iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-08	32.7	305	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvl 35
           gHt  v+ l++  ++++++sGs+D+ +  WDl tg+ 
   Q: 305  GHTQIVNILRLngQEDRFLSGSWDKRLLEWDLQTGDI 341
           79999999999765599***************99986 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Required, directly or indirectly, for TATA-binding protein function at particular promoters. May promote a functional interaction between SPT3 and TATA-binding protein. Functions as a component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs).

Protein Sequence
(Fasta)

MDEVDDILIN NQVVDDEEDD EEMLSGLEND SKQDLEGNDD GGEDEEDDDD DDEDDDDDED 60
EREDDDEQED DDGEDDAARM DKTATPTNEH QHDEQKAAAA GAGGAGDSGD AVTKIGSEDV 120

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Nucleotide Sequence
(Fasta)

ATGGACGAGG TTGACGATAT TCTAATTAAC AACCAGGTGG TGGATGACGA GGAGGATGAC 60
GAAGAGATGC TGAGTGGGCT GGAAAACGAC TCAAAGCAGG ACCTCGAGGG GAATGATGAC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0000124--C:SAGA complex
GO:0017025--F:TBP-class protein binding
GO:0003712--F:transcription cofactor activity
GO:0006325--P:chromatin organization
GO:0016573--P:histone acetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

sce:YLR055C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007730	Ashbya gossypii	54.89	6.00e-157	545.00
IUUC-Acl-008082	Aspergillus clavatus	45.81	8.00e-46	176.00
IUUC-Afl-008500	Aspergillus flavus	45.35	5.00e-45	173.00
IUUC-Afu-008923	Aspergillus fumigatus	45.20	3.00e-46	177.00
IUUC-Ani-009147	Aspergillus nidulans	43.23	8.00e-47	179.00
IUUC-Ang-009566	Aspergillus niger	35.17	2.00e-79	287.00
IUUC-Aor-010108	Aspergillus oryzae	45.35	4.00e-45	174.00
IUUC-Ate-010560	Aspergillus terreus	35.71	6.00e-35	139.00
IUUC-Bgr-012309	Blumeria graminis	35.06	4.00e-82	296.00
IUUC-Bci-013614	Botrytis cinerea	35.44	3.00e-87	314.00
IUUC-Cgl-026527	Colletotrichum gloeosporioides	42.86	4.00e-42	164.00
IUUC-Cne-027016	Cryptococcus neoformans	42.70	9.00e-40	156.00
IUUC-Dse-031194	Dothistroma septosporum	41.09	4.00e-44	171.00
IUUC-Fox-037991	Fusarium oxysporum	46.73	4.00e-49	187.00
IUUC-Fso-038399	Fusarium solani	41.92	1.00e-47	182.00
IUUC-Ggr-039756	Gaeumannomyces graminis	48.59	3.00e-48	184.00
IUUC-Kpa-049379	Komagataella pastoris	42.04	1.00e-107	381.00
IUUC-Lma-053094	Leptosphaeria maculans	35.01	2.00e-91	328.00
IUUC-Mor-056920	Magnaporthe oryzae	44.63	3.00e-45	174.00
IUUC-Mla-058891	Melampsora laricipopulina	35.28	4.00e-71	260.00
IUUC-Mvi-060352	Microbotryum violaceum	37.71	1.00e-32	132.00
IUUC-Nfi-068276	Neosartorya fischeri	39.11	2.00e-34	138.00
IUUC-Ncr-068871	Neurospora crassa	43.22	4.00e-46	177.00
IUUC-Pno-094917	Phaeosphaeria nodorum	46.89	2.00e-47	181.00
IUUC-Pop-099827	Populus trichocarpa	25.85	2.00e-05	42.40
IUUC-Pgr-103632	Puccinia graminis	41.79	7.00e-37	147.00
IUUC-Ptt-103790	Puccinia triticina	39.80	2.00e-32	132.00
IUUC-Pte-104169	Pyrenophora teres	46.55	2.00e-47	181.00
IUUC-Pyt-104624	Pyrenophora triticirepentis	43.78	1.00e-47	182.00
IUUC-Sja-107893	Schizosaccharomyces japonicus	37.34	6.00e-83	299.00
IUUC-Spo-108330	Schizosaccharomyces pombe	39.09	2.00e-90	324.00
IUUC-Sre-114899	Sporisorium reilianum	40.88	9.00e-38	150.00
IUUC-Tre-122019	Trichoderma reesei	39.59	7.00e-46	176.00
IUUC-Tvi-122319	Trichoderma virens	45.71	5.00e-45	174.00
IUUC-Tme-126977	Tuber melanosporum	37.15	7.00e-80	288.00
IUUC-Uma-129635	Ustilago maydis	40.98	4.00e-39	154.00
IUUC-Vda-129679	Verticillium dahliae	46.89	5.00e-46	177.00
IUUC-Yli-134619	Yarrowia lipolytica	41.40	4.00e-98	349.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence