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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106459
UUCD1 version UUC-SaC-00150
Ensembl Protein ID YGR200C
UniProt Accession P42935; D6VUY2; E9P8V1; ELP2_YEAST
Genbank Protein ID CAA88993.1; CAA97227.1; AAS56426.1; DAA08293.1
Protein Name Elongator complex protein 2; Gamma-toxin target 2
Genbank Nucleotide ID Z49133; Z72985; AY558100; BK006941
Gene Name ELP2; TOT2; YGR200C; G7725
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGR200C YGR200C YGR200C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.70e-41 135.5 57 89
UBD/Beta-Prp 4.10e-50 169.1 20 130
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gH+++vtc++f +d +++vs+s D+ +k+W ++
   Q: 57   GHEAEVTCVRFvPDsDFMVSASEDHHVKIWKFT 89
           8***********999***************987 PP
   

   UBD/Beta-Prp
   S: 15   cvkfspdksllatgsrdgtikvwdvttgkl...lrslsgheaevtavkfspdgkilvtgseDrtikvw...dlstgkcvhtlkghedsvlslsfspsgdkl 109
           + ++++ k+++a g   +ti +wd  +++     ++l+gheaevt+v+f pd++++v++seD+++k+w   d+s  +c++t++  ++++++ls  p  + +
   Q: 20   VSDIHKVKKIVAFGA-GKTIALWDPIEPNNkgvYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWkftDYSHLQCIQTIQHYSKTIVALSALP--SLI 117
           335566899999996.9*******9887777779**************************************************************..999 PP
   S: 110  vsGshdrtirvwd 122
            +G +d ti +w 
   Q: 118  SVGCADGTISIWR 130
           99**********5 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitiviy to Pichia inositovora toxin. May be involved in tRNA modification. ELP2 is dispensable for the complex integrity and, in vitro, is not required for complex HAT activity. It is not required for the association of the complex with nascent RNA transcript. Independently, ELP2 may be involved in polarized exocytosis. Is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.
 Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitiviy to Pichia inositovora toxin. May be involved in tRNA modification. ELP2 is dispensable for the complex integrity and, in vitro, is not required for complex HAT activity. It is not required for the association of the complex with nascent RNA transcript. Independently, ELP2 may be involved in polarized exocytosis. Is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.
Protein Sequence
(Fasta)
MVECITPEAI FIGANKQTQV SDIHKVKKIV AFGAGKTIAL WDPIEPNNKG VYATLKGHEA 60
EVTCVRFVPD SDFMVSASED HHVKIWKFTD YSHLQCIQTI QHYSKTIVAL SALPSLISVG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106459|E3,WD_repeat;UBD,Beta-Prp|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGTGGAAT GTATCACTCC CGAAGCCATT TTTATAGGTG CTAACAAGCA AACTCAGGTT 60
AGCGATATAC ACAAAGTTAA AAAAATCGTC GCATTTGGCG CAGGTAAAAC TATTGCATTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106459|E3,WD_repeat;UBD,Beta-Prp|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0033588--C:Elongator holoenzyme complex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0008017--F:microtubule binding
GO:0015031--P:protein transport
GO:0032447--P:protein urmylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0002098--P:tRNA wobble uridine modification
KEGG sce:YGR200C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000056 Aegilops tauschii 30.34 4.00e-80 290.00
IUUC-Aml-002049 Ailuropoda melanoleuca 30.91 1.00e-86 312.00
IUUC-Atr-002456 Amborella trichopoda 29.37 3.00e-85 307.00
IUUC-Apl-004053 Anas platyrhynchos 32.34 2.00e-100 358.00
IUUC-Aca-004535 Anolis carolinensis 28.08 6.00e-88 316.00
IUUC-Aly-005746 Arabidopsis lyrata 29.11 1.00e-80 292.00
IUUC-Ath-006664 Arabidopsis thaliana 29.31 5.00e-80 290.00
IUUC-Ago-007971 Ashbya gossypii 52.93 0.00e+00 809.00
IUUC-Acl-008173 Aspergillus clavatus 39.10 5.00e-152 529.00
IUUC-Afl-008665 Aspergillus flavus 38.50 6.00e-66 243.00
IUUC-Afu-008976 Aspergillus fumigatus 38.81 2.00e-151 527.00
IUUC-Ani-009284 Aspergillus nidulans 37.96 1.00e-142 498.00
IUUC-Ang-009809 Aspergillus niger 38.16 2.00e-149 520.00
IUUC-Aor-009959 Aspergillus oryzae 40.66 7.00e-155 538.00
IUUC-Ate-010442 Aspergillus terreus 38.78 7.00e-148 515.00
IUUC-Ame-011409 Astyanax mexicanus 31.20 4.00e-92 330.00
IUUC-Bgr-012137 Blumeria graminis 38.17 6.00e-139 486.00
IUUC-Bta-012892 Bos taurus 32.44 1.00e-104 372.00
IUUC-Bci-013944 Botrytis cinerea 38.68 7.00e-137 479.00
IUUC-Bdi-014512 Brachypodium distachyon 30.20 6.00e-88 316.00
IUUC-Bol-015741 Brassica oleracea 30.67 4.00e-86 310.00
IUUC-Bra-017367 Brassica rapa 30.83 1.00e-88 319.00
IUUC-Cel-018712 Caenorhabditis elegans 30.96 1.00e-69 256.00
IUUC-Cja-018865 Callithrix jacchus 29.72 3.00e-97 347.00
IUUC-Cfa-021006 Canis familiaris 32.69 2.00e-102 364.00
IUUC-Cpo-021370 Cavia porcellus 30.75 2.00e-96 345.00
IUUC-Csa-023845 Chlorocebus sabaeus 31.33 4.00e-100 357.00
IUUC-Cho-024640 Choloepus hoffmanni 28.16 6.00e-53 200.00
IUUC-Cin-025772 Ciona intestinalis 30.97 1.00e-96 345.00
IUUC-Csv-025891 Ciona savignyi 31.29 2.00e-100 357.00
IUUC-Cgl-026443 Colletotrichum gloeosporioides 40.08 3.00e-145 507.00
IUUC-Cne-027081 Cryptococcus neoformans 32.57 1.00e-98 352.00
IUUC-Cme-027225 Cyanidioschyzon merolae 27.20 5.00e-35 140.00
IUUC-Dre-028250 Danio rerio 31.38 4.00e-94 337.00
IUUC-Dno-028847 Dasypus novemcinctus 31.94 2.00e-100 357.00
IUUC-Dor-030351 Dipodomys ordii 30.12 7.00e-97 346.00
IUUC-Dse-031317 Dothistroma septosporum 35.82 5.00e-129 453.00
IUUC-Dme-032019 Drosophila melanogaster 31.70 6.00e-102 363.00
IUUC-Ete-033194 Echinops telfairi 27.10 4.00e-45 174.00
IUUC-Eca-033779 Equus caballus 31.88 2.00e-100 358.00
IUUC-Eeu-034790 Erinaceus europaeus 32.21 7.00e-60 223.00
IUUC-Fca-036090 Felis catus 31.95 1.00e-99 355.00
IUUC-Fal-037663 Ficedula albicollis 30.39 2.00e-92 331.00
IUUC-Fox-037828 Fusarium oxysporum 39.33 5.00e-138 483.00
IUUC-Fso-038462 Fusarium solani 40.18 3.00e-138 483.00
IUUC-Gmo-039450 Gadus morhua 31.29 3.00e-101 361.00
IUUC-Ggr-040023 Gaeumannomyces graminis 38.61 4.00e-130 457.00
IUUC-Gga-040480 Gallus gallus 31.55 9.00e-101 359.00
IUUC-Gac-041544 Gasterosteus aculeatus 31.95 5.00e-103 366.00
IUUC-Gma-044048 Glycine max 28.24 2.00e-88 318.00
IUUC-Ggo-045381 Gorilla gorilla 29.55 2.00e-93 335.00
IUUC-Hsa-046096 Homo sapiens 29.14 5.00e-93 333.00
IUUC-Hvu-047494 Hordeum vulgare 30.14 1.00e-84 306.00
IUUC-Itr-048823 Ictidomys tridecemlineatus 29.40 8.00e-77 280.00
IUUC-Kpa-049241 Komagataella pastoris 48.42 0.00e+00 696.00
IUUC-Lch-050512 Latimeria chalumnae 32.91 6.00e-90 323.00
IUUC-Lpe-051448 Leersia perrieri 29.82 4.00e-83 300.00
IUUC-Loc-051882 Lepisosteus oculatus 32.17 9.00e-103 365.00
IUUC-Lma-053023 Leptosphaeria maculans 39.05 2.00e-145 507.00
IUUC-Laf-054519 Loxodonta africana 31.92 5.00e-98 350.00
IUUC-Mcc-055580 Macaca mulatta 29.21 2.00e-96 345.00
IUUC-Meu-056606 Macropus eugenii 39.90 3.00e-31 128.00
IUUC-Mor-057109 Magnaporthe oryzae 37.47 1.00e-147 514.00
IUUC-Mpo-057297 Magnaporthe poae 35.70 5.00e-133 466.00
IUUC-Mtr-058348 Medicago truncatula 28.42 9.00e-89 319.00
IUUC-Mla-059159 Melampsora laricipopulina 29.78 3.00e-85 307.00
IUUC-Mga-059778 Meleagris gallopavo 29.58 2.00e-60 225.00
IUUC-Mvi-060447 Microbotryum violaceum 30.11 1.00e-90 325.00
IUUC-Mmr-061139 Microcebus murinus 30.13 9.00e-98 349.00
IUUC-Mdo-061866 Monodelphis domestica 31.63 1.00e-100 358.00
IUUC-Mmu-063390 Mus musculus 31.50 2.00e-99 355.00
IUUC-Mac-064693 Musa acuminata 30.30 5.00e-86 310.00
IUUC-Mpu-066547 Mustela putorius furo 32.56 5.00e-99 353.00
IUUC-Mlu-067156 Myotis lucifugus 31.46 3.00e-99 354.00
IUUC-Nfi-068616 Neosartorya fischeri 39.49 1.00e-155 541.00
IUUC-Ncr-068915 Neurospora crassa 36.03 6.00e-130 456.00
IUUC-Nle-069958 Nomascus leucogenys 31.17 1.00e-98 352.00
IUUC-Opr-071093 Ochotona princeps 26.38 9.00e-33 133.00
IUUC-Ont-072178 Oreochromis niloticus 31.03 1.00e-102 365.00
IUUC-Oan-073667 Ornithorhynchus anatinus 30.42 4.00e-92 330.00
IUUC-Ocu-074662 Oryctolagus cuniculus 31.45 1.00e-97 348.00
IUUC-Oba-075577 Oryza barthii 29.92 8.00e-88 316.00
IUUC-Obr-076566 Oryza brachyantha 29.68 7.00e-90 323.00
IUUC-Ogl-077054 Oryza glaberrima 30.05 4.00e-88 317.00
IUUC-Ogu-078846 Oryza glumaepatula 29.92 2.00e-87 314.00
IUUC-Oin-079084 Oryza indica 29.88 3.00e-86 311.00
IUUC-Olo-080933 Oryza longistaminata 27.14 2.00e-66 244.00
IUUC-Ome-081500 Oryza meridionalis 27.80 1.00e-72 265.00
IUUC-Oni-082352 Oryza nivara 29.88 9.00e-87 312.00
IUUC-Opu-084116 Oryza punctata 29.02 7.00e-88 316.00
IUUC-Oru-085249 Oryza rufipogon 29.88 3.00e-86 311.00
IUUC-Osa-086270 Oryza sativa 29.88 3.00e-86 311.00
IUUC-Ola-086625 Oryzias latipes 29.55 1.00e-87 315.00
IUUC-Olu-087638 Ostreococcus lucimarinus 29.15 2.00e-61 228.00
IUUC-Oga-088634 Otolemur garnettii 28.16 6.00e-88 316.00
IUUC-Oar-089475 Ovis aries 32.48 2.00e-102 365.00
IUUC-Ptr-091131 Pan troglodytes 31.03 3.00e-100 357.00
IUUC-Pan-092869 Papio anubis 30.87 3.00e-101 360.00
IUUC-Psi-093146 Pelodiscus sinensis 34.21 5.00e-91 326.00
IUUC-Pma-094479 Petromyzon marinus 29.96 3.00e-88 318.00
IUUC-Pno-095061 Phaeosphaeria nodorum 36.23 3.00e-103 367.00
IUUC-Ppa-095618 Physcomitrella patens 28.95 1.00e-77 283.00
IUUC-Pfo-096816 Poecilia formosa 32.31 2.00e-102 364.00
IUUC-Pab-097548 Pongo abelii 31.28 5.00e-101 360.00
IUUC-Pop-099643 Populus trichocarpa 28.59 2.00e-91 328.00
IUUC-Pca-100983 Procavia capensis 26.33 9.00e-36 143.00
IUUC-Ppe-101301 Prunus persica 31.35 2.00e-91 328.00
IUUC-Pva-102460 Pteropus vampyrus 30.77 4.00e-97 347.00
IUUC-Pgr-103507 Puccinia graminis 32.39 2.00e-90 325.00
IUUC-Ptt-103892 Puccinia triticina 30.84 7.00e-79 286.00
IUUC-Pte-104283 Pyrenophora teres 37.92 2.00e-141 494.00
IUUC-Pyt-104465 Pyrenophora triticirepentis 37.72 6.00e-137 479.00
IUUC-Rno-105842 Rattus norvegicus 31.76 2.00e-100 358.00
IUUC-Sha-106586 Sarcophilus harrisii 26.03 3.00e-60 224.00
IUUC-Sja-107868 Schizosaccharomyces japonicus 35.37 9.00e-113 399.00
IUUC-Spo-108302 Schizosaccharomyces pombe 35.06 2.00e-110 391.00
IUUC-Smo-108919 Selaginella moellendorffii 29.57 1.00e-82 299.00
IUUC-Sit-109915 Setaria italica 28.92 8.00e-86 309.00
IUUC-Sly-111714 Solanum lycopersicum 30.03 9.00e-89 319.00
IUUC-Stu-112631 Solanum tuberosum 29.32 6.00e-89 320.00
IUUC-Sar-113200 Sorex araneus 28.91 4.00e-55 207.00
IUUC-Sbi-114582 Sorghum bicolor 28.15 9.00e-87 312.00
IUUC-Sre-115001 Sporisorium reilianum 26.22 4.00e-38 151.00
IUUC-Ssc-115519 Sus scrofa 31.76 3.00e-100 357.00
IUUC-Tgu-116987 Taeniopygia guttata 30.75 2.00e-94 337.00
IUUC-Tru-118476 Takifugu rubripes 31.28 3.00e-95 340.00
IUUC-Tsy-119230 Tarsius syrichta 42.64 2.00e-26 112.00
IUUC-Tni-120448 Tetraodon nigroviridis 28.01 7.00e-31 127.00
IUUC-Tca-121650 Theobroma cacao 29.48 2.00e-89 321.00
IUUC-Tre-122086 Trichoderma reesei 39.51 3.00e-136 477.00
IUUC-Tvi-122397 Trichoderma virens 39.27 3.00e-128 450.00
IUUC-Tae-123972 Triticum aestivum 29.04 7.00e-86 309.00
IUUC-Tur-126578 Triticum urartu 30.33 9.00e-85 306.00
IUUC-Tme-126927 Tuber melanosporum 39.27 1.00e-142 498.00
IUUC-Tbe-127922 Tupaia belangeri 41.26 7.00e-40 157.00
IUUC-Ttr-128918 Tursiops truncatus 32.39 2.00e-101 362.00
IUUC-Uma-129474 Ustilago maydis 35.02 4.00e-36 145.00
IUUC-Vda-129944 Verticillium dahliae 38.63 7.00e-135 472.00
IUUC-Vpa-130693 Vicugna pacos 32.47 4.00e-97 347.00
IUUC-Vvi-130949 Vitis vinifera 29.59 2.00e-90 325.00
IUUC-Xtr-132639 Xenopus tropicalis 30.73 1.00e-92 332.00
IUUC-Xma-134223 Xiphophorus maculatus 37.92 4.00e-73 266.00
IUUC-Yli-134601 Yarrowia lipolytica 40.81 2.00e-148 517.00
IUUC-Zma-135952 Zea mays 28.59 5.00e-86 310.00
Created Date 25-Jun-2017

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