iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000119318.12	ENST00000358015.7	ENSP00000350708.3
ENSG00000119318.12	ENST00000442587.1	ENSP00000415821.1
ENSG00000119318.12	ENST00000457811.1	ENSP00000396975.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	12832454
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	16020535; 10915768; 11677784; 14585839

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	4.80e-19	69.5	190	227
ULD/UDP/UBQ/UBQ_PIM	7.30e-27	94.8	1	78

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLld 40
           +e ++ ++++MG++re+++ aLra++nn+++AveyLl 
   Q: 190  YENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLM 227
           5789********************************95 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           m++t+ktl++++f++++++++tv++lKeki++e+g   +p++ qkLIyaGkiL+Ddt L+e++i+++++v+++v+k+k
   Q: 1    MQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGkdaFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPK 78
           99*************************************************************************997 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the XPC complex composed of XPC, RAD23B and CETN2. Interacts with NGLY1 and PSMC1. Interacts with ATXN3. Interacts with PSMD4 and PSMC5. Interacts with AMFR. Interacts with VCP; the interaction is indirect and mediated by NGLY1 (By similarity).

Protein Sequence
(Fasta)

MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILNDDTALK 60
EYKIDEKNFV VVMVTKPKAV STPAPATTQQ SAPASTTAVT SSTTTTVAQA PTPVPALAPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTTCCGCC CCGCCCCCAA TTCTGGGGCG GAGTCCTCGG CCGCGCCGGC GCAAAGCGTC 60
GCCGCACCCC ACGCCTGCGC GCTTCGCCCG CCCGGCCCCA TCCCCCCAGG TTTTTCGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR004806--Rad23
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR015360--XPC-bd

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin
PF09280--XPC-binding

PRINTS

PR01839--RAD23PROTEIN

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0071942--C:XPC complex
GO:0003684--F:damaged DNA binding
GO:0031593--F:polyubiquitin binding
GO:0003697--F:single-stranded DNA binding
GO:0048568--P:embryonic organ development
GO:0070911--P:global genome nucleotide-excision repair
GO:0006289--P:nucleotide-excision repair
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0000717--P:nucleotide-excision repair, DNA duplex unwinding
GO:0006294--P:nucleotide-excision repair, preincision complex assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0006457--P:protein folding
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0007283--P:spermatogenesis

KEGG

hsa:5887

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001195	Ailuropoda melanoleuca	94.40	3.00e-95	342.00
IUUC-Atr-003116	Amborella trichopoda	36.58	5.00e-31	128.00
IUUC-Apl-003371	Anas platyrhynchos	72.75	4.00e-122	431.00
IUUC-Aca-004599	Anolis carolinensis	81.66	6.00e-94	337.00
IUUC-Aly-006159	Arabidopsis lyrata	34.53	2.00e-54	206.00
IUUC-Ath-006676	Arabidopsis thaliana	39.84	2.00e-40	160.00
IUUC-Ago-007830	Ashbya gossypii	31.12	4.00e-19	89.00
IUUC-Acl-008212	Aspergillus clavatus	47.01	5.00e-19	89.00
IUUC-Afl-008605	Aspergillus flavus	44.12	1.00e-19	90.90
IUUC-Afu-008877	Aspergillus fumigatus	46.27	1.00e-18	87.40
IUUC-Aor-010032	Aspergillus oryzae	44.12	3.00e-19	89.70
IUUC-Ate-010458	Aspergillus terreus	40.73	7.00e-30	124.00
IUUC-Ame-011107	Astyanax mexicanus	67.96	1.00e-33	137.00
IUUC-Bta-012922	Bos taurus	92.91	1.00e-131	462.00
IUUC-Bdi-014253	Brachypodium distachyon	36.65	2.00e-32	133.00
IUUC-Bol-016493	Brassica oleracea	36.29	2.00e-35	143.00
IUUC-Cja-018772	Callithrix jacchus	97.07	2.00e-142	499.00
IUUC-Cfa-020683	Canis familiaris	82.64	3.00e-137	481.00
IUUC-Cpo-022145	Cavia porcellus	92.67	2.00e-140	492.00
IUUC-Cre-022810	Chlamydomonas reinhardtii	36.87	9.00e-30	124.00
IUUC-Csa-023714	Chlorocebus sabaeus	99.27	4.00e-160	557.00
IUUC-Cho-024814	Choloepus hoffmanni	73.33	3.00e-84	305.00
IUUC-Cin-025741	Ciona intestinalis	41.28	5.00e-36	144.00
IUUC-Csv-025823	Ciona savignyi	40.89	2.00e-42	165.00
IUUC-Cne-027056	Cryptococcus neoformans	47.44	2.00e-15	77.40
IUUC-Cme-027260	Cyanidioschyzon merolae	29.16	3.00e-27	115.00
IUUC-Dre-028369	Danio rerio	72.40	6.00e-83	300.00
IUUC-Dno-029543	Dasypus novemcinctus	91.20	1.00e-137	482.00
IUUC-Dse-031336	Dothistroma septosporum	47.41	1.00e-17	84.30
IUUC-Dme-032027	Drosophila melanogaster	37.19	3.00e-64	239.00
IUUC-Ete-032583	Echinops telfairi	84.84	1.00e-98	353.00
IUUC-Eca-034243	Equus caballus	98.72	8.00e-94	337.00
IUUC-Eeu-034721	Erinaceus europaeus	88.99	1.00e-73	269.00
IUUC-Fca-035679	Felis catus	93.40	4.00e-135	474.00
IUUC-Fal-037148	Ficedula albicollis	72.21	7.00e-119	420.00
IUUC-Fox-037960	Fusarium oxysporum	44.19	1.00e-15	77.40
IUUC-Fso-038107	Fusarium solani	52.63	9.00e-17	81.30
IUUC-Ggr-040116	Gaeumannomyces graminis	46.27	5.00e-16	79.00
IUUC-Gga-040544	Gallus gallus	72.19	9.00e-126	443.00
IUUC-Gac-042239	Gasterosteus aculeatus	56.87	2.00e-100	359.00
IUUC-Gma-043835	Glycine max	35.85	4.00e-39	155.00
IUUC-Ggo-045125	Gorilla gorilla	100.00	3.00e-105	375.00
IUUC-Hvu-047832	Hordeum vulgare	37.05	2.00e-32	133.00
IUUC-Itr-048295	Ictidomys tridecemlineatus	92.18	5.00e-130	457.00
IUUC-Kpa-049314	Komagataella pastoris	37.66	3.00e-30	125.00
IUUC-Lch-050553	Latimeria chalumnae	67.50	3.00e-101	362.00
IUUC-Lpe-050801	Leersia perrieri	36.78	2.00e-34	140.00
IUUC-Loc-051748	Lepisosteus oculatus	68.52	3.00e-75	275.00
IUUC-Lma-053328	Leptosphaeria maculans	48.68	1.00e-13	67.40
IUUC-Laf-054293	Loxodonta africana	94.83	1.00e-124	439.00
IUUC-Mcc-055600	Macaca mulatta	100.00	1.00e-113	402.00
IUUC-Meu-056082	Macropus eugenii	66.55	2.00e-70	259.00
IUUC-Mor-057287	Magnaporthe oryzae	50.00	2.00e-16	80.10
IUUC-Mpo-057609	Magnaporthe poae	46.51	3.00e-15	75.90
IUUC-Mtr-058148	Medicago truncatula	38.22	2.00e-40	159.00
IUUC-Mla-058961	Melampsora laricipopulina	46.62	4.00e-26	112.00
IUUC-Mga-060060	Meleagris gallopavo	45.29	4.00e-30	125.00
IUUC-Mvi-060220	Microbotryum violaceum	43.61	2.00e-21	97.40
IUUC-Mmr-061159	Microcebus murinus	97.52	1.00e-98	353.00
IUUC-Mdo-061967	Monodelphis domestica	80.10	6.00e-124	437.00
IUUC-Mmu-063258	Mus musculus	87.77	7.00e-149	520.00
IUUC-Mpu-066389	Mustela putorius furo	94.80	8.00e-96	343.00
IUUC-Mlu-067999	Myotis lucifugus	90.23	2.00e-119	422.00
IUUC-Nfi-068390	Neosartorya fischeri	46.27	1.00e-18	87.40
IUUC-Ncr-068685	Neurospora crassa	44.78	3.00e-24	105.00
IUUC-Nle-069655	Nomascus leucogenys	98.53	1.00e-153	535.00
IUUC-Opr-070234	Ochotona princeps	83.95	7.00e-30	124.00
IUUC-Ont-072484	Oreochromis niloticus	57.62	4.00e-103	368.00
IUUC-Ocu-074831	Oryctolagus cuniculus	83.90	8.00e-134	470.00
IUUC-Ogl-077067	Oryza glaberrima	33.56	2.00e-52	199.00
IUUC-Oin-079203	Oryza indica	33.64	2.00e-52	199.00
IUUC-Osa-085951	Oryza sativa	33.64	2.00e-52	199.00
IUUC-Ola-086540	Oryzias latipes	61.94	6.00e-64	238.00
IUUC-Olu-087843	Ostreococcus lucimarinus	42.79	9.00e-39	154.00
IUUC-Oga-088023	Otolemur garnettii	88.86	9.00e-138	483.00
IUUC-Oar-089964	Ovis aries	92.51	8.00e-118	417.00
IUUC-Ptr-091165	Pan troglodytes	99.48	2.00e-133	468.00
IUUC-Pan-092009	Papio anubis	98.54	1.00e-153	535.00
IUUC-Psi-093477	Pelodiscus sinensis	77.47	7.00e-111	394.00
IUUC-Ppa-095964	Physcomitrella patens	43.61	1.00e-27	117.00
IUUC-Pfo-097385	Poecilia formosa	58.84	1.00e-101	363.00
IUUC-Pab-097868	Pongo abelii	100.00	2.00e-104	372.00
IUUC-Pop-099642	Populus trichocarpa	35.68	1.00e-55	210.00
IUUC-Pca-100652	Procavia capensis	97.00	2.00e-70	259.00
IUUC-Pva-102137	Pteropus vampyrus	98.77	5.00e-99	354.00
IUUC-Ptt-103717	Puccinia triticina	45.93	2.00e-25	110.00
IUUC-Pte-104303	Pyrenophora teres	50.00	8.00e-20	91.30
IUUC-Pyt-104580	Pyrenophora triticirepentis	50.00	1.00e-19	90.90
IUUC-Rno-104844	Rattus norvegicus	88.46	1.00e-150	526.00
IUUC-Sce-106214	Saccharomyces cerevisiae	35.77	5.00e-13	68.90
IUUC-Sha-107073	Sarcophilus harrisii	84.36	2.00e-109	389.00
IUUC-Spo-108298	Schizosaccharomyces pombe	42.04	6.00e-38	151.00
IUUC-Ssl-108382	Sclerotinia sclerotiorum	43.75	6.00e-17	81.60
IUUC-Stu-112054	Solanum tuberosum	34.02	2.00e-55	209.00
IUUC-Sar-112925	Sorex araneus	88.76	3.00e-90	325.00
IUUC-Sre-114894	Sporisorium reilianum	51.61	4.00e-11	62.80
IUUC-Ssc-116329	Sus scrofa	95.11	1.00e-137	483.00
IUUC-Tgu-116918	Taeniopygia guttata	75.43	4.00e-133	468.00
IUUC-Tru-118651	Takifugu rubripes	53.40	9.00e-97	347.00
IUUC-Tsy-118836	Tarsius syrichta	99.26	5.00e-49	188.00
IUUC-Tca-121594	Theobroma cacao	34.99	2.00e-51	196.00
IUUC-Tvi-122617	Trichoderma virens	52.56	2.00e-18	86.70
IUUC-Tme-127092	Tuber melanosporum	37.66	2.00e-27	116.00
IUUC-Tbe-127493	Tupaia belangeri	83.70	3.00e-72	265.00
IUUC-Ttr-128464	Tursiops truncatus	97.74	5.00e-101	361.00
IUUC-Uma-129484	Ustilago maydis	47.54	1.00e-11	64.70
IUUC-Vpa-130357	Vicugna pacos	88.00	3.00e-89	322.00
IUUC-Vvi-131039	Vitis vinifera	37.65	8.00e-40	157.00
IUUC-Xtr-132679	Xenopus tropicalis	71.90	4.00e-108	385.00
IUUC-Xma-133503	Xiphophorus maculatus	56.42	4.00e-104	371.00
IUUC-Yli-134615	Yarrowia lipolytica	41.67	4.00e-36	145.00
IUUC-Zma-135929	Zea mays	30.34	4.00e-50	192.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence