iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013112

Ensembl Protein ID

ENSBTAP00000009422.5

UniProt Accession

F1MX59; F1MX59_BOVIN

Genbank Protein ID

ENSBTAP00000009422

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

DAAA02027176

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000007159.5	ENSBTAT00000009422.5	ENSBTAP00000009422.5

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	89.26	0.00e+00	937.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKAS GMALLHQIQA NELEPLNRPQ LKIPLERPLG EVYMDSSKPA VYNYPEGAAY 60
DFNAAAPASA PVYGQSGLPY GPGSEAAAFG ANGLGAFPPL NSVSPSPLVL LHPPPQPLSP 120

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Nucleotide Sequence
(Fasta)

ATGACCATGA CCCTGCACAC CAAAGCGTCC GGCATGGCCC TGCTGCACCA GATCCAAGCC 60
AACGAGCTGG AGCCCCTGAA CCGCCCGCAG CTCAAGATCC CCCTGGAGCG GCCCCTGGGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	93.10	0.00e+00	798.00
IUUC-Apl-003688	Anas platyrhynchos	78.29	0.00e+00	800.00
IUUC-Aca-005222	Anolis carolinensis	76.78	0.00e+00	866.00
IUUC-Ame-010731	Astyanax mexicanus	56.45	3.00e-135	475.00
IUUC-Cja-019408	Callithrix jacchus	90.27	0.00e+00	989.00
IUUC-Cfa-020694	Canis familiaris	87.94	0.00e+00	944.00
IUUC-Cpo-021426	Cavia porcellus	83.08	0.00e+00	902.00
IUUC-Csa-023736	Chlorocebus sabaeus	90.78	0.00e+00	852.00
IUUC-Dre-027698	Danio rerio	52.18	4.00e-131	461.00
IUUC-Dno-029477	Dasypus novemcinctus	83.03	0.00e+00	830.00
IUUC-Dor-030572	Dipodomys ordii	89.64	0.00e+00	747.00
IUUC-Ete-032849	Echinops telfairi	68.69	0.00e+00	647.00
IUUC-Eca-033605	Equus caballus	87.58	0.00e+00	976.00
IUUC-Eeu-034683	Erinaceus europaeus	90.65	4.00e-109	388.00
IUUC-Fca-035928	Felis catus	92.17	0.00e+00	790.00
IUUC-Fal-036754	Ficedula albicollis	76.21	0.00e+00	880.00
IUUC-Gmo-038872	Gadus morhua	54.05	7.00e-112	397.00
IUUC-Gga-040988	Gallus gallus	77.29	0.00e+00	865.00
IUUC-Gac-042015	Gasterosteus aculeatus	62.60	1.00e-127	450.00
IUUC-Gma-043508	Glycine max	34.78	2.50e+00	28.10
IUUC-Ggo-044749	Gorilla gorilla	90.27	0.00e+00	990.00
IUUC-Hsa-046944	Homo sapiens	89.77	0.00e+00	982.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	87.46	0.00e+00	959.00
IUUC-Loc-052414	Lepisosteus oculatus	58.16	0.00e+00	632.00
IUUC-Mcc-054781	Macaca mulatta	90.27	0.00e+00	989.00
IUUC-Meu-056232	Macropus eugenii	84.54	0.00e+00	922.00
IUUC-Mga-059319	Meleagris gallopavo	77.80	0.00e+00	870.00
IUUC-Mmr-061636	Microcebus murinus	88.62	3.00e-167	581.00
IUUC-Mdo-062661	Monodelphis domestica	85.23	0.00e+00	942.00
IUUC-Mmu-063330	Mus musculus	86.67	0.00e+00	914.00
IUUC-Mpu-065757	Mustela putorius furo	90.47	0.00e+00	972.00
IUUC-Mlu-067712	Myotis lucifugus	86.34	0.00e+00	839.00
IUUC-Nle-069283	Nomascus leucogenys	90.10	0.00e+00	943.00
IUUC-Opr-070391	Ochotona princeps	85.88	0.00e+00	967.00
IUUC-Ont-071369	Oreochromis niloticus	50.72	5.00e-120	424.00
IUUC-Oan-073734	Ornithorhynchus anatinus	72.89	1.00e-131	462.00
IUUC-Ocu-074292	Oryctolagus cuniculus	88.50	0.00e+00	958.00
IUUC-Oba-075103	Oryza barthii	28.21	4.00e-03	36.20
IUUC-Ogu-079042	Oryza glumaepatula	28.21	8.00e-04	38.50
IUUC-Olo-080944	Oryza longistaminata	28.21	2.00e-03	35.80
IUUC-Oni-082560	Oryza nivara	28.21	3.00e-03	36.60
IUUC-Ola-087052	Oryzias latipes	50.00	8.00e-131	460.00
IUUC-Oga-088586	Otolemur garnettii	89.32	0.00e+00	972.00
IUUC-Oar-090156	Ovis aries	98.21	0.00e+00	881.00
IUUC-Ptr-091321	Pan troglodytes	90.44	0.00e+00	990.00
IUUC-Pan-092851	Papio anubis	90.10	0.00e+00	987.00
IUUC-Psi-093434	Pelodiscus sinensis	77.18	0.00e+00	915.00
IUUC-Pfo-097379	Poecilia formosa	56.76	3.00e-132	465.00
IUUC-Pab-097735	Pongo abelii	90.27	0.00e+00	988.00
IUUC-Pva-102125	Pteropus vampyrus	86.91	0.00e+00	951.00
IUUC-Rno-106121	Rattus norvegicus	86.69	0.00e+00	914.00
IUUC-Sha-107547	Sarcophilus harrisii	84.90	0.00e+00	932.00
IUUC-Sar-113650	Sorex araneus	76.87	1.00e-176	612.00
IUUC-Tgu-117175	Taeniopygia guttata	76.38	0.00e+00	880.00
IUUC-Tru-117545	Takifugu rubripes	55.67	3.00e-135	476.00
IUUC-Tsy-119586	Tarsius syrichta	76.68	0.00e+00	821.00
IUUC-Tni-120121	Tetraodon nigroviridis	54.39	8.00e-136	477.00
IUUC-Tbe-127548	Tupaia belangeri	81.98	0.00e+00	639.00
IUUC-Ttr-128374	Tursiops truncatus	88.26	0.00e+00	892.00
IUUC-Vpa-130464	Vicugna pacos	84.15	9.00e-160	556.00
IUUC-Xtr-132171	Xenopus tropicalis	68.79	0.00e+00	733.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence