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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045885
UUCD1 version UUC-HoS-01187
Ensembl Protein ID ENSP00000381717.3
UniProt Accession P62837; D3DQC9; P51669; Q3MN78; Q96RP6; UB2D2_HUMAN
Genbank Protein ID AAA91460.1; AAC41750.1; AAX35690.1; AAK93958.1; BAG50891.1; BAG50911.1; EAW62095.1; EAW62096.1; EAW62097.1; AAH33349.1
Protein Name Ubiquitin-conjugating enzyme E2 D2; (E3-independent) E2 ubiquitin-conjugating enzyme D2; E2 ubiquitin-conjugating enzyme D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2; p53-regulated ubiquitin-conjugating enzyme 1
Genbank Nucleotide ID U39317; L40146; AY651263; AF317220; AK001311; AK001428; AC010378; CH471062; CH471062; BC033349
Gene Name UBE2D2; PUBC1; UBC4; UBC5B; UBCH4; UBCH5B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000131508.15 ENST00000398733.7 ENSP00000381717.3
ENSG00000131508.15 ENST00000253815.3 ENSP00000253815.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
DrugBank
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 20704751; 20625400; 20145714; 18703417; 19690162; 19687296; 19578373; 19264966; 17786241; 18643997; 18633460; 18451177; 17604280; 17513889; 17341663; 16288031; 16203730; 12615916; 15920166; 11823428
UBD/UBC-like/UBD_UBC UBD_UBC 22902369
Classification
Family E-value Score Start End
E2/UBC 1.90e-56 191.3 5 139
UBD/UBC-like/UBD_UBC 3.40e-85 284.8 5 142
Active Site
Position(s) Description Evidence
85 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           R++kel++l++dpp+++sa+pv + d+++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv f+t+i+hPn+++nG++Cl+il+  ++W
   Q: 5    RIHKELNDLARDPPAQCSAGPVGD-DMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--SQW 93
           99**********************.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           spal++++vllsi+sll++pnp++pl  e+a+++k++re+y++++r
   Q: 94   SPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAR 139
           ******************************************9987 PP
   

   UBD/UBC-like/UBD_UBC
   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaa 92
           ri+kel+dl+rd++aq+sa++v+dd+f+++ati+gp+dspy+ggvfflti++ptdypfkppkvaf+t+iyhpninsngsicldilrsqws+a
   Q: 5    RIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPA 96
           8******************************************************************************************* PP
   S: 93   ltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           lt+skvlls+csll+d++pddplv+eiariyktd+eky+riarewt
   Q: 97   LTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWT 142
           *********************************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
Protein Sequence
(Fasta)
MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 60
PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045885|E2,E2/UBC;UBD,UBD_UBC|Homo sapiens
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Nucleotide Sequence
(Fasta)
CATCCCTGTG GGGGACTCCG GCCAGCCTGA GTGACGCGAT CCAAAGAGCG CTCCCGGGTA 60
GGAAATTGCC CTGGTGGAAT GCCTCGCCAG AGCAGCGTGT AGCAGGCCCC CGCGGAGGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045885|E2,E2/UBC;UBD,UBD_UBC|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:7322
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001778 Ailuropoda melanoleuca 100.00 1.00e-81 294.00
IUUC-Apl-003199 Anas platyrhynchos 100.00 3.00e-81 293.00
IUUC-Aca-005236 Anolis carolinensis 100.00 4.00e-86 309.00
IUUC-Ago-007967 Ashbya gossypii 80.95 2.00e-71 260.00
IUUC-Ang-009725 Aspergillus niger 84.80 4.00e-62 229.00
IUUC-Ame-011831 Astyanax mexicanus 96.60 3.00e-83 300.00
IUUC-Bgr-012238 Blumeria graminis 80.27 1.00e-69 254.00
IUUC-Bta-013158 Bos taurus 100.00 4.00e-86 309.00
IUUC-Cel-018362 Caenorhabditis elegans 93.88 2.00e-81 294.00
IUUC-Cja-019886 Callithrix jacchus 100.00 4.00e-86 309.00
IUUC-Cfa-020436 Canis familiaris 100.00 4.00e-86 309.00
IUUC-Cpo-021714 Cavia porcellus 97.96 3.00e-84 303.00
IUUC-Csa-023148 Chlorocebus sabaeus 95.27 5.00e-81 292.00
IUUC-Csv-026311 Ciona savignyi 85.62 9.00e-73 265.00
IUUC-Dre-027758 Danio rerio 98.64 6.00e-85 305.00
IUUC-Dno-028952 Dasypus novemcinctus 100.00 8.00e-82 295.00
IUUC-Dme-031594 Drosophila melanogaster 94.56 2.00e-81 293.00
IUUC-Ete-032295 Echinops telfairi 100.00 3.00e-81 293.00
IUUC-Eca-033293 Equus caballus 100.00 2.00e-81 294.00
IUUC-Fox-038021 Fusarium oxysporum 84.35 1.00e-73 268.00
IUUC-Ggr-039912 Gaeumannomyces graminis 79.61 2.00e-69 254.00
IUUC-Gga-040758 Gallus gallus 100.00 4.00e-86 309.00
IUUC-Gac-042231 Gasterosteus aculeatus 97.28 6.00e-84 302.00
IUUC-Ggo-045375 Gorilla gorilla 95.95 3.00e-82 296.00
IUUC-Itr-048882 Ictidomys tridecemlineatus 96.62 4.00e-82 296.00
IUUC-Lma-053121 Leptosphaeria maculans 84.35 4.00e-74 270.00
IUUC-Laf-053580 Loxodonta africana 100.00 1.00e-81 295.00
IUUC-Mcc-054673 Macaca mulatta 100.00 2.00e-81 294.00
IUUC-Mor-057235 Magnaporthe oryzae 83.67 5.00e-73 266.00
IUUC-Mpo-057596 Magnaporthe poae 79.61 5.00e-69 253.00
IUUC-Mvi-060397 Microbotryum violaceum 82.31 7.00e-72 262.00
IUUC-Mdo-062962 Monodelphis domestica 100.00 4.00e-86 309.00
IUUC-Mmu-063518 Mus musculus 100.00 4.00e-86 309.00
IUUC-Mpu-066604 Mustela putorius furo 95.89 3.00e-82 296.00
IUUC-Ont-071766 Oreochromis niloticus 98.64 4.00e-85 306.00
IUUC-Ocu-074315 Oryctolagus cuniculus 100.00 4.00e-86 309.00
IUUC-Ola-086331 Oryzias latipes 98.64 4.00e-85 306.00
IUUC-Ptr-090707 Pan troglodytes 100.00 4.00e-86 309.00
IUUC-Pan-092143 Papio anubis 100.00 4.00e-86 309.00
IUUC-Pma-094405 Petromyzon marinus 94.81 1.00e-75 274.00
IUUC-Pno-094765 Phaeosphaeria nodorum 84.35 4.00e-74 270.00
IUUC-Pfo-096753 Poecilia formosa 98.64 4.00e-85 306.00
IUUC-Pab-097764 Pongo abelii 100.00 4.00e-86 309.00
IUUC-Pgr-103381 Puccinia graminis 82.31 1.00e-69 256.00
IUUC-Ptt-103723 Puccinia triticina 77.86 2.00e-61 227.00
IUUC-Sce-106153 Saccharomyces cerevisiae 80.56 4.00e-70 256.00
IUUC-Sja-107729 Schizosaccharomyces japonicus 84.35 5.00e-73 266.00
IUUC-Sar-113302 Sorex araneus 100.00 3.00e-81 293.00
IUUC-Tru-118272 Takifugu rubripes 98.64 1.00e-84 305.00
IUUC-Tni-120056 Tetraodon nigroviridis 98.64 1.00e-84 305.00
IUUC-Tre-122125 Trichoderma reesei 82.31 2.00e-71 261.00
IUUC-Tvi-122296 Trichoderma virens 82.31 2.00e-71 261.00
IUUC-Tbe-127609 Tupaia belangeri 100.00 1.00e-67 247.00
IUUC-Uma-129648 Ustilago maydis 81.63 1.00e-71 261.00
IUUC-Vpa-130446 Vicugna pacos 99.29 2.00e-80 291.00
IUUC-Xtr-132329 Xenopus tropicalis 100.00 4.00e-86 309.00
Created Date 25-Jun-2017

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