iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-026884

Ensembl Protein ID

AAW46757

UniProt Accession

Q5K7J7; Q55I13; Q5K7J7_CRYNJ

Genbank Protein ID

AAW46757.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AE017353

Gene Name

CNM02190

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CNM02190	AAW46756	AAW46756
CNM02190	AAW46757	AAW46757

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	7.50e-69	231.3	46	558

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitele 101
           YDRQ+rlw + +q++l++a+vllvG+++ G+  lKnLvl G++++t++  +  + +++  +F+++++++g + A+ + + l+elnp v++eah e++  + 
   Q: 46   YDRQLRLWASAGQRSLEQARVLLVGCDAAGSQSLKNLVLPGISQFTILSSKITTAQDVATNFFLHPDSIGSNIAQESVKYLQELNPAVKGEAHMEDPALII 146
           ***************************************************************************************************** PP
   S: 102  eeiv.FfkkfdvVvlaldnrearrkvnrlclna.......rvpliesgtlGllGqvrviikgltecyscsd..dppqktiPfctlketpn.........aa 183
           ++++ Ff  f +++l +      +++++++++a       ++pli ++  G+++ v++ ++++t+ +s++d    ++ ++Pf+ l ++ +          +
   Q: 147  KTNPrFFLSFALIILSNVEPYLENQIAEILWEAsssvdgpDIPLIAIRNSGFISRVQIQLREHTVVDSHPDttHTLRIDQPFPALEQHARsldfanmdsME 247
           ************************************************************************99**************88888888888** PP
   S: 184  ehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv......... 274
           +++i+w+vl+   ++ +++++ ++ + ++eek e+k+k k+e  +edeen++ea++ a + + k++ +  ik ll++ + +++++++++  +         
   Q: 248  HSHIPWVVLLVRAASLWKESHGGKLPETNEEKAEFKEKLKAEKIKEDEENYDEAMAQAYRVWIKSELPWeIKCLLDDETVKNISTNSKNLHIllhtlsqyi 348
           *********************************************************************9*******9999988888877778******** PP
   S: 275  .............................................................................sfcsnaealqvp...ekvekdeev 295
                                                                                        +  ++++++++    ++ ++++ +
   Q: 349  ipaphlpptspslpdmhsstahyvalqnmykaqyqadlkqfksllnevlrniglptdtvpdeelegfvknvggvgiiKGTPLSDSKNIRgllPTELENFDE 449
           ***************************************99999999999999999999999999888888888888777777777755444444444444 PP
   S: 296  vkasap...lylllralerfekkkgrkpgelsfekddds...avdlvtaaanlraeslgiep.kldddlikeiagniipaiattnavvgGlaaqEviKvvs 389
             +sa+   +yl+l+a e+f + ++r pg +s++  +++   +++++ ++       ++    ++ ++ ++e+++ +++ +  t+a+vgG++aqE+iK+v+
   Q: 450  EIDSATclsMYLALLASETFFESEKRWPGASSLDNLAADnekVQQILLDLF----PIFSEGLpEILEQSVEEVIRGGFATVPNTAAFVGGIVAQEAIKLVT 546
           444444788************************998874334555555555....55555555599*********************************** PP
   S: 390  gkfeplknfflf 401
           ++++pl+n+++ 
   Q: 547  NQYSPLDNTVVL 558
           ********9876 PP

Organism

Cryptococcus neoformans

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

Protein Sequence
(Fasta)

MPPSPSDLES RPTKITKMDD SMDVADAVTG TAPVPSYRPD AKARRYDRQL RLWASAGQRS 60
LEQARVLLVG CDAAGSQSLK NLVLPGISQF TILSSKITTA QDVATNFFLH PDSIGSNIAQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCACGCTTGA ACATTGCAGT TATCCCGTTT CCGACAGAAT AGACTCATAA GGTTTTTGAG 60
TCGTCTGGGC TATAAAATTA GCAAATGCCC CCTTCCCCTT CCGATCTTGA AAGTCGTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

cne:CNM02190

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	31.25	2.00e-77	281.00
IUUC-Aml-002333	Ailuropoda melanoleuca	30.51	2.00e-80	291.00
IUUC-Atr-002644	Amborella trichopoda	33.65	2.00e-76	278.00
IUUC-Apl-003446	Anas platyrhynchos	29.57	4.00e-70	256.00
IUUC-Aca-004450	Anolis carolinensis	31.53	2.00e-85	308.00
IUUC-Aly-006187	Arabidopsis lyrata	31.89	9.00e-81	292.00
IUUC-Ath-006692	Arabidopsis thaliana	30.43	5.00e-80	290.00
IUUC-Ago-007900	Ashbya gossypii	23.82	6.00e-24	103.00
IUUC-Acl-008333	Aspergillus clavatus	30.30	2.00e-66	244.00
IUUC-Afl-008529	Aspergillus flavus	31.14	5.00e-72	263.00
IUUC-Afu-009071	Aspergillus fumigatus	31.22	2.00e-72	264.00
IUUC-Ani-009443	Aspergillus nidulans	29.95	2.00e-62	231.00
IUUC-Ang-009669	Aspergillus niger	31.77	7.00e-71	259.00
IUUC-Aor-009914	Aspergillus oryzae	31.14	1.00e-70	258.00
IUUC-Ate-010450	Aspergillus terreus	32.44	7.00e-75	272.00
IUUC-Ame-011183	Astyanax mexicanus	29.31	2.00e-77	281.00
IUUC-Bgr-012111	Blumeria graminis	32.91	3.00e-57	214.00
IUUC-Bta-012583	Bos taurus	30.63	2.00e-82	297.00
IUUC-Bci-013892	Botrytis cinerea	31.95	1.00e-55	209.00
IUUC-Bdi-014592	Brachypodium distachyon	32.51	4.00e-76	276.00
IUUC-Bol-016399	Brassica oleracea	31.55	1.00e-79	288.00
IUUC-Bra-017506	Brassica rapa	31.17	8.00e-80	289.00
IUUC-Cel-018456	Caenorhabditis elegans	28.18	2.00e-63	234.00
IUUC-Cja-020007	Callithrix jacchus	30.28	6.00e-81	293.00
IUUC-Cfa-020324	Canis familiaris	30.63	3.00e-82	297.00
IUUC-Cpo-022248	Cavia porcellus	28.77	3.00e-46	177.00
IUUC-Csa-023149	Chlorocebus sabaeus	27.00	1.00e-57	215.00
IUUC-Cho-024537	Choloepus hoffmanni	25.37	3.00e-45	174.00
IUUC-Cin-025763	Ciona intestinalis	34.89	8.00e-88	315.00
IUUC-Csv-026113	Ciona savignyi	32.79	2.00e-84	304.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	28.76	2.00e-52	197.00
IUUC-Cme-027210	Cyanidioschyzon merolae	24.20	8.00e-17	80.10
IUUC-Dre-028140	Danio rerio	30.67	2.00e-82	297.00
IUUC-Dno-030033	Dasypus novemcinctus	31.19	8.00e-73	265.00
IUUC-Dor-030513	Dipodomys ordii	49.48	3.00e-22	97.80
IUUC-Dse-031536	Dothistroma septosporum	30.69	5.00e-70	256.00
IUUC-Dme-031683	Drosophila melanogaster	32.04	2.00e-73	268.00
IUUC-Ete-032420	Echinops telfairi	27.82	1.00e-64	238.00
IUUC-Eca-033992	Equus caballus	27.11	2.00e-56	211.00
IUUC-Eeu-034713	Erinaceus europaeus	51.06	2.00e-24	105.00
IUUC-Fca-036548	Felis catus	30.44	4.00e-80	290.00
IUUC-Fal-037600	Ficedula albicollis	30.58	4.00e-73	266.00
IUUC-Fox-038037	Fusarium oxysporum	30.16	5.00e-59	219.00
IUUC-Fso-038387	Fusarium solani	30.10	1.00e-58	219.00
IUUC-Gmo-038562	Gadus morhua	29.07	9.00e-78	282.00
IUUC-Ggr-040005	Gaeumannomyces graminis	31.46	1.00e-61	228.00
IUUC-Gga-041129	Gallus gallus	30.63	3.00e-75	274.00
IUUC-Gac-042558	Gasterosteus aculeatus	30.37	1.00e-78	285.00
IUUC-Gma-043610	Glycine max	33.52	4.00e-78	283.00
IUUC-Ggo-045611	Gorilla gorilla	30.28	1.00e-80	291.00
IUUC-Hsa-046563	Homo sapiens	30.44	2.00e-82	297.00
IUUC-Hvu-047790	Hordeum vulgare	29.13	4.00e-49	186.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	30.26	4.00e-81	293.00
IUUC-Kpa-049309	Komagataella pastoris	33.65	1.00e-76	278.00
IUUC-Lch-050038	Latimeria chalumnae	30.88	3.00e-78	283.00
IUUC-Lpe-051535	Leersia perrieri	30.24	4.00e-61	226.00
IUUC-Loc-051917	Lepisosteus oculatus	28.67	5.00e-73	266.00
IUUC-Lma-053112	Leptosphaeria maculans	31.88	5.00e-69	253.00
IUUC-Laf-053690	Loxodonta africana	31.37	3.00e-84	303.00
IUUC-Mcc-055117	Macaca mulatta	29.12	5.00e-76	276.00
IUUC-Meu-056761	Macropus eugenii	24.81	2.00e-49	187.00
IUUC-Mor-057230	Magnaporthe oryzae	32.62	3.00e-63	234.00
IUUC-Mpo-057514	Magnaporthe poae	32.11	6.00e-60	223.00
IUUC-Mtr-058551	Medicago truncatula	33.09	2.00e-73	268.00
IUUC-Mla-059183	Melampsora laricipopulina	37.21	6.00e-96	342.00
IUUC-Mga-060144	Meleagris gallopavo	29.61	2.00e-71	261.00
IUUC-Mvi-060221	Microbotryum violaceum	36.56	3.00e-87	314.00
IUUC-Mmr-061325	Microcebus murinus	29.54	1.00e-76	278.00
IUUC-Mdo-062532	Monodelphis domestica	31.00	1.00e-81	295.00
IUUC-Mmu-063956	Mus musculus	30.26	5.00e-82	296.00
IUUC-Mac-064521	Musa acuminata	32.96	7.00e-79	285.00
IUUC-Mpu-066716	Mustela putorius furo	30.24	5.00e-74	270.00
IUUC-Mlu-067459	Myotis lucifugus	30.88	3.00e-82	296.00
IUUC-Nfi-068245	Neosartorya fischeri	31.22	4.00e-72	263.00
IUUC-Ncr-068910	Neurospora crassa	31.07	4.00e-61	226.00
IUUC-Nle-070034	Nomascus leucogenys	28.89	1.00e-73	268.00
IUUC-Opr-070552	Ochotona princeps	27.70	4.00e-58	217.00
IUUC-Ont-071426	Oreochromis niloticus	29.74	2.00e-83	301.00
IUUC-Oan-073389	Ornithorhynchus anatinus	28.38	4.00e-50	190.00
IUUC-Ocu-074911	Oryctolagus cuniculus	31.31	3.00e-82	297.00
IUUC-Oba-075437	Oryza barthii	30.81	1.00e-67	248.00
IUUC-Obr-076684	Oryza brachyantha	31.32	9.00e-64	236.00
IUUC-Ogl-077170	Oryza glaberrima	30.81	1.00e-67	248.00
IUUC-Ogu-078844	Oryza glumaepatula	30.06	1.00e-62	232.00
IUUC-Oin-079105	Oryza indica	30.81	3.00e-67	247.00
IUUC-Olo-080943	Oryza longistaminata	28.99	2.00e-57	214.00
IUUC-Oni-082891	Oryza nivara	29.30	3.00e-62	230.00
IUUC-Opu-083457	Oryza punctata	30.81	1.00e-67	248.00
IUUC-Oru-084960	Oryza rufipogon	28.60	1.00e-57	215.00
IUUC-Osa-085358	Oryza sativa	31.19	7.00e-67	246.00
IUUC-Ola-086420	Oryzias latipes	26.53	6.00e-48	182.00
IUUC-Olu-087625	Ostreococcus lucimarinus	23.35	1.00e-34	139.00
IUUC-Oga-088810	Otolemur garnettii	30.44	3.00e-82	296.00
IUUC-Oar-089196	Ovis aries	30.46	1.00e-80	291.00
IUUC-Ptr-090617	Pan troglodytes	30.44	7.00e-82	295.00
IUUC-Pan-092761	Papio anubis	30.44	1.00e-81	295.00
IUUC-Psi-093191	Pelodiscus sinensis	29.27	7.00e-74	269.00
IUUC-Pma-094380	Petromyzon marinus	31.68	5.00e-75	273.00
IUUC-Pno-095084	Phaeosphaeria nodorum	28.57	3.00e-53	202.00
IUUC-Ppa-095798	Physcomitrella patens	31.32	4.00e-78	283.00
IUUC-Pfo-096467	Poecilia formosa	29.63	4.00e-79	286.00
IUUC-Pab-098255	Pongo abelii	30.75	7.00e-73	265.00
IUUC-Pop-099871	Populus trichocarpa	31.55	2.00e-79	288.00
IUUC-Pca-100807	Procavia capensis	37.06	4.00e-37	147.00
IUUC-Ppe-101280	Prunus persica	32.63	5.00e-80	290.00
IUUC-Pva-102333	Pteropus vampyrus	29.81	1.00e-74	272.00
IUUC-Pgr-103401	Puccinia graminis	28.50	1.00e-70	258.00
IUUC-Ptt-103889	Puccinia triticina	26.80	3.00e-57	214.00
IUUC-Pte-104355	Pyrenophora teres	30.19	4.00e-67	246.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	30.31	3.00e-66	243.00
IUUC-Rno-105810	Rattus norvegicus	30.44	5.00e-82	296.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.62	3.00e-24	103.00
IUUC-Sha-106770	Sarcophilus harrisii	39.55	1.00e-57	214.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	27.32	6.00e-63	233.00
IUUC-Spo-108276	Schizosaccharomyces pombe	29.35	1.00e-59	221.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.74	2.00e-57	214.00
IUUC-Smo-109296	Selaginella moellendorffii	31.73	2.00e-76	277.00
IUUC-Sit-110157	Setaria italica	32.39	2.00e-79	287.00
IUUC-Sly-111105	Solanum lycopersicum	30.78	7.00e-76	276.00
IUUC-Stu-112469	Solanum tuberosum	31.84	7.00e-78	282.00
IUUC-Sar-113083	Sorex araneus	30.37	1.00e-29	122.00
IUUC-Sbi-113813	Sorghum bicolor	32.76	3.00e-80	290.00
IUUC-Sre-115058	Sporisorium reilianum	35.03	6.00e-81	293.00
IUUC-Tgu-116772	Taeniopygia guttata	31.31	7.00e-75	272.00
IUUC-Tru-118686	Takifugu rubripes	29.78	5.00e-83	300.00
IUUC-Tsy-119111	Tarsius syrichta	34.07	1.00e-45	175.00
IUUC-Tni-120231	Tetraodon nigroviridis	27.41	3.00e-69	254.00
IUUC-Tca-121491	Theobroma cacao	32.89	1.00e-74	271.00
IUUC-Tre-122103	Trichoderma reesei	30.70	5.00e-59	219.00
IUUC-Tvi-122672	Trichoderma virens	31.84	2.00e-58	218.00
IUUC-Tae-125684	Triticum aestivum	30.93	8.00e-78	282.00
IUUC-Tur-126487	Triticum urartu	30.21	1.00e-72	265.00
IUUC-Tme-127097	Tuber melanosporum	29.96	2.00e-69	254.00
IUUC-Ttr-128465	Tursiops truncatus	29.17	1.00e-70	258.00
IUUC-Uma-129645	Ustilago maydis	33.01	6.00e-94	336.00
IUUC-Vda-129989	Verticillium dahliae	26.98	9.00e-38	149.00
IUUC-Vpa-130529	Vicugna pacos	28.62	4.00e-71	259.00
IUUC-Vvi-131059	Vitis vinifera	32.89	2.00e-78	284.00
IUUC-Xtr-132002	Xenopus tropicalis	31.61	2.00e-88	318.00
IUUC-Xma-133930	Xiphophorus maculatus	29.55	4.00e-79	286.00
IUUC-Yli-134505	Yarrowia lipolytica	29.03	8.00e-65	239.00
IUUC-Zma-135619	Zea mays	32.19	1.00e-76	278.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence