollis	74.35	0.00e+00	1303.00
IUUC-Fox-037986	Fusarium oxysporum	41.67	3.00e-64	240.00
IUUC-Gmo-038866	Gadus morhua	68.54	0.00e+00	859.00
IUUC-Ggr-039740	Gaeumannomyces graminis	43.59	5.00e-62	233.00
IUUC-Gga-040729	Gallus gallus	69.76	0.00e+00	1268.00
IUUC-Gac-042631	Gasterosteus aculeatus	67.36	0.00e+00	1262.00
IUUC-Ggo-045337	Gorilla gorilla	91.94	0.00e+00	1521.00
IUUC-Hsa-045669	Homo sapiens	93.56	0.00e+00	1706.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	92.74	0.00e+00	1718.00
IUUC-Lch-050533	Latimeria chalumnae	68.20	0.00e+00	1196.00
IUUC-Lpe-051424	Leersia perrieri	36.79	3.00e-149	522.00
IUUC-Loc-051800	Lepisosteus oculatus	65.98	0.00e+00	1319.00
IUUC-Laf-053803	Loxodonta africana	92.74	0.00e+00	1726.00
IUUC-Mcc-055556	Macaca mulatta	89.62	0.00e+00	1601.00
IUUC-Meu-056742	Macropus eugenii	71.35	0.00e+00	1328.00
IUUC-Mor-056985	Magnaporthe oryzae	43.22	8.00e-62	233.00
IUUC-Mpo-057486	Magnaporthe poae	44.32	4.00e-62	234.00
IUUC-Mtr-058563	Medicago truncatula	34.27	2.00e-134	473.00
IUUC-Mga-059300	Meleagris gallopavo	70.23	0.00e+00	1233.00
IUUC-Mdo-061848	Monodelphis domestica	83.37	0.00e+00	1559.00
IUUC-Mmu-063960	Mus musculus	89.72	0.00e+00	1660.00
IUUC-Mpu-066920	Mustela putorius furo	94.29	0.00e+00	1726.00
IUUC-Mlu-068088	Myotis lucifugus	92.84	0.00e+00	1716.00
IUUC-Ncr-068879	Neurospora crassa	44.91	2.00e-61	231.00
IUUC-Nle-070010	Nomascus leucogenys	93.67	0.00e+00	1707.00
IUUC-Opr-070740	Ochotona princeps	89.74	0.00e+00	1219.00
IUUC-Ont-072573	Oreochromis niloticus	67.01	0.00e+00	1281.00
IUUC-Oan-073363	Ornithorhynchus anatinus	77.09	0.00e+00	1425.00
IUUC-Ocu-074242	Oryctolagus cuniculus	88.04	0.00e+00	1606.00
IUUC-Oba-075553	Oryza barthii	41.84	1.00e-130	460.00
IUUC-Obr-076902	Oryza brachyantha	37.02	9.00e-148	517.00
IUUC-Ogl-077583	Oryza glaberrima	41.84	1.00e-130	460.00
IUUC-Ogu-077990	Oryza glumaepatula	41.34	5.00e-125	442.00
IUUC-Oin-079300	Oryza indica	41.99	9.00e-132	464.00
IUUC-Olo-080315	Oryza longistaminata	36.30	1.00e-145	510.00
IUUC-Oni-082303	Oryza nivara	41.19	1.00e-125	444.00
IUUC-Opu-083770	Oryza punctata	41.93	5.00e-129	455.00
IUUC-Oru-085141	Oryza rufipogon	41.60	9.00e-128	451.00
IUUC-Osa-085641	Oryza sativa	41.99	9.00e-132	464.00
IUUC-Ola-086553	Oryzias latipes	66.97	0.00e+00	1288.00
IUUC-Olu-087717	Ostreococcus lucimarinus	40.49	8.00e-126	444.00
IUUC-Oga-088562	Otolemur garnettii	85.58	0.00e+00	1488.00
IUUC-Ptr-090801	Pan troglodytes	93.56	0.00e+00	1704.00
IUUC-Pan-092717	Papio anubis	88.59	0.00e+00	1569.00
IUUC-Psi-093942	Pelodiscus sinensis	74.33	0.00e+00	1310.00
IUUC-Pfo-097060	Poecilia formosa	65.60	0.00e+00	1273.00
IUUC-Pab-098522	Pongo abelii	92.35	0.00e+00	1236.00
IUUC-Pop-099801	Populus trichocarpa	37.35	2.00e-149	523.00
IUUC-Pca-100161	Procavia capensis	82.68	0.00e+00	1487.00
IUUC-Rno-106081	Rattus norvegicus	88.90	0.00e+00	1667.00
IUUC-Sha-106937	Sarcophilus harrisii	81.86	0.00e+00	1532.00
IUUC-Spo-108291	Schizosaccharomyces pombe	43.69	2.00e-74	274.00
IUUC-Sit-109948	Setaria italica	36.45	2.00e-141	496.00
IUUC-Sly-111746	Solanum lycopersicum	37.54	6.00e-151	528.00
IUUC-Stu-112671	Solanum tuberosum	37.58	6.00e-149	521.00
IUUC-Sar-113542	Sorex araneus	87.14	0.00e+00	1613.00
IUUC-Sbi-114031	Sorghum bicolor	42.30	3.00e-126	446.00
IUUC-Sre-115130	Sporisorium reilianum	38.72	9.00e-78	285.00
IUUC-Ssc-115637	Sus scrofa	95.33	0.00e+00	1736.00
IUUC-Tgu-117267	Taeniopygia guttata	70.89	0.00e+00	1295.00
IUUC-Tru-118634	Takifugu rubripes	66.77	0.00e+00	1216.00
IUUC-Tca-121001	Theobroma cacao	36.68	2.00e-156	546.00
IUUC-Tae-125295	Triticum aestivum	35.36	4.00e-148	518.00
IUUC-Tme-127062	Tuber melanosporum	33.08	3.00e-126	446.00
IUUC-Tbe-127669	Tupaia belangeri	75.73	0.00e+00	917.00
IUUC-Ttr-128778	Tursiops truncatus	94.70	0.00e+00	1739.00
IUUC-Vda-129781	Verticillium dahliae	29.65	3.00e-68	254.00
IUUC-Vpa-130571	Vicugna pacos	97.25	0.00e+00	1153.00
IUUC-Vvi-131010	Vitis vinifera	38.86	3.00e-152	532.00
IUUC-Xtr-132305	Xenopus tropicalis	69.22	0.00e+00	1290.00
IUUC-Xma-133176	Xiphophorus maculatus	71.26	0.00e+00	844.00
IUUC-Yli-134392	Yarrowia lipolytica	43.17	6.00e-62	233.00
IUUC-Zma-135699	Zea mays	36.17	6.00e-144	504.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence