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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046441
Ensembl Protein ID ENSP00000221855.3
UniProt Accession Q99426; O00111; O00674; O14728; Q6FGY5; TBCB_HUMAN
Genbank Protein ID AAB67716.1; AAP36092.1; CAG46769.1; AAB51182.1; AAH05969.1; AAH52812.1; BAA08572.1
Protein Name Tubulin-folding cofactor B; Cytoskeleton-associated protein 1; Cytoskeleton-associated protein CKAPI; Tubulin-specific chaperone B
Genbank Nucleotide ID AF013488; BT007424; CR541971; AD001527; BC005969; BC052812; D49738
Gene Name TBCB; CG22; CKAP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000105254.11 ENST00000221855.7 ENSP00000221855.3
ENSG00000105254.11 ENST00000589996.5 ENSP00000465447.1
ENSG00000105254.11 ENST00000591296.1 ENSP00000465979.2
ENSG00000105254.11 ENST00000589624.5 ENSP00000467825.1
ENSG00000105254.11 ENST00000586868.1 ENSP00000468055.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 41.74 2.00e-43 172.00 IUUC-Cel-018176
ULD/UDP/UBQ/UBQ_Other 34.19 3.00e-29 122.00 IUUC-Spo-108310
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).
 Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).
Protein Sequence
(Fasta)
MEVTGVSAPT VTVFISSSLN TFRSEKRYSR SLTIAEFKCK LELLVGSPAS CMELELYGVD 60
DKFYSKLDQE DALLGSYPVD DGCRIHVIDH SGARLGEYED VSRVEKYTIS QEAYDQRQDT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046441|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGCCTCCAG AGCCAACACC CCCGCCCCCA GCTCAGGGCC CGCCACTCAC TCCACTTCGT 60
GCGTGATCTT GTTGACATAG ATGCAGCTGT TGTCGGCCTC CTGCTGGTAA TCACAGTTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046441|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR000938--CAP-Gly_domain
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
Pfam

PF01302--CAP_GLY
PF14560--Ubiquitin_2
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0030154--P:cell differentiation
GO:0007399--P:nervous system development
KEGG hsa:1155
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000863 Aegilops tauschii 39.02 9.00e-26 110.00
IUUC-Aml-002358 Ailuropoda melanoleuca 90.36 4.00e-122 430.00
IUUC-Atr-003043 Amborella trichopoda 37.15 2.00e-34 138.00
IUUC-Aca-004737 Anolis carolinensis 73.30 2.00e-81 294.00
IUUC-Aly-005916 Arabidopsis lyrata 36.91 3.00e-33 134.00
IUUC-Ath-007038 Arabidopsis thaliana 36.91 3.00e-33 135.00
IUUC-Ago-007723 Ashbya gossypii 34.88 2.00e-12 65.90
IUUC-Acl-008216 Aspergillus clavatus 34.31 9.00e-30 123.00
IUUC-Afl-008534 Aspergillus flavus 33.59 1.00e-28 120.00
IUUC-Afu-008927 Aspergillus fumigatus 33.48 5.00e-28 118.00
IUUC-Ani-009283 Aspergillus nidulans 35.83 5.00e-29 121.00
IUUC-Ang-009564 Aspergillus niger 34.58 3.00e-28 118.00
IUUC-Aor-010034 Aspergillus oryzae 33.59 1.00e-28 120.00
IUUC-Ate-010424 Aspergillus terreus 34.80 2.00e-28 119.00
IUUC-Ame-011741 Astyanax mexicanus 61.07 2.00e-78 285.00
IUUC-Bgr-011988 Blumeria graminis 35.37 4.00e-30 124.00
IUUC-Bta-013304 Bos taurus 87.70 2.00e-118 418.00
IUUC-Bci-013694 Botrytis cinerea 42.60 4.00e-37 147.00
IUUC-Bdi-014585 Brachypodium distachyon 37.61 1.00e-31 130.00
IUUC-Bol-015891 Brassica oleracea 37.77 5.00e-33 134.00
IUUC-Bra-017389 Brassica rapa 37.77 7.00e-34 137.00
IUUC-Cel-018176 Caenorhabditis elegans 43.04 8.00e-46 176.00
IUUC-Cja-019754 Callithrix jacchus 99.18 3.00e-127 447.00
IUUC-Cfa-020813 Canis familiaris 93.85 6.00e-126 443.00
IUUC-Cpo-021932 Cavia porcellus 91.80 3.00e-122 431.00
IUUC-Cre-022753 Chlamydomonas reinhardtii 37.23 6.00e-30 124.00
IUUC-Csa-023261 Chlorocebus sabaeus 99.59 4.00e-127 446.00
IUUC-Cin-025428 Ciona intestinalis 48.58 2.00e-60 225.00
IUUC-Csv-025811 Ciona savignyi 50.93 2.00e-57 215.00
IUUC-Cgl-026504 Colletotrichum gloeosporioides 37.27 6.00e-31 127.00
IUUC-Cne-026867 Cryptococcus neoformans 36.33 2.00e-29 122.00
IUUC-Cme-027227 Cyanidioschyzon merolae 38.93 5.00e-13 68.20
IUUC-Dre-028683 Danio rerio 62.81 3.00e-78 284.00
IUUC-Dno-029817 Dasypus novemcinctus 89.75 3.00e-118 417.00
IUUC-Dor-030906 Dipodomys ordii 88.11 5.00e-112 396.00
IUUC-Dse-031240 Dothistroma septosporum 36.45 2.00e-29 122.00
IUUC-Dme-031894 Drosophila melanogaster 43.16 5.00e-46 177.00
IUUC-Eca-034216 Equus caballus 90.16 6.00e-125 439.00
IUUC-Eeu-035155 Erinaceus europaeus 86.89 2.00e-96 345.00
IUUC-Fca-035461 Felis catus 92.62 3.00e-124 437.00
IUUC-Fal-037458 Ficedula albicollis 50.70 1.00e-13 72.00
IUUC-Fox-037822 Fusarium oxysporum 36.44 2.00e-32 132.00
IUUC-Fso-038149 Fusarium solani 35.40 2.00e-32 132.00
IUUC-Gmo-038810 Gadus morhua 54.96 1.00e-67 249.00
IUUC-Ggr-039751 Gaeumannomyces graminis 29.55 2.00e-18 86.30
IUUC-Gga-040168 Gallus gallus 56.36 4.00e-14 72.40
IUUC-Gac-041700 Gasterosteus aculeatus 58.85 7.00e-75 273.00
IUUC-Gma-044336 Glycine max 40.00 6.00e-37 147.00
IUUC-Ggo-044442 Gorilla gorilla 99.52 2.00e-105 374.00
IUUC-Hvu-047163 Hordeum vulgare 38.64 4.00e-28 117.00
IUUC-Itr-048652 Ictidomys tridecemlineatus 90.98 2.00e-124 437.00
IUUC-Kpa-049126 Komagataella pastoris 32.00 1.00e-31 130.00
IUUC-Lch-050256 Latimeria chalumnae 67.63 3.00e-90 324.00
IUUC-Lpe-051676 Leersia perrieri 37.34 2.00e-30 125.00
IUUC-Loc-051891 Lepisosteus oculatus 67.56 2.00e-85 308.00
IUUC-Lma-052977 Leptosphaeria maculans 36.48 2.00e-32 132.00
IUUC-Laf-053381 Loxodonta africana 91.39 3.00e-120 424.00
IUUC-Mcc-055434 Macaca mulatta 99.59 4.00e-127 446.00
IUUC-Meu-056675 Macropus eugenii 69.96 8.00e-85 306.00
IUUC-Mor-056937 Magnaporthe oryzae 41.63 2.00e-30 125.00
IUUC-Mpo-057404 Magnaporthe poae 36.25 2.00e-28 119.00
IUUC-Mtr-058357 Medicago truncatula 40.45 6.00e-34 137.00
IUUC-Mla-059125 Melampsora laricipopulina 42.34 9.00e-42 163.00
IUUC-Mga-059996 Meleagris gallopavo 50.70 9.00e-14 71.60
IUUC-Mvi-060558 Microbotryum violaceum 33.07 7.00e-32 130.00
IUUC-Mmr-061473 Microcebus murinus 95.49 5.00e-126 443.00
IUUC-Mdo-061846 Monodelphis domestica 81.07 5.00e-106 376.00
IUUC-Mmu-063321 Mus musculus 89.34 2.00e-117 414.00
IUUC-Mac-065590 Musa acuminata 37.39 5.00e-34 137.00
IUUC-Mpu-066149 Mustela putorius furo 93.44 2.00e-125 441.00
IUUC-Mlu-067002 Myotis lucifugus 91.39 4.00e-123 433.00
IUUC-Nfi-068351 Neosartorya fischeri 33.19 2.00e-26 112.00
IUUC-Ncr-068854 Neurospora crassa 34.91 3.00e-30 125.00
IUUC-Nle-069008 Nomascus leucogenys 94.26 3.00e-118 417.00
IUUC-Opr-070608 Ochotona princeps 85.25 4.00e-114 403.00
IUUC-Ont-071543 Oreochromis niloticus 61.16 6.00e-84 303.00
IUUC-Oan-073488 Ornithorhynchus anatinus 76.76 3.00e-71 260.00
IUUC-Ocu-073951 Oryctolagus cuniculus 93.03 1.00e-123 435.00
IUUC-Oba-075033 Oryza barthii 37.50 4.00e-34 137.00
IUUC-Obr-076908 Oryza brachyantha 36.64 3.00e-35 141.00
IUUC-Ogl-077907 Oryza glaberrima 38.36 1.00e-36 146.00
IUUC-Ogu-078871 Oryza glumaepatula 37.50 4.00e-34 137.00
IUUC-Oin-080206 Oryza indica 38.24 1.00e-36 146.00
IUUC-Olo-080756 Oryza longistaminata 50.56 4.00e-20 89.70
IUUC-Ome-081319 Oryza meridionalis 51.81 6.00e-20 89.00
IUUC-Oni-082550 Oryza nivara 37.50 2.00e-33 136.00
IUUC-Opu-083656 Oryza punctata 34.92 9.00e-32 130.00
IUUC-Oru-084482 Oryza rufipogon 37.50 4.00e-34 137.00
IUUC-Osa-085952 Oryza sativa 38.36 1.00e-36 146.00
IUUC-Ola-087407 Oryzias latipes 56.50 3.00e-75 275.00
IUUC-Olu-087778 Ostreococcus lucimarinus 38.62 1.00e-35 143.00
IUUC-Oga-088233 Otolemur garnettii 92.62 9.00e-120 422.00
IUUC-Oar-089581 Ovis aries 87.70 5.00e-122 430.00
IUUC-Ptr-091547 Pan troglodytes 100.00 1.00e-127 448.00
IUUC-Pan-092061 Papio anubis 99.59 4.00e-127 446.00
IUUC-Psi-093234 Pelodiscus sinensis 72.92 1.00e-73 268.00
IUUC-Pma-094359 Petromyzon marinus 57.08 2.00e-69 255.00
IUUC-Pno-094999 Phaeosphaeria nodorum 37.75 1.00e-34 139.00
IUUC-Ppa-095653 Physcomitrella patens 36.71 2.00e-28 119.00
IUUC-Pfo-096130 Poecilia formosa 58.85 8.00e-80 289.00
IUUC-Pop-099133 Populus trichocarpa 37.61 1.00e-34 139.00
IUUC-Pca-100784 Procavia capensis 76.64 8.00e-94 336.00
IUUC-Ppe-101764 Prunus persica 41.63 5.00e-37 147.00
IUUC-Pva-102882 Pteropus vampyrus 92.62 7.00e-126 442.00
IUUC-Pgr-103337 Puccinia graminis 39.50 3.00e-40 158.00
IUUC-Ptt-103764 Puccinia triticina 34.41 2.00e-28 119.00
IUUC-Pte-104265 Pyrenophora teres 37.39 3.00e-28 118.00
IUUC-Pyt-104528 Pyrenophora triticirepentis 55.56 2.00e-18 86.70
IUUC-Rno-104851 Rattus norvegicus 89.75 3.00e-115 407.00
IUUC-Sce-106183 Saccharomyces cerevisiae 29.24 3.00e-12 65.10
IUUC-Sha-106933 Sarcophilus harrisii 37.65 2.00e-06 47.40
IUUC-Sja-107978 Schizosaccharomyces japonicus 37.56 2.00e-29 122.00
IUUC-Spo-108310 Schizosaccharomyces pombe 34.19 2.00e-29 122.00
IUUC-Ssl-108484 Sclerotinia sclerotiorum 33.93 9.00e-23 100.00
IUUC-Sit-110751 Setaria italica 36.25 2.00e-30 125.00
IUUC-Sly-111811 Solanum lycopersicum 38.96 2.00e-35 142.00
IUUC-Stu-111984 Solanum tuberosum 39.39 3.00e-36 144.00
IUUC-Sar-113382 Sorex araneus 87.36 4.00e-84 303.00
IUUC-Sbi-113807 Sorghum bicolor 36.32 9.00e-27 113.00
IUUC-Sre-115083 Sporisorium reilianum 34.54 1.00e-32 133.00
IUUC-Ssc-116306 Sus scrofa 89.75 3.00e-122 430.00
IUUC-Tru-117880 Takifugu rubripes 61.98 3.00e-85 308.00
IUUC-Tni-119713 Tetraodon nigroviridis 61.30 2.00e-78 285.00
IUUC-Tca-121819 Theobroma cacao 39.91 1.00e-35 143.00
IUUC-Tre-122044 Trichoderma reesei 39.73 2.00e-33 135.00
IUUC-Tvi-122273 Trichoderma virens 39.29 7.00e-33 134.00
IUUC-Tae-123023 Triticum aestivum 38.64 3.00e-28 118.00
IUUC-Tur-126446 Triticum urartu 41.03 6.00e-23 100.00
IUUC-Tme-127153 Tuber melanosporum 37.86 8.00e-37 147.00
IUUC-Tbe-127834 Tupaia belangeri 94.44 3.00e-62 230.00
IUUC-Ttr-128351 Tursiops truncatus 71.72 9.00e-97 346.00
IUUC-Uma-129608 Ustilago maydis 33.73 2.00e-29 122.00
IUUC-Vda-129806 Verticillium dahliae 34.82 2.00e-29 122.00
IUUC-Vpa-130329 Vicugna pacos 45.68 3.00e-14 73.60
IUUC-Vvi-131178 Vitis vinifera 38.79 1.00e-33 136.00
IUUC-Xtr-132139 Xenopus tropicalis 69.87 4.00e-92 330.00
IUUC-Xma-134015 Xiphophorus maculatus 59.26 5.00e-80 290.00
IUUC-Yli-134439 Yarrowia lipolytica 37.40 2.00e-32 132.00
IUUC-Zma-135720 Zea mays 37.17 1.00e-26 112.00
Created Date 25-Jun-2017

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