iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089986

Ensembl Protein ID

ENSOARP00000008525.1

UniProt Accession

W5PDL1; W5PDL1_SHEEP

Genbank Protein ID

ENSOARP00000008525

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01100190

Gene Name

WDR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000007939.1	ENSOART00000008649.1	ENSOARP00000008525.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-36	122.8	268	298
UBD/Beta-Prp	3.90e-56	190.6	96	313

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++++++++ +d t+l+s+s+D+t k+WD+
   Q: 268  HDGGIYAISWsPDsTHLLSASGDKTSKIWDV 298
           99*********999****************7 PP

UBD/Beta-Prp

   S: 14   tcvkf.spdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkghedsv 97
           t+ k+ +  +++ a+g  +g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e   ++  v+  ++g+ v  ++gh++ +
   Q: 96   TVWKYyIHTRTYXASGDVSGKLRIWDTTQKEHLLKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDSGSSVGEITGHNKVI 184
           5556668999*******************998777742334567***********99999999887777777789************** PP
   S: 98   lslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgghtdsv 183
            s+++ +s+ ++lv+Gs+d+ +  ++ +  +    t   h ++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l  +++h++ +
   Q: 185  NSVDIKQSRpYRLVTGSDDNCAAFFEGPPFKFKF-TIGDHGRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALggSKAHDGGI 272
           *******999*****************9999998.99********************************************888***** PP
   S: 184  yslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdn 224
           y +s+++++++l+s+s d+t k+wd+  +++v+t++  ++ 
   Q: 273  YAISWSPDSTHLLSASGDKTSKIWDVNVNSVVNTFTMGSNV 313
           **********************************9876544 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

AETGPGPPPF SFFLSPFPSP PPSARRGAGP QVPGCVCVSA EKVFASLPQV ERGVSKIVGG 60
DPKGNNFLYT NGKCVILRNI DAGCVAEMIG SHRRFTVWKY YIHTRTYXAS GDVSGKLRIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGGCGCCC CAAAGTTGGC GATGCGGTCG GGGCCCCGCG GAAGCCCCCG TATCTCCCTG 60
CAGGGCCTGG ATAAGGGAGC GCGCGGACCA GGAAGTCGCA CCCGTCCCCT GCGCTCCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR011043--Gal_Oxase/kelch_b-propeller
IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	34.77	4.00e-78	285.00
IUUC-Aml-002368	Ailuropoda melanoleuca	89.14	0.00e+00	1113.00
IUUC-Atr-003160	Amborella trichopoda	35.11	1.00e-100	360.00
IUUC-Apl-004012	Anas platyrhynchos	82.46	0.00e+00	1009.00
IUUC-Aca-004707	Anolis carolinensis	77.70	0.00e+00	970.00
IUUC-Aly-006465	Arabidopsis lyrata	34.57	3.00e-96	345.00
IUUC-Ath-006740	Arabidopsis thaliana	34.41	1.00e-95	343.00
IUUC-Ago-007920	Ashbya gossypii	28.17	1.00e-69	257.00
IUUC-Acl-008262	Aspergillus clavatus	34.89	6.00e-97	348.00
IUUC-Afl-008471	Aspergillus flavus	28.43	1.00e-61	230.00
IUUC-Afu-008989	Aspergillus fumigatus	37.59	1.00e-91	330.00
IUUC-Ani-009167	Aspergillus nidulans	35.97	8.00e-104	370.00
IUUC-Ang-009595	Aspergillus niger	35.75	2.00e-93	336.00
IUUC-Aor-009908	Aspergillus oryzae	34.29	3.00e-91	329.00
IUUC-Ate-010580	Aspergillus terreus	35.27	7.00e-97	349.00
IUUC-Ame-011269	Astyanax mexicanus	55.64	5.00e-119	421.00
IUUC-Bgr-011996	Blumeria graminis	32.42	6.00e-94	338.00
IUUC-Bta-013278	Bos taurus	92.79	0.00e+00	1142.00
IUUC-Bci-013925	Botrytis cinerea	33.33	1.00e-94	340.00
IUUC-Bdi-014659	Brachypodium distachyon	33.87	6.00e-91	328.00
IUUC-Bol-016043	Brassica oleracea	34.47	5.00e-96	345.00
IUUC-Bra-017139	Brassica rapa	34.35	1.00e-94	340.00
IUUC-Cel-018417	Caenorhabditis elegans	38.27	8.00e-112	397.00
IUUC-Cja-019952	Callithrix jacchus	88.52	0.00e+00	1075.00
IUUC-Cfa-020225	Canis familiaris	90.33	0.00e+00	1097.00
IUUC-Cpo-021900	Cavia porcellus	88.52	0.00e+00	1097.00
IUUC-Csa-023028	Chlorocebus sabaeus	90.00	0.00e+00	1082.00
IUUC-Cho-025030	Choloepus hoffmanni	63.88	0.00e+00	700.00
IUUC-Cin-025152	Ciona intestinalis	51.76	2.00e-73	268.00
IUUC-Csv-025986	Ciona savignyi	36.02	4.00e-90	325.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	35.74	3.00e-97	349.00
IUUC-Cne-026814	Cryptococcus neoformans	33.12	1.00e-87	317.00
IUUC-Dre-027498	Danio rerio	71.58	1.00e-78	285.00
IUUC-Dno-029383	Dasypus novemcinctus	88.36	0.00e+00	1065.00
IUUC-Dor-030633	Dipodomys ordii	87.68	0.00e+00	1000.00
IUUC-Dse-031526	Dothistroma septosporum	36.10	2.00e-105	376.00
IUUC-Dme-031597	Drosophila melanogaster	43.82	2.00e-150	525.00
IUUC-Ete-032780	Echinops telfairi	81.09	0.00e+00	971.00
IUUC-Eca-034306	Equus caballus	89.02	0.00e+00	1068.00
IUUC-Eeu-034531	Erinaceus europaeus	73.83	2.00e-134	472.00
IUUC-Fca-036301	Felis catus	90.66	0.00e+00	1123.00
IUUC-Fal-037361	Ficedula albicollis	83.69	0.00e+00	1055.00
IUUC-Fox-037924	Fusarium oxysporum	33.07	3.00e-89	322.00
IUUC-Fso-038199	Fusarium solani	32.85	1.00e-86	314.00
IUUC-Gmo-039238	Gadus morhua	67.43	0.00e+00	830.00
IUUC-Ggr-039830	Gaeumannomyces graminis	33.44	9.00e-86	311.00
IUUC-Gga-040235	Gallus gallus	83.28	0.00e+00	1035.00
IUUC-Gac-042363	Gasterosteus aculeatus	67.43	0.00e+00	855.00
IUUC-Gma-044189	Glycine max	34.47	2.00e-97	349.00
IUUC-Ggo-044632	Gorilla gorilla	87.40	0.00e+00	1045.00
IUUC-Hsa-045792	Homo sapiens	89.67	0.00e+00	1090.00
IUUC-Hvu-047517	Hordeum vulgare	33.76	8.00e-96	344.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	89.72	0.00e+00	1090.00
IUUC-Kpa-049183	Komagataella pastoris	31.12	2.00e-74	273.00
IUUC-Lch-050428	Latimeria chalumnae	71.69	0.00e+00	919.00
IUUC-Lpe-051306	Leersia perrieri	34.63	3.00e-97	349.00
IUUC-Loc-052096	Lepisosteus oculatus	66.45	0.00e+00	807.00
IUUC-Lma-053313	Leptosphaeria maculans	36.88	2.00e-102	369.00
IUUC-Laf-054060	Loxodonta africana	87.05	0.00e+00	1058.00
IUUC-Mcc-055619	Macaca mulatta	88.42	0.00e+00	1062.00
IUUC-Meu-056689	Macropus eugenii	72.52	1.00e-163	569.00
IUUC-Mor-056940	Magnaporthe oryzae	32.80	2.00e-86	313.00
IUUC-Mpo-057557	Magnaporthe poae	29.23	9.00e-59	221.00
IUUC-Mtr-057922	Medicago truncatula	33.55	3.00e-97	349.00
IUUC-Mla-059103	Melampsora laricipopulina	31.72	2.00e-70	260.00
IUUC-Mga-060150	Meleagris gallopavo	83.77	0.00e+00	1036.00
IUUC-Mvi-060448	Microbotryum violaceum	31.63	2.00e-75	276.00
IUUC-Mmr-061226	Microcebus murinus	87.21	0.00e+00	1068.00
IUUC-Mdo-062674	Monodelphis domestica	86.07	0.00e+00	1056.00
IUUC-Mmu-064170	Mus musculus	88.69	0.00e+00	1095.00
IUUC-Mac-065124	Musa acuminata	34.95	9.00e-100	357.00
IUUC-Mpu-066001	Mustela putorius furo	86.53	0.00e+00	1076.00
IUUC-Mlu-067253	Myotis lucifugus	89.51	0.00e+00	1095.00
IUUC-Nfi-068550	Neosartorya fischeri	36.00	2.00e-100	359.00
IUUC-Ncr-068948	Neurospora crassa	34.40	2.00e-101	363.00
IUUC-Nle-070115	Nomascus leucogenys	88.01	0.00e+00	982.00
IUUC-Opr-070254	Ochotona princeps	86.21	0.00e+00	1026.00
IUUC-Ont-071666	Oreochromis niloticus	69.84	0.00e+00	878.00
IUUC-Oan-073594	Ornithorhynchus anatinus	88.01	2.00e-164	571.00
IUUC-Ocu-074824	Oryctolagus cuniculus	87.05	0.00e+00	1043.00
IUUC-Oba-075010	Oryza barthii	35.11	1.00e-98	353.00
IUUC-Obr-076364	Oryza brachyantha	35.44	4.00e-100	358.00
IUUC-Ogl-077019	Oryza glaberrima	35.11	1.00e-98	353.00
IUUC-Ogu-078496	Oryza glumaepatula	35.11	1.00e-98	353.00
IUUC-Oin-080116	Oryza indica	35.28	3.00e-99	355.00
IUUC-Olo-080290	Oryza longistaminata	35.11	2.00e-98	352.00
IUUC-Ome-081969	Oryza meridionalis	35.11	1.00e-98	353.00
IUUC-Oni-082075	Oryza nivara	35.11	1.00e-98	353.00
IUUC-Opu-083959	Oryza punctata	34.95	2.00e-98	353.00
IUUC-Oru-084711	Oryza rufipogon	35.11	1.00e-98	353.00
IUUC-Osa-085958	Oryza sativa	35.28	3.00e-99	355.00
IUUC-Ola-086968	Oryzias latipes	70.89	0.00e+00	883.00
IUUC-Oga-089108	Otolemur garnettii	88.94	0.00e+00	1108.00
IUUC-Ptr-091281	Pan troglodytes	89.98	0.00e+00	1090.00
IUUC-Pan-092585	Papio anubis	90.00	0.00e+00	1083.00
IUUC-Psi-093811	Pelodiscus sinensis	82.95	0.00e+00	1054.00
IUUC-Pma-094542	Petromyzon marinus	64.73	0.00e+00	821.00
IUUC-Pno-095086	Phaeosphaeria nodorum	34.80	5.00e-95	342.00
IUUC-Ppa-095876	Physcomitrella patens	35.07	5.00e-100	358.00
IUUC-Pfo-096973	Poecilia formosa	70.39	0.00e+00	903.00
IUUC-Pab-098391	Pongo abelii	89.34	0.00e+00	1080.00
IUUC-Pop-098850	Populus trichocarpa	35.17	3.00e-98	352.00
IUUC-Pca-100257	Procavia capensis	66.97	2.00e-73	270.00
IUUC-Ppe-101578	Prunus persica	35.88	8.00e-101	361.00
IUUC-Pva-102872	Pteropus vampyrus	84.94	0.00e+00	1044.00
IUUC-Pgr-103593	Puccinia graminis	32.13	1.00e-73	270.00
IUUC-Pte-104365	Pyrenophora teres	36.60	1.00e-98	353.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	36.28	1.00e-98	353.00
IUUC-Rno-105737	Rattus norvegicus	90.16	0.00e+00	1118.00
IUUC-Sce-106383	Saccharomyces cerevisiae	29.20	8.00e-64	238.00
IUUC-Sha-107084	Sarcophilus harrisii	84.15	0.00e+00	943.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	33.66	4.00e-97	348.00
IUUC-Spo-108309	Schizosaccharomyces pombe	31.40	4.00e-82	298.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	33.71	3.00e-94	338.00
IUUC-Smo-109255	Selaginella moellendorffii	32.85	1.00e-88	320.00
IUUC-Sit-109962	Setaria italica	35.82	3.00e-101	362.00
IUUC-Sly-110897	Solanum lycopersicum	35.82	1.00e-100	360.00
IUUC-Stu-111971	Solanum tuberosum	35.66	9.00e-100	357.00
IUUC-Sar-113415	Sorex araneus	66.04	3.00e-95	342.00
IUUC-Sbi-114857	Sorghum bicolor	35.66	3.00e-99	355.00
IUUC-Sre-114900	Sporisorium reilianum	33.61	1.00e-82	300.00
IUUC-Tgu-117256	Taeniopygia guttata	83.28	0.00e+00	1048.00
IUUC-Tru-117871	Takifugu rubripes	66.23	0.00e+00	816.00
IUUC-Tsy-119172	Tarsius syrichta	95.83	6.00e-137	480.00
IUUC-Tni-120339	Tetraodon nigroviridis	66.56	0.00e+00	852.00
IUUC-Tca-121609	Theobroma cacao	34.59	1.00e-97	350.00
IUUC-Tre-122076	Trichoderma reesei	33.87	7.00e-81	294.00
IUUC-Tvi-122528	Trichoderma virens	33.12	2.00e-85	309.00
IUUC-Tae-124549	Triticum aestivum	34.09	1.00e-96	347.00
IUUC-Tur-126845	Triticum urartu	34.74	3.00e-77	282.00
IUUC-Tme-127217	Tuber melanosporum	33.86	1.00e-93	337.00
IUUC-Tbe-127526	Tupaia belangeri	87.23	0.00e+00	1064.00
IUUC-Ttr-128898	Tursiops truncatus	86.74	0.00e+00	1059.00
IUUC-Uma-129631	Ustilago maydis	32.15	4.00e-85	308.00
IUUC-Vda-129732	Verticillium dahliae	33.02	8.00e-84	304.00
IUUC-Vvi-131217	Vitis vinifera	35.71	1.00e-98	353.00
IUUC-Xtr-132860	Xenopus tropicalis	69.04	0.00e+00	860.00
IUUC-Xma-133830	Xiphophorus maculatus	70.39	0.00e+00	904.00
IUUC-Yli-134335	Yarrowia lipolytica	30.98	7.00e-67	248.00
IUUC-Zma-135907	Zea mays	35.49	5.00e-100	358.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence