iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012354

UUCD1 version

UUC-BoT-00586

Ensembl Protein ID

ENSBTAP00000020074.5

UniProt Accession

Q3ZBT2; F1MVQ0; FBX9_BOVIN

Genbank Protein ID

AAI03125.1

Protein Name

F-box only protein 9

Genbank Nucleotide ID

DAAA02055275

Gene Name

FBXO9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000015083.5	ENSBTAT00000020074.5	ENSBTAP00000020074.5

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	25.64	1.00e-13	72.40	IUUC-Sce-106426
E3 adaptor/Cullin RING/SCF/F-box	28.84	4.00e-18	87.00	IUUC-Spo-108193

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).

Protein Sequence
(Fasta)

MAEAEEDCHS EAVREGDDDD ENESPAETDL QAQLQRFRAQ WMFELAPGGG SGNLESRPCR 60
AARGSLLRAA DTRGKQELAK EEKARELFLK AVEEEQNGAL YEAIKFYRRA MQLVPDIEFK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTGCGCAT GCTCGCCGCG CCGGCGCAGG TTTCCGCAGC AGACTAGCAG CTCCGCTGCG 60
GCGTCCGGGG TTTTCAGCAG GGCCGGCGCT CCGGTTCGCG CAGAGTCCTT GGCCTCTCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR007330--MIT
IPR011990--TPR-like_helical_dom

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0045444--P:fat cell differentiation
GO:0045087--P:innate immune response
GO:0016567--P:protein ubiquitination
GO:0032006--P:regulation of TOR signaling
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

