iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Hvu-047191

Ensembl Protein ID

MLOC_60529.1

UniProt Accession

M0XJ49; M0XJ49_HORVV

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MLOC_60529	MLOC_60529.1	MLOC_60529.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.60e-164	547.9	386	873

Active Site

Position(s)	Description	Evidence
567	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           YD Q+ ++G++ q+k+++a+ ++vG g+lGcE+lKnL+l+Gv     g++t++D+d +e+snl+rqFLfr++++g+ K+ vaa a+  +np+ +++a
   Q: 386  YDAQVSVFGSKLQKKMEEANTFVVGSGALGCEFLKNLALMGVscsskGKLTITDDDIIEKSNLSRQFLFRDWNIGQAKSTVAATAASAINPSLHIDA 482
           ************************************************************************************************* PP
   S: 93   heesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaeht 186
            +++ ++++e+++   F + +dvV++aldn+ ar++++ +cl+ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p +++h+
   Q: 483  LQNRACPDTENVFhdtFWEGLDVVINALDNVNARMYMDMRCLYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHC 579
           ***********8899999999**************************************************************************** PP
   S: 187  iewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtksksp 271
           ++wa              +n +l++ a+      k   ++ +e +++v++ l++ + ++f+++i++a+ +f+ +++n +kql+  f+ d  t+ +++
   Q: 580  LTWArsefegllektpNEVNSFLSNPAQYAAAMRKAGDAQARELLERVSECLNKDRCSTFDDCISWARLKFEDYFSNRVKQLTFTFPEDAATSMGAS 676
           ***************99999999999999999999************************************************************** PP
   S: 272  fwv......................................................sfcsnaealqvpekvekdeevvkasap.....lylllral 309
           fw+                                                       +++++ ++ v+  ++++  ++++++      ++ ll++l
   Q: 677  FWSapkrfpralqfsaadqshlnfimsasilraesfgvaipewakdtskladvvkkiAVPTFEPKQGVNIVTDEKASNLSSTSVddvavIEDLLAKL 773
           *********9999999999999999999999999999999999999997777777764444444444443333333333333335556778888888 PP
   S: 310  erfekk..kgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknffl 400
           ++ +k+  +g +++ ++fekddd   ++dl+  +an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++E++Kv+ g  + e ++n+f 
   Q: 774  QEYAKRlpPGFQMKPIQFEKDDDTnfHMDLISGLANMRARNYSIPE-VDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKVIAGehPVEDYRNTFA 869
           88887655899***********************************.*************************************9999999*****9 PP
   S: 401  fdae 404
           ++a+
   Q: 870  NLAL 873
           9875 PP

Organism

Hordeum vulgare

Protein Sequence
(Fasta)

MRRLFASDVL VSGLNGLGAE TAKNLALAGV KSVTIHDVKN VEMWDLSGNF FLSEDDIGKN 60
RAAACVAKLQ ELNNAVLISA LTEELTTEHL SKFQAVVFTD IGLDKAYEFD EYCHNHQPPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCCAAGCT CGGCGCGGGC GGCGGCGGGG GCCCGAACGG GGCCGCGCCG CAGGAGATCG 60
ACGAGGACCT CCACAGCAGG CAGCTCGCCG TGTACGGGAG GGAGACCATG CGGCGCCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000144	Aegilops tauschii	97.88	0.00e+00	1994.00
IUUC-Bdi-014009	Brachypodium distachyon	89.30	0.00e+00	1756.00
IUUC-Lpe-051299	Leersia perrieri	88.80	0.00e+00	1802.00
IUUC-Oba-075934	Oryza barthii	89.00	0.00e+00	1808.00
IUUC-Obr-076244	Oryza brachyantha	87.59	0.00e+00	1739.00
IUUC-Ogl-077762	Oryza glaberrima	89.00	0.00e+00	1807.00
IUUC-Ogu-078305	Oryza glumaepatula	88.90	0.00e+00	1808.00
IUUC-Oin-080154	Oryza indica	89.10	0.00e+00	1807.00
IUUC-Olo-081089	Oryza longistaminata	89.30	0.00e+00	1812.00
IUUC-Oni-082447	Oryza nivara	89.00	0.00e+00	1808.00
IUUC-Opu-083863	Oryza punctata	88.29	0.00e+00	1792.00
IUUC-Oru-084469	Oryza rufipogon	89.20	0.00e+00	1812.00
IUUC-Osa-085625	Oryza sativa	89.20	0.00e+00	1808.00
IUUC-Sit-110294	Setaria italica	87.59	0.00e+00	1820.00
IUUC-Sbi-114774	Sorghum bicolor	88.70	0.00e+00	1841.00
IUUC-Tae-125702	Triticum aestivum	98.28	0.00e+00	2002.00
IUUC-Tur-126011	Triticum urartu	95.29	0.00e+00	1974.00
IUUC-Tbe-127714	Tupaia belangeri	36.39	7.00e-137	480.00
IUUC-Vpa-130716	Vicugna pacos	37.75	0.00e+00	659.00
IUUC-Xtr-132026	Xenopus tropicalis	38.47	2.00e-177	614.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence