• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031605
Ensembl Protein ID FBpp0088115
UniProt Accession A1Z6W3; A1Z6V4; A1Z6V8; Q9N9H6; Q9U5X0; Q9U5X1; PRIC1_DROME
Genbank Protein ID CAB57344.3; CAB57345.3; CAB99211.2; AAF59281.2; AAF59284.2; AAM68908.1
Protein Name Protein prickle; Protein spiny legs
Genbank Nucleotide ID AJ243708; AJ243710; AJ243709; AE013599; AE013599; AE013599
Gene Name pk; CG11084
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0003090 FBtr0089042 FBpp0088113
FBgn0003090 FBtr0089044 FBpp0088115
FBgn0003090 FBtr0089043 FBpp0088114
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNA
Protein-protein Interaction
IIDiRefIndex
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UIM 26.81 9.00e-05 47.00 IUUC-Ath-007530
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye.
 Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye.
Protein Sequence
(Fasta)
MSSLSTGGGA GGSSGGPGGA DAAAAPAAGQ ATVTATGNME PAMVPRTANL LACKQWWRVC 60
FLYGDQQKYY RQLYSKAAAQ RLADANQEPD NARDREYDTV DCDLIAGQLD AVEDADDGID 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031605|UBD,UIM|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTCTGCTGC GCGCCTCGCA CGAACATCGA ACTCGCGGAC GTGCGCGTGC GCGAACGGAA 60
CGCTCGAAGG CAAACGAAAC GGAAAGGAAC GTTAGGGAAC GCACGGAAAC GGAACGGATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031605|UBD,UIM|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0440--LIM domain
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
Interpro

IPR033725--LIM1_prickle
IPR033726--LIM2_prickle
IPR033727--LIM3_prickle
IPR010442--PET_domain
IPR033723--PET_prickle
IPR001781--Znf_LIM
PROSITE

PS00478--LIM_DOMAIN_1
PS50023--LIM_DOMAIN_2
PS51303--PET
Pfam

PF00412--LIM
PF06297--PET
SMART

SM00132--LIM
Gene Ontology

GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0008270--F:zinc ion binding
GO:0009948--P:anterior/posterior axis specification
GO:0098930--P:axonal transport
GO:0001737--P:establishment of imaginal disc-derived wing hair orientation
GO:0042067--P:establishment of ommatidial planar polarity
GO:0001736--P:establishment of planar polarity
GO:0045184--P:establishment of protein localization
GO:0007164--P:establishment of tissue polarity
GO:0007163--P:establishment or maintenance of cell polarity
GO:0030951--P:establishment or maintenance of microtubule cytoskeleton polarity
GO:0016348--P:imaginal disc-derived leg joint morphogenesis
GO:0045185--P:maintenance of protein location
GO:0001738--P:morphogenesis of a polarized epithelium
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0045773--P:positive regulation of axon extension
GO:1902669--P:positive regulation of axon guidance
GO:0008104--P:protein localization
KEGG dme:Dmel_CG11084
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000888 Aegilops tauschii 27.21 5.00e-07 48.10
IUUC-Atr-002465 Amborella trichopoda 27.21 2.00e-06 46.60
IUUC-Aly-005589 Arabidopsis lyrata 26.81 3.00e-06 45.80
IUUC-Ath-007530 Arabidopsis thaliana 26.81 2.00e-06 46.60
IUUC-Ame-011762 Astyanax mexicanus 67.30 4.00e-136 478.00
IUUC-Bdi-014217 Brachypodium distachyon 27.21 1.00e-06 47.40
IUUC-Bol-015361 Brassica oleracea 26.43 1.00e-06 47.40
IUUC-Bra-016788 Brassica rapa 27.07 6.00e-04 37.70
IUUC-Cpo-021667 Cavia porcellus 28.81 2.00e-22 100.00
IUUC-Dre-027455 Danio rerio 70.21 4.00e-134 471.00
IUUC-Dse-031181 Dothistroma septosporum 28.37 5.00e-10 58.90
IUUC-Fal-037626 Ficedula albicollis 29.38 5.00e-23 102.00
IUUC-Gga-040724 Gallus gallus 67.92 2.00e-130 459.00
IUUC-Gma-043250 Glycine max 27.41 3.00e-07 48.90
IUUC-Hvu-047787 Hordeum vulgare 26.12 5.00e-05 42.00
IUUC-Lpe-050858 Leersia perrieri 27.21 2.00e-06 46.20
IUUC-Loc-052468 Lepisosteus oculatus 66.77 2.00e-134 472.00
IUUC-Mtr-058103 Medicago truncatula 26.43 1.00e-06 47.40
IUUC-Mla-059141 Melampsora laricipopulina 21.66 6.00e-14 71.60
IUUC-Mmr-060595 Microcebus murinus 28.93 1.00e-22 100.00
IUUC-Ncr-068674 Neurospora crassa 30.70 5.00e-12 65.90
IUUC-Oba-075285 Oryza barthii 27.21 2.00e-06 46.60
IUUC-Obr-076433 Oryza brachyantha 27.94 7.00e-07 47.80
IUUC-Ogl-077044 Oryza glaberrima 27.21 2.00e-06 46.60
IUUC-Ogu-078868 Oryza glumaepatula 27.21 2.00e-06 46.60
IUUC-Oin-079737 Oryza indica 27.21 1.00e-06 48.10
IUUC-Olo-080337 Oryza longistaminata 27.21 2.00e-06 47.40
IUUC-Oni-082197 Oryza nivara 27.21 2.00e-06 46.60
IUUC-Opu-083815 Oryza punctata 26.95 2.00e-05 43.10
IUUC-Oru-085246 Oryza rufipogon 27.21 2.00e-06 46.60
IUUC-Osa-086082 Oryza sativa 27.21 2.00e-06 46.60
IUUC-Ola-087406 Oryzias latipes 29.21 2.00e-13 70.10
IUUC-Olu-087728 Ostreococcus lucimarinus 27.72 5.00e-02 31.60
IUUC-Pno-094933 Phaeosphaeria nodorum 25.42 2.00e-08 53.90
IUUC-Ppa-096027 Physcomitrella patens 26.83 1.00e-08 54.30
IUUC-Pfo-097294 Poecilia formosa 29.38 5.00e-21 95.10
IUUC-Pab-098372 Pongo abelii 65.20 3.00e-135 474.00
IUUC-Pop-099698 Populus trichocarpa 29.50 4.00e-06 45.10
IUUC-Ptt-104003 Puccinia triticina 22.62 6.60e-02 31.60
IUUC-Pte-104256 Pyrenophora teres 26.40 1.00e-10 60.80
IUUC-Pyt-104720 Pyrenophora triticirepentis 25.60 2.00e-09 55.80
IUUC-Sit-110147 Setaria italica 27.21 1.00e-06 47.00
IUUC-Sly-111106 Solanum lycopersicum 27.21 6.00e-07 48.10
IUUC-Stu-112570 Solanum tuberosum 27.21 4.00e-07 48.90
IUUC-Sbi-114752 Sorghum bicolor 27.21 2.00e-06 46.20
IUUC-Sre-115199 Sporisorium reilianum 26.05 2.00e-15 77.40
IUUC-Ssc-116398 Sus scrofa 65.20 9.00e-135 473.00
IUUC-Tgu-116824 Taeniopygia guttata 29.80 2.00e-22 100.00
IUUC-Tca-121863 Theobroma cacao 26.47 8.00e-05 41.20
IUUC-Tae-125101 Triticum aestivum 27.21 2.00e-07 50.10
IUUC-Tur-126006 Triticum urartu 27.21 7.00e-07 48.10
IUUC-Tbe-127395 Tupaia belangeri 28.98 5.00e-17 81.30
IUUC-Uma-129653 Ustilago maydis 24.65 4.00e-14 73.20
IUUC-Vpa-130784 Vicugna pacos 28.98 1.00e-16 80.90
IUUC-Vvi-131286 Vitis vinifera 27.94 1.00e-05 43.50
IUUC-Xma-134125 Xiphophorus maculatus 29.38 9.00e-21 94.70
IUUC-Zma-135630 Zea mays 25.74 3.00e-06 45.80
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved