iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	18948957; 19277118

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.0023	18.9	124	174

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 105  rlpeei..........lveilklldkeellraarvcrrwqelasqkalwktvt 147
           +l+++i          l+e+lk+l++++ll+aarvc+ w+e+++  ++wk+++
   Q: 124  QLDTDIvqpgrfhavgLWEVLKRLPPSSLLMAARVCKGWRETSR--KMWKAAE 174
           555555666666666699**********************9999..9999875 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Essential protein for male fertility. Component of the SCF(ASK-cullin-F-box) E3 ubiquitin ligase complex SCF(FBL17), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Enables the switch in cell cycle control leading to male germ cell lineage formation from microspores after meiosis. Targets CDKA-1 inhibitors the degradation specifically in male germ cells (e.g. KRP6 and KRP7) and thus enables CDKA-1 activation and germ cell S-phase progression. Promotes twin sperm cell production and double fertilization.

Protein Sequence
(Fasta)

MQPQPHISPN TATAAISAAL ESQRSRKNRG SYNCGRCGQP KKGHVCLLTA PPDIPTTPIA 60
SEPVSCISAA ASSSRSTVLS LTAAPSSRQT FTHLRRALSF DDVDARNSLD ESDLDAASMD 120

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Nucleotide Sequence
(Fasta)

TATTTTCAGC ACAGGTTAAG TACAGTGGAT CCCAACGTCT ACAAAAAAAA GACCACGTGA 60
CGTGATCTAT TCCAAAACCA AGGACAAAAC TGTCATTCAC CAAGCTAGAC CTCACGCTCT 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp

Pfam

PF00646--F-box

SMART

SM00367--LRR_CC

Gene Ontology

GO:0001673--C:male germ cell nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0009793--P:embryo development ending in seed dormancy
GO:0055047--P:generative cell mitosis
GO:0009555--P:pollen development
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0048316--P:seed development

KEGG

ath:AT3G54650

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000445	Aegilops tauschii	53.71	5.00e-103	367.00
IUUC-Atr-002985	Amborella trichopoda	58.75	9.00e-132	463.00
IUUC-Aly-005592	Arabidopsis lyrata	96.96	0.00e+00	975.00
IUUC-Ani-009335	Aspergillus nidulans	23.60	3.30e-02	35.40
IUUC-Ang-009675	Aspergillus niger	22.47	1.20e-02	35.00
IUUC-Bdi-014107	Brachypodium distachyon	49.39	4.00e-113	401.00
IUUC-Bol-015754	Brassica oleracea	82.15	0.00e+00	847.00
IUUC-Bra-017822	Brassica rapa	83.53	0.00e+00	881.00
IUUC-Csv-025861	Ciona savignyi	28.74	1.00e-04	41.60
IUUC-Gma-042847	Glycine max	61.06	6.00e-165	573.00
IUUC-Hvu-047594	Hordeum vulgare	52.63	2.00e-111	395.00
IUUC-Lpe-051054	Leersia perrieri	56.23	6.00e-113	400.00
IUUC-Mtr-057878	Medicago truncatula	68.93	1.00e-154	539.00
IUUC-Mvi-060550	Microbotryum violaceum	27.27	8.60e-02	32.30
IUUC-Mac-065661	Musa acuminata	52.31	2.00e-155	541.00
IUUC-Oba-075222	Oryza barthii	51.43	1.00e-109	389.00
IUUC-Obr-076319	Oryza brachyantha	55.63	4.00e-122	430.00
IUUC-Ogl-077268	Oryza glaberrima	57.14	2.00e-116	411.00
IUUC-Ogu-078988	Oryza glumaepatula	55.22	2.00e-122	432.00
IUUC-Oin-079671	Oryza indica	56.28	3.00e-122	431.00
IUUC-Olo-080720	Oryza longistaminata	55.56	2.00e-104	372.00
IUUC-Oni-082672	Oryza nivara	56.03	2.00e-122	432.00
IUUC-Opu-083555	Oryza punctata	57.72	8.00e-125	440.00
IUUC-Oru-085222	Oryza rufipogon	56.03	1.00e-122	432.00
IUUC-Osa-085326	Oryza sativa	55.21	6.00e-124	437.00
IUUC-Pno-094956	Phaeosphaeria nodorum	33.33	2.50e-02	35.80
IUUC-Pop-099984	Populus trichocarpa	59.30	7.00e-161	560.00
IUUC-Ppe-102083	Prunus persica	60.18	3.00e-178	617.00
IUUC-Sit-110802	Setaria italica	54.42	2.00e-116	412.00
IUUC-Sly-111264	Solanum lycopersicum	57.62	8.00e-161	559.00
IUUC-Stu-112225	Solanum tuberosum	58.62	6.00e-158	550.00
IUUC-Sbi-114580	Sorghum bicolor	48.98	3.00e-126	444.00
IUUC-Tca-121854	Theobroma cacao	62.85	3.00e-176	611.00
IUUC-Tae-123806	Triticum aestivum	53.78	4.00e-112	397.00
IUUC-Tur-126204	Triticum urartu	50.61	7.00e-93	333.00
IUUC-Vvi-130932	Vitis vinifera	62.13	2.00e-156	544.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence