iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046413

UUCD1 version

UUC-HoS-00291

Ensembl Protein ID

ENSP00000217169.3

UniProt Accession

Q96CA5; Q9BQV0; Q9H2A8; Q9HAP7; BIRC7_HUMAN

Genbank Protein ID

AAG37878.1; CAC37337.1; CAC37338.1; AAG33622.1; AAQ89194.1; AAQ89195.1; AAH14475.1

Protein Name

Baculoviral IAP repeat-containing protein 7; Kidney inhibitor of apoptosis protein; Livin; Melanoma inhibitor of apoptosis protein; RING finger protein 50; RING-type E3 ubiquitin transferase BIRC7; Baculoviral IAP repeat-containing protein 7 30kDa subunit

Genbank Nucleotide ID

AF301009; AJ309298; AJ309298; AF311388; AY358835; AY358836; AL121827

Gene Name

BIRC7; KIAP; LIVIN; MLIAP; RNF50; UNQ5800/PRO19607/PRO21344

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000101197.12	ENST00000342412.10	ENSP00000345213.6
ENSG00000101197.12	ENST00000217169.7	ENSP00000217169.3
ENSG00000101197.12	ENST00000395306.1	ENSP00000378717.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16729033

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.012	17.8	252	286

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +Cl++     +++pCgH+ +a+C          + + ++CP+Cr
   Q: 252  CKVCLDRAVS-IVFVPCGHLVCAEC----------APGLQLCPICR 286
           99****9988.888***********..........99********8 PP

Organism

Homo sapiens

Functional Description
(View)

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

Protein Sequence
(Fasta)

MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR 60
PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCCCAGAG GCCACCCTGG CCACTTCCAG AAAGCTGTGG GCCCTGGGAT ACTCCCCTCC 60
CAGGGTGTCT GGTGGCAGGC CTGTGCCTAT CCCTGCTGTC CCCAGGGTGG GCCCCGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0646--Protease inhibitor
KW-1185--Reference proteome
KW-0789--Thiol protease inhibitor
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS01282--BIR_REPEAT_1
PS50143--BIR_REPEAT_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00653--BIR

SMART

SM00238--BIR
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005815--C:microtubule organizing center
GO:0005634--C:nucleus
GO:0004869--F:cysteine-type endopeptidase inhibitor activity
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0019899--F:enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007257--P:activation of JUN kinase activity
GO:1990001--P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0016567--P:protein ubiquitination
GO:0042127--P:regulation of cell proliferation
GO:0070247--P:regulation of natural killer cell apoptotic process
GO:0009966--P:regulation of signal transduction

KEGG

hsa:79444

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001950	Ailuropoda melanoleuca	57.55	3.00e-88	318.00
IUUC-Bta-013536	Bos taurus	66.56	1.00e-90	326.00
IUUC-Cja-019401	Callithrix jacchus	83.22	1.00e-113	402.00
IUUC-Cfa-020317	Canis familiaris	56.52	6.00e-78	284.00
IUUC-Csa-023921	Chlorocebus sabaeus	91.95	3.00e-144	504.00
IUUC-Ete-033129	Echinops telfairi	52.78	1.00e-44	171.00
IUUC-Eeu-035289	Erinaceus europaeus	63.64	7.00e-88	317.00
IUUC-Fca-035361	Felis catus	52.70	2.00e-76	280.00
IUUC-Ggo-045535	Gorilla gorilla	98.66	9.00e-146	509.00
IUUC-Laf-054484	Loxodonta africana	62.15	7.00e-83	300.00
IUUC-Mcc-055393	Macaca mulatta	91.61	1.00e-128	452.00
IUUC-Mmr-060668	Microcebus murinus	68.90	9.00e-85	306.00
IUUC-Mdo-062361	Monodelphis domestica	47.52	2.00e-71	262.00
IUUC-Mpu-066228	Mustela putorius furo	64.47	2.00e-96	345.00
IUUC-Nle-070054	Nomascus leucogenys	94.63	2.00e-135	475.00
IUUC-Oba-075516	Oryza barthii	43.75	1.00e-06	49.30
IUUC-Olo-080871	Oryza longistaminata	43.75	8.00e-07	49.30
IUUC-Ome-081390	Oryza meridionalis	43.75	1.00e-06	49.30
IUUC-Oni-082480	Oryza nivara	43.75	1.00e-06	49.30
IUUC-Oru-084229	Oryza rufipogon	43.75	1.00e-06	49.30
IUUC-Oga-088631	Otolemur garnettii	69.90	6.00e-94	337.00
IUUC-Oar-089909	Ovis aries	53.87	8.00e-82	297.00
IUUC-Pan-091824	Papio anubis	91.61	4.00e-129	453.00
IUUC-Pca-100515	Procavia capensis	58.75	1.00e-85	309.00
IUUC-Pva-102311	Pteropus vampyrus	67.00	6.00e-84	303.00
IUUC-Sha-107551	Sarcophilus harrisii	42.17	1.00e-61	230.00
IUUC-Sit-110296	Setaria italica	37.04	2.00e-09	58.20
IUUC-Tsy-119148	Tarsius syrichta	80.00	4.00e-35	141.00
IUUC-Tur-126712	Triticum urartu	34.52	1.00e-08	54.30
IUUC-Tbe-127390	Tupaia belangeri	63.42	3.00e-90	324.00
IUUC-Vvi-131275	Vitis vinifera	43.86	6.00e-09	56.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence