iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066314

Ensembl Protein ID

ENSMPUP00000012318.1

UniProt Accession

M3YLW1; M3YLW1_MUSPF

Genbank Protein ID

ENSMPUP00000012318

Protein Name

Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47

Genbank Nucleotide ID

AEYP01030112

Gene Name

Eif3f; EIF3F; EIF3S5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000012412.1	ENSMPUT00000012519.1	ENSMPUP00000012318.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/JAMM	100.00	1.00e-160	563.00	IUUC-Hsa-046860

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mustela putorius furo

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

TPSLPPAPAP APAPASSSDS ATAAATTAAP GQTPASTPAP AQTPAQSLPG PALPGPFPGG 60
RVVRLHPVIL ASIVDSYERR NEGAARVIGT LLGTVDKHSV EVTNCFSVPH NESEDEVAVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTCCCTCCC TTCCGCTCNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome

Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0016020--C:membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0075522--P:IRES-dependent viral translational initiation
GO:0016579--P:protein deubiquitination
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001150	Aegilops tauschii	36.88	8.00e-47	180.00
IUUC-Aml-001527	Ailuropoda melanoleuca	100.00	2.00e-160	558.00
IUUC-Atr-002686	Amborella trichopoda	41.06	8.00e-50	190.00
IUUC-Apl-003977	Anas platyrhynchos	91.07	4.00e-122	429.00
IUUC-Aca-004335	Anolis carolinensis	90.74	1.00e-148	518.00
IUUC-Aly-005945	Arabidopsis lyrata	38.78	5.00e-50	191.00
IUUC-Ath-007045	Arabidopsis thaliana	39.16	5.00e-50	191.00
IUUC-Acl-008365	Aspergillus clavatus	34.80	3.00e-41	162.00
IUUC-Afl-008742	Aspergillus flavus	35.53	3.00e-40	158.00
IUUC-Afu-009030	Aspergillus fumigatus	34.43	8.00e-41	160.00
IUUC-Ani-009212	Aspergillus nidulans	35.42	1.00e-41	163.00
IUUC-Ang-009712	Aspergillus niger	34.43	7.00e-40	157.00
IUUC-Aor-009885	Aspergillus oryzae	35.53	8.00e-42	164.00
IUUC-Ate-010315	Aspergillus terreus	35.53	2.00e-39	156.00
IUUC-Ame-010801	Astyanax mexicanus	52.41	3.00e-67	248.00
IUUC-Bgr-011982	Blumeria graminis	35.64	3.00e-40	159.00
IUUC-Bta-012804	Bos taurus	98.93	1.00e-166	579.00
IUUC-Bci-013891	Botrytis cinerea	34.91	5.00e-35	141.00
IUUC-Bdi-014328	Brachypodium distachyon	38.38	2.00e-48	186.00
IUUC-Bol-015446	Brassica oleracea	39.16	5.00e-51	194.00
IUUC-Bra-016862	Brassica rapa	39.54	2.00e-51	196.00
IUUC-Cel-018171	Caenorhabditis elegans	35.19	1.00e-46	179.00
IUUC-Cja-019335	Callithrix jacchus	100.00	3.00e-163	567.00
IUUC-Cfa-020138	Canis familiaris	99.63	5.00e-160	556.00
IUUC-Cpo-022109	Cavia porcellus	87.64	1.00e-136	478.00
IUUC-Cre-022664	Chlamydomonas reinhardtii	38.81	1.00e-57	216.00
IUUC-Csa-023994	Chlorocebus sabaeus	100.00	4.00e-163	567.00
IUUC-Cho-024351	Choloepus hoffmanni	76.84	4.00e-115	407.00
IUUC-Cin-025801	Ciona intestinalis	54.55	3.00e-88	318.00
IUUC-Csv-025805	Ciona savignyi	55.39	5.00e-86	310.00
IUUC-Cgl-026643	Colletotrichum gloeosporioides	31.87	2.00e-35	142.00
IUUC-Cne-026868	Cryptococcus neoformans	29.15	3.00e-28	119.00
IUUC-Cme-027328	Cyanidioschyzon merolae	27.22	1.00e-22	100.00
IUUC-Dre-028085	Danio rerio	80.30	2.00e-129	454.00
IUUC-Dno-030099	Dasypus novemcinctus	99.63	9.00e-160	556.00
IUUC-Dor-030324	Dipodomys ordii	91.04	1.00e-140	492.00
IUUC-Dse-031314	Dothistroma septosporum	36.26	2.00e-44	172.00
IUUC-Dme-031926	Drosophila melanogaster	49.26	7.00e-77	280.00
IUUC-Ete-032569	Echinops telfairi	93.17	1.00e-152	532.00
IUUC-Eca-033502	Equus caballus	94.66	2.00e-155	541.00
IUUC-Eeu-034883	Erinaceus europaeus	82.16	7.00e-83	299.00
IUUC-Fca-035873	Felis catus	100.00	1.00e-160	558.00
IUUC-Fal-036921	Ficedula albicollis	92.22	2.00e-149	521.00
IUUC-Fox-037765	Fusarium oxysporum	32.73	6.00e-30	124.00
IUUC-Fso-038240	Fusarium solani	33.09	3.00e-32	132.00
IUUC-Gmo-038864	Gadus morhua	78.44	3.00e-129	454.00
IUUC-Ggr-039862	Gaeumannomyces graminis	31.52	4.00e-30	125.00
IUUC-Gga-040952	Gallus gallus	92.28	8.00e-151	526.00
IUUC-Gac-041677	Gasterosteus aculeatus	79.55	1.00e-129	455.00
IUUC-Gma-043061	Glycine max	41.06	2.00e-49	189.00
IUUC-Ggo-045591	Gorilla gorilla	100.00	1.00e-163	568.00
IUUC-Hsa-046860	Homo sapiens	100.00	3.00e-163	567.00
IUUC-Hvu-047410	Hordeum vulgare	31.08	3.00e-20	90.50
IUUC-Itr-048211	Ictidomys tridecemlineatus	99.63	5.00e-160	556.00
IUUC-Lch-049410	Latimeria chalumnae	74.27	3.00e-87	314.00
IUUC-Lpe-051102	Leersia perrieri	40.00	3.00e-47	181.00
IUUC-Loc-052016	Lepisosteus oculatus	69.20	3.00e-114	404.00
IUUC-Lma-053157	Leptosphaeria maculans	34.27	6.00e-43	167.00
IUUC-Laf-054568	Loxodonta africana	99.26	2.00e-162	565.00
IUUC-Mcc-054613	Macaca mulatta	100.00	3.00e-163	567.00
IUUC-Meu-056832	Macropus eugenii	72.86	1.00e-82	298.00
IUUC-Mor-057104	Magnaporthe oryzae	31.32	4.00e-30	125.00
IUUC-Mtr-058445	Medicago truncatula	40.68	3.00e-58	218.00
IUUC-Mla-059038	Melampsora laricipopulina	30.69	2.00e-32	132.00
IUUC-Mga-059548	Meleagris gallopavo	91.95	2.00e-129	454.00
IUUC-Mvi-060520	Microbotryum violaceum	27.95	3.00e-22	99.00
IUUC-Mdo-062376	Monodelphis domestica	94.40	9.00e-151	526.00
IUUC-Mmu-063254	Mus musculus	99.25	4.00e-159	553.00
IUUC-Mac-065635	Musa acuminata	41.09	3.00e-52	198.00
IUUC-Mlu-067512	Myotis lucifugus	98.13	3.00e-158	550.00
IUUC-Nfi-068262	Neosartorya fischeri	34.43	8.00e-41	160.00
IUUC-Ncr-068872	Neurospora crassa	32.36	8.00e-33	134.00
IUUC-Nle-070118	Nomascus leucogenys	100.00	2.00e-160	558.00
IUUC-Opr-071228	Ochotona princeps	99.57	8.00e-140	489.00
IUUC-Ont-072600	Oreochromis niloticus	80.67	3.00e-132	464.00
IUUC-Oan-073584	Ornithorhynchus anatinus	93.64	4.00e-133	466.00
IUUC-Ocu-074542	Oryctolagus cuniculus	99.63	1.00e-159	555.00
IUUC-Oba-075923	Oryza barthii	38.99	2.00e-50	192.00
IUUC-Obr-076313	Oryza brachyantha	40.00	1.00e-48	186.00
IUUC-Ogl-076932	Oryza glaberrima	38.99	2.00e-50	192.00
IUUC-Ogu-078152	Oryza glumaepatula	38.99	2.00e-50	192.00
IUUC-Oin-079528	Oryza indica	38.99	2.00e-50	192.00
IUUC-Olo-080401	Oryza longistaminata	38.99	2.00e-50	192.00
IUUC-Ome-081553	Oryza meridionalis	38.63	6.00e-50	190.00
IUUC-Oni-082090	Oryza nivara	38.99	2.00e-50	192.00
IUUC-Opu-083583	Oryza punctata	40.00	5.00e-48	184.00
IUUC-Oru-084492	Oryza rufipogon	38.99	2.00e-50	192.00
IUUC-Osa-085383	Oryza sativa	38.99	2.00e-50	192.00
IUUC-Ola-086835	Oryzias latipes	79.55	4.00e-129	453.00
IUUC-Olu-087716	Ostreococcus lucimarinus	29.70	2.00e-28	119.00
IUUC-Oga-088886	Otolemur garnettii	99.25	2.00e-159	554.00
IUUC-Oar-090079	Ovis aries	98.94	2.00e-167	581.00
IUUC-Ptr-091457	Pan troglodytes	100.00	4.00e-163	567.00
IUUC-Pan-092317	Papio anubis	100.00	9.00e-108	382.00
IUUC-Psi-093129	Pelodiscus sinensis	85.71	4.00e-130	457.00
IUUC-Pma-094488	Petromyzon marinus	72.35	4.00e-124	437.00
IUUC-Pno-095049	Phaeosphaeria nodorum	34.27	3.00e-43	168.00
IUUC-Ppa-095341	Physcomitrella patens	41.57	4.00e-64	238.00
IUUC-Pfo-096286	Poecilia formosa	79.18	6.00e-130	456.00
IUUC-Pab-097765	Pongo abelii	100.00	4.00e-163	567.00
IUUC-Pop-099131	Populus trichocarpa	40.68	2.00e-54	205.00
IUUC-Pca-100524	Procavia capensis	82.91	3.00e-108	384.00
IUUC-Ppe-101934	Prunus persica	41.83	4.00e-59	221.00
IUUC-Pva-102577	Pteropus vampyrus	99.25	1.00e-159	555.00
IUUC-Pgr-103521	Puccinia graminis	30.19	1.00e-31	130.00
IUUC-Pte-104304	Pyrenophora teres	34.97	1.00e-43	170.00
IUUC-Pyt-104563	Pyrenophora triticirepentis	34.97	9.00e-44	170.00
IUUC-Rno-105717	Rattus norvegicus	99.63	8.00e-160	556.00
IUUC-Sha-107190	Sarcophilus harrisii	94.64	1.00e-146	512.00
IUUC-Sja-107918	Schizosaccharomyces japonicus	35.89	1.00e-45	176.00
IUUC-Spo-108355	Schizosaccharomyces pombe	35.84	1.00e-45	176.00
IUUC-Smo-109374	Selaginella moellendorffii	44.28	1.00e-68	252.00
IUUC-Sit-110119	Setaria italica	39.54	5.00e-49	187.00
IUUC-Sly-111570	Solanum lycopersicum	37.34	4.00e-46	177.00
IUUC-Stu-112308	Solanum tuberosum	39.66	5.00e-52	197.00
IUUC-Sar-113515	Sorex araneus	97.87	3.00e-52	197.00
IUUC-Sbi-114605	Sorghum bicolor	39.16	7.00e-49	187.00
IUUC-Sre-114906	Sporisorium reilianum	39.78	5.00e-52	197.00
IUUC-Tgu-117087	Taeniopygia guttata	90.25	5.00e-127	446.00
IUUC-Tru-117700	Takifugu rubripes	79.18	2.00e-129	454.00
IUUC-Tni-120470	Tetraodon nigroviridis	79.93	3.00e-130	457.00
IUUC-Tca-121109	Theobroma cacao	39.92	5.00e-48	184.00
IUUC-Tre-122095	Trichoderma reesei	33.94	3.00e-32	132.00
IUUC-Tvi-122580	Trichoderma virens	33.57	1.00e-31	130.00
IUUC-Tae-125129	Triticum aestivum	39.15	2.00e-51	195.00
IUUC-Tur-126658	Triticum urartu	36.43	9.00e-43	166.00
IUUC-Tme-127043	Tuber melanosporum	38.58	9.00e-48	183.00
IUUC-Tbe-127927	Tupaia belangeri	100.00	1.00e-160	558.00
IUUC-Ttr-129231	Tursiops truncatus	99.63	5.00e-160	556.00
IUUC-Uma-129578	Ustilago maydis	39.42	5.00e-51	194.00
IUUC-Vda-129730	Verticillium dahliae	32.36	6.00e-37	147.00
IUUC-Vpa-130677	Vicugna pacos	64.75	5.00e-42	164.00
IUUC-Vvi-130968	Vitis vinifera	41.44	1.00e-53	202.00
IUUC-Xtr-132203	Xenopus tropicalis	84.76	2.00e-136	478.00
IUUC-Xma-133972	Xiphophorus maculatus	78.81	1.00e-129	455.00
IUUC-Yli-134553	Yarrowia lipolytica	36.33	5.00e-40	157.00
IUUC-Zma-134941	Zea mays	38.78	2.00e-44	172.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence