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Tag Content
UUCD2 ID IUUC-Pop-099722
UUCD1 version UUC-PoT-01617
Ensembl Protein ID POPTR_0012s06310.1
UniProt Accession U5FWS8; U5FWS8_POPTR
Genbank Protein ID ERP54573.1; ERP54574.1
Protein Name NEDD8-activating enzyme E1 regulatory subunit
Genbank Nucleotide ID CM000348; CM000348
Gene Name POPTRDRAFT_552785; POPTR_0012s06310g
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
POPTR_0012s06310 POPTR_0012s06310.1 POPTR_0012s06310.1
POPTR_0012s06310 POPTR_0012s06310.3 POPTR_0012s06310.3
Status Unreviewed
Classification
Family E-Value Score Start End
E1 3.80e-115 386.5 8 514
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnve 91
           YDRQ+r+wGe++q +l++a+++l+++g++G+E+lKnLvl+Gvgsitv+D+++ve+ +l+++F+++++ vg+sKA++++ +l+eln+ v+++
   Q: 8    YDRQLRIWGEQGQTALEKASICLLNCGPTGSETLKNLVLGGVGSITVIDGSKVELGDLGNNFMVDESCVGQSKAKCVCTFLQELNDAVKAK 98
           ******************************************************************************************* PP
   S: 92   aheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlke 178
           + ee +++l ++++ Ff++f++Vv+++  ++++ k+ ++c++a+v li ++++Gl G+vr ++k++ +++s++d   d++++++P+++lk 
   Q: 99   FIEEYPEALVDSNPsFFSQFTLVVATQLAEDSMVKLEKICREANVLLIFARSYGLTGFVRNSVKEHAVIESKPDhflDDLRLNNPWPELKR 189
           ******************************************************************************************* PP
   S: 179  tpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllks 259
           + +         +a+++++++v++ k++ee+a+++ ++ ++++ ek+e+k++ k+++++ de+n++eaie+++k fa++ i+s   q++++
   Q: 190  FAEsidlkvadpVAHKHTPYVVILVKMAEEWAKAHGGALPSTRDEKKEFKELLKAGMVAIDEDNYKEAIEASFKVFAPRGISSdLLQIIHD 280
           *99999999999******************************************************************************* PP
   S: 260  fecdivtkskspfwv...........................................................................s 275
            +c +v +++s+fwv                                                                           s
   Q: 281  -SCSEVDSNSSDFWVmvaalkefivnegggeaplegsipdmtsstelyvnlqkiylakaeadflviqqrvksilkrigrdpdsiskavikS 370
           .****************************************************************************************** PP
   S: 276  fcsnaealq...........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgie 350
           fc+na++l+           +++ v + +++++++++     +y+llra++rf++++++ pg+++ e+d+d + +l+ta+  l   +lg++
   Q: 371  FCKNARKLKvcryrliedefSNPAVPEVQKYLTDEEYsvamgFYILLRAVDRFSANYNSFPGQFEGEMDED-ISRLKTAVVGLL-NDLGCN 459
           *********888887777776688888888888888899999*****************************.*********998.****** PP
   S: 351  p.kldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +  +++dli e++++++++++ ++a++gG+a+qEviK+++++f+p+  +f+f+++
   Q: 460  GsTVTEDLINEMCRFGASELHAVAAFIGGIASQEVIKLITKQFVPMVGTFIFNGI 514
           ****************************************************986 PP
   
Organism Populus trichocarpa
Functional Description
(View)

Functional Description


     Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.
 Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.
Protein Sequence
(Fasta)
MAEPKTKYDR QLRIWGEQGQ TALEKASICL LNCGPTGSET LKNLVLGGVG SITVIDGSKV 60
ELGDLGNNFM VDESCVGQSK AKCVCTFLQE LNDAVKAKFI EEYPEALVDS NPSFFSQFTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Pop-099722|E1,E1_ThiF|Populus trichocarpa
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCTCCCTCT GTCGTCCTCT CCTTGTCCGC TCGCAAGCTG CGTAACTATC AAGCGAAGTT 60
GACAGTAGCA ATAGCTAAAG CAAACCCTAA ACAATGGCGG AGCCAAAAAC CAAATACGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pop-099722|E1,E1_ThiF|Populus trichocarpa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
Pfam

PF00899--ThiF
Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation
KEGG pop:POPTR_0012s06310g
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000764 Aegilops tauschii 69.39 0.00e+00 768.00
IUUC-Aml-002333 Ailuropoda melanoleuca 40.82 2.00e-124 438.00
IUUC-Atr-002644 Amborella trichopoda 76.67 0.00e+00 815.00
IUUC-Aca-004450 Anolis carolinensis 40.00 2.00e-119 422.00
IUUC-Aly-005466 Arabidopsis lyrata 77.67 0.00e+00 875.00
IUUC-Ath-006692 Arabidopsis thaliana 78.63 0.00e+00 884.00
IUUC-Ago-007900 Ashbya gossypii 25.97 3.00e-37 149.00
IUUC-Afl-008529 Aspergillus flavus 33.03 8.00e-76 277.00
IUUC-Ani-009443 Aspergillus nidulans 31.62 1.00e-62 233.00
IUUC-Ang-009669 Aspergillus niger 31.89 2.00e-73 269.00
IUUC-Aor-009914 Aspergillus oryzae 32.68 3.00e-74 271.00
IUUC-Ate-010450 Aspergillus terreus 31.78 4.00e-73 268.00
IUUC-Ame-011183 Astyanax mexicanus 40.45 9.00e-123 433.00
IUUC-Bgr-012111 Blumeria graminis 33.96 5.00e-66 244.00
IUUC-Bta-012583 Bos taurus 40.75 1.00e-125 443.00
IUUC-Bci-013892 Botrytis cinerea 31.80 1.00e-59 223.00
IUUC-Bdi-014592 Brachypodium distachyon 68.91 0.00e+00 764.00
IUUC-Bol-016399 Brassica oleracea 79.16 0.00e+00 887.00
IUUC-Bra-017506 Brassica rapa 74.29 0.00e+00 828.00
IUUC-Cel-018456 Caenorhabditis elegans 32.65 3.00e-75 275.00
IUUC-Cja-020007 Callithrix jacchus 40.74 3.00e-124 438.00
IUUC-Cfa-020324 Canis familiaris 40.75 4.00e-126 444.00
IUUC-Cpo-022248 Cavia porcellus 35.98 3.00e-67 248.00
IUUC-Csa-023149 Chlorocebus sabaeus 37.74 4.00e-97 348.00
IUUC-Cho-024537 Choloepus hoffmanni 34.20 3.00e-83 301.00
IUUC-Cin-025763 Ciona intestinalis 41.18 5.00e-113 400.00
IUUC-Csv-026113 Ciona savignyi 39.96 2.00e-107 382.00
IUUC-Cgl-026428 Colletotrichum gloeosporioides 30.51 7.00e-59 221.00
IUUC-Cme-027210 Cyanidioschyzon merolae 24.38 4.00e-14 72.40
IUUC-Dre-028140 Danio rerio 42.22 9.00e-129 453.00
IUUC-Dno-030033 Dasypus novemcinctus 39.96 3.00e-106 378.00
IUUC-Dme-031683 Drosophila melanogaster 39.13 2.00e-100 358.00
IUUC-Ete-032420 Echinops telfairi 36.94 7.00e-107 380.00
IUUC-Eca-033992 Equus caballus 38.96 1.00e-96 346.00
IUUC-Eeu-034713 Erinaceus europaeus 31.97 3.00e-36 145.00
IUUC-Fca-036548 Felis catus 40.37 4.00e-125 441.00
IUUC-Fso-038387 Fusarium solani 32.80 4.00e-68 251.00
IUUC-Gmo-038562 Gadus morhua 40.12 7.00e-121 426.00
IUUC-Gac-042558 Gasterosteus aculeatus 40.87 3.00e-123 434.00
IUUC-Gma-043610 Glycine max 82.22 0.00e+00 894.00
IUUC-Ggo-045611 Gorilla gorilla 40.80 5.00e-123 434.00
IUUC-Hsa-046563 Homo sapiens 41.03 4.00e-124 437.00
IUUC-Hvu-047790 Hordeum vulgare 68.12 4.00e-158 550.00
IUUC-Itr-048066 Ictidomys tridecemlineatus 40.56 1.00e-124 439.00
IUUC-Lch-050038 Latimeria chalumnae 40.42 4.00e-120 424.00
IUUC-Lpe-051535 Leersia perrieri 67.61 0.00e+00 683.00
IUUC-Loc-051917 Lepisosteus oculatus 38.88 7.00e-110 390.00
IUUC-Laf-053690 Loxodonta africana 41.31 9.00e-126 443.00
IUUC-Mcc-055117 Macaca mulatta 40.07 7.00e-121 427.00
IUUC-Meu-056761 Macropus eugenii 32.90 3.00e-88 318.00
IUUC-Mor-057230 Magnaporthe oryzae 30.38 2.00e-64 239.00
IUUC-Mtr-058551 Medicago truncatula 76.62 0.00e+00 829.00
IUUC-Mmr-061325 Microcebus murinus 39.78 4.00e-121 427.00
IUUC-Mdo-062532 Monodelphis domestica 41.13 3.00e-124 438.00
IUUC-Mmu-063956 Mus musculus 40.56 7.00e-125 440.00
IUUC-Mac-064521 Musa acuminata 73.22 0.00e+00 818.00
IUUC-Mpu-066716 Mustela putorius furo 40.16 9.00e-116 410.00
IUUC-Mlu-067459 Myotis lucifugus 41.51 6.00e-127 447.00
IUUC-Ncr-068910 Neurospora crassa 32.49 9.00e-70 257.00
IUUC-Nle-070034 Nomascus leucogenys 39.96 2.00e-118 418.00
IUUC-Opr-070552 Ochotona princeps 37.10 7.00e-96 343.00
IUUC-Ont-071426 Oreochromis niloticus 40.45 1.00e-123 436.00
IUUC-Oan-073389 Ornithorhynchus anatinus 38.27 2.00e-89 322.00
IUUC-Ocu-074911 Oryctolagus cuniculus 41.31 5.00e-127 447.00
IUUC-Oba-075437 Oryza barthii 71.02 0.00e+00 744.00
IUUC-Obr-076684 Oryza brachyantha 69.75 0.00e+00 698.00
IUUC-Ogl-077170 Oryza glaberrima 71.02 0.00e+00 744.00
IUUC-Ogu-078844 Oryza glumaepatula 69.82 0.00e+00 692.00
IUUC-Oin-079105 Oryza indica 70.83 0.00e+00 741.00
IUUC-Olo-080943 Oryza longistaminata 68.22 0.00e+00 671.00
IUUC-Oni-082891 Oryza nivara 68.71 0.00e+00 715.00
IUUC-Opu-083457 Oryza punctata 71.02 0.00e+00 744.00
IUUC-Oru-084960 Oryza rufipogon 68.15 0.00e+00 673.00
IUUC-Osa-085358 Oryza sativa 70.63 0.00e+00 738.00
IUUC-Ola-086420 Oryzias latipes 39.36 2.00e-79 288.00
IUUC-Olu-087625 Ostreococcus lucimarinus 31.24 4.00e-62 232.00
IUUC-Oga-088810 Otolemur garnettii 40.93 3.00e-125 441.00
IUUC-Oar-089196 Ovis aries 40.71 4.00e-124 437.00
IUUC-Ptr-090617 Pan troglodytes 41.03 2.00e-124 438.00
IUUC-Pan-092761 Papio anubis 40.75 1.00e-125 442.00
IUUC-Psi-093191 Pelodiscus sinensis 38.42 7.00e-117 413.00
IUUC-Pma-094380 Petromyzon marinus 40.93 2.00e-113 402.00
IUUC-Ppa-095798 Physcomitrella patens 55.09 0.00e+00 630.00
IUUC-Pfo-096467 Poecilia formosa 40.23 8.00e-119 420.00
IUUC-Pab-098255 Pongo abelii 40.45 4.00e-102 364.00
IUUC-Pca-100807 Procavia capensis 49.46 3.00e-51 195.00
IUUC-Ppe-101280 Prunus persica 85.66 0.00e+00 938.00
IUUC-Pva-102333 Pteropus vampyrus 39.81 3.00e-118 418.00
IUUC-Pgr-103401 Puccinia graminis 29.27 1.00e-70 260.00
IUUC-Ptt-103889 Puccinia triticina 29.57 2.00e-63 236.00
IUUC-Rno-105810 Rattus norvegicus 40.65 2.00e-123 435.00
IUUC-Smo-109296 Selaginella moellendorffii 52.60 2.00e-161 561.00
IUUC-Sit-110157 Setaria italica 70.94 0.00e+00 808.00
IUUC-Sly-111105 Solanum lycopersicum 76.91 0.00e+00 878.00
IUUC-Stu-112469 Solanum tuberosum 77.65 0.00e+00 890.00
IUUC-Sar-113083 Sorex araneus 38.16 3.00e-43 169.00
IUUC-Sbi-113813 Sorghum bicolor 69.98 0.00e+00 801.00
IUUC-Tru-118686 Takifugu rubripes 39.51 7.00e-123 433.00
IUUC-Tsy-119111 Tarsius syrichta 42.12 1.00e-60 226.00
IUUC-Tni-120231 Tetraodon nigroviridis 37.90 5.00e-108 384.00
IUUC-Tca-121491 Theobroma cacao 86.62 0.00e+00 912.00
IUUC-Tvi-122672 Trichoderma virens 32.54 3.00e-66 245.00
IUUC-Tae-125316 Triticum aestivum 70.25 0.00e+00 775.00
IUUC-Tur-126487 Triticum urartu 68.67 0.00e+00 744.00
IUUC-Tme-127097 Tuber melanosporum 34.19 3.00e-77 281.00
IUUC-Ttr-128465 Tursiops truncatus 38.66 2.00e-110 392.00
IUUC-Vda-129989 Verticillium dahliae 28.28 2.00e-48 186.00
IUUC-Vpa-130529 Vicugna pacos 39.78 2.00e-114 405.00
IUUC-Vvi-131059 Vitis vinifera 85.85 0.00e+00 929.00
IUUC-Xtr-132002 Xenopus tropicalis 40.50 5.00e-124 437.00
IUUC-Xma-133930 Xiphophorus maculatus 40.54 2.00e-121 428.00
IUUC-Yli-134505 Yarrowia lipolytica 33.21 7.00e-82 297.00
IUUC-Zma-135895 Zea mays 68.71 0.00e+00 786.00
Created Date 25-Jun-2017

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