bta:511798

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000378	Aegilops tauschii	35.54	1.00e-14	73.20
IUUC-Aml-001660	Ailuropoda melanoleuca	92.91	0.00e+00	852.00
IUUC-Atr-003042	Amborella trichopoda	33.33	6.00e-23	101.00
IUUC-Apl-004118	Anas platyrhynchos	82.00	0.00e+00	706.00
IUUC-Aca-005282	Anolis carolinensis	81.09	0.00e+00	713.00
IUUC-Aly-005616	Arabidopsis lyrata	31.82	3.00e-19	89.00
IUUC-Ath-007590	Arabidopsis thaliana	32.39	2.00e-19	89.70
IUUC-Acl-008135	Aspergillus clavatus	26.11	3.00e-16	79.70
IUUC-Afl-008699	Aspergillus flavus	28.18	7.00e-19	88.60
IUUC-Afu-008824	Aspergillus fumigatus	25.00	3.00e-16	80.10
IUUC-Ani-009388	Aspergillus nidulans	26.10	3.00e-16	80.10
IUUC-Ang-009815	Aspergillus niger	25.17	3.00e-16	80.10
IUUC-Aor-010113	Aspergillus oryzae	51.43	6.00e-06	44.70
IUUC-Ate-010365	Aspergillus terreus	34.65	5.00e-14	72.80
IUUC-Ame-011406	Astyanax mexicanus	70.17	3.00e-177	614.00
IUUC-Bgr-012145	Blumeria graminis	27.80	2.00e-18	86.70
IUUC-Bci-013686	Botrytis cinerea	26.19	1.00e-20	94.70
IUUC-Bdi-014609	Brachypodium distachyon	35.19	2.00e-24	105.00
IUUC-Bol-016149	Brassica oleracea	32.20	7.00e-20	91.30
IUUC-Bra-017126	Brassica rapa	32.20	6.00e-20	91.70
IUUC-Cfa-020387	Canis familiaris	93.14	0.00e+00	856.00
IUUC-Cpo-021298	Cavia porcellus	89.70	0.00e+00	796.00
IUUC-Cre-022803	Chlamydomonas reinhardtii	33.92	2.00e-19	89.40
IUUC-Csa-024074	Chlorocebus sabaeus	93.38	0.00e+00	833.00
IUUC-Cho-024705	Choloepus hoffmanni	93.00	2.00e-142	498.00
IUUC-Cin-025508	Ciona intestinalis	34.82	6.00e-64	237.00
IUUC-Csv-026173	Ciona savignyi	33.82	1.00e-60	226.00
IUUC-Cgl-026681	Colletotrichum gloeosporioides	25.52	1.00e-17	84.70
IUUC-Cne-026854	Cryptococcus neoformans	25.30	4.00e-21	96.30
IUUC-Cme-027201	Cyanidioschyzon merolae	36.09	6.00e-23	101.00
IUUC-Dre-027811	Danio rerio	66.44	1.00e-172	598.00
IUUC-Dno-029907	Dasypus novemcinctus	93.61	0.00e+00	857.00
IUUC-Dor-030126	Dipodomys ordii	88.30	0.00e+00	794.00
IUUC-Dse-031460	Dothistroma septosporum	43.21	3.00e-13	69.70
IUUC-Dme-031882	Drosophila melanogaster	34.97	2.00e-65	243.00
IUUC-Ete-032852	Echinops telfairi	78.64	0.00e+00	680.00
IUUC-Eca-033835	Equus caballus	93.38	0.00e+00	851.00
IUUC-Eeu-034960	Erinaceus europaeus	81.78	0.00e+00	708.00
IUUC-Fca-035547	Felis catus	92.91	0.00e+00	846.00
IUUC-Fal-037181	Ficedula albicollis	79.50	0.00e+00	664.00
IUUC-Fox-038043	Fusarium oxysporum	22.42	7.00e-15	75.50
IUUC-Fso-038242	Fusarium solani	26.35	1.00e-16	81.30
IUUC-Gmo-039658	Gadus morhua	62.72	4.00e-150	524.00
IUUC-Ggr-040039	Gaeumannomyces graminis	45.00	1.00e-13	71.20
IUUC-Gga-040387	Gallus gallus	82.23	0.00e+00	712.00
IUUC-Gac-042247	Gasterosteus aculeatus	64.30	4.00e-172	597.00
IUUC-Gma-043457	Glycine max	35.63	9.00e-23	100.00
IUUC-Ggo-045216	Gorilla gorilla	93.39	0.00e+00	833.00
IUUC-Hsa-046445	Homo sapiens	93.36	0.00e+00	831.00
IUUC-Hvu-047506	Hordeum vulgare	34.57	8.00e-24	104.00
IUUC-Itr-048990	Ictidomys tridecemlineatus	90.41	9.00e-113	399.00
IUUC-Kpa-049180	Komagataella pastoris	24.73	2.00e-17	82.80
IUUC-Lch-049659	Latimeria chalumnae	73.12	0.00e+00	679.00
IUUC-Lpe-051160	Leersia perrieri	25.81	4.00e-09	55.10
IUUC-Loc-051734	Lepisosteus oculatus	73.99	0.00e+00	642.00
IUUC-Lma-053018	Leptosphaeria maculans	38.68	9.00e-14	72.00
IUUC-Laf-053937	Loxodonta africana	92.68	0.00e+00	840.00
IUUC-Mcc-055178	Macaca mulatta	93.61	0.00e+00	837.00
IUUC-Mor-056938	Magnaporthe oryzae	44.59	1.00e-12	68.20
IUUC-Mpo-057448	Magnaporthe poae	45.00	4.00e-14	72.40
IUUC-Mtr-058008	Medicago truncatula	37.93	2.00e-24	106.00
IUUC-Mla-058994	Melampsora laricipopulina	29.20	1.00e-15	78.20
IUUC-Mga-059979	Meleagris gallopavo	81.51	0.00e+00	705.00
IUUC-Mvi-060524	Microbotryum violaceum	28.74	4.00e-20	92.80
IUUC-Mmr-061163	Microcebus murinus	73.85	4.00e-172	597.00
IUUC-Mdo-062767	Monodelphis domestica	87.04	0.00e+00	780.00
IUUC-Mmu-064355	Mus musculus	89.50	0.00e+00	820.00
IUUC-Mac-064946	Musa acuminata	33.53	2.00e-21	96.70
IUUC-Mpu-066278	Mustela putorius furo	91.42	0.00e+00	784.00
IUUC-Mlu-068028	Myotis lucifugus	92.89	0.00e+00	854.00
IUUC-Nfi-068607	Neosartorya fischeri	25.00	2.00e-17	84.00
IUUC-Ncr-068733	Neurospora crassa	29.28	9.00e-14	72.00
IUUC-Nle-070061	Nomascus leucogenys	93.15	0.00e+00	833.00
IUUC-Opr-071040	Ochotona princeps	55.38	4.00e-123	434.00
IUUC-Ont-071715	Oreochromis niloticus	71.14	1.00e-178	619.00
IUUC-Oan-073385	Ornithorhynchus anatinus	85.13	0.00e+00	772.00
IUUC-Ocu-074608	Oryctolagus cuniculus	92.02	0.00e+00	822.00
IUUC-Oba-075531	Oryza barthii	31.71	5.00e-09	54.70
IUUC-Obr-076891	Oryza brachyantha	33.95	3.00e-23	102.00
IUUC-Ogl-077925	Oryza glaberrima	33.95	2.00e-23	102.00
IUUC-Ogu-078352	Oryza glumaepatula	31.71	5.00e-09	54.70
IUUC-Oin-080025	Oryza indica	33.95	2.00e-23	102.00
IUUC-Olo-080624	Oryza longistaminata	29.03	1.00e-15	77.00
IUUC-Ome-081745	Oryza meridionalis	33.95	2.00e-23	103.00
IUUC-Oni-082992	Oryza nivara	34.57	1.00e-23	103.00
IUUC-Opu-083594	Oryza punctata	30.06	2.00e-15	76.60
IUUC-Oru-084792	Oryza rufipogon	31.71	4.00e-09	55.10
IUUC-Osa-086272	Oryza sativa	34.48	1.00e-09	55.50
IUUC-Ola-086443	Oryzias latipes	68.05	1.00e-173	602.00
IUUC-Olu-087849	Ostreococcus lucimarinus	27.38	1.00e-14	73.90
IUUC-Oga-087973	Otolemur garnettii	85.68	0.00e+00	765.00
IUUC-Oar-089479	Ovis aries	99.31	0.00e+00	907.00
IUUC-Ptr-091217	Pan troglodytes	93.61	0.00e+00	837.00
IUUC-Pan-092809	Papio anubis	93.61	0.00e+00	837.00
IUUC-Psi-093838	Pelodiscus sinensis	82.88	0.00e+00	764.00
IUUC-Pma-094194	Petromyzon marinus	49.29	3.00e-109	388.00
IUUC-Pno-094974	Phaeosphaeria nodorum	22.48	2.00e-16	80.10
IUUC-Ppa-095612	Physcomitrella patens	37.79	8.00e-22	97.40
IUUC-Pfo-097152	Poecilia formosa	66.43	2.00e-172	598.00
IUUC-Pab-098181	Pongo abelii	93.38	0.00e+00	837.00
IUUC-Pop-098903	Populus trichocarpa	36.42	8.00e-21	94.40
IUUC-Pca-100097	Procavia capensis	85.58	0.00e+00	763.00
IUUC-Ppe-101770	Prunus persica	36.65	1.00e-22	100.00
IUUC-Pva-103016	Pteropus vampyrus	94.04	0.00e+00	863.00
IUUC-Pgr-103565	Puccinia graminis	47.06	7.00e-13	69.30
IUUC-Ptt-103963	Puccinia triticina	23.13	3.00e-03	37.00
IUUC-Pte-104397	Pyrenophora teres	37.61	1.00e-12	68.20
IUUC-Pyt-104618	Pyrenophora triticirepentis	55.56	9.00e-03	35.00
IUUC-Rno-104872	Rattus norvegicus	90.16	0.00e+00	831.00
IUUC-Sce-106426	Saccharomyces cerevisiae	25.64	3.00e-14	72.80
IUUC-Sha-106487	Sarcophilus harrisii	87.68	7.00e-179	619.00
IUUC-Sja-107695	Schizosaccharomyces japonicus	30.28	9.00e-20	90.90
IUUC-Spo-108193	Schizosaccharomyces pombe	28.84	1.00e-18	87.00
IUUC-Ssl-108468	Sclerotinia sclerotiorum	28.48	8.00e-22	98.20
IUUC-Smo-109062	Selaginella moellendorffii	36.26	8.00e-21	94.40
IUUC-Sit-110175	Setaria italica	34.86	5.00e-25	108.00
IUUC-Sly-111632	Solanum lycopersicum	36.43	3.00e-21	95.90
IUUC-Stu-112393	Solanum tuberosum	36.43	2.00e-21	96.30
IUUC-Sar-113758	Sorex araneus	88.46	0.00e+00	763.00
IUUC-Sbi-114191	Sorghum bicolor	35.19	2.00e-24	105.00
IUUC-Sre-115169	Sporisorium reilianum	35.11	8.00e-16	79.30
IUUC-Ssc-116249	Sus scrofa	92.26	0.00e+00	834.00
IUUC-Tgu-117421	Taeniopygia guttata	79.00	0.00e+00	659.00
IUUC-Tru-118114	Takifugu rubripes	63.88	5.00e-160	556.00
IUUC-Tsy-119305	Tarsius syrichta	80.78	0.00e+00	701.00
IUUC-Tni-120491	Tetraodon nigroviridis	63.96	7.00e-165	573.00
IUUC-Tca-120948	Theobroma cacao	37.89	3.00e-22	99.00
IUUC-Tre-121934	Trichoderma reesei	27.73	5.00e-17	82.40
IUUC-Tvi-122432	Trichoderma virens	25.63	1.00e-15	77.80
IUUC-Tae-123129	Triticum aestivum	35.19	1.00e-23	103.00
IUUC-Tur-126459	Triticum urartu	35.06	2.00e-09	55.10
IUUC-Tme-127190	Tuber melanosporum	30.05	6.00e-17	82.00
IUUC-Tbe-127313	Tupaia belangeri	66.67	3.00e-120	424.00
IUUC-Ttr-128471	Tursiops truncatus	95.41	0.00e+00	865.00
IUUC-Uma-129486	Ustilago maydis	32.12	2.00e-14	75.10
IUUC-Vda-129897	Verticillium dahliae	24.72	1.00e-19	90.90
IUUC-Vpa-130277	Vicugna pacos	69.28	3.00e-129	454.00
IUUC-Vvi-130912	Vitis vinifera	35.06	5.00e-23	101.00
IUUC-Xtr-132405	Xenopus tropicalis	76.77	0.00e+00	669.00
IUUC-Xma-133338	Xiphophorus maculatus	67.14	6.00e-174	603.00
IUUC-Yli-134647	Yarrowia lipolytica	45.95	3.00e-14	73.20
IUUC-Zma-135447	Zea mays	35.19	2.00e-24	106.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence