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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-063568
UUCD1 version UUC-MuM-01068
Ensembl Protein ID ENSMUSP00000147409.1
UniProt Accession Q9R1T2; Q3TRG9; Q3TWJ0; Q9CSW9; SAE1_MOUSE
Genbank Protein ID BAA82876.1; BAB26845.1; BAB27838.1; BAC39925.1; BAC41044.1; BAE32401.1; BAE35276.1; BAE37060.1; AAH68164.1
Protein Name SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; SUMO-activating enzyme subunit 1, N-terminally processed
Genbank Nucleotide ID AB024303; AK010313; AK011783; AK087556; AK090012; AK154139; AK159672; AK162789; BC068164
Gene Name Sae1; Aos1; Sua1; Ubl1a1; Uble1a
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000052833.9 ENSMUST00000211741.1 ENSMUSP00000147771.1
ENSMUSG00000052833.9 ENSMUST00000210999.1 ENSMUSP00000147409.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E1 E1_ThiF 11481243; 20682785
Classification
Family E-value Score Start End
E1 6.70e-90 303.4 23 339
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E1

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
    YDRQirlwG eaq++l+ ++vl+vG++glG+E++KnL+laGv+ +t++D+++v+ +++++qFL++ +vg+++Ae+++e++++lnp+v+
   Q: 23 YDRQIRLWGLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPEDPGAQFLIQTGSVGRNRAEASLERAQNLNPMVD 111
    ***************************************************************************************** PP
   S: 90 veaheesiteleeeivFfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlke 178
    v++++e+++++ e+ Ff+kfd V+l++++r+ kv+++c+ +++++++++++G++G++ f +l+e
   Q: 112 VKVDTEDVEKKPES--FFTKFDAVCLTCCSRDVIIKVDQICHRNSIKFFTGDVFGYHGYT-----------------------FANLGE 175
    **************..********************************************.......................****** PP
   S: 179 tpnaaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtk 267
    ++ ++e+t + ++ e+g+e +++klds+e++++k+kv
   Q: 176 HEFVEEKTKVAK----VSQGVEDGPEAKRAKLDSSETTMVKKKV--------------------------------------------- 215
    *********955....88999*********************99............................................. PP
   S: 268 skspfwvsfcsnaealqvpekvekdeevvkasaplylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldd 355
    fc+++eal+v++++ek ++++k++ap y+ll++l +f+++kgr+p++ s+++d++ ++++ +++ slgi+p l+d
   Q: 216 -------LFCPVKEALEVDWSGEKAKAALKRTAPDYFLLQVLLKFRTDKGRDPTSESYKEDAELLLQIRNDVF----DSLGISPdLLPD 293
    .......8*****************************************************************....*******66666 PP
   S: 356 dlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdaee 405
    d+++ ++++++a+++avvgG++aqE++K++s++ p++nff+fd+++
   Q: 294 DFVR----YCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMK 339
    6665....789************************************985 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).
Protein Sequence
(Fasta)
MVEKEEAGGG GGGGISEEEA AQYDRQIRLW GLEAQKRLRA SRVLIVGMKG LGAEIAKNLI 60
LAGVKGLTML DHEQVSPEDP GAQFLIQTGS VGRNRAEASL ERAQNLNPMV DVKVDTEDVE 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063568|E1,E1_ThiF|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGACTCGCTG CTGGCGGTTA GCGAGAGCGG GAGCGGGTGA GCTGAAAGCC GGCGCCATGG 60
TAGAGAAGGA GGAGGCTGGC GGCGGCGGCG GCGGTGGCAT CAGCGAGGAG GAGGCAGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063568|E1,E1_ThiF|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0436--Ligase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR000011--UBQ/SUMO-activ_enz_E1-like

Pfam

PF00899--ThiF

PRINTS

PR01849--UBIQUITINACT

Gene Ontology

GO:0005634--C:nucleus
GO:0031510--C:SUMO activating enzyme complex
GO:0043008--F:ATP-dependent protein binding
GO:0008022--F:protein C-terminus binding
GO:0046982--F:protein heterodimerization activity
GO:0019948--F:SUMO activating enzyme activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016925--P:protein sumoylation

KEGG mmu:56459
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000695 Aegilops tauschii 29.56 3.00e-39 155.00
IUUC-Aml-001477 Ailuropoda melanoleuca 91.79 0.00e+00 634.00
IUUC-Atr-002536 Amborella trichopoda 32.04 9.00e-41 160.00
IUUC-Apl-003982 Anas platyrhynchos 72.90 1.00e-105 375.00
IUUC-Aca-004868 Anolis carolinensis 77.58 1.00e-148 519.00
IUUC-Aly-005588 Arabidopsis lyrata 32.93 2.00e-44 172.00
IUUC-Ath-006677 Arabidopsis thaliana 33.23 9.00e-45 173.00
IUUC-Ago-007891 Ashbya gossypii 33.23 5.00e-43 168.00
IUUC-Acl-008197 Aspergillus clavatus 34.11 4.00e-50 191.00
IUUC-Afl-008520 Aspergillus flavus 33.14 2.00e-50 192.00
IUUC-Afu-009107 Aspergillus fumigatus 31.95 2.00e-45 176.00
IUUC-Ani-009143 Aspergillus nidulans 31.09 4.00e-41 162.00
IUUC-Ang-009804 Aspergillus niger 33.72 3.00e-51 195.00
IUUC-Aor-010190 Aspergillus oryzae 33.14 2.00e-50 192.00
IUUC-Ame-011043 Astyanax mexicanus 69.11 2.00e-126 445.00
IUUC-Bgr-012084 Blumeria graminis 32.27 6.00e-46 178.00
IUUC-Bta-012723 Bos taurus 91.49 0.00e+00 638.00
IUUC-Bci-013809 Botrytis cinerea 32.65 2.00e-48 186.00
IUUC-Bdi-014800 Brachypodium distachyon 32.14 3.00e-44 172.00
IUUC-Bol-015744 Brassica oleracea 31.74 2.00e-40 159.00
IUUC-Bra-016683 Brassica rapa 32.34 5.00e-42 164.00
IUUC-Cel-018434 Caenorhabditis elegans 30.97 3.00e-40 159.00
IUUC-Cja-019815 Callithrix jacchus 93.35 0.00e+00 652.00
IUUC-Cfa-020329 Canis familiaris 90.58 0.00e+00 630.00
IUUC-Cpo-022208 Cavia porcellus 92.19 0.00e+00 643.00
IUUC-Csa-023592 Chlorocebus sabaeus 92.45 2.00e-155 541.00
IUUC-Cho-024345 Choloepus hoffmanni 80.80 1.00e-120 426.00
IUUC-Cin-025351 Ciona intestinalis 44.55 2.00e-83 302.00
IUUC-Cgl-026491 Colletotrichum gloeosporioides 33.43 3.00e-43 169.00
IUUC-Dre-028263 Danio rerio 69.72 1.00e-127 449.00
IUUC-Dno-030055 Dasypus novemcinctus 89.36 0.00e+00 626.00
IUUC-Dor-030864 Dipodomys ordii 90.10 9.00e-171 592.00
IUUC-Dse-031565 Dothistroma septosporum 32.17 1.00e-46 180.00
IUUC-Dme-032011 Drosophila melanogaster 39.02 2.00e-57 216.00
IUUC-Ete-032982 Echinops telfairi 80.06 8.00e-154 536.00
IUUC-Eca-034164 Equus caballus 90.76 5.00e-174 603.00
IUUC-Eeu-035135 Erinaceus europaeus 73.85 2.00e-95 342.00
IUUC-Fca-035564 Felis catus 92.10 0.00e+00 637.00
IUUC-Fox-037928 Fusarium oxysporum 32.76 3.00e-46 179.00
IUUC-Fso-038404 Fusarium solani 32.29 6.00e-45 175.00
IUUC-Gmo-038867 Gadus morhua 67.58 3.00e-124 437.00
IUUC-Ggr-040068 Gaeumannomyces graminis 35.42 7.00e-49 188.00
IUUC-Gga-041197 Gallus gallus 75.08 1.00e-129 456.00
IUUC-Gac-042609 Gasterosteus aculeatus 65.96 5.00e-124 437.00
IUUC-Gma-044135 Glycine max 31.27 4.00e-44 171.00
IUUC-Ggo-044600 Gorilla gorilla 93.01 0.00e+00 646.00
IUUC-Hsa-046731 Homo sapiens 93.01 0.00e+00 646.00
IUUC-Itr-049038 Ictidomys tridecemlineatus 93.31 0.00e+00 645.00
IUUC-Kpa-049371 Komagataella pastoris 29.39 2.00e-33 136.00
IUUC-Lch-050045 Latimeria chalumnae 76.90 5.00e-155 540.00
IUUC-Lpe-051103 Leersia perrieri 31.23 9.00e-42 164.00
IUUC-Loc-051749 Lepisosteus oculatus 63.34 9.00e-121 426.00
IUUC-Lma-053150 Leptosphaeria maculans 36.47 2.00e-50 193.00
IUUC-Laf-053875 Loxodonta africana 91.79 0.00e+00 638.00
IUUC-Mcc-055107 Macaca mulatta 92.74 5.00e-171 593.00
IUUC-Meu-056076 Macropus eugenii 60.73 3.00e-114 404.00
IUUC-Mor-057029 Magnaporthe oryzae 33.62 6.00e-46 178.00
IUUC-Mtr-058633 Medicago truncatula 32.14 2.00e-41 162.00
IUUC-Mvi-060367 Microbotryum violaceum 33.63 5.00e-48 184.00
IUUC-Mmr-061294 Microcebus murinus 91.09 4.00e-169 587.00
IUUC-Mdo-062827 Monodelphis domestica 84.04 3.00e-172 597.00
IUUC-Mac-064495 Musa acuminata 29.55 4.00e-40 158.00
IUUC-Mpu-065826 Mustela putorius furo 91.49 0.00e+00 632.00
IUUC-Mlu-067751 Myotis lucifugus 89.17 2.00e-170 591.00
IUUC-Nfi-068597 Neosartorya fischeri 34.02 1.00e-52 200.00
IUUC-Ncr-068768 Neurospora crassa 32.96 3.00e-44 172.00
IUUC-Nle-069882 Nomascus leucogenys 94.97 2.00e-90 325.00
IUUC-Opr-071077 Ochotona princeps 66.26 1.00e-120 426.00
IUUC-Ont-072576 Oreochromis niloticus 69.18 6.00e-119 420.00
IUUC-Oan-073560 Ornithorhynchus anatinus 81.52 9.00e-153 532.00
IUUC-Ocu-074732 Oryctolagus cuniculus 83.83 5.00e-165 573.00
IUUC-Oba-075956 Oryza barthii 31.85 2.00e-44 172.00
IUUC-Obr-076004 Oryza brachyantha 31.16 5.00e-42 164.00
IUUC-Ogu-078335 Oryza glumaepatula 31.85 3.00e-44 172.00
IUUC-Oin-079177 Oryza indica 31.85 5.00e-45 174.00
IUUC-Olo-080537 Oryza longistaminata 29.64 4.00e-37 148.00
IUUC-Ome-081880 Oryza meridionalis 31.85 5.00e-45 174.00
IUUC-Oni-082688 Oryza nivara 32.14 1.00e-45 177.00
IUUC-Opu-083231 Oryza punctata 32.15 3.00e-46 179.00
IUUC-Oru-084759 Oryza rufipogon 31.85 5.00e-45 174.00
IUUC-Osa-085601 Oryza sativa 31.55 2.00e-44 172.00
IUUC-Ola-086496 Oryzias latipes 68.67 3.00e-119 421.00
IUUC-Oga-089005 Otolemur garnettii 85.20 2.00e-169 588.00
IUUC-Oar-089611 Ovis aries 91.49 0.00e+00 637.00
IUUC-Ptr-091337 Pan troglodytes 93.01 0.00e+00 646.00
IUUC-Pan-092401 Papio anubis 86.93 1.00e-172 598.00
IUUC-Pma-094210 Petromyzon marinus 58.91 1.00e-114 405.00
IUUC-Pno-094975 Phaeosphaeria nodorum 33.72 8.00e-48 184.00
IUUC-Ppa-095925 Physcomitrella patens 35.00 9.00e-51 193.00
IUUC-Pfo-096890 Poecilia formosa 67.77 4.00e-124 437.00
IUUC-Pab-098173 Pongo abelii 93.01 0.00e+00 647.00
IUUC-Pop-099145 Populus trichocarpa 32.34 7.00e-46 177.00
IUUC-Pca-100899 Procavia capensis 74.77 4.00e-135 474.00
IUUC-Ppe-101274 Prunus persica 27.88 3.00e-30 125.00
IUUC-Pva-102625 Pteropus vampyrus 91.19 0.00e+00 634.00
IUUC-Pgr-103426 Puccinia graminis 36.28 2.00e-52 199.00
IUUC-Pte-104082 Pyrenophora teres 34.20 7.00e-47 181.00
IUUC-Pyt-104818 Pyrenophora triticirepentis 34.20 5.00e-47 181.00
IUUC-Rno-106129 Rattus norvegicus 96.07 0.00e+00 661.00
IUUC-Sce-106370 Saccharomyces cerevisiae 32.34 2.00e-40 159.00
IUUC-Sha-107120 Sarcophilus harrisii 81.90 2.00e-152 531.00
IUUC-Sja-107996 Schizosaccharomyces japonicus 30.25 5.00e-38 151.00
IUUC-Spo-108321 Schizosaccharomyces pombe 29.27 2.00e-31 129.00
IUUC-Ssl-108608 Sclerotinia sclerotiorum 32.12 7.00e-47 181.00
IUUC-Smo-109539 Selaginella moellendorffii 29.62 5.00e-34 138.00
IUUC-Sit-110166 Setaria italica 32.45 4.00e-46 178.00
IUUC-Sly-111116 Solanum lycopersicum 31.53 1.00e-42 167.00
IUUC-Stu-112397 Solanum tuberosum 31.83 1.00e-42 166.00
IUUC-Sar-113506 Sorex araneus 80.97 9.00e-160 556.00
IUUC-Sbi-114548 Sorghum bicolor 33.63 2.00e-46 179.00
IUUC-Sre-115022 Sporisorium reilianum 25.74 4.00e-27 115.00
IUUC-Ssc-115891 Sus scrofa 91.79 0.00e+00 638.00
IUUC-Tru-118469 Takifugu rubripes 63.75 6.00e-119 420.00
IUUC-Tsy-119304 Tarsius syrichta 82.75 1.00e-152 531.00
IUUC-Tni-119803 Tetraodon nigroviridis 58.91 3.00e-114 404.00
IUUC-Tca-121747 Theobroma cacao 32.34 2.00e-44 172.00
IUUC-Tre-122060 Trichoderma reesei 32.76 2.00e-44 173.00
IUUC-Tvi-122324 Trichoderma virens 33.62 2.00e-46 179.00
IUUC-Tae-123151 Triticum aestivum 31.85 1.00e-43 170.00
IUUC-Tur-126224 Triticum urartu 31.29 1.00e-42 167.00
IUUC-Tme-126939 Tuber melanosporum 35.82 2.00e-53 202.00
IUUC-Tbe-127982 Tupaia belangeri 81.46 4.00e-162 563.00
IUUC-Ttr-128758 Tursiops truncatus 91.49 0.00e+00 639.00
IUUC-Uma-129422 Ustilago maydis 26.87 3.00e-28 119.00
IUUC-Vda-129664 Verticillium dahliae 32.47 4.00e-42 166.00
IUUC-Vpa-130778 Vicugna pacos 77.26 1.00e-131 462.00
IUUC-Vvi-131399 Vitis vinifera 30.84 5.00e-43 168.00
IUUC-Xtr-131919 Xenopus tropicalis 71.69 3.00e-141 494.00
IUUC-Xma-133482 Xiphophorus maculatus 68.98 8.00e-122 430.00
IUUC-Yli-134596 Yarrowia lipolytica 29.23 2.00e-34 139.00
IUUC-Zma-135688 Zea mays 33.33 2.00e-46 179.00
Created Date 25-Jun-2017

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