iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106171

UUCD1 version

UUC-SaC-00227

Ensembl Protein ID

YGR133W

UniProt Accession

P29340; D6VUR5; UBCX_YEAST

Genbank Protein ID

CAA46467.1; CAA97146.1; AAS56102.1; DAA08226.1

Protein Name

Ubiquitin-conjugating enzyme E2-21 kDa; E2 ubiquitin-conjugating enzyme PEX4; Peroxin-4; Ubiquitin carrier protein; Ubiquitin-protein ligase

Genbank Nucleotide ID

X65470; Z72918; AY557776; BK006941

Gene Name

PEX4; PAS2; UBC10; YGR133W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YGR133W	YGR133W	YGR133W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	19687296

Classification

Family	E-value	Score	Start	End
E2/UBC	3.90e-36	122.3	49	170

Active Site

Position(s)	Description	Evidence
115	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 18   sakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk.ifhPnvyen.GkvClsilkeeekWspalsvesvllsiqsllaepnpesp 117
           s++p de+dl +we+ i Gp+dtpYe+++F++ ie+p++YP++PPk++f+++ i+h+nv+++ G++Cl+ilk +e+W+p++++ +++ ++++ll+ep ++sp
   Q: 49   SLNPIDETDLSKWEAIISGPSDTPYENHQFRILIEVPSSYPMNPPKISFMQNnILHCNVKSAtGEICLNILK-PEEWTPVWDLLHCVHAVWRLLREPVCDSP 149
           57899*********************************************998********99********6.***************************** PP
   S: 118  lneeaaellkknre.eykkkv 137
           l++++ ++++  +  +y+ +v
   Q: 150  LDVDIGNIIRCGDMsAYQGIV 170
           ******999875543777766 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Essential for peroxisome biogenesis. Required for UBC4-independent ubiquitination of PEX5.

Protein Sequence
(Fasta)

MPNFWILENR RSYTSDTCMS RIVKEYKVIL KTLASDDPIA NPYRGIIESL NPIDETDLSK 60
WEAIISGPSD TPYENHQFRI LIEVPSSYPM NPPKISFMQN NILHCNVKSA TGEICLNILK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCAAACT TCTGGATTCT TGAGAATCGT AGGAGCTATA CGTCTGATAC ATGTATGTCG 60
AGGATCGTGA AGGAGTACAA AGTCATACTG AAAACATTGG CCAGTGATGA CCCCATAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0576--Peroxisome
KW-0962--Peroxisome biogenesis
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005777--C:peroxisome
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006635--P:fatty acid beta-oxidation
GO:0007031--P:peroxisome organization
GO:0051865--P:protein autoubiquitination
GO:0016562--P:protein import into peroxisome matrix, receptor recycling
GO:0006513--P:protein monoubiquitination
GO:0016567--P:protein ubiquitination

KEGG

sce:YGR133W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000555	Aegilops tauschii	36.88	6.00e-29	117.00
IUUC-Atr-002740	Amborella trichopoda	38.96	2.00e-28	115.00
IUUC-Ago-007985	Ashbya gossypii	44.72	4.00e-33	131.00
IUUC-Ani-009452	Aspergillus nidulans	38.89	4.00e-29	118.00
IUUC-Bgr-012271	Blumeria graminis	36.57	4.00e-21	92.00
IUUC-Bdi-014648	Brachypodium distachyon	38.31	6.00e-29	117.00
IUUC-Bol-015108	Brassica oleracea	38.31	2.00e-29	119.00
IUUC-Bra-017810	Brassica rapa	36.26	1.00e-30	123.00
IUUC-Cre-022583	Chlamydomonas reinhardtii	38.65	9.00e-30	120.00
IUUC-Cgl-026528	Colletotrichum gloeosporioides	39.10	1.00e-24	104.00
IUUC-Fox-038063	Fusarium oxysporum	42.19	2.00e-25	106.00
IUUC-Fso-038239	Fusarium solani	40.62	8.00e-25	104.00
IUUC-Ggr-039993	Gaeumannomyces graminis	37.98	1.00e-21	93.20
IUUC-Kpa-049387	Komagataella pastoris	29.69	5.00e-25	105.00
IUUC-Lpe-051399	Leersia perrieri	36.14	3.00e-28	116.00
IUUC-Mor-057199	Magnaporthe oryzae	37.40	2.00e-24	102.00
IUUC-Mtr-058439	Medicago truncatula	37.01	5.00e-28	114.00
IUUC-Mvi-060238	Microbotryum violaceum	43.41	7.00e-27	110.00
IUUC-Nfi-068258	Neosartorya fischeri	38.79	2.00e-29	119.00
IUUC-Ncr-068671	Neurospora crassa	39.74	2.00e-19	86.30
IUUC-Oba-075919	Oryza barthii	37.66	6.00e-28	115.00
IUUC-Obr-076554	Oryza brachyantha	37.66	4.00e-28	115.00
IUUC-Ogu-078897	Oryza glumaepatula	41.67	9.00e-27	111.00
IUUC-Opu-083715	Oryza punctata	37.66	7.00e-28	114.00
IUUC-Oru-084851	Oryza rufipogon	37.66	6.00e-28	115.00
IUUC-Osa-085417	Oryza sativa	37.66	4.00e-28	115.00
IUUC-Ppa-095796	Physcomitrella patens	38.22	3.00e-28	115.00
IUUC-Pop-099861	Populus trichocarpa	38.96	2.00e-29	119.00
IUUC-Ppe-101953	Prunus persica	37.01	3.00e-28	115.00
IUUC-Sja-107788	Schizosaccharomyces japonicus	40.16	9.00e-24	100.00
IUUC-Sit-110178	Setaria italica	38.31	2.00e-28	115.00
IUUC-Sly-111535	Solanum lycopersicum	37.01	9.00e-29	117.00
IUUC-Stu-112232	Solanum tuberosum	37.01	9.00e-29	117.00
IUUC-Sbi-113774	Sorghum bicolor	38.31	2.00e-28	116.00
IUUC-Tca-121736	Theobroma cacao	38.96	3.00e-29	119.00
IUUC-Tre-121936	Trichoderma reesei	38.51	2.00e-20	89.70
IUUC-Tvi-122646	Trichoderma virens	42.11	7.00e-28	114.00
IUUC-Tae-125597	Triticum aestivum	37.66	1.00e-28	117.00
IUUC-Tur-126566	Triticum urartu	37.66	2.00e-28	116.00
IUUC-Vda-129894	Verticillium dahliae	41.22	3.00e-24	102.00
IUUC-Vvi-131056	Vitis vinifera	38.31	4.00e-29	118.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence