iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092114

Ensembl Protein ID

ENSPANP00000008150.1

UniProt Accession

A0A096N6N8; A0A096N6N8_PAPAN

Genbank Protein ID

ENSPANP00000008150

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01111174

Gene Name

UBA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000005321.1	ENSPANT00000022988.1	ENSPANP00000008150.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.70e-238	791.7	451	931

Active Site

Position(s)	Description	Evidence
632	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q++++G++ qekl+++k++lvGag++GcEllKn++++G+     g+i v+Dmdt+e+snlnrqFLfr++dv k K+++aa+a++++
   Q: 451  YDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLgcregGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQM 539
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np+++v++h++++ +++e+i+   Ff+++d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ lte+ys+s+dpp+k+
   Q: 540  NPHIRVTSHQNRVGPDTERIYdddFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKS 628
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa            + +n++l ++++++e++ +l+ ++++e++++v+++l+ ++++++++++++a++++++
   Q: 629  IPICTLKNFPNAIEHTLQWArdefeglfkqpaENVNQYL-TDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHT 716
           ***************************************.999999******************************************* PP
   S: 248  ttinsikqllksfecdivtkskspfwv..........................................sfcsnaealqvp........ 286
           +++n+i+qll++f++d++t+s++pfw+                                           + ++ +++qvp        
   Q: 717  QYSNNIRQLLHNFPPDQLTSSGAPFWSgpkrcphpltfdvnnplhldyvmaaanlfaqtygltgsqdraAVATLLQSVQVPeftpksgv 805
           *****************************************************************999966666666666655555555 PP
   S: 287  ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipa 368
           + +++d+e ++a+a+     l+ l+++l + +k +g k++ ++fekddds  ++d++ aa+nlrae+++i+p +d+++ k iag+iipa
   Q: 806  KIHVSDQELQSANASvddsrLEELKATLPSPDKLPGFKMYPIDFEKDDDSnfHMDFIVAASNLRAENYDIPP-ADRHKSKLIAGKIIPA 893
           66666666666666688889****************************************************.**************** PP
   S: 369  iattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           iatt+a+v Gl+++E++Kvv+g  + + +kn fl++a+
   Q: 894  IATTTAAVVGLVCLELYKVVQGhrQLDSYKNGFLNLAL 931
           **********************999*********9875 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MSSSPLSKKR RVSGPDPKPG SNCSPAQSVL SEVPSVPTNG MAKNGSEADI DEGLYSRQLY 60
VLGHEAMKRL QTSSVLVSGL RGLGVEIAKN IILGGVKAVT LHDQGTAQWA DLSSQFYLRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGTCTGAA ACGGGCACCA GCGACGCGGG AGCAGGGACC GACGCCCCTC TAGCAGAGCA 60
TCTGTGGTAC ATCCCAGACC CGGGGCTCTC CGAGGCCCCG CGCTTCCGAG CTCCGCGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005829--C:cytosol
GO:0030057--C:desmosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0000792--C:heterochromatin
GO:0005765--C:lysosomal membrane
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0006974--P:cellular response to DNA damage stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	46.76	0.00e+00	871.00
IUUC-Aml-001311	Ailuropoda melanoleuca	96.42	0.00e+00	2095.00
IUUC-Atr-002684	Amborella trichopoda	45.59	0.00e+00	897.00
IUUC-Aca-004620	Anolis carolinensis	80.94	0.00e+00	1796.00
IUUC-Aly-005515	Arabidopsis lyrata	45.84	0.00e+00	917.00
IUUC-Ath-006891	Arabidopsis thaliana	46.33	0.00e+00	925.00
IUUC-Ago-007873	Ashbya gossypii	54.38	0.00e+00	1063.00
IUUC-Acl-008181	Aspergillus clavatus	54.21	0.00e+00	1071.00
IUUC-Afl-008455	Aspergillus flavus	54.03	0.00e+00	1035.00
IUUC-Afu-009065	Aspergillus fumigatus	53.67	0.00e+00	1085.00
IUUC-Ani-009371	Aspergillus nidulans	53.68	0.00e+00	1058.00
IUUC-Ang-009737	Aspergillus niger	54.23	0.00e+00	1075.00
IUUC-Aor-010007	Aspergillus oryzae	54.03	0.00e+00	1035.00
IUUC-Ate-010466	Aspergillus terreus	53.88	0.00e+00	1100.00
IUUC-Ame-010933	Astyanax mexicanus	78.94	0.00e+00	1682.00
IUUC-Bgr-012281	Blumeria graminis	53.53	0.00e+00	1086.00
IUUC-Bta-012767	Bos taurus	96.88	0.00e+00	2111.00
IUUC-Bci-013721	Botrytis cinerea	54.22	0.00e+00	1031.00
IUUC-Bdi-014843	Brachypodium distachyon	46.07	0.00e+00	881.00
IUUC-Bol-015665	Brassica oleracea	44.60	0.00e+00	905.00
IUUC-Bra-017252	Brassica rapa	44.52	0.00e+00	907.00
IUUC-Cel-018260	Caenorhabditis elegans	49.66	0.00e+00	958.00
IUUC-Cja-019152	Callithrix jacchus	98.49	0.00e+00	2135.00
IUUC-Cfa-020622	Canis familiaris	95.56	0.00e+00	2025.00
IUUC-Cpo-022526	Cavia porcellus	96.98	0.00e+00	2086.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	45.40	0.00e+00	848.00
IUUC-Csa-023780	Chlorocebus sabaeus	99.34	0.00e+00	2155.00
IUUC-Cho-024896	Choloepus hoffmanni	87.87	8.00e-119	421.00
IUUC-Cin-025790	Ciona intestinalis	63.47	0.00e+00	1367.00
IUUC-Csv-026084	Ciona savignyi	60.59	0.00e+00	1348.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	54.05	0.00e+00	1107.00
IUUC-Cne-026960	Cryptococcus neoformans	55.85	0.00e+00	1118.00
IUUC-Cme-027290	Cyanidioschyzon merolae	44.77	0.00e+00	843.00
IUUC-Dre-028149	Danio rerio	78.85	0.00e+00	1715.00
IUUC-Dno-028884	Dasypus novemcinctus	96.88	0.00e+00	2115.00
IUUC-Dor-030229	Dipodomys ordii	92.25	0.00e+00	1993.00
IUUC-Dse-031524	Dothistroma septosporum	52.46	0.00e+00	1074.00
IUUC-Dme-032045	Drosophila melanogaster	60.43	0.00e+00	1278.00
IUUC-Ete-032544	Echinops telfairi	85.52	0.00e+00	881.00
IUUC-Eca-033330	Equus caballus	97.92	0.00e+00	2133.00
IUUC-Fca-036255	Felis catus	97.92	0.00e+00	2098.00
IUUC-Fal-037445	Ficedula albicollis	49.13	0.00e+00	888.00
IUUC-Fox-038007	Fusarium oxysporum	53.85	2.00e-167	582.00
IUUC-Fso-038339	Fusarium solani	54.24	0.00e+00	1065.00
IUUC-Gmo-039338	Gadus morhua	75.62	0.00e+00	1617.00
IUUC-Ggr-039823	Gaeumannomyces graminis	54.24	0.00e+00	1120.00
IUUC-Gga-040365	Gallus gallus	47.41	0.00e+00	819.00
IUUC-Gac-041773	Gasterosteus aculeatus	75.81	0.00e+00	1620.00
IUUC-Gma-043198	Glycine max	44.52	0.00e+00	885.00
IUUC-Ggo-045336	Gorilla gorilla	98.87	0.00e+00	2120.00
IUUC-Hsa-045982	Homo sapiens	98.68	0.00e+00	2115.00
IUUC-Hvu-047418	Hordeum vulgare	46.38	0.00e+00	890.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	97.83	0.00e+00	2127.00
IUUC-Kpa-049112	Komagataella pastoris	51.47	0.00e+00	1015.00
IUUC-Lch-050371	Latimeria chalumnae	80.36	0.00e+00	1785.00
IUUC-Lpe-051299	Leersia perrieri	44.95	0.00e+00	901.00
IUUC-Loc-052936	Lepisosteus oculatus	80.83	0.00e+00	1766.00
IUUC-Lma-053315	Leptosphaeria maculans	52.64	0.00e+00	1104.00
IUUC-Laf-053948	Loxodonta africana	94.33	0.00e+00	2048.00
IUUC-Mcc-055843	Macaca mulatta	99.62	0.00e+00	2167.00
IUUC-Meu-056258	Macropus eugenii	87.71	0.00e+00	1917.00
IUUC-Mor-057269	Magnaporthe oryzae	54.58	0.00e+00	1101.00
IUUC-Mpo-057435	Magnaporthe poae	54.39	0.00e+00	1086.00
IUUC-Mtr-058572	Medicago truncatula	44.78	0.00e+00	872.00
IUUC-Mla-059176	Melampsora laricipopulina	56.05	0.00e+00	1103.00
IUUC-Mvi-060437	Microbotryum violaceum	53.63	0.00e+00	1070.00
IUUC-Mmr-061405	Microcebus murinus	95.65	0.00e+00	2065.00
IUUC-Mdo-062032	Monodelphis domestica	86.22	0.00e+00	1890.00
IUUC-Mmu-063280	Mus musculus	95.65	0.00e+00	2068.00
IUUC-Mac-065505	Musa acuminata	46.07	0.00e+00	894.00
IUUC-Mpu-066409	Mustela putorius furo	97.54	0.00e+00	2122.00
IUUC-Mlu-067217	Myotis lucifugus	96.03	0.00e+00	2087.00
IUUC-Nfi-068407	Neosartorya fischeri	53.96	0.00e+00	1065.00
IUUC-Ncr-068698	Neurospora crassa	55.74	0.00e+00	1118.00
IUUC-Nle-070072	Nomascus leucogenys	93.31	0.00e+00	1991.00
IUUC-Ont-071671	Oreochromis niloticus	78.49	0.00e+00	1697.00
IUUC-Ocu-074544	Oryctolagus cuniculus	96.88	0.00e+00	2108.00
IUUC-Oba-075120	Oryza barthii	46.13	0.00e+00	887.00
IUUC-Obr-076557	Oryza brachyantha	46.61	0.00e+00	879.00
IUUC-Ogl-077887	Oryza glaberrima	46.13	0.00e+00	889.00
IUUC-Ogu-078305	Oryza glumaepatula	44.52	0.00e+00	894.00
IUUC-Oin-080154	Oryza indica	44.52	0.00e+00	893.00
IUUC-Olo-081089	Oryza longistaminata	44.71	0.00e+00	895.00
IUUC-Ome-081942	Oryza meridionalis	46.13	0.00e+00	887.00
IUUC-Oni-082365	Oryza nivara	46.03	0.00e+00	890.00
IUUC-Opu-083977	Oryza punctata	46.41	0.00e+00	892.00
IUUC-Oru-084469	Oryza rufipogon	44.62	0.00e+00	897.00
IUUC-Osa-085949	Oryza sativa	46.33	0.00e+00	896.00
IUUC-Ola-087002	Oryzias latipes	77.63	0.00e+00	1684.00
IUUC-Olu-087687	Ostreococcus lucimarinus	44.21	0.00e+00	818.00
IUUC-Oga-088594	Otolemur garnettii	97.54	0.00e+00	2091.00
IUUC-Oar-090068	Ovis aries	96.60	0.00e+00	2105.00
IUUC-Pma-094214	Petromyzon marinus	58.14	3.00e-53	200.00
IUUC-Pno-095154	Phaeosphaeria nodorum	52.71	0.00e+00	1101.00
IUUC-Ppa-095416	Physcomitrella patens	46.15	0.00e+00	905.00
IUUC-Pfo-097184	Poecilia formosa	77.63	0.00e+00	1680.00
IUUC-Pab-097861	Pongo abelii	98.58	0.00e+00	2106.00
IUUC-Pop-098934	Populus trichocarpa	45.18	0.00e+00	925.00
IUUC-Pca-100347	Procavia capensis	91.65	0.00e+00	1651.00
IUUC-Ppe-102012	Prunus persica	44.64	0.00e+00	906.00
IUUC-Pva-102584	Pteropus vampyrus	97.54	0.00e+00	2134.00
IUUC-Pgr-103336	Puccinia graminis	54.46	0.00e+00	1062.00
IUUC-Ptt-103939	Puccinia triticina	53.99	0.00e+00	1066.00
IUUC-Pte-104200	Pyrenophora teres	53.84	0.00e+00	1101.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	52.73	0.00e+00	1088.00
IUUC-Rno-105462	Rattus norvegicus	96.60	0.00e+00	2064.00
IUUC-Sce-106245	Saccharomyces cerevisiae	52.09	0.00e+00	1082.00
IUUC-Sha-107142	Sarcophilus harrisii	87.62	0.00e+00	1934.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	55.41	0.00e+00	1143.00
IUUC-Spo-108034	Schizosaccharomyces pombe	53.91	0.00e+00	1082.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	54.39	0.00e+00	1053.00
IUUC-Smo-109211	Selaginella moellendorffii	46.21	0.00e+00	896.00
IUUC-Sit-110281	Setaria italica	46.44	0.00e+00	907.00
IUUC-Sly-111237	Solanum lycopersicum	46.09	0.00e+00	869.00
IUUC-Stu-112109	Solanum tuberosum	44.99	0.00e+00	914.00
IUUC-Sar-113737	Sorex araneus	96.31	0.00e+00	2087.00
IUUC-Sbi-114089	Sorghum bicolor	46.14	0.00e+00	904.00
IUUC-Sre-115148	Sporisorium reilianum	54.94	0.00e+00	1092.00
IUUC-Ssc-115777	Sus scrofa	97.83	0.00e+00	2123.00
IUUC-Tru-118742	Takifugu rubripes	77.44	0.00e+00	1629.00
IUUC-Tsy-119485	Tarsius syrichta	98.02	2.00e-175	608.00
IUUC-Tni-120401	Tetraodon nigroviridis	77.72	0.00e+00	1631.00
IUUC-Tca-121672	Theobroma cacao	44.99	0.00e+00	914.00
IUUC-Tre-122009	Trichoderma reesei	53.82	0.00e+00	1048.00
IUUC-Tvi-122259	Trichoderma virens	53.92	0.00e+00	1033.00
IUUC-Tae-125113	Triticum aestivum	46.76	0.00e+00	872.00
IUUC-Tur-126189	Triticum urartu	46.31	0.00e+00	868.00
IUUC-Tme-127055	Tuber melanosporum	53.62	0.00e+00	1018.00
IUUC-Tbe-127487	Tupaia belangeri	96.46	0.00e+00	1046.00
IUUC-Ttr-128331	Tursiops truncatus	97.16	0.00e+00	2099.00
IUUC-Uma-129387	Ustilago maydis	55.16	0.00e+00	1094.00
IUUC-Vda-129977	Verticillium dahliae	53.81	0.00e+00	1017.00
IUUC-Vvi-130857	Vitis vinifera	45.61	0.00e+00	912.00
IUUC-Xtr-132026	Xenopus tropicalis	64.37	0.00e+00	1288.00
IUUC-Xma-133805	Xiphophorus maculatus	77.15	0.00e+00	1654.00
IUUC-Yli-134547	Yarrowia lipolytica	54.25	0.00e+00	1113.00
IUUC-Zma-135052	Zea mays	46.18	0.00e+00	908.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence