iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-061903

Ensembl Protein ID

ENSMODP00000026231.3

UniProt Accession

F6S603; F6S603_MONDO

Protein Name

Uncharacterized protein

Gene Name

PHIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000018435.3	ENSMODT00000026698.3	ENSMODP00000026231.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.30e-33	111.3	181	218
UBD/Beta-Prp	1.80e-52	178.5	280	541

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 181  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 218
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl......lrslsgheaevt..avkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l       +  +   ++v+  + +fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 280  SGSKRYLSSTGADGTICFWLWDAGTLkinqrpTKFTERPRPGVQmiCSSFSAGGMFLATGSTDHIIRVYyfGSGQPEKISELEFHTDKV 368
           67899***********999999988866666433335555666611566888888**************665569999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 369  DSIQFSNTSSRFVSGSRDGTARIWQYKRREWKSIlldmatrpsgqnlqgvEDKITKLKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQ 457
           ********************************99***************888888889******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 458  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGAKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 541
           ******9.*********999999..89********************9999875544445666667777999999999999888887 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSCESKGLSE LRSELYFLIA RFLEDGPCQQ AAQVLIREVA EKELLPRRTD WTGKEHPRTY 60
QNLVKYYRHL APDHLLQICH RLGPLLEQEI PQSVPGVQTL LGAGRQSLLR TNKSCKHVVW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTTGTG AGAGCAAAGG CCTCTCGGAG CTGCGATCGG GTAAGTGGGG AGGCTGCGGG 60
CGCCGCTGGC ACGGGGCGCG TCCGTTCCCG GTGCCCCGAG CCCGGCGTTG AGTCTGTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	31.38	4.00e-63	237.00
IUUC-Aml-002299	Ailuropoda melanoleuca	90.88	0.00e+00	3056.00
IUUC-Atr-002600	Amborella trichopoda	31.70	8.00e-70	259.00
IUUC-Apl-003700	Anas platyrhynchos	87.50	0.00e+00	2896.00
IUUC-Aca-004474	Anolis carolinensis	84.09	0.00e+00	2870.00
IUUC-Bta-013125	Bos taurus	90.53	0.00e+00	2955.00
IUUC-Cja-018868	Callithrix jacchus	89.05	0.00e+00	3130.00
IUUC-Cfa-021179	Canis familiaris	90.47	0.00e+00	3016.00
IUUC-Cpo-022077	Cavia porcellus	84.86	0.00e+00	2884.00
IUUC-Csa-023618	Chlorocebus sabaeus	95.25	0.00e+00	1725.00
IUUC-Cho-024794	Choloepus hoffmanni	88.15	0.00e+00	854.00
IUUC-Csv-025813	Ciona savignyi	44.46	0.00e+00	642.00
IUUC-Dno-030048	Dasypus novemcinctus	90.41	0.00e+00	3060.00
IUUC-Dor-030195	Dipodomys ordii	82.02	0.00e+00	1429.00
IUUC-Ete-032748	Echinops telfairi	77.11	0.00e+00	1025.00
IUUC-Eca-034274	Equus caballus	91.72	0.00e+00	3014.00
IUUC-Eeu-034688	Erinaceus europaeus	91.78	0.00e+00	1276.00
IUUC-Fca-035451	Felis catus	90.52	0.00e+00	2913.00
IUUC-Fal-037465	Ficedula albicollis	86.83	0.00e+00	2924.00
IUUC-Gmo-039451	Gadus morhua	68.58	0.00e+00	722.00
IUUC-Gga-040798	Gallus gallus	87.73	0.00e+00	3004.00
IUUC-Ggo-045347	Gorilla gorilla	95.50	0.00e+00	1623.00
IUUC-Hsa-046757	Homo sapiens	95.60	0.00e+00	1704.00
IUUC-Hvu-047706	Hordeum vulgare	31.48	2.00e-37	149.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	82.77	0.00e+00	1053.00
IUUC-Lch-050646	Latimeria chalumnae	78.74	0.00e+00	2754.00
IUUC-Lpe-051619	Leersia perrieri	31.19	2.00e-69	258.00
IUUC-Laf-054140	Loxodonta africana	91.05	0.00e+00	3051.00
IUUC-Mcc-055061	Macaca mulatta	94.68	0.00e+00	1713.00
IUUC-Mmr-060837	Microcebus murinus	90.31	0.00e+00	3093.00
IUUC-Mmu-063772	Mus musculus	90.47	0.00e+00	3116.00
IUUC-Mac-065343	Musa acuminata	30.54	4.00e-75	277.00
IUUC-Mpu-066359	Mustela putorius furo	90.99	0.00e+00	2795.00
IUUC-Mlu-067928	Myotis lucifugus	89.50	0.00e+00	3035.00
IUUC-Nle-070094	Nomascus leucogenys	93.52	0.00e+00	1655.00
IUUC-Opr-070971	Ochotona princeps	71.41	0.00e+00	921.00
IUUC-Ont-072221	Oreochromis niloticus	75.57	0.00e+00	1329.00
IUUC-Oan-073185	Ornithorhynchus anatinus	88.67	0.00e+00	2935.00
IUUC-Ocu-074033	Oryctolagus cuniculus	90.26	0.00e+00	2743.00
IUUC-Oba-075709	Oryza barthii	30.22	2.00e-61	232.00
IUUC-Obr-076619	Oryza brachyantha	31.15	5.00e-71	263.00
IUUC-Ogl-077493	Oryza glaberrima	25.07	4.00e-35	144.00
IUUC-Ogu-078641	Oryza glumaepatula	23.69	6.00e-29	124.00
IUUC-Oin-079669	Oryza indica	31.65	7.00e-53	202.00
IUUC-Olo-080755	Oryza longistaminata	32.07	5.00e-55	210.00
IUUC-Oni-082991	Oryza nivara	23.71	2.00e-29	125.00
IUUC-Opu-083233	Oryza punctata	29.80	1.00e-65	245.00
IUUC-Oru-085195	Oryza rufipogon	30.22	2.00e-61	231.00
IUUC-Oga-088578	Otolemur garnettii	90.36	0.00e+00	2987.00
IUUC-Oar-090247	Ovis aries	90.41	0.00e+00	2965.00
IUUC-Ptr-091266	Pan troglodytes	95.01	0.00e+00	1600.00
IUUC-Pan-092734	Papio anubis	95.49	0.00e+00	1727.00
IUUC-Pfo-096191	Poecilia formosa	73.46	0.00e+00	2096.00
IUUC-Pab-098402	Pongo abelii	95.60	0.00e+00	1705.00
IUUC-Pop-099185	Populus trichocarpa	36.50	6.00e-70	260.00
IUUC-Pca-101128	Procavia capensis	82.26	0.00e+00	2714.00
IUUC-Ppe-101849	Prunus persica	32.04	1.00e-74	276.00
IUUC-Pva-103058	Pteropus vampyrus	88.59	0.00e+00	1458.00
IUUC-Rno-106013	Rattus norvegicus	88.89	0.00e+00	2971.00
IUUC-Sha-107496	Sarcophilus harrisii	97.02	0.00e+00	3281.00
IUUC-Sit-110017	Setaria italica	31.47	2.00e-55	212.00
IUUC-Sar-113520	Sorex araneus	84.75	0.00e+00	1396.00
IUUC-Sbi-114195	Sorghum bicolor	29.87	2.00e-60	227.00
IUUC-Ssc-115461	Sus scrofa	87.63	0.00e+00	2981.00
IUUC-Tgu-116821	Taeniopygia guttata	86.89	0.00e+00	2954.00
IUUC-Tsy-119132	Tarsius syrichta	79.36	0.00e+00	2420.00
IUUC-Tni-120716	Tetraodon nigroviridis	76.48	0.00e+00	1348.00
IUUC-Tae-125478	Triticum aestivum	31.09	2.00e-72	268.00
IUUC-Tur-126809	Triticum urartu	31.09	2.00e-70	261.00
IUUC-Tbe-127479	Tupaia belangeri	84.48	0.00e+00	1320.00
IUUC-Ttr-128427	Tursiops truncatus	86.15	0.00e+00	2915.00
IUUC-Vpa-130160	Vicugna pacos	88.02	0.00e+00	2894.00
IUUC-Vvi-131362	Vitis vinifera	30.54	5.00e-73	270.00
IUUC-Xtr-132717	Xenopus tropicalis	75.28	0.00e+00	2575.00
IUUC-Xma-134120	Xiphophorus maculatus	78.77	0.00e+00	1296.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence