iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000015786.3	ENSXETT00000034423.3	ENSXETP00000034423.3
ENSXETG00000015786.3	ENSXETT00000066355.1	ENSXETP00000060015.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.40e-41	137.0	353	391
UBD/Beta-Prp	8.70e-89	297.8	270	516

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v+++++ ++  +l+s+sdD t+k+W+++++v+++
   Q: 353  GHTNEVNAIKWdPSgMHLASCSDDMTLKIWSMKEDVCVH 391
           8***********66699*******************987 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
           +hk++i ++k+ ++++++++++ d+t+++wd++tg + +++  h+a+  +v++++++ +++++s+D+ i+v  l    +v t++gh+++
   Q: 270  QHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT-TFASCSTDMCIHVCRLGCDRPVKTFQGHTNE 357
           799*****************************************************8.9****************************** PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqclee.......tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltg 177
           v +++++psg +l+s s+d t+++w ++++ c+++       + +++ + +   +++p++  +l+s+s D+tvrlWd+++g +++tlt+
   Q: 358  VNAIKWDPSGMHLASCSDDMTLKIWSMKEDVCVHDlqahskeIYTIKWSPTGPGTSNPNSnIMLASASFDSTVRLWDVERGVCIHTLTK 446
           **********************************644444444444444444455667776789************************9 PP
   S: 178  ghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsi 246
            h+ + y l+   +++ +++  +  +   +  + +q+g+ v++++g    + +    + d+  +s+s Dgs+
   Q: 447  -HQMPLYYLTgliYEEGKNYTCTSTHIDCIACFHYQSGSLVHSYRGTGGIFEVCWNARGDKVGASAS-DGSV 516
           .**********988888899999999999****************9887777666666666666665.6666 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

FSVTLMPVCY CNGCLFLFSG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV 60
EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR EKLAQQQAAS TVTAPCAAPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCATAA CTAGTGACGA AGTTAATTTC TTGGTGTATC GATATCTCCA GGAGTCAGGT 60
AAATTTTGCC GTTTTAAGCA TTTGCTTGTA ATTCTGTAAA CCTCAACTTC TAAACAACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0003714--F:transcription corepressor activity
GO:0016575--P:histone deacetylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cne-026946	Cryptococcus neoformans	38.01	3.00e-30	126.00
IUUC-Mac-065508	Musa acuminata	44.57	4.00e-99	354.00
IUUC-Olu-087589	Ostreococcus lucimarinus	46.11	2.00e-129	455.00
IUUC-Psi-093358	Pelodiscus sinensis	85.41	0.00e+00	878.00
IUUC-Pma-094105	Petromyzon marinus	60.63	6.00e-91	327.00
IUUC-Sre-115175	Sporisorium reilianum	39.72	5.00e-56	212.00
IUUC-Tur-126856	Triticum urartu	57.55	9.00e-61	227.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence