iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065882

Ensembl Protein ID

ENSMPUP00000014782.1

UniProt Accession

M3YTX2; M3YTX2_MUSPF

Genbank Protein ID

ENSMPUP00000014782

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01021493

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000014893.1	ENSMPUT00000015017.1	ENSMPUP00000014782.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-65	213.2	197	240
UBD/Beta-Prp	3.20e-79	266.2	106	303

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 197  GHSKWITGLSWeplhanPEcRYVASSSKDGSVRVWDTTVGRCER 240
           8***************9889*********************986 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t +gh + vls+s+sp+g+kl+sG +   i +wd  tg+ +  +
   Q: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKNGQILLWDPGTGKQVGRP 194
           5799************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 195  LAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRVWDTTVGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 281
           **********9873332257889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderlvs 239
           tl+gh  +v+ +++s  d  l +
   Q: 282  TLQGHGHWVNTMALS-TDYALRT 303
           **************9.4444444 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MAAAAADEAA AGDVQRLLVQ FQDEGGQVLG SPFDVPVDIT PDKLQLVCNA LLAQEDPLPL 60
AFYVHDAEII SSLGKTLESQ AVETEKVLDI IYQPQAIFRV RAVTRCTSSL EGHSEAVISV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGCTCCG TCCCGCCGGA GTGTTTCTCC TCCACGTGGG GACGCGGGAT GGCGGCCGCT 60
GCGGCGGTGG GTGTGCGTGA GTGCGGGCGG GGGCGCTCAG GTCCAGGGTC CCCAAGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	58.15	2.00e-168	585.00
IUUC-Aml-001793	Ailuropoda melanoleuca	97.67	0.00e+00	947.00
IUUC-Atr-002507	Amborella trichopoda	58.85	3.00e-167	581.00
IUUC-Apl-003964	Anas platyrhynchos	83.92	0.00e+00	808.00
IUUC-Aly-006396	Arabidopsis lyrata	54.47	3.00e-160	557.00
IUUC-Ath-007278	Arabidopsis thaliana	54.68	4.00e-160	557.00
IUUC-Ago-007951	Ashbya gossypii	48.36	6.00e-128	451.00
IUUC-Acl-008298	Aspergillus clavatus	47.41	3.00e-120	425.00
IUUC-Afl-008581	Aspergillus flavus	52.22	7.00e-109	387.00
IUUC-Afu-008906	Aspergillus fumigatus	46.41	3.00e-120	425.00
IUUC-Ani-009189	Aspergillus nidulans	44.76	7.00e-116	410.00
IUUC-Ang-009630	Aspergillus niger	49.76	2.00e-122	432.00
IUUC-Aor-010038	Aspergillus oryzae	47.41	6.00e-127	447.00
IUUC-Ate-010278	Aspergillus terreus	46.72	3.00e-121	428.00
IUUC-Ame-011890	Astyanax mexicanus	80.17	0.00e+00	820.00
IUUC-Bgr-012011	Blumeria graminis	46.91	2.00e-129	455.00
IUUC-Bta-012964	Bos taurus	95.77	0.00e+00	935.00
IUUC-Bci-013592	Botrytis cinerea	44.94	3.00e-120	425.00
IUUC-Bdi-015035	Brachypodium distachyon	58.24	7.00e-170	590.00
IUUC-Bol-015501	Brassica oleracea	55.34	1.00e-160	559.00
IUUC-Bra-017642	Brassica rapa	55.13	8.00e-160	556.00
IUUC-Cel-018430	Caenorhabditis elegans	57.38	7.00e-166	577.00
IUUC-Cja-019125	Callithrix jacchus	95.14	0.00e+00	928.00
IUUC-Cfa-021013	Canis familiaris	96.30	0.00e+00	857.00
IUUC-Cpo-021743	Cavia porcellus	94.50	0.00e+00	927.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	47.77	2.00e-123	436.00
IUUC-Csa-024270	Chlorocebus sabaeus	95.98	0.00e+00	934.00
IUUC-Cin-025795	Ciona intestinalis	65.67	0.00e+00	679.00
IUUC-Csv-025953	Ciona savignyi	66.74	0.00e+00	677.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	51.46	2.00e-107	382.00
IUUC-Cne-026901	Cryptococcus neoformans	49.20	1.00e-139	489.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.25	2.00e-114	406.00
IUUC-Dre-028515	Danio rerio	77.00	0.00e+00	794.00
IUUC-Dno-029596	Dasypus novemcinctus	95.98	0.00e+00	934.00
IUUC-Dor-030494	Dipodomys ordii	95.54	0.00e+00	923.00
IUUC-Dse-031538	Dothistroma septosporum	48.45	9.00e-131	460.00
IUUC-Dme-031974	Drosophila melanogaster	59.17	5.00e-168	583.00
IUUC-Ete-032948	Echinops telfairi	96.17	6.00e-116	410.00
IUUC-Eca-033399	Equus caballus	97.45	0.00e+00	942.00
IUUC-Eeu-035013	Erinaceus europaeus	97.00	6.00e-115	407.00
IUUC-Fca-035860	Felis catus	96.62	0.00e+00	940.00
IUUC-Fal-037069	Ficedula albicollis	86.85	1.00e-130	458.00
IUUC-Fox-038059	Fusarium oxysporum	46.11	1.00e-125	442.00
IUUC-Fso-038445	Fusarium solani	46.41	4.00e-126	444.00
IUUC-Gmo-039319	Gadus morhua	75.58	0.00e+00	731.00
IUUC-Ggr-040095	Gaeumannomyces graminis	47.08	4.00e-122	431.00
IUUC-Gga-040303	Gallus gallus	86.45	9.00e-132	462.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.06	0.00e+00	759.00
IUUC-Gma-043974	Glycine max	57.66	3.00e-170	591.00
IUUC-Ggo-044637	Gorilla gorilla	95.75	0.00e+00	926.00
IUUC-Hsa-046128	Homo sapiens	96.19	0.00e+00	936.00
IUUC-Hvu-047373	Hordeum vulgare	57.20	5.00e-168	583.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	95.61	0.00e+00	935.00
IUUC-Kpa-049274	Komagataella pastoris	44.58	2.00e-125	442.00
IUUC-Lch-049907	Latimeria chalumnae	82.14	0.00e+00	816.00
IUUC-Lpe-050778	Leersia perrieri	53.60	2.00e-151	528.00
IUUC-Loc-051889	Lepisosteus oculatus	80.17	0.00e+00	822.00
IUUC-Lma-053041	Leptosphaeria maculans	49.07	2.00e-116	413.00
IUUC-Laf-053598	Loxodonta africana	96.19	0.00e+00	939.00
IUUC-Mcc-055660	Macaca mulatta	95.77	0.00e+00	933.00
IUUC-Meu-056197	Macropus eugenii	80.43	0.00e+00	773.00
IUUC-Mor-056949	Magnaporthe oryzae	45.96	5.00e-119	421.00
IUUC-Mpo-057571	Magnaporthe poae	46.13	6.00e-64	238.00
IUUC-Mtr-058530	Medicago truncatula	57.66	1.00e-164	573.00
IUUC-Mla-059133	Melampsora laricipopulina	45.67	3.00e-122	431.00
IUUC-Mga-059252	Meleagris gallopavo	84.93	0.00e+00	663.00
IUUC-Mvi-060522	Microbotryum violaceum	49.39	1.00e-133	469.00
IUUC-Mmr-061117	Microcebus murinus	95.15	0.00e+00	923.00
IUUC-Mdo-062892	Monodelphis domestica	89.24	0.00e+00	887.00
IUUC-Mmu-064108	Mus musculus	95.36	0.00e+00	908.00
IUUC-Mac-064430	Musa acuminata	59.31	2.00e-172	598.00
IUUC-Mlu-068123	Myotis lucifugus	96.19	0.00e+00	938.00
IUUC-Nfi-068484	Neosartorya fischeri	46.89	5.00e-120	424.00
IUUC-Ncr-068649	Neurospora crassa	44.07	8.00e-116	410.00
IUUC-Nle-069140	Nomascus leucogenys	95.97	0.00e+00	929.00
IUUC-Opr-070220	Ochotona princeps	87.66	0.00e+00	806.00
IUUC-Ont-072643	Oreochromis niloticus	79.54	0.00e+00	808.00
IUUC-Ocu-074007	Oryctolagus cuniculus	95.35	0.00e+00	902.00
IUUC-Oba-075904	Oryza barthii	58.67	8.00e-171	593.00
IUUC-Obr-076280	Oryza brachyantha	58.24	7.00e-170	590.00
IUUC-Ogl-077425	Oryza glaberrima	58.67	7.00e-171	593.00
IUUC-Ogu-078586	Oryza glumaepatula	58.67	1.00e-170	592.00
IUUC-Oin-079489	Oryza indica	56.53	9.00e-162	563.00
IUUC-Olo-080766	Oryza longistaminata	58.55	1.00e-170	592.00
IUUC-Ome-081905	Oryza meridionalis	58.67	9.00e-171	593.00
IUUC-Oni-083022	Oryza nivara	58.67	4.00e-171	594.00
IUUC-Opu-083615	Oryza punctata	58.67	6.00e-171	593.00
IUUC-Oru-085076	Oryza rufipogon	58.67	4.00e-171	594.00
IUUC-Osa-085744	Oryza sativa	58.89	2.00e-171	595.00
IUUC-Ola-087290	Oryzias latipes	77.64	0.00e+00	794.00
IUUC-Olu-087898	Ostreococcus lucimarinus	53.35	3.00e-143	501.00
IUUC-Oga-088980	Otolemur garnettii	95.54	0.00e+00	928.00
IUUC-Oar-089580	Ovis aries	95.60	0.00e+00	810.00
IUUC-Ptr-090845	Pan troglodytes	95.54	0.00e+00	923.00
IUUC-Pan-092836	Papio anubis	95.56	0.00e+00	933.00
IUUC-Psi-093965	Pelodiscus sinensis	83.48	2.00e-57	213.00
IUUC-Pno-095052	Phaeosphaeria nodorum	46.82	1.00e-121	430.00
IUUC-Ppa-095432	Physcomitrella patens	58.42	5.00e-170	590.00
IUUC-Pfo-096963	Poecilia formosa	71.10	0.00e+00	694.00
IUUC-Pab-097716	Pongo abelii	92.57	0.00e+00	884.00
IUUC-Pop-099224	Populus trichocarpa	58.30	9.00e-170	589.00
IUUC-Pca-100682	Procavia capensis	91.83	0.00e+00	670.00
IUUC-Ppe-101819	Prunus persica	58.42	8.00e-169	586.00
IUUC-Pva-102338	Pteropus vampyrus	96.08	0.00e+00	711.00
IUUC-Pgr-103583	Puccinia graminis	54.85	6.00e-132	464.00
IUUC-Ptt-103737	Puccinia triticina	45.50	8.00e-100	357.00
IUUC-Pte-104150	Pyrenophora teres	49.55	5.00e-120	424.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	49.32	9.00e-120	423.00
IUUC-Rno-105987	Rattus norvegicus	94.92	0.00e+00	928.00
IUUC-Sce-106315	Saccharomyces cerevisiae	46.75	3.00e-127	448.00
IUUC-Sha-107273	Sarcophilus harrisii	90.51	0.00e+00	899.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	46.75	2.00e-119	422.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.28	2.00e-122	432.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	43.98	4.00e-115	408.00
IUUC-Smo-108855	Selaginella moellendorffii	55.85	8.00e-163	566.00
IUUC-Sit-110329	Setaria italica	59.10	9.00e-171	593.00
IUUC-Sly-111830	Solanum lycopersicum	59.53	1.00e-173	602.00
IUUC-Stu-112603	Solanum tuberosum	59.53	1.00e-173	602.00
IUUC-Sar-113504	Sorex araneus	92.91	7.00e-74	271.00
IUUC-Sbi-114560	Sorghum bicolor	58.03	5.00e-168	583.00
IUUC-Sre-115133	Sporisorium reilianum	41.62	2.00e-123	436.00
IUUC-Ssc-115903	Sus scrofa	96.62	0.00e+00	935.00
IUUC-Tgu-116798	Taeniopygia guttata	84.57	0.00e+00	849.00
IUUC-Tru-118361	Takifugu rubripes	77.85	0.00e+00	796.00
IUUC-Tsy-118849	Tarsius syrichta	96.80	0.00e+00	932.00
IUUC-Tni-120094	Tetraodon nigroviridis	77.85	0.00e+00	795.00
IUUC-Tca-121634	Theobroma cacao	58.09	5.00e-168	583.00
IUUC-Tre-122051	Trichoderma reesei	46.11	8.00e-119	420.00
IUUC-Tvi-122322	Trichoderma virens	46.93	3.00e-123	435.00
IUUC-Tae-125822	Triticum aestivum	58.03	1.00e-168	585.00
IUUC-Tur-126766	Triticum urartu	51.51	1.00e-160	559.00
IUUC-Tme-127175	Tuber melanosporum	51.37	2.00e-131	462.00
IUUC-Tbe-127779	Tupaia belangeri	94.85	0.00e+00	823.00
IUUC-Ttr-128224	Tursiops truncatus	92.52	0.00e+00	810.00
IUUC-Uma-129537	Ustilago maydis	41.65	7.00e-125	441.00
IUUC-Vda-129927	Verticillium dahliae	45.61	2.00e-109	389.00
IUUC-Vpa-130658	Vicugna pacos	84.26	0.00e+00	791.00
IUUC-Vvi-131659	Vitis vinifera	58.21	3.00e-170	591.00
IUUC-Xtr-132918	Xenopus tropicalis	77.00	0.00e+00	786.00
IUUC-Xma-133700	Xiphophorus maculatus	79.54	0.00e+00	806.00
IUUC-Yli-134478	Yarrowia lipolytica	49.59	1.00e-137	483.00
IUUC-Zma-135835	Zea mays	55.58	1.00e-164	573.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence