iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036444

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02084099

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000011714.3	ENSFCAT00000011719.3	ENSFCAP00000010874.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-96	324.0	1656	2035

Active Site

Position(s)	Description	Evidence
2002	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1656 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1738
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1739 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletltm 1825
           **********************************654444**************999999855555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1826 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYF 1900
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1901 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1987
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 1988 stENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2035
           988888***************************************985 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSHLGQAK HKGYSPPESR KSNSKAPKVQ 60
SNTTSELSRG HLSKRSCSSS SAVIVPQPED PDRANPSERQ KTGQVPKKDN SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATGGTAG TGTCTAGAAA GGGTATGTCC CTTCAAGAGA GAGGTGCCAA TGTCCAACCG 60
GCCTAATAAC AATCCAGGGG GGTCACTGCG ACGTTCACAG AGGAACACTG CCGGGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.79	7.00e-125	442.00
IUUC-Aml-001502	Ailuropoda melanoleuca	98.87	0.00e+00	3694.00
IUUC-Atr-002821	Amborella trichopoda	37.13	3.00e-115	410.00
IUUC-Apl-003531	Anas platyrhynchos	92.10	0.00e+00	3373.00
IUUC-Aly-005962	Arabidopsis lyrata	44.68	2.00e-113	404.00
IUUC-Ath-006636	Arabidopsis thaliana	44.49	9.00e-114	405.00
IUUC-Ago-007875	Ashbya gossypii	36.20	7.00e-82	299.00
IUUC-Acl-008242	Aspergillus clavatus	35.93	3.00e-113	404.00
IUUC-Afl-008736	Aspergillus flavus	38.83	1.00e-110	395.00
IUUC-Afu-008812	Aspergillus fumigatus	39.01	8.00e-114	405.00
IUUC-Ani-009407	Aspergillus nidulans	37.21	7.00e-111	396.00
IUUC-Ang-009763	Aspergillus niger	40.00	4.00e-106	380.00
IUUC-Aor-009941	Aspergillus oryzae	30.72	1.00e-112	401.00
IUUC-Ate-010459	Aspergillus terreus	37.31	1.00e-85	311.00
IUUC-Ame-011761	Astyanax mexicanus	86.32	0.00e+00	2891.00
IUUC-Bgr-012265	Blumeria graminis	34.71	5.00e-103	370.00
IUUC-Bta-013070	Bos taurus	97.55	0.00e+00	3536.00
IUUC-Bci-013890	Botrytis cinerea	39.72	1.00e-102	369.00
IUUC-Bdi-014046	Brachypodium distachyon	38.57	5.00e-122	433.00
IUUC-Bol-015942	Brassica oleracea	44.23	1.00e-114	408.00
IUUC-Bra-016849	Brassica rapa	44.23	4.00e-114	406.00
IUUC-Cja-019046	Callithrix jacchus	97.21	0.00e+00	3625.00
IUUC-Cfa-020521	Canis familiaris	96.91	0.00e+00	3543.00
IUUC-Cpo-021639	Cavia porcellus	94.18	0.00e+00	3548.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.88	8.00e-90	324.00
IUUC-Csa-023231	Chlorocebus sabaeus	97.10	0.00e+00	3623.00
IUUC-Cho-024380	Choloepus hoffmanni	90.11	0.00e+00	3316.00
IUUC-Cin-025482	Ciona intestinalis	51.21	7.00e-160	556.00
IUUC-Csv-026121	Ciona savignyi	48.93	0.00e+00	1529.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	36.27	4.00e-111	396.00
IUUC-Cne-026857	Cryptococcus neoformans	39.89	9.00e-95	342.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.14	2.00e-74	275.00
IUUC-Dre-028174	Danio rerio	86.07	0.00e+00	2942.00
IUUC-Dor-030939	Dipodomys ordii	87.64	0.00e+00	2755.00
IUUC-Dse-031444	Dothistroma septosporum	39.31	2.00e-105	378.00
IUUC-Dme-032162	Drosophila melanogaster	63.41	6.00e-158	553.00
IUUC-Ete-032345	Echinops telfairi	91.69	0.00e+00	2285.00
IUUC-Eca-033229	Equus caballus	98.29	0.00e+00	3592.00
IUUC-Eeu-035205	Erinaceus europaeus	85.31	0.00e+00	3070.00
IUUC-Fal-037131	Ficedula albicollis	91.59	0.00e+00	3446.00
IUUC-Fox-038035	Fusarium oxysporum	36.85	3.00e-110	392.00
IUUC-Fso-038320	Fusarium solani	37.29	3.00e-110	394.00
IUUC-Gmo-039497	Gadus morhua	87.33	0.00e+00	2976.00
IUUC-Ggr-040057	Gaeumannomyces graminis	35.28	2.00e-108	387.00
IUUC-Gga-041021	Gallus gallus	93.04	0.00e+00	3454.00
IUUC-Gac-042474	Gasterosteus aculeatus	81.09	0.00e+00	3020.00
IUUC-Gma-043060	Glycine max	38.75	7.00e-120	426.00
IUUC-Ggo-044855	Gorilla gorilla	97.26	0.00e+00	3628.00
IUUC-Hsa-046147	Homo sapiens	94.76	0.00e+00	3527.00
IUUC-Hvu-047775	Hordeum vulgare	39.06	5.00e-124	439.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	94.59	0.00e+00	3447.00
IUUC-Kpa-049098	Komagataella pastoris	38.10	5.00e-86	313.00
IUUC-Lch-049818	Latimeria chalumnae	82.99	0.00e+00	3011.00
IUUC-Lpe-051017	Leersia perrieri	38.48	5.00e-119	423.00
IUUC-Loc-051777	Lepisosteus oculatus	86.29	0.00e+00	3255.00
IUUC-Lma-052990	Leptosphaeria maculans	39.74	4.00e-112	400.00
IUUC-Laf-053727	Loxodonta africana	98.09	0.00e+00	3633.00
IUUC-Mcc-055799	Macaca mulatta	95.65	0.00e+00	3529.00
IUUC-Meu-056065	Macropus eugenii	93.28	0.00e+00	2079.00
IUUC-Mor-057054	Magnaporthe oryzae	38.86	3.00e-107	384.00
IUUC-Mpo-057417	Magnaporthe poae	39.55	2.00e-109	391.00
IUUC-Mtr-057849	Medicago truncatula	37.32	9.00e-112	399.00
IUUC-Mla-058870	Melampsora laricipopulina	42.57	6.00e-107	382.00
IUUC-Mga-059580	Meleagris gallopavo	93.85	0.00e+00	2994.00
IUUC-Mvi-060507	Microbotryum violaceum	39.82	6.00e-113	403.00
IUUC-Mmr-060816	Microcebus murinus	97.05	0.00e+00	3619.00
IUUC-Mdo-062866	Monodelphis domestica	92.37	0.00e+00	3325.00
IUUC-Mmu-063906	Mus musculus	93.96	0.00e+00	3507.00
IUUC-Mac-064675	Musa acuminata	40.79	2.00e-111	396.00
IUUC-Mpu-066199	Mustela putorius furo	95.84	0.00e+00	3529.00
IUUC-Mlu-067110	Myotis lucifugus	94.49	0.00e+00	3509.00
IUUC-Nfi-068482	Neosartorya fischeri	39.19	7.00e-114	405.00
IUUC-Ncr-068906	Neurospora crassa	39.13	2.00e-109	391.00
IUUC-Nle-069410	Nomascus leucogenys	97.99	0.00e+00	3616.00
IUUC-Opr-070401	Ochotona princeps	86.67	0.00e+00	3049.00
IUUC-Ont-072100	Oreochromis niloticus	81.67	0.00e+00	3047.00
IUUC-Oan-073121	Ornithorhynchus anatinus	93.29	0.00e+00	3575.00
IUUC-Ocu-074623	Oryctolagus cuniculus	94.97	0.00e+00	3529.00
IUUC-Oba-075380	Oryza barthii	40.36	3.00e-113	403.00
IUUC-Obr-076915	Oryza brachyantha	37.66	9.00e-119	422.00
IUUC-Ogl-077055	Oryza glaberrima	38.60	5.00e-118	419.00
IUUC-Ogu-078892	Oryza glumaepatula	40.36	8.00e-113	402.00
IUUC-Oin-079256	Oryza indica	38.42	7.00e-117	416.00
IUUC-Olo-080343	Oryza longistaminata	38.42	2.00e-117	417.00
IUUC-Ome-081422	Oryza meridionalis	38.14	1.00e-116	415.00
IUUC-Oni-083047	Oryza nivara	40.54	1.00e-114	408.00
IUUC-Opu-083641	Oryza punctata	40.00	1.00e-110	395.00
IUUC-Oru-084439	Oryza rufipogon	40.36	3.00e-113	403.00
IUUC-Osa-085972	Oryza sativa	38.34	4.00e-116	412.00
IUUC-Ola-087173	Oryzias latipes	79.79	0.00e+00	2981.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.89	6.00e-89	321.00
IUUC-Oga-087908	Otolemur garnettii	97.07	0.00e+00	3627.00
IUUC-Oar-090277	Ovis aries	95.97	0.00e+00	3521.00
IUUC-Ptr-091543	Pan troglodytes	94.76	0.00e+00	3532.00
IUUC-Pan-092243	Papio anubis	95.60	0.00e+00	3528.00
IUUC-Psi-093150	Pelodiscus sinensis	94.67	0.00e+00	3569.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.09	4.00e-113	403.00
IUUC-Ppa-095181	Physcomitrella patens	42.14	1.00e-107	384.00
IUUC-Pfo-096267	Poecilia formosa	86.31	0.00e+00	2956.00
IUUC-Pab-098072	Pongo abelii	98.29	0.00e+00	3629.00
IUUC-Pop-099190	Populus trichocarpa	41.34	3.00e-116	414.00
IUUC-Pca-100311	Procavia capensis	91.08	0.00e+00	3252.00
IUUC-Ppe-101284	Prunus persica	43.97	6.00e-115	409.00
IUUC-Pva-102215	Pteropus vampyrus	98.01	0.00e+00	1376.00
IUUC-Pgr-103694	Puccinia graminis	40.68	1.00e-104	375.00
IUUC-Ptt-103916	Puccinia triticina	39.00	2.00e-98	354.00
IUUC-Pte-104346	Pyrenophora teres	39.59	2.00e-110	394.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.66	1.00e-110	395.00
IUUC-Rno-105315	Rattus norvegicus	94.93	0.00e+00	3472.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.00	4.00e-71	263.00
IUUC-Sha-106835	Sarcophilus harrisii	94.93	0.00e+00	3608.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.58	1.00e-94	341.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.54	2.00e-94	341.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	39.92	4.00e-106	380.00
IUUC-Smo-109590	Selaginella moellendorffii	43.28	3.00e-112	400.00
IUUC-Sit-110717	Setaria italica	37.69	1.00e-119	424.00
IUUC-Sly-111469	Solanum lycopersicum	39.31	2.00e-121	431.00
IUUC-Stu-112896	Solanum tuberosum	38.33	6.00e-106	378.00
IUUC-Sar-113224	Sorex araneus	88.03	0.00e+00	1909.00
IUUC-Sbi-114313	Sorghum bicolor	37.92	1.00e-122	435.00
IUUC-Sre-114993	Sporisorium reilianum	34.24	3.00e-100	361.00
IUUC-Ssc-115535	Sus scrofa	90.70	0.00e+00	3387.00
IUUC-Tgu-117493	Taeniopygia guttata	93.44	0.00e+00	2733.00
IUUC-Tru-118669	Takifugu rubripes	81.74	0.00e+00	3018.00
IUUC-Tsy-119373	Tarsius syrichta	93.52	0.00e+00	1835.00
IUUC-Tni-120049	Tetraodon nigroviridis	78.17	0.00e+00	869.00
IUUC-Tca-121779	Theobroma cacao	38.19	2.00e-114	407.00
IUUC-Tre-122195	Trichoderma reesei	36.53	1.00e-105	379.00
IUUC-Tvi-122650	Trichoderma virens	36.65	1.00e-108	389.00
IUUC-Tae-123580	Triticum aestivum	38.41	6.00e-123	435.00
IUUC-Tur-126295	Triticum urartu	38.64	1.00e-123	438.00
IUUC-Tme-126964	Tuber melanosporum	40.48	1.00e-105	378.00
IUUC-Tbe-128149	Tupaia belangeri	80.83	0.00e+00	1436.00
IUUC-Ttr-128165	Tursiops truncatus	95.88	0.00e+00	3041.00
IUUC-Uma-129365	Ustilago maydis	36.07	7.00e-89	323.00
IUUC-Vda-129725	Verticillium dahliae	41.08	4.00e-109	390.00
IUUC-Vpa-130678	Vicugna pacos	98.26	0.00e+00	2660.00
IUUC-Vvi-131147	Vitis vinifera	39.06	9.00e-120	425.00
IUUC-Xtr-132636	Xenopus tropicalis	86.34	0.00e+00	3209.00
IUUC-Xma-133458	Xiphophorus maculatus	81.57	0.00e+00	3041.00
IUUC-Yli-134481	Yarrowia lipolytica	39.56	9.00e-98	352.00
IUUC-Zma-135782	Zea mays	37.34	8.00e-119	422.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence