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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046442
Ensembl Protein ID ENSP00000263208.5
UniProt Accession P54198; Q05BU9; Q8IXN2; HIRA_HUMAN
Genbank Protein ID CAA57436.1; CAA54721.1; CAA61979.1; CAA62800.1; CAG30389.1; AAH32721.1; AAH39835.1; CAA53044.1
Protein Name Protein HIRA; TUP1-like enhancer of split protein 1
Genbank Nucleotide ID X81844; X77633; X89887; X91501; CR456503; BC032721; BC039835; X75296
Gene Name HIRA; DGCR1; HIR; TUPLE1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100084.14 ENST00000340170.8 ENSP00000345350.4
ENSG00000100084.14 ENST00000263208.5 ENSP00000263208.5
ENSG00000100084.14 ENST00000452818.1 ENSP00000404792.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.90e-20 71.6 69 98
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 69   HLACVNCVRWsNSgMYLASGGDDKLIMVWK 98
           8899******955699*************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
 Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Protein Sequence
(Fasta)
MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ EDDEKDENIP 60
KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA TYIGPSTVFG SSGKLANVEQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046442|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCTGCGAA CAGTGGCAGC GCGACCTGGC CAGCTGCCGC GACTGGGAGG AGCGCCGGAA 60
CGCCGAGGCC CAGGTGCGCC GGGAGGGAGC GGGGCGGCGC TTCGGAGCGC CTTGCGGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046442|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0043234--C:protein complex
GO:0031491--F:nucleosome binding
GO:0003714--F:transcription corepressor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0009653--P:anatomical structure morphogenesis
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0007369--P:gastrulation
GO:0042692--P:muscle cell differentiation
GO:0001649--P:osteoblast differentiation
GO:0031935--P:regulation of chromatin silencing
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG hsa:7290
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001039 Aegilops tauschii 40.28 6.00e-90 325.00
IUUC-Aml-001723 Ailuropoda melanoleuca 96.72 0.00e+00 1773.00
IUUC-Atr-003132 Amborella trichopoda 41.67 1.00e-88 321.00
IUUC-Apl-003197 Anas platyrhynchos 84.38 0.00e+00 1641.00
IUUC-Aca-004733 Anolis carolinensis 82.07 0.00e+00 1614.00
IUUC-Aly-005446 Arabidopsis lyrata 35.61 3.00e-82 300.00
IUUC-Ath-007627 Arabidopsis thaliana 36.80 1.00e-85 311.00
IUUC-Ago-007766 Ashbya gossypii 31.31 7.00e-59 222.00
IUUC-Acl-008104 Aspergillus clavatus 29.52 3.00e-64 240.00
IUUC-Afl-008591 Aspergillus flavus 30.40 3.00e-65 243.00
IUUC-Afu-008781 Aspergillus fumigatus 33.33 3.00e-58 221.00
IUUC-Ani-009272 Aspergillus nidulans 28.17 9.00e-54 205.00
IUUC-Ang-009655 Aspergillus niger 33.42 5.00e-65 243.00
IUUC-Aor-010119 Aspergillus oryzae 30.40 8.00e-66 245.00
IUUC-Ate-010530 Aspergillus terreus 27.17 4.00e-56 213.00
IUUC-Ame-011147 Astyanax mexicanus 85.00 7.00e-53 197.00
IUUC-Bgr-012237 Blumeria graminis 33.50 1.00e-62 235.00
IUUC-Bta-013320 Bos taurus 90.40 0.00e+00 1748.00
IUUC-Bci-013795 Botrytis cinerea 33.92 6.00e-68 253.00
IUUC-Bdi-014075 Brachypodium distachyon 42.60 5.00e-92 332.00
IUUC-Bol-016440 Brassica oleracea 35.30 4.00e-89 323.00
IUUC-Bra-016651 Brassica rapa 40.61 5.00e-87 316.00
IUUC-Cel-018692 Caenorhabditis elegans 38.10 6.00e-76 279.00
IUUC-Cja-018987 Callithrix jacchus 98.67 0.00e+00 1732.00
IUUC-Cfa-020132 Canis familiaris 95.67 0.00e+00 1771.00
IUUC-Cpo-021484 Cavia porcellus 97.15 0.00e+00 1817.00
IUUC-Cre-022846 Chlamydomonas reinhardtii 36.20 9.00e-62 232.00
IUUC-Csa-023081 Chlorocebus sabaeus 99.41 0.00e+00 1842.00
IUUC-Cin-025182 Ciona intestinalis 55.03 1.00e-155 544.00
IUUC-Csv-026154 Ciona savignyi 55.62 8.00e-152 531.00
IUUC-Cgl-026655 Colletotrichum gloeosporioides 30.55 2.00e-66 248.00
IUUC-Cne-026891 Cryptococcus neoformans 41.08 5.00e-83 302.00
IUUC-Cme-027349 Cyanidioschyzon merolae 29.00 1.00e-51 198.00
IUUC-Dre-027655 Danio rerio 69.31 0.00e+00 1374.00
IUUC-Dno-029557 Dasypus novemcinctus 84.35 0.00e+00 1107.00
IUUC-Dor-030687 Dipodomys ordii 82.03 0.00e+00 742.00
IUUC-Dse-031334 Dothistroma septosporum 30.92 5.00e-63 236.00
IUUC-Dme-031746 Drosophila melanogaster 55.72 6.00e-159 555.00
IUUC-Ete-032384 Echinops telfairi 89.24 0.00e+00 1638.00
IUUC-Eca-033430 Equus caballus 96.22 0.00e+00 1754.00
IUUC-Fca-036121 Felis catus 95.94 0.00e+00 1772.00
IUUC-Fal-036817 Ficedula albicollis 84.36 0.00e+00 1645.00
IUUC-Fox-037906 Fusarium oxysporum 34.86 7.00e-69 255.00
IUUC-Fso-038409 Fusarium solani 33.73 1.00e-67 251.00
IUUC-Gmo-039151 Gadus morhua 86.52 0.00e+00 704.00
IUUC-Ggr-040016 Gaeumannomyces graminis 32.16 1.00e-70 261.00
IUUC-Gga-040936 Gallus gallus 85.64 0.00e+00 1731.00
IUUC-Gac-041405 Gasterosteus aculeatus 63.12 0.00e+00 1219.00
IUUC-Gma-044252 Glycine max 36.62 8.00e-91 328.00
IUUC-Ggo-045430 Gorilla gorilla 99.51 0.00e+00 1841.00
IUUC-Hvu-047587 Hordeum vulgare 37.69 2.00e-80 294.00
IUUC-Itr-048910 Ictidomys tridecemlineatus 99.67 2.00e-175 607.00
IUUC-Kpa-049145 Komagataella pastoris 30.88 7.00e-60 225.00
IUUC-Lch-050474 Latimeria chalumnae 76.39 0.00e+00 1442.00
IUUC-Lpe-051209 Leersia perrieri 35.53 5.00e-84 306.00
IUUC-Loc-052119 Lepisosteus oculatus 72.46 0.00e+00 1394.00
IUUC-Lma-053237 Leptosphaeria maculans 30.92 5.00e-67 249.00
IUUC-Laf-053718 Loxodonta africana 95.58 0.00e+00 1788.00
IUUC-Mcc-055621 Macaca mulatta 99.08 0.00e+00 1741.00
IUUC-Meu-055914 Macropus eugenii 78.12 0.00e+00 1476.00
IUUC-Mor-057090 Magnaporthe oryzae 33.97 1.00e-67 252.00
IUUC-Mpo-057364 Magnaporthe poae 32.58 3.00e-73 270.00
IUUC-Mtr-057744 Medicago truncatula 37.67 8.00e-92 332.00
IUUC-Mla-058914 Melampsora laricipopulina 41.40 2.00e-84 307.00
IUUC-Mga-060181 Meleagris gallopavo 83.84 0.00e+00 1675.00
IUUC-Mvi-060432 Microbotryum violaceum 37.78 7.00e-74 272.00
IUUC-Mmr-060871 Microcebus murinus 97.44 0.00e+00 1872.00
IUUC-Mdo-062301 Monodelphis domestica 86.40 0.00e+00 1645.00
IUUC-Mmu-063888 Mus musculus 95.67 0.00e+00 1778.00
IUUC-Mac-065137 Musa acuminata 38.84 9.00e-91 328.00
IUUC-Mpu-066732 Mustela putorius furo 96.32 0.00e+00 1805.00
IUUC-Mlu-067542 Myotis lucifugus 95.37 0.00e+00 1739.00
IUUC-Nfi-068396 Neosartorya fischeri 33.99 2.00e-58 221.00
IUUC-Ncr-068842 Neurospora crassa 32.46 1.00e-68 255.00
IUUC-Nle-070156 Nomascus leucogenys 99.21 0.00e+00 1852.00
IUUC-Opr-070808 Ochotona princeps 95.98 0.00e+00 1449.00
IUUC-Ont-072105 Oreochromis niloticus 67.83 0.00e+00 1345.00
IUUC-Ocu-074962 Oryctolagus cuniculus 97.01 0.00e+00 1798.00
IUUC-Oba-075178 Oryza barthii 36.59 5.00e-91 329.00
IUUC-Obr-076399 Oryza brachyantha 36.50 7.00e-92 332.00
IUUC-Ogu-078797 Oryza glumaepatula 36.59 5.00e-91 329.00
IUUC-Oin-080085 Oryza indica 35.24 4.00e-78 286.00
IUUC-Olo-081048 Oryza longistaminata 41.04 2.00e-66 248.00
IUUC-Ome-081324 Oryza meridionalis 42.09 6.00e-91 329.00
IUUC-Oni-082548 Oryza nivara 36.59 3.00e-91 330.00
IUUC-Opu-084008 Oryza punctata 42.09 4.00e-91 329.00
IUUC-Oru-084339 Oryza rufipogon 36.41 1.00e-90 328.00
IUUC-Osa-085782 Oryza sativa 36.41 1.00e-90 328.00
IUUC-Ola-087302 Oryzias latipes 68.63 0.00e+00 812.00
IUUC-Olu-087611 Ostreococcus lucimarinus 36.05 1.00e-89 324.00
IUUC-Oga-087935 Otolemur garnettii 96.92 0.00e+00 1767.00
IUUC-Oar-089229 Ovis aries 69.62 0.00e+00 1051.00
IUUC-Ptr-090715 Pan troglodytes 99.90 0.00e+00 1852.00
IUUC-Pan-092318 Papio anubis 99.30 0.00e+00 1812.00
IUUC-Psi-094053 Pelodiscus sinensis 83.82 0.00e+00 1656.00
IUUC-Pno-094985 Phaeosphaeria nodorum 32.60 7.00e-59 222.00
IUUC-Ppa-095819 Physcomitrella patens 39.80 5.00e-89 322.00
IUUC-Pfo-096857 Poecilia formosa 67.05 0.00e+00 1301.00
IUUC-Pab-098047 Pongo abelii 99.71 0.00e+00 1848.00
IUUC-Pop-099587 Populus trichocarpa 39.55 8.00e-90 325.00
IUUC-Pca-100558 Procavia capensis 95.06 0.00e+00 748.00
IUUC-Ppe-101261 Prunus persica 38.27 4.00e-91 330.00
IUUC-Pva-102683 Pteropus vampyrus 96.07 0.00e+00 1795.00
IUUC-Pgr-103660 Puccinia graminis 40.88 1.00e-77 284.00
IUUC-Ptt-103900 Puccinia triticina 41.83 2.00e-79 290.00
IUUC-Pte-104209 Pyrenophora teres 34.27 3.00e-65 243.00
IUUC-Pyt-104802 Pyrenophora triticirepentis 31.37 6.00e-65 243.00
IUUC-Rno-105566 Rattus norvegicus 95.48 0.00e+00 1806.00
IUUC-Sce-106291 Saccharomyces cerevisiae 32.59 5.00e-61 229.00
IUUC-Sha-107514 Sarcophilus harrisii 80.59 0.00e+00 1516.00
IUUC-Sja-107833 Schizosaccharomyces japonicus 34.62 2.00e-81 297.00
IUUC-Spo-108162 Schizosaccharomyces pombe 36.36 1.00e-77 285.00
IUUC-Smo-109533 Selaginella moellendorffii 37.22 7.00e-92 332.00
IUUC-Sit-109980 Setaria italica 37.77 9.00e-93 335.00
IUUC-Sly-111547 Solanum lycopersicum 37.95 1.00e-92 334.00
IUUC-Stu-112705 Solanum tuberosum 37.95 6.00e-93 335.00
IUUC-Sar-113222 Sorex araneus 90.17 0.00e+00 1554.00
IUUC-Sbi-114272 Sorghum bicolor 37.88 2.00e-93 337.00
IUUC-Sre-115061 Sporisorium reilianum 27.73 3.00e-96 346.00
IUUC-Ssc-116364 Sus scrofa 94.54 0.00e+00 1841.00
IUUC-Tgu-116645 Taeniopygia guttata 84.36 0.00e+00 1669.00
IUUC-Tru-117590 Takifugu rubripes 66.63 0.00e+00 1311.00
IUUC-Tsy-119212 Tarsius syrichta 91.70 0.00e+00 1004.00
IUUC-Tni-119915 Tetraodon nigroviridis 66.83 0.00e+00 1292.00
IUUC-Tca-121765 Theobroma cacao 37.72 4.00e-91 330.00
IUUC-Tre-121887 Trichoderma reesei 33.90 9.00e-61 229.00
IUUC-Tvi-122262 Trichoderma virens 33.90 9.00e-61 229.00
IUUC-Tae-124148 Triticum aestivum 45.36 5.00e-39 156.00
IUUC-Tur-126483 Triticum urartu 38.89 6.00e-94 339.00
IUUC-Tme-127202 Tuber melanosporum 30.72 5.00e-57 216.00
IUUC-Tbe-127350 Tupaia belangeri 82.93 0.00e+00 642.00
IUUC-Ttr-129077 Tursiops truncatus 90.74 0.00e+00 1775.00
IUUC-Uma-129465 Ustilago maydis 35.91 5.00e-79 289.00
IUUC-Vda-129844 Verticillium dahliae 34.56 1.00e-66 248.00
IUUC-Vvi-131397 Vitis vinifera 37.40 3.00e-92 333.00
IUUC-Xtr-132057 Xenopus tropicalis 76.27 0.00e+00 1446.00
IUUC-Xma-134139 Xiphophorus maculatus 68.15 0.00e+00 805.00
IUUC-Yli-134424 Yarrowia lipolytica 31.94 6.00e-66 246.00
IUUC-Zma-135839 Zea mays 37.52 4.00e-92 333.00
Created Date 25-Jun-2017

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