iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062564

UUCD1 version

UUC-MoD-00434

Ensembl Protein ID

ENSMODP00000024442.3

UniProt Accession

F6Y8S9; F6Y8S9_MONDO

Protein Name

Uncharacterized protein

Gene Name

ERCC8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000019590.3	ENSMODT00000024876.3	ENSMODP00000024442.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.80e-29	98.7	184	217
UBD/Beta-Prp	9.70e-48	163.0	101	362

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd..tllvsGsdDgtikvWDlr 31
           gH  ++ ++++ +    +l+++s D ++k+WD+r
   Q: 184  GHRQEILAVSWsPRyeYILATASADSKVKLWDIR 217
           89*********94344668*************87 PP

UBD/Beta-Prp

   S: 12   vitcvkf.spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk...ilvtgseDrtikvwdlstgkcvhtlkgheds 96
            +  v++   d+ +++++s d+t+k+wd+ t +  + +   e++v++  +sp +    +++ g +   +++ dl++g+c h+l+gh ++
   Q: 101  SVETVQWyPHDTGMFTSSSFDKTLKIWDTNTLQP-ADVFHFEGTVYSHHMSPVATkhcLIAVGTKGPKVQLCDLKSGSCSHILQGHRQE 188
           4555777455666777788999999999998444.666777778888888887777778999999999999999999999999999999 PP
   S: 97   vlslsfsp.sgdklvsGshdrtirvwdletgq.clee...............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlkt 168
           +l++s+sp + + l+++s+d+ +++wd++  + cl +                ++ h+g vn++++  dg  l + ++D  +rlW++++
   Q: 189  ILAVSWSPrYEYILATASADSKVKLWDIRRASgCLITldqhngekskasseaANTAHNGRVNGLCFTRDGLHLLTIGTDDRMRLWNSSN 277
           99999999777999999999999999998766355559999999999999999999999999999999996666666677789998855 PP
   S: 169  gkllrtl.....tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           g+           +   +  + ++ +  ++e+v + + + + ++ + +ge +  l+gh ++v +  f pn + l+sgs D  i  W
   Q: 278  GENTLVNygkvcNE-SRKGLKFTISHGCSPEFVFVPYGSAIAVYTVYSGELITMLRGHYNTVDCCVFQPNFQELYSGSRDCNILAW 362
           54333334444322.34444555566666999999999999999999999999999999999999999999999999999999888 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MLGFLEARQV GLDDPGRLRR AEATRRVLKL ELNKDRDVER IHGSGVNTLD IEPVEGRYML 60
SGGSDGIIAL YDLENFSRKV HYTCKSICSV GRNHPDVHKY SVETVQWYPH DTGMFTSSSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTTTCGGG TGACAAGAAC GGTCGGGCCT CGGCTTCCGC ATTCACTCTG GGAAGGAGCA 60
AAGTGGGGAC TCTCCGGATG GACCCTTTTT CCCCTTCCCA AGTGAGTGCA GCCTTAAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0016363--C:nuclear matrix
GO:0000109--C:nucleotide-excision repair complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006979--P:response to oxidative stress
GO:0009411--P:response to UV
GO:0010165--P:response to X-ray
GO:0006283--P:transcription-coupled nucleotide-excision repair

KEGG

mdo:100032223

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001170	Aegilops tauschii	31.69	3.00e-38	153.00
IUUC-Aml-002201	Ailuropoda melanoleuca	86.15	0.00e+00	728.00
IUUC-Atr-002784	Amborella trichopoda	38.79	4.00e-43	168.00
IUUC-Apl-003202	Anas platyrhynchos	82.23	0.00e+00	682.00
IUUC-Aca-004708	Anolis carolinensis	83.33	0.00e+00	637.00
IUUC-Aly-006144	Arabidopsis lyrata	35.35	2.00e-69	256.00
IUUC-Ath-007489	Arabidopsis thaliana	33.87	1.00e-65	243.00
IUUC-Acl-008195	Aspergillus clavatus	38.64	1.00e-43	170.00
IUUC-Afl-008406	Aspergillus flavus	38.06	2.00e-40	159.00
IUUC-Afu-008759	Aspergillus fumigatus	34.93	6.00e-41	161.00
IUUC-Ani-009380	Aspergillus nidulans	37.64	2.00e-41	163.00
IUUC-Ang-009820	Aspergillus niger	34.89	7.00e-39	154.00
IUUC-Aor-010092	Aspergillus oryzae	38.64	2.00e-45	176.00
IUUC-Ate-010491	Aspergillus terreus	38.43	2.00e-46	180.00
IUUC-Bta-012825	Bos taurus	85.93	0.00e+00	723.00
IUUC-Bci-013856	Botrytis cinerea	32.50	3.00e-53	202.00
IUUC-Bdi-014899	Brachypodium distachyon	33.09	4.00e-58	219.00
IUUC-Bol-015337	Brassica oleracea	32.82	2.00e-67	249.00
IUUC-Bra-018089	Brassica rapa	32.82	1.00e-67	250.00
IUUC-Cja-018725	Callithrix jacchus	84.38	0.00e+00	713.00
IUUC-Cfa-021162	Canis familiaris	85.64	0.00e+00	723.00
IUUC-Cpo-022190	Cavia porcellus	86.15	0.00e+00	724.00
IUUC-Cre-022960	Chlamydomonas reinhardtii	37.62	3.00e-40	159.00
IUUC-Csa-023610	Chlorocebus sabaeus	85.14	0.00e+00	724.00
IUUC-Cho-024689	Choloepus hoffmanni	84.91	0.00e+00	664.00
IUUC-Cin-025324	Ciona intestinalis	41.10	4.00e-83	301.00
IUUC-Csv-026059	Ciona savignyi	37.78	5.00e-74	271.00
IUUC-Cgl-026384	Colletotrichum gloeosporioides	34.80	4.00e-39	155.00
IUUC-Cme-027182	Cyanidioschyzon merolae	28.66	1.00e-13	71.60
IUUC-Dre-028696	Danio rerio	75.06	0.00e+00	638.00
IUUC-Dno-029102	Dasypus novemcinctus	85.89	0.00e+00	725.00
IUUC-Dor-030361	Dipodomys ordii	70.28	1.00e-162	565.00
IUUC-Dse-031167	Dothistroma septosporum	29.98	2.00e-47	183.00
IUUC-Ete-032856	Echinops telfairi	71.03	3.00e-166	577.00
IUUC-Eca-033611	Equus caballus	86.47	3.00e-179	620.00
IUUC-Eeu-034583	Erinaceus europaeus	63.73	1.00e-142	499.00
IUUC-Fca-036481	Felis catus	84.89	0.00e+00	718.00
IUUC-Fal-037327	Ficedula albicollis	83.53	3.00e-175	607.00
IUUC-Fox-037684	Fusarium oxysporum	34.68	3.00e-43	169.00
IUUC-Fso-038306	Fusarium solani	36.28	1.00e-52	201.00
IUUC-Gmo-039043	Gadus morhua	71.07	1.00e-174	605.00
IUUC-Ggr-039783	Gaeumannomyces graminis	28.15	2.00e-38	153.00
IUUC-Gga-041085	Gallus gallus	89.08	0.00e+00	663.00
IUUC-Gac-042328	Gasterosteus aculeatus	70.82	2.00e-170	591.00
IUUC-Gma-043004	Glycine max	34.74	1.00e-60	226.00
IUUC-Ggo-045627	Gorilla gorilla	78.86	0.00e+00	659.00
IUUC-Hsa-046028	Homo sapiens	85.14	0.00e+00	724.00
IUUC-Hvu-047678	Hordeum vulgare	39.88	3.00e-24	105.00
IUUC-Itr-048648	Ictidomys tridecemlineatus	85.14	0.00e+00	726.00
IUUC-Kpa-049386	Komagataella pastoris	30.25	9.00e-45	174.00
IUUC-Lch-050590	Latimeria chalumnae	80.46	2.00e-166	578.00
IUUC-Lpe-051725	Leersia perrieri	35.08	4.00e-39	155.00
IUUC-Loc-051788	Lepisosteus oculatus	77.86	0.00e+00	657.00
IUUC-Lma-053082	Leptosphaeria maculans	34.95	4.00e-57	215.00
IUUC-Laf-053809	Loxodonta africana	86.43	0.00e+00	727.00
IUUC-Mcc-054998	Macaca mulatta	85.82	3.00e-149	521.00
IUUC-Meu-055929	Macropus eugenii	87.94	0.00e+00	716.00
IUUC-Mor-057003	Magnaporthe oryzae	34.12	6.00e-46	178.00
IUUC-Mtr-057921	Medicago truncatula	31.51	2.00e-59	223.00
IUUC-Mga-059449	Meleagris gallopavo	68.33	4.00e-128	450.00
IUUC-Mmr-061609	Microcebus murinus	82.14	0.00e+00	668.00
IUUC-Mmu-063904	Mus musculus	83.17	0.00e+00	700.00
IUUC-Mac-064716	Musa acuminata	28.50	3.00e-43	169.00
IUUC-Mpu-066617	Mustela putorius furo	85.14	0.00e+00	716.00
IUUC-Mlu-067054	Myotis lucifugus	84.17	0.00e+00	704.00
IUUC-Nfi-068467	Neosartorya fischeri	35.27	3.00e-35	142.00
IUUC-Nle-069731	Nomascus leucogenys	85.14	0.00e+00	724.00
IUUC-Opr-070297	Ochotona princeps	61.86	7.00e-79	287.00
IUUC-Ont-072558	Oreochromis niloticus	73.57	2.00e-176	611.00
IUUC-Oan-072864	Ornithorhynchus anatinus	92.98	2.00e-28	116.00
IUUC-Ocu-074415	Oryctolagus cuniculus	86.90	0.00e+00	732.00
IUUC-Oba-075759	Oryza barthii	40.65	1.00e-45	177.00
IUUC-Obr-076387	Oryza brachyantha	30.66	2.00e-48	186.00
IUUC-Ogl-077924	Oryza glaberrima	41.48	2.00e-19	89.00
IUUC-Ogu-078186	Oryza glumaepatula	36.13	7.00e-67	247.00
IUUC-Oin-079389	Oryza indica	35.51	1.00e-49	190.00
IUUC-Olo-080916	Oryza longistaminata	31.87	8.00e-17	79.70
IUUC-Ome-081471	Oryza meridionalis	39.72	3.00e-42	166.00
IUUC-Oni-082449	Oryza nivara	39.63	1.00e-42	167.00
IUUC-Opu-083210	Oryza punctata	34.47	1.00e-62	233.00
IUUC-Oru-085159	Oryza rufipogon	40.65	1.00e-45	177.00
IUUC-Osa-085926	Oryza sativa	44.59	2.00e-34	138.00
IUUC-Ola-087084	Oryzias latipes	71.39	1.00e-177	615.00
IUUC-Olu-087853	Ostreococcus lucimarinus	30.13	6.00e-41	161.00
IUUC-Oga-089008	Otolemur garnettii	83.46	0.00e+00	715.00
IUUC-Oar-089259	Ovis aries	86.18	0.00e+00	723.00
IUUC-Ptr-091112	Pan troglodytes	84.52	0.00e+00	713.00
IUUC-Pan-092303	Papio anubis	83.59	2.00e-62	230.00
IUUC-Psi-093050	Pelodiscus sinensis	87.91	0.00e+00	730.00
IUUC-Pma-094259	Petromyzon marinus	58.17	2.00e-131	461.00
IUUC-Pno-094798	Phaeosphaeria nodorum	33.17	3.00e-54	206.00
IUUC-Ppa-095477	Physcomitrella patens	30.16	7.00e-52	197.00
IUUC-Pfo-096855	Poecilia formosa	70.90	3.00e-176	610.00
IUUC-Pab-098096	Pongo abelii	84.63	0.00e+00	718.00
IUUC-Pop-098800	Populus trichocarpa	32.44	1.00e-68	253.00
IUUC-Pca-100187	Procavia capensis	88.35	9.00e-108	383.00
IUUC-Ppe-101759	Prunus persica	38.89	2.00e-46	180.00
IUUC-Pva-102438	Pteropus vampyrus	73.17	3.00e-86	311.00
IUUC-Pte-104197	Pyrenophora teres	33.90	6.00e-51	194.00
IUUC-Pyt-104421	Pyrenophora triticirepentis	33.81	6.00e-51	194.00
IUUC-Rno-106087	Rattus norvegicus	83.42	0.00e+00	711.00
IUUC-Sce-106276	Saccharomyces cerevisiae	26.29	2.00e-12	67.00
IUUC-Sha-106831	Sarcophilus harrisii	91.21	0.00e+00	759.00
IUUC-Sja-107681	Schizosaccharomyces japonicus	33.00	4.00e-57	215.00
IUUC-Spo-108294	Schizosaccharomyces pombe	36.16	5.00e-66	244.00
IUUC-Ssl-108613	Sclerotinia sclerotiorum	33.71	5.00e-53	201.00
IUUC-Smo-109008	Selaginella moellendorffii	39.47	1.00e-75	276.00
IUUC-Sit-110300	Setaria italica	32.76	3.00e-57	216.00
IUUC-Sly-111441	Solanum lycopersicum	34.50	4.00e-61	228.00
IUUC-Stu-111995	Solanum tuberosum	34.03	9.00e-62	231.00
IUUC-Sar-113196	Sorex araneus	74.52	2.00e-114	405.00
IUUC-Sbi-113790	Sorghum bicolor	42.64	2.00e-44	172.00
IUUC-Ssc-115609	Sus scrofa	86.40	0.00e+00	725.00
IUUC-Tgu-116927	Taeniopygia guttata	84.71	0.00e+00	699.00
IUUC-Tru-118164	Takifugu rubripes	71.96	0.00e+00	630.00
IUUC-Tsy-119151	Tarsius syrichta	78.84	0.00e+00	657.00
IUUC-Tni-120896	Tetraodon nigroviridis	70.75	1.00e-171	595.00
IUUC-Tca-121592	Theobroma cacao	32.08	5.00e-64	238.00
IUUC-Tre-122023	Trichoderma reesei	35.09	6.00e-48	185.00
IUUC-Tvi-122507	Trichoderma virens	34.19	6.00e-50	191.00
IUUC-Tae-125730	Triticum aestivum	30.86	1.00e-44	173.00
IUUC-Tur-126092	Triticum urartu	32.48	2.00e-35	143.00
IUUC-Tbe-127422	Tupaia belangeri	64.96	1.00e-136	479.00
IUUC-Ttr-129097	Tursiops truncatus	84.13	0.00e+00	706.00
IUUC-Vda-130014	Verticillium dahliae	37.30	1.00e-49	190.00
IUUC-Vpa-130782	Vicugna pacos	85.93	0.00e+00	723.00
IUUC-Vvi-131494	Vitis vinifera	33.18	3.00e-66	245.00
IUUC-Xtr-132165	Xenopus tropicalis	81.35	0.00e+00	656.00
IUUC-Xma-133205	Xiphophorus maculatus	71.32	1.00e-178	618.00
IUUC-Yli-134614	Yarrowia lipolytica	33.84	5.00e-57	214.00
IUUC-Zma-135861	Zea mays	36.36	5.00e-64	238.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence