iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012692

UUCD1 version

UUC-BoT-00967

Ensembl Protein ID

ENSBTAP00000021630.4

UniProt Accession

Q3ZCC3; TRAF6_BOVIN

Genbank Protein ID

ABC47877.1; ABD72516.1; AAI02523.1

Protein Name

TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6

Genbank Nucleotide ID

DQ319074; DQ407276; BC102522

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000036009.2	ENSBTAT00000021630.4	ENSBTAP00000021630.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.60e-07	29.9	67	128

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 67   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 128
           5689*****************************999999*****************999977 PP

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Protein Sequence
(Fasta)

MSLLHCENSC GSSQSESDCC AAMAASSCGT AAKDDSVSGT ASTVTLSSSF MEEIQGYDVE 60
FDPPLESKYE CPICLMALRE AVQTPCGHRF CKACIIKSIR DAGHKCPVDN EILLENQLFP 120

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Nucleotide Sequence
(Fasta)

TGGGGTCGGG CTCCGGGCGC CCAAGGGACG CAGCAGTGGC GGCCTTCAAG TTAGGAGACT 60
GGCTTTCCGG CCACTTCGGC GCGGAGCGCG GCGCCTTCCT CTTCTGGCGC CTTGGCCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0391--Immunity
KW-1017--Isopeptide bond
KW-0551--Lipid droplet
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0987--Osteopetrosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0005938--C:cell cortex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

bta:539124

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	92.42	0.00e+00	972.00
IUUC-Apl-004062	Anas platyrhynchos	74.05	0.00e+00	837.00
IUUC-Aca-004636	Anolis carolinensis	69.66	0.00e+00	770.00
IUUC-Ame-011682	Astyanax mexicanus	54.48	1.00e-164	573.00
IUUC-Cja-019426	Callithrix jacchus	88.01	0.00e+00	961.00
IUUC-Cfa-020948	Canis familiaris	90.20	0.00e+00	858.00
IUUC-Cpo-021378	Cavia porcellus	89.34	0.00e+00	959.00
IUUC-Csa-024045	Chlorocebus sabaeus	88.93	0.00e+00	978.00
IUUC-Cho-024973	Choloepus hoffmanni	75.10	1.00e-105	376.00
IUUC-Csv-026300	Ciona savignyi	41.99	1.00e-47	182.00
IUUC-Dre-027557	Danio rerio	57.93	4.00e-179	620.00
IUUC-Dno-030032	Dasypus novemcinctus	87.46	4.00e-148	516.00
IUUC-Dor-030790	Dipodomys ordii	87.27	0.00e+00	951.00
IUUC-Dme-031921	Drosophila melanogaster	27.43	3.00e-41	162.00
IUUC-Ete-032952	Echinops telfairi	83.78	5.00e-168	583.00
IUUC-Eca-033924	Equus caballus	86.21	0.00e+00	880.00
IUUC-Eeu-034734	Erinaceus europaeus	80.66	0.00e+00	849.00
IUUC-Fca-036222	Felis catus	84.53	0.00e+00	865.00
IUUC-Fal-036834	Ficedula albicollis	75.00	0.00e+00	741.00
IUUC-Fox-037935	Fusarium oxysporum	29.77	5.00e-22	99.00
IUUC-Gmo-039061	Gadus morhua	61.79	4.00e-88	318.00
IUUC-Ggr-040084	Gaeumannomyces graminis	25.79	1.00e-12	67.80
IUUC-Gga-040599	Gallus gallus	75.32	0.00e+00	845.00
IUUC-Gac-041977	Gasterosteus aculeatus	54.06	7.00e-169	587.00
IUUC-Ggo-044508	Gorilla gorilla	83.09	0.00e+00	889.00
IUUC-Hsa-046349	Homo sapiens	89.48	0.00e+00	1007.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	88.38	0.00e+00	980.00
IUUC-Lch-049821	Latimeria chalumnae	67.86	0.00e+00	755.00
IUUC-Loc-051995	Lepisosteus oculatus	63.01	0.00e+00	649.00
IUUC-Laf-054115	Loxodonta africana	86.35	0.00e+00	959.00
IUUC-Mcc-055298	Macaca mulatta	88.56	0.00e+00	973.00
IUUC-Mor-057263	Magnaporthe oryzae	30.56	1.00e-17	84.70
IUUC-Mpo-057517	Magnaporthe poae	28.78	5.00e-15	75.90
IUUC-Mga-059340	Meleagris gallopavo	74.36	0.00e+00	821.00
IUUC-Mvi-060553	Microbotryum violaceum	28.57	1.00e-15	78.20
IUUC-Mmr-061063	Microcebus murinus	89.85	0.00e+00	962.00
IUUC-Mdo-062075	Monodelphis domestica	80.00	0.00e+00	898.00
IUUC-Mmu-063780	Mus musculus	85.06	0.00e+00	900.00
IUUC-Mpu-065748	Mustela putorius furo	92.25	0.00e+00	984.00
IUUC-Mlu-067888	Myotis lucifugus	88.01	0.00e+00	954.00
IUUC-Ncr-068632	Neurospora crassa	28.00	3.00e-17	83.60
IUUC-Nle-069234	Nomascus leucogenys	89.11	0.00e+00	983.00
IUUC-Opr-070393	Ochotona princeps	95.31	2.00e-122	432.00
IUUC-Ont-072459	Oreochromis niloticus	53.89	4.00e-177	614.00
IUUC-Oan-073578	Ornithorhynchus anatinus	81.65	0.00e+00	907.00
IUUC-Ocu-074201	Oryctolagus cuniculus	89.48	0.00e+00	971.00
IUUC-Ola-087319	Oryzias latipes	58.71	4.00e-89	322.00
IUUC-Olu-087748	Ostreococcus lucimarinus	23.29	8.00e-11	61.20
IUUC-Oga-087936	Otolemur garnettii	86.72	0.00e+00	946.00
IUUC-Oar-089379	Ovis aries	98.52	0.00e+00	1083.00
IUUC-Ptr-090758	Pan troglodytes	89.48	0.00e+00	981.00
IUUC-Pan-092590	Papio anubis	88.75	0.00e+00	974.00
IUUC-Psi-093948	Pelodiscus sinensis	72.18	0.00e+00	811.00
IUUC-Pma-094434	Petromyzon marinus	43.72	6.00e-127	447.00
IUUC-Pfo-096912	Poecilia formosa	52.46	3.00e-169	588.00
IUUC-Pab-097651	Pongo abelii	89.48	0.00e+00	984.00
IUUC-Pca-100958	Procavia capensis	84.69	0.00e+00	706.00
IUUC-Pva-103247	Pteropus vampyrus	90.51	2.00e-128	452.00
IUUC-Pte-104279	Pyrenophora teres	25.57	2.00e-12	67.80
IUUC-Rno-104994	Rattus norvegicus	83.03	0.00e+00	905.00
IUUC-Sha-106494	Sarcophilus harrisii	81.37	0.00e+00	915.00
IUUC-Sar-113375	Sorex araneus	85.82	0.00e+00	924.00
IUUC-Sre-115218	Sporisorium reilianum	26.52	1.00e-15	78.20
IUUC-Ssc-115417	Sus scrofa	93.53	0.00e+00	1004.00
IUUC-Tgu-117232	Taeniopygia guttata	73.26	0.00e+00	798.00
IUUC-Tru-118321	Takifugu rubripes	53.10	7.00e-166	577.00
IUUC-Tni-120475	Tetraodon nigroviridis	55.88	7.00e-164	570.00
IUUC-Tbe-127719	Tupaia belangeri	77.57	0.00e+00	815.00
IUUC-Ttr-129264	Tursiops truncatus	94.86	8.00e-130	457.00
IUUC-Uma-129620	Ustilago maydis	25.76	4.00e-17	83.20
IUUC-Vpa-130244	Vicugna pacos	92.09	4.00e-130	458.00
IUUC-Xtr-131948	Xenopus tropicalis	65.59	0.00e+00	756.00
IUUC-Xma-133132	Xiphophorus maculatus	57.17	4.00e-170	591.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence