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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046825
Ensembl Protein ID ENSP00000325240.6
UniProt Accession Q14847; B4DGQ0; Q96ED2; Q96IG0; LASP1_HUMAN
Genbank Protein ID CAA57833.1; BAG57861.1; AAH07560.1; AAH12460.1
Protein Name LIM and SH3 domain protein 1; Metastatic lymph node gene 50 protein
Genbank Nucleotide ID X82456; AK294704; AC006441; BC012460
Gene Name LASP1; MLN50
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000002834.17 ENST00000318008.10 ENSP00000325240.6
ENSG00000002834.17 ENST00000585841.5 ENSP00000468664.1
ENSG00000002834.17 ENST00000443937.7 ENSP00000414803.3
ENSG00000002834.17 ENST00000579123.1 ENSP00000462564.1
ENSG00000002834.17 ENST00000433206.6 ENSP00000401048.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
miRecordsRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 4.00e-14 54.0 206 261
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           + ++ ydy+a+++de +++ Gd++  +  ++ d gW++g+ e +g  G++P+n+ve +
   Q: 206  RYRAVYDYSAADEDEVSFQDGDTIVNV--QQIDDGWMYGTVERTGDTGMLPANYVEAI 261
           56899*******************999..99************************975 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
 Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
Protein Sequence
(Fasta)
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ 60
SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046825|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGTCAGCC TGAGAGCGCT GAGGCGCCAG CACCGCGGGC CCCGCCGTCC CCCCAGGAAC 60
CCGCCCCCGC GCAGCCCCAC GTCGCCCGGA GAGCGCGCCT CGCTGCGCGT GCCCTTGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046825|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0406--Ion transport
KW-0440--LIM domain
KW-0479--Metal-binding
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0813--Transport
KW-0862--Zinc
Interpro

IPR000900--Nebulin_repeat
IPR001452--SH3_domain
IPR001781--Znf_LIM
PROSITE

PS00478--LIM_DOMAIN_1
PS50023--LIM_DOMAIN_2
PS51216--NEBULIN
PS50002--SH3
Pfam

PF00412--LIM
PF00880--Nebulin
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00132--LIM
SM00227--NEBU
SM00326--SH3
Gene Ontology

GO:0030864--C:cortical actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0045296--F:cadherin binding
GO:0015075--F:ion transmembrane transporter activity
GO:0005070--F:SH3/SH2 adaptor activity
GO:0008270--F:zinc ion binding
GO:0006811--P:ion transport
KEGG hsa:3927
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000663 Aegilops tauschii 29.63 5.00e-04 39.30
IUUC-Aml-001609 Ailuropoda melanoleuca 93.10 2.00e-111 395.00
IUUC-Atr-002465 Amborella trichopoda 26.67 4.70e-02 32.70
IUUC-Apl-003494 Anas platyrhynchos 73.23 4.00e-94 337.00
IUUC-Aca-004462 Anolis carolinensis 85.02 9.00e-119 419.00
IUUC-Ame-011113 Astyanax mexicanus 64.37 3.00e-76 277.00
IUUC-Bta-012469 Bos taurus 95.79 7.00e-132 462.00
IUUC-Cel-018413 Caenorhabditis elegans 52.80 2.00e-36 145.00
IUUC-Cja-019344 Callithrix jacchus 90.62 2.00e-64 238.00
IUUC-Cfa-020384 Canis familiaris 92.75 1.00e-113 402.00
IUUC-Cpo-022244 Cavia porcellus 86.72 8.00e-111 392.00
IUUC-Csa-023039 Chlorocebus sabaeus 98.08 1.00e-121 429.00
IUUC-Cin-025236 Ciona intestinalis 51.39 2.00e-36 145.00
IUUC-Csv-026030 Ciona savignyi 36.16 5.00e-39 154.00
IUUC-Dre-028335 Danio rerio 65.90 2.00e-86 311.00
IUUC-Dno-029377 Dasypus novemcinctus 92.95 5.00e-96 343.00
IUUC-Dor-031101 Dipodomys ordii 76.89 2.00e-88 318.00
IUUC-Dme-031598 Drosophila melanogaster 57.03 4.00e-41 162.00
IUUC-Eca-033966 Equus caballus 94.17 5.00e-111 393.00
IUUC-Fca-035699 Felis catus 93.87 4.00e-121 427.00
IUUC-Gmo-038981 Gadus morhua 44.44 3.00e-56 211.00
IUUC-Gga-040316 Gallus gallus 79.27 5.00e-116 410.00
IUUC-Gac-042632 Gasterosteus aculeatus 61.30 3.00e-77 281.00
IUUC-Gma-042981 Glycine max 28.33 1.00e-03 38.10
IUUC-Ggo-044835 Gorilla gorilla 99.62 8.00e-119 419.00
IUUC-Hvu-047787 Hordeum vulgare 27.94 6.00e-04 39.30
IUUC-Itr-048498 Ictidomys tridecemlineatus 93.75 9.00e-113 399.00
IUUC-Loc-052082 Lepisosteus oculatus 67.80 5.00e-89 320.00
IUUC-Laf-053578 Loxodonta africana 89.73 2.00e-113 401.00
IUUC-Mcc-055650 Macaca mulatta 98.47 2.00e-123 434.00
IUUC-Meu-056479 Macropus eugenii 89.67 7.00e-111 392.00
IUUC-Mtr-058399 Medicago truncatula 29.69 2.00e-03 36.20
IUUC-Mga-059763 Meleagris gallopavo 78.52 1.00e-103 369.00
IUUC-Mmr-061164 Microcebus murinus 95.79 1.00e-116 412.00
IUUC-Mdo-061979 Monodelphis domestica 90.60 7.00e-127 446.00
IUUC-Mmu-063302 Mus musculus 95.44 3.00e-135 474.00
IUUC-Mac-065516 Musa acuminata 30.56 2.00e-03 35.00
IUUC-Mpu-066114 Mustela putorius furo 92.72 2.00e-122 432.00
IUUC-Mlu-068217 Myotis lucifugus 95.79 7.00e-122 429.00
IUUC-Nle-069636 Nomascus leucogenys 88.55 3.00e-96 344.00
IUUC-Opr-070892 Ochotona princeps 95.79 9.00e-130 456.00
IUUC-Ont-072280 Oreochromis niloticus 63.00 2.00e-85 308.00
IUUC-Oan-073220 Ornithorhynchus anatinus 90.67 2.00e-32 130.00
IUUC-Ocu-073804 Oryctolagus cuniculus 92.42 2.00e-132 464.00
IUUC-Oba-075638 Oryza barthii 27.78 2.00e-03 37.40
IUUC-Obr-076045 Oryza brachyantha 27.54 1.00e-03 38.10
IUUC-Ogl-077659 Oryza glaberrima 27.54 2.00e-03 37.40
IUUC-Ogu-078055 Oryza glumaepatula 28.12 5.40e-02 32.70
IUUC-Oin-079541 Oryza indica 27.94 3.00e-03 37.00
IUUC-Oni-082309 Oryza nivara 28.12 4.10e-02 33.10
IUUC-Opu-083412 Oryza punctata 27.54 1.00e-03 38.50
IUUC-Oru-085213 Oryza rufipogon 28.12 4.10e-02 33.10
IUUC-Osa-085312 Oryza sativa 27.54 2.00e-03 37.40
IUUC-Ola-086514 Oryzias latipes 61.54 4.00e-91 327.00
IUUC-Oga-088707 Otolemur garnettii 95.02 8.00e-125 439.00
IUUC-Oar-089771 Ovis aries 96.17 2.00e-133 468.00
IUUC-Ptr-091237 Pan troglodytes 100.00 8.00e-126 442.00
IUUC-Pan-092656 Papio anubis 98.47 2.00e-123 434.00
IUUC-Pma-094377 Petromyzon marinus 58.50 2.00e-65 241.00
IUUC-Pfo-097079 Poecilia formosa 56.70 1.00e-82 299.00
IUUC-Pab-097833 Pongo abelii 99.62 7.00e-119 419.00
IUUC-Pop-099698 Populus trichocarpa 31.25 2.00e-04 40.40
IUUC-Pca-100691 Procavia capensis 90.53 9.00e-116 409.00
IUUC-Pva-102270 Pteropus vampyrus 95.79 1.00e-118 418.00
IUUC-Rno-105362 Rattus norvegicus 96.20 2.00e-135 474.00
IUUC-Sha-107134 Sarcophilus harrisii 86.85 9.00e-112 396.00
IUUC-Smo-108841 Selaginella moellendorffii 28.33 6.00e-03 35.40
IUUC-Sit-110147 Setaria italica 26.67 8.70e-02 32.00
IUUC-Sly-111106 Solanum lycopersicum 28.33 7.00e-03 35.80
IUUC-Stu-112570 Solanum tuberosum 28.33 7.00e-03 35.80
IUUC-Sbi-114441 Sorghum bicolor 27.08 2.30e-02 33.90
IUUC-Sre-115023 Sporisorium reilianum 55.77 4.00e-11 63.20
IUUC-Tru-118693 Takifugu rubripes 54.68 1.00e-74 273.00
IUUC-Tni-120393 Tetraodon nigroviridis 59.00 2.00e-76 278.00
IUUC-Tca-121863 Theobroma cacao 26.67 1.60e-02 34.70
IUUC-Tae-125394 Triticum aestivum 27.94 5.00e-04 39.70
IUUC-Tur-126326 Triticum urartu 28.99 5.00e-04 39.30
IUUC-Ttr-128639 Tursiops truncatus 93.87 1.00e-125 442.00
IUUC-Uma-129649 Ustilago maydis 53.85 7.00e-11 62.80
IUUC-Vpa-130114 Vicugna pacos 93.82 4.00e-67 246.00
IUUC-Vvi-131569 Vitis vinifera 24.56 4.00e-02 33.10
IUUC-Xtr-131827 Xenopus tropicalis 78.93 1.00e-110 392.00
IUUC-Xma-134054 Xiphophorus maculatus 62.84 3.00e-85 307.00
Created Date 25-Jun-2017

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