iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ate-010466

Ensembl Protein ID

CADATEAP00005078

UniProt Accession

Q0CV33; Q0CV33_ASPTN

Genbank Protein ID

EAU37413.1

Protein Name

Ubiquitin-activating enzyme E1 1

Genbank Nucleotide ID

CH476596

Gene Name

ATEG_02451

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADATEAG00005078	CADATEAT00005078	CADATEAP00005078

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.60e-188	625.4	438	924

Active Site

Position(s)	Description	Evidence
621	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdv 88
           YD+Qi+++G ++q+k+ +   +lvGag++GcE+lKn +++G+     g+i+v+Dmd++e+snlnrqFLfr +dvgk K+e+a +a++ +np  
   Q: 438  YDGQIAVFGKDYQDKIANVTQFLVGAGAIGCETLKNWAMMGLgtgpkGKIYVTDMDQIEKSNLNRQFLFRSKDVGKLKSECASAAVQAMNPEL 530
           ********************************************************************************************* PP
   S: 89   nveahe..esiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctl 176
           ++++++  +++ +++e+++   F + +d+V +aldn++ar++v+r+c+  r+pl+esgtlG++G+++v+++++te+ys+s+dpp+k++P+ctl
   Q: 531  QGKIVTmrDRVGPDTEHVFneeFWEGLDGVTNALDNVDARTYVDRRCVFFRKPLLESGTLGTKGNTQVVLPHITESYSSSQDPPEKSFPMCTL 623
           9988764479******98899999999****************************************************************** PP
   S: 177  ketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqll 257
           k++pn +ehti wa            + +n++l++ +  e++l++  + + ++++++  + l++ ++ +f+++i +a+++f+ +++n i+qll
   Q: 624  KSFPNRIEHTIAWArdlfqtyfvgppESVNMYLSQPNYIEQTLKQ--AGNEKQTLEQLHAFLVTDKPLTFDDCIVWARHQFEAQYNNAIQQLL 714
           **************************9999998777666666664..3444444555556689999*************************** PP
   S: 258  ksfecdivtkskspfwv............................................................sfcsnaealqvpekve 290
            +f+ d  t+s++pfw+                                                            s ++ ++  ++p+ ++
   Q: 715  YNFPRDSKTSSGQPFWSgpkrapsplkfdssnpthlgfiiaaanlhafnygiknpgadkeyyrkvvdnmiipefspkSGVKIQADENEPDPNA 807
           ************************************************************************888886677777777777777 PP
   S: 291  kdeevvkasap.lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGla 380
           +    + ++++ ++ l+ +l + ++  g   + ++fekddd   ++d++taa+nlra +++i++ +d++++k iag+iipaiatt+a v Gl+
   Q: 808  QASGSSFDDNSeIQRLVDSLPSPKSLAGFHLNPVEFEKDDDTnhHIDFITAASNLRADNYEIPQ-ADRHKTKFIAGKIIPAIATTTALVTGLV 899
           776666555557*****************************999********************.**************************** PP
   S: 381  aqEviKvvsg..kfeplknfflfda 403
           a+E++K+++g  + e++kn f ++a
   Q: 900  ALELYKIIDGkdDIEQYKNGFANLA 924
           **********777888***999977 PP

Organism

Aspergillus terreus

Protein Sequence
(Fasta)

MTDVKMQVDN PQETVEKIKQ GEIDESLYSR QLYVLGHEAM KRMGSSNVLI VGLKGLGVEI 60
GKYTGFHLLD VAHSSLAKNI ALAGVKSLTL YDPAPVAISD LSSQFFLQPQ DVGKPRAEVT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGGTAT GCATTCGAAT AGTCCCTGCG ATTTTGCATT CGGATTACCT GCGCATATGT 60
GCTAACACTT TCCAGGACGT CAAGATGCAG GTGGACAATC CACAGGAGAC TGTGGAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004839--F:ubiquitin activating enzyme activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	46.57	0.00e+00	830.00
IUUC-Aml-001311	Ailuropoda melanoleuca	53.59	0.00e+00	1102.00
IUUC-Atr-002684	Amborella trichopoda	44.50	0.00e+00	849.00
IUUC-Apl-004158	Anas platyrhynchos	41.94	0.00e+00	696.00
IUUC-Aca-004620	Anolis carolinensis	54.59	0.00e+00	1098.00
IUUC-Aly-005418	Arabidopsis lyrata	45.19	0.00e+00	871.00
IUUC-Ath-006891	Arabidopsis thaliana	45.01	0.00e+00	862.00
IUUC-Ago-007873	Ashbya gossypii	59.79	0.00e+00	1207.00
IUUC-Acl-008181	Aspergillus clavatus	89.05	0.00e+00	1897.00
IUUC-Afl-008455	Aspergillus flavus	91.43	0.00e+00	1889.00
IUUC-Afu-009065	Aspergillus fumigatus	89.76	0.00e+00	1934.00
IUUC-Ani-009371	Aspergillus nidulans	88.00	0.00e+00	1833.00
IUUC-Ang-009737	Aspergillus niger	89.90	0.00e+00	1907.00
IUUC-Aor-010007	Aspergillus oryzae	91.48	0.00e+00	1882.00
IUUC-Ame-010933	Astyanax mexicanus	54.30	0.00e+00	1036.00
IUUC-Bgr-012281	Blumeria graminis	69.35	0.00e+00	1481.00
IUUC-Bta-012767	Bos taurus	53.96	0.00e+00	1112.00
IUUC-Bci-013721	Botrytis cinerea	72.59	0.00e+00	1492.00
IUUC-Bdi-014009	Brachypodium distachyon	44.83	0.00e+00	858.00
IUUC-Bol-015665	Brassica oleracea	46.15	0.00e+00	868.00
IUUC-Bra-017252	Brassica rapa	44.69	0.00e+00	869.00
IUUC-Cel-018260	Caenorhabditis elegans	45.54	0.00e+00	814.00
IUUC-Cja-019152	Callithrix jacchus	53.32	0.00e+00	1098.00
IUUC-Cfa-020622	Canis familiaris	52.25	0.00e+00	1046.00
IUUC-Cpo-022526	Cavia porcellus	54.07	0.00e+00	1089.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	44.03	0.00e+00	788.00
IUUC-Csa-023780	Chlorocebus sabaeus	53.97	0.00e+00	1099.00
IUUC-Cho-024682	Choloepus hoffmanni	40.89	4.00e-96	344.00
IUUC-Cin-025790	Ciona intestinalis	52.60	0.00e+00	1076.00
IUUC-Csv-026084	Ciona savignyi	52.94	0.00e+00	1076.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	70.16	0.00e+00	1537.00
IUUC-Cne-026960	Cryptococcus neoformans	60.17	0.00e+00	1230.00
IUUC-Cme-027290	Cyanidioschyzon merolae	44.08	0.00e+00	833.00
IUUC-Dre-028149	Danio rerio	54.78	0.00e+00	1076.00
IUUC-Dno-028884	Dasypus novemcinctus	53.68	0.00e+00	1103.00
IUUC-Dor-030229	Dipodomys ordii	51.58	0.00e+00	1036.00
IUUC-Dse-031524	Dothistroma septosporum	72.38	0.00e+00	1551.00
IUUC-Dme-032045	Drosophila melanogaster	52.08	0.00e+00	1034.00
IUUC-Ete-033124	Echinops telfairi	41.27	7.00e-144	503.00
IUUC-Eca-033330	Equus caballus	53.68	0.00e+00	1099.00
IUUC-Eeu-035323	Erinaceus europaeus	42.96	7.00e-154	536.00
IUUC-Fca-036255	Felis catus	53.97	0.00e+00	1102.00
IUUC-Fal-036848	Ficedula albicollis	43.37	0.00e+00	710.00
IUUC-Fox-038007	Fusarium oxysporum	70.21	0.00e+00	806.00
IUUC-Fso-038339	Fusarium solani	69.50	0.00e+00	1454.00
IUUC-Gmo-039338	Gadus morhua	52.53	0.00e+00	1033.00
IUUC-Ggr-039823	Gaeumannomyces graminis	69.19	0.00e+00	1529.00
IUUC-Gga-040747	Gallus gallus	42.75	0.00e+00	698.00
IUUC-Gac-041773	Gasterosteus aculeatus	52.20	0.00e+00	1023.00
IUUC-Gma-043198	Glycine max	45.31	0.00e+00	870.00
IUUC-Ggo-045336	Gorilla gorilla	53.97	0.00e+00	1086.00
IUUC-Hsa-045982	Homo sapiens	54.07	0.00e+00	1087.00
IUUC-Hvu-047418	Hordeum vulgare	46.13	0.00e+00	858.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	53.97	0.00e+00	1102.00
IUUC-Kpa-049112	Komagataella pastoris	60.36	0.00e+00	1201.00
IUUC-Lch-050371	Latimeria chalumnae	53.73	0.00e+00	1082.00
IUUC-Lpe-051299	Leersia perrieri	43.87	0.00e+00	868.00
IUUC-Loc-052936	Lepisosteus oculatus	54.11	0.00e+00	1078.00
IUUC-Lma-053315	Leptosphaeria maculans	73.69	0.00e+00	1624.00
IUUC-Laf-053948	Loxodonta africana	53.30	0.00e+00	1065.00
IUUC-Mcc-055843	Macaca mulatta	53.97	0.00e+00	1102.00
IUUC-Meu-056258	Macropus eugenii	53.30	0.00e+00	1074.00
IUUC-Mor-057269	Magnaporthe oryzae	69.34	0.00e+00	1503.00
IUUC-Mpo-057435	Magnaporthe poae	68.36	0.00e+00	1480.00
IUUC-Mtr-058572	Medicago truncatula	44.75	0.00e+00	852.00
IUUC-Mla-059176	Melampsora laricipopulina	58.77	0.00e+00	1174.00
IUUC-Mga-059721	Meleagris gallopavo	42.73	0.00e+00	674.00
IUUC-Mvi-060437	Microbotryum violaceum	56.93	0.00e+00	1163.00
IUUC-Mmr-061405	Microcebus murinus	52.82	0.00e+00	1063.00
IUUC-Mdo-062032	Monodelphis domestica	52.37	0.00e+00	1043.00
IUUC-Mmu-063280	Mus musculus	53.49	0.00e+00	1085.00
IUUC-Mac-065505	Musa acuminata	46.09	0.00e+00	867.00
IUUC-Mpu-066409	Mustela putorius furo	53.78	0.00e+00	1104.00
IUUC-Mlu-067217	Myotis lucifugus	53.78	0.00e+00	1091.00
IUUC-Nfi-068407	Neosartorya fischeri	89.95	0.00e+00	1911.00
IUUC-Ncr-068698	Neurospora crassa	69.31	0.00e+00	1478.00
IUUC-Nle-070072	Nomascus leucogenys	51.48	0.00e+00	1006.00
IUUC-Opr-070715	Ochotona princeps	36.75	9.00e-171	592.00
IUUC-Ont-071671	Oreochromis niloticus	54.40	0.00e+00	1061.00
IUUC-Oan-073268	Ornithorhynchus anatinus	42.43	0.00e+00	656.00
IUUC-Ocu-074544	Oryctolagus cuniculus	54.16	0.00e+00	1108.00
IUUC-Oba-075120	Oryza barthii	45.76	0.00e+00	842.00
IUUC-Obr-076557	Oryza brachyantha	46.32	0.00e+00	840.00
IUUC-Ogl-077887	Oryza glaberrima	45.76	0.00e+00	842.00
IUUC-Ogu-078305	Oryza glumaepatula	44.20	0.00e+00	855.00
IUUC-Oin-080154	Oryza indica	44.10	0.00e+00	855.00
IUUC-Olo-081089	Oryza longistaminata	44.30	0.00e+00	860.00
IUUC-Ome-081942	Oryza meridionalis	45.85	0.00e+00	845.00
IUUC-Oni-082365	Oryza nivara	45.85	0.00e+00	847.00
IUUC-Opu-083977	Oryza punctata	45.19	0.00e+00	845.00
IUUC-Oru-084469	Oryza rufipogon	44.20	0.00e+00	856.00
IUUC-Osa-085949	Oryza sativa	45.95	0.00e+00	850.00
IUUC-Ola-087002	Oryzias latipes	54.30	0.00e+00	1072.00
IUUC-Olu-087687	Ostreococcus lucimarinus	43.55	0.00e+00	775.00
IUUC-Oga-088594	Otolemur garnettii	54.16	0.00e+00	1088.00
IUUC-Oar-090068	Ovis aries	54.02	0.00e+00	1110.00
IUUC-Ptr-090609	Pan troglodytes	42.74	0.00e+00	699.00
IUUC-Pan-092114	Papio anubis	53.88	0.00e+00	1101.00
IUUC-Psi-093489	Pelodiscus sinensis	42.68	0.00e+00	711.00
IUUC-Pma-094214	Petromyzon marinus	40.41	2.00e-31	126.00
IUUC-Pno-095154	Phaeosphaeria nodorum	73.12	0.00e+00	1612.00
IUUC-Ppa-095227	Physcomitrella patens	47.09	0.00e+00	879.00
IUUC-Pfo-097184	Poecilia formosa	53.96	0.00e+00	1059.00
IUUC-Pab-097861	Pongo abelii	53.78	0.00e+00	1070.00
IUUC-Pop-099577	Populus trichocarpa	45.38	0.00e+00	881.00
IUUC-Pca-100347	Procavia capensis	52.76	0.00e+00	925.00
IUUC-Ppe-102012	Prunus persica	44.26	0.00e+00	864.00
IUUC-Pva-102584	Pteropus vampyrus	54.16	0.00e+00	1136.00
IUUC-Pgr-103336	Puccinia graminis	57.03	0.00e+00	1095.00
IUUC-Ptt-103939	Puccinia triticina	56.41	0.00e+00	1089.00
IUUC-Pte-104200	Pyrenophora teres	75.05	0.00e+00	1661.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	73.62	0.00e+00	1645.00
IUUC-Rno-105462	Rattus norvegicus	53.30	0.00e+00	1079.00
IUUC-Sce-106245	Saccharomyces cerevisiae	59.94	0.00e+00	1249.00
IUUC-Sha-107142	Sarcophilus harrisii	53.21	0.00e+00	1077.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	59.73	0.00e+00	1264.00
IUUC-Spo-108034	Schizosaccharomyces pombe	59.88	0.00e+00	1249.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	72.29	0.00e+00	1505.00
IUUC-Smo-109211	Selaginella moellendorffii	46.89	0.00e+00	861.00
IUUC-Sit-110281	Setaria italica	46.04	0.00e+00	872.00
IUUC-Sly-110914	Solanum lycopersicum	45.59	0.00e+00	899.00
IUUC-Stu-112109	Solanum tuberosum	45.40	0.00e+00	900.00
IUUC-Sar-113737	Sorex araneus	53.40	0.00e+00	1098.00
IUUC-Sbi-114520	Sorghum bicolor	45.96	0.00e+00	875.00
IUUC-Sre-115148	Sporisorium reilianum	56.80	0.00e+00	1135.00
IUUC-Ssc-115777	Sus scrofa	53.74	0.00e+00	1105.00
IUUC-Tgu-116565	Taeniopygia guttata	43.37	0.00e+00	712.00
IUUC-Tru-118742	Takifugu rubripes	53.59	0.00e+00	1022.00
IUUC-Tsy-119436	Tarsius syrichta	37.51	3.00e-166	577.00
IUUC-Tni-120401	Tetraodon nigroviridis	53.82	0.00e+00	1030.00
IUUC-Tca-121672	Theobroma cacao	45.74	0.00e+00	885.00
IUUC-Tre-122009	Trichoderma reesei	68.93	0.00e+00	1431.00
IUUC-Tvi-122259	Trichoderma virens	69.58	0.00e+00	1436.00
IUUC-Tae-125113	Triticum aestivum	46.57	0.00e+00	829.00
IUUC-Tur-126189	Triticum urartu	46.57	0.00e+00	829.00
IUUC-Tme-127055	Tuber melanosporum	66.29	0.00e+00	1353.00
IUUC-Tbe-127587	Tupaia belangeri	42.31	2.00e-156	545.00
IUUC-Ttr-128331	Tursiops truncatus	53.40	0.00e+00	1087.00
IUUC-Uma-129387	Ustilago maydis	57.58	0.00e+00	1143.00
IUUC-Vda-129977	Verticillium dahliae	69.08	0.00e+00	1432.00
IUUC-Vpa-130716	Vicugna pacos	41.42	0.00e+00	682.00
IUUC-Vvi-130857	Vitis vinifera	45.59	0.00e+00	882.00
IUUC-Xtr-132026	Xenopus tropicalis	46.05	0.00e+00	797.00
IUUC-Xma-133805	Xiphophorus maculatus	53.35	0.00e+00	1036.00
IUUC-Yli-134547	Yarrowia lipolytica	58.48	0.00e+00	1241.00
IUUC-Zma-135052	Zea mays	45.79	0.00e+00	871.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence