iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007613

UUCD1 version

UUC-ArT-01592

Ensembl Protein ID

AT5G41340.1

UniProt Accession

P42748; Q4TZ05; Q9FN66; UBC4_ARATH

Genbank Protein ID

AAA32900.1; AAY44845.1; BAB08506.1; AED94667.1; AAM20237.1; AAL38801.1

Protein Name

Ubiquitin-conjugating enzyme E2 4; E2 ubiquitin-conjugating enzyme 4; Ubiquitin carrier protein 4; Ubiquitin-conjugating enzyme E2-21 kDa 1; Ubiquitin-protein ligase 4

Genbank Nucleotide ID

L19354; DQ027019; AB006707; CP002688; AY096587; AY065360

Gene Name

UBC4; At5g41340; MYC6.5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G41340	AT5G41340.1	AT5G41340.1
AT5G41340	AT5G41340.2	AT5G41340.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	16339806

Classification

Family	E-value	Score	Start	End
E2/UBC	6.40e-34	117.6	12	141

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 9    lekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvl.ls 104
           ++k  ++ +++++ ++  ++e+ v++ Gp+d+ Y+ggv+k+++e+p+ YP+k+P+v f+tki+hPnv+e  G+vCl++++  ++Wsp+ ++ +v+ + 
   Q: 12   MMKLMMSDYKVETIND-GMQEFYVEFNGPKDSLYQGGVWKIRVELPDAYPYKSPSVGFITKIYHPNVDELsGSVCLDVIN--QTWSPMFDLVNVFeTF 106
           4456677889999999.7***************************************************99********9..*************788 PP
   S: 105  iqsllaepnpesplneeaaellkknreeykkkvre 139
           + +ll  pnp++pln eaa l+ ++r +y+++v+e
   Q: 107  LPQLLLYPNPSDPLNGEAAALMMRDRPAYEQRVKE 141
           99******************************985 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.

Protein Sequence
(Fasta)

MSSPSKRREM DMMKLMMSDY KVETINDGMQ EFYVEFNGPK DSLYQGGVWK IRVELPDAYP 60
YKSPSVGFIT KIYHPNVDEL SGSVCLDVIN QTWSPMFDLV NVFETFLPQL LLYPNPSDPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGATTCTTA TTTCTAACAA AGGATATATA TTTAGAGATA CGATCTCCTT CGGTGGTTCA 60
CTCCCATCAT CGATGTACGT GAAAATATAT AAATAAAAAA TCAATAAACG AAAATCTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G41340

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000745	Aegilops tauschii	89.93	1.00e-80	291.00
IUUC-Aly-006070	Arabidopsis lyrata	87.83	5.00e-87	312.00
IUUC-Bra-018015	Brassica rapa	93.05	1.00e-84	304.00
IUUC-Cho-024517	Choloepus hoffmanni	41.91	9.00e-23	99.00
IUUC-Fox-037912	Fusarium oxysporum	72.73	2.00e-44	170.00
IUUC-Lma-052971	Leptosphaeria maculans	55.36	4.00e-50	190.00
IUUC-Mac-064837	Musa acuminata	76.47	4.00e-80	289.00
IUUC-Pop-099283	Populus trichocarpa	91.95	6.00e-81	292.00
IUUC-Pca-100436	Procavia capensis	46.15	4.00e-33	132.00
IUUC-Ppe-101420	Prunus persica	92.62	6.00e-81	292.00
IUUC-Ptt-104010	Puccinia triticina	70.45	6.00e-55	206.00
IUUC-Sja-107813	Schizosaccharomyces japonicus	63.76	2.00e-58	218.00
IUUC-Tae-124343	Triticum aestivum	89.93	1.00e-80	290.00
IUUC-Tur-126414	Triticum urartu	89.93	1.00e-80	290.00
IUUC-Tbe-128053	Tupaia belangeri	49.09	7.00e-27	112.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence