iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012999

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF138; RING finger protein 138; RING-type E3 ubiquitin transferase RNF138

Genbank Nucleotide ID

BC109497

Gene Name

RNF138

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000020160.3	ENSBTAT00000026851.3	ENSBTAP00000026851.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.60e-07	30.4	18	58

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++C+e +k+++++  C+Hvf+++C+  ++          ++CPlCr
   Q: 18   CPVCQEVLKTPVRTAACQHVFCRKCFlTAM------RESGIHCPLCR 58
           **********999999*********96666......999*******8 PP

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.

Protein Sequence
(Fasta)

MAEELSAATS YTEDDFYCPV CQEVLKTPVR TAACQHVFCR KCFLTAMRES GIHCPLCRGN 60
VTRRERACPE RALDLENIMR KFSGSCRCCA KQIKFYRMRH HYKSCKKYQD EYGVSSIIPN 120

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Nucleotide Sequence
(Fasta)

CAGCTGGAGA GGGCGGCGGG ATCCCAGTGC ACCATGAGCC TCGGGCCCGG CCCCGTTTCG 60
GGCCGATGTG CACCACGTAT TCCGCCCGCC TCTCCCCTCC CGGCCTCGCC CGCGAAGGCG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51803--ZF_C2HC_RNF
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0003697--F:single-stranded DNA binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0010792--P:DNA double-strand break processing involved in repair via single-strand annealing
GO:0000724--P:double-strand break repair via homologous recombination
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0016055--P:Wnt signaling pathway

KEGG

bta:538445

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001267	Ailuropoda melanoleuca	97.14	7.00e-144	502.00
IUUC-Apl-003941	Anas platyrhynchos	68.83	2.00e-92	331.00
IUUC-Aca-005233	Anolis carolinensis	68.16	1.00e-100	359.00
IUUC-Cja-019489	Callithrix jacchus	97.14	5.00e-144	503.00
IUUC-Cfa-020567	Canis familiaris	97.99	2.00e-115	407.00
IUUC-Cpo-022165	Cavia porcellus	96.73	2.00e-143	500.00
IUUC-Csa-024096	Chlorocebus sabaeus	97.55	2.00e-144	504.00
IUUC-Cho-024686	Choloepus hoffmanni	87.98	7.00e-105	372.00
IUUC-Cgl-026426	Colletotrichum gloeosporioides	39.71	6.00e-09	55.50
IUUC-Dno-029625	Dasypus novemcinctus	97.96	2.00e-144	504.00
IUUC-Dor-030983	Dipodomys ordii	82.86	5.00e-115	406.00
IUUC-Ete-032453	Echinops telfairi	73.06	9.00e-100	355.00
IUUC-Eca-034367	Equus caballus	97.12	2.00e-121	427.00
IUUC-Eeu-034722	Erinaceus europaeus	76.92	3.00e-88	317.00
IUUC-Fca-036590	Felis catus	98.37	2.00e-145	507.00
IUUC-Fal-037287	Ficedula albicollis	72.40	4.00e-106	377.00
IUUC-Fox-037926	Fusarium oxysporum	37.80	1.00e-09	56.20
IUUC-Gga-041055	Gallus gallus	72.15	4.00e-103	367.00
IUUC-Ggo-045324	Gorilla gorilla	97.14	5.00e-144	503.00
IUUC-Hsa-046364	Homo sapiens	97.14	5.00e-144	503.00
IUUC-Itr-048181	Ictidomys tridecemlineatus	97.55	5.00e-143	499.00
IUUC-Loc-052428	Lepisosteus oculatus	37.72	5.00e-45	174.00
IUUC-Laf-054506	Loxodonta africana	97.55	1.00e-144	504.00
IUUC-Mcc-054595	Macaca mulatta	97.60	7.00e-122	429.00
IUUC-Mpo-057316	Magnaporthe poae	45.45	5.00e-08	52.40
IUUC-Mga-060068	Meleagris gallopavo	70.95	6.00e-102	363.00
IUUC-Mmr-061516	Microcebus murinus	95.97	5.00e-141	493.00
IUUC-Mdo-062243	Monodelphis domestica	87.80	4.00e-130	456.00
IUUC-Mmu-063719	Mus musculus	94.29	4.00e-141	493.00
IUUC-Mpu-065869	Mustela putorius furo	98.37	2.00e-145	507.00
IUUC-Mlu-068157	Myotis lucifugus	97.12	1.00e-121	427.00
IUUC-Nle-069538	Nomascus leucogenys	82.45	3.00e-113	400.00
IUUC-Opr-070640	Ochotona princeps	95.10	8.00e-142	495.00
IUUC-Oan-072919	Ornithorhynchus anatinus	86.43	2.00e-96	344.00
IUUC-Ocu-074897	Oryctolagus cuniculus	97.14	7.00e-144	502.00
IUUC-Oga-088165	Otolemur garnettii	96.33	1.00e-143	501.00
IUUC-Oar-090364	Ovis aries	100.00	8.00e-119	418.00
IUUC-Ptr-090784	Pan troglodytes	97.14	5.00e-144	503.00
IUUC-Pan-091874	Papio anubis	97.55	2.00e-144	504.00
IUUC-Psi-093531	Pelodiscus sinensis	77.20	4.00e-106	377.00
IUUC-Pab-098013	Pongo abelii	97.14	5.00e-144	503.00
IUUC-Pca-100822	Procavia capensis	90.13	5.00e-119	419.00
IUUC-Pva-102936	Pteropus vampyrus	96.73	2.00e-144	504.00
IUUC-Rno-106110	Rattus norvegicus	57.69	7.00e-73	266.00
IUUC-Sha-107403	Sarcophilus harrisii	92.46	8.00e-112	395.00
IUUC-Sar-113678	Sorex araneus	97.59	1.00e-45	176.00
IUUC-Ssc-116192	Sus scrofa	98.37	2.00e-145	507.00
IUUC-Tgu-116820	Taeniopygia guttata	71.91	7.00e-99	352.00
IUUC-Tsy-119211	Tarsius syrichta	79.81	2.00e-93	334.00
IUUC-Tbe-127480	Tupaia belangeri	61.22	2.00e-76	278.00
IUUC-Ttr-128859	Tursiops truncatus	97.14	1.00e-144	505.00
IUUC-Vda-129783	Verticillium dahliae	37.68	2.00e-09	57.00
IUUC-Vpa-130682	Vicugna pacos	92.65	6.00e-132	462.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence