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Tag Content
UUCD2 ID IUUC-Xtr-131811
UUCD1 version UUC-XeT-00940
Ensembl Protein ID ENSXETP00000011183.3
UniProt Accession Q640S2; CRBN_XENTR
Genbank Protein ID AAH82517.1
Protein Name Protein cereblon
Genbank Nucleotide ID BC082517
Gene Name crbn
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000005146.3 ENSXETT00000011183.3 ENSXETP00000011183.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 73.36 0.00e+00 650.00 IUUC-Hsa-046888
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description



     Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning.
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning.
Protein Sequence
(Fasta)
MADDEGEEDP GINNMGNLLQ VISSESEEED EMELEDAKTA DSESPNIINF DTSLPTSHAY 60
LGVDMEEFHG RTLHDDDSCQ QIPVLPHVQV MLIPGQTLPL HLSRPQEVSM VRGLIQRDRT 120
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Protein Fasta Sequence



>IUUC-Xtr-131811|E3,E3 activity/Other|Xenopus tropicalis
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Nucleotide Sequence
(Fasta)
CTGGTAAACA GCAATGGCTG ACGACGAAGG CGAGGAGGAT CCCGGCATCA ATAACATGGG 60
CAATCTGCTG CAAGTTATAA GCTCGGGTAA TGATGGCAGC GCCCCCTAGT TAGGGACACG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Xtr-131811|E3,E3 activity/Other|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR034750--CULT
IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR004910--Yippee/Mis18/Cereblon

PROSITE

PS51788--CULT
PS51787--LON_N

Pfam

PF02190--LON_substr_bdg
PF03226--Yippee-Mis18

SMART

SM00464--LON

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG xtr:493554
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000549 Aegilops tauschii 31.09 7.00e-24 104.00
IUUC-Aml-002159 Ailuropoda melanoleuca 73.38 0.00e+00 645.00
IUUC-Atr-002820 Amborella trichopoda 39.34 8.00e-36 144.00
IUUC-Apl-003508 Anas platyrhynchos 78.73 0.00e+00 675.00
IUUC-Aca-004675 Anolis carolinensis 79.37 0.00e+00 688.00
IUUC-Aly-005404 Arabidopsis lyrata 34.39 9.00e-38 151.00
IUUC-Ath-006819 Arabidopsis thaliana 37.10 2.00e-37 150.00
IUUC-Ame-010773 Astyanax mexicanus 69.25 1.00e-171 595.00
IUUC-Bta-012711 Bos taurus 71.43 0.00e+00 635.00
IUUC-Bdi-014416 Brachypodium distachyon 34.18 1.00e-35 144.00
IUUC-Bol-015668 Brassica oleracea 35.43 4.00e-40 159.00
IUUC-Bra-016836 Brassica rapa 35.43 8.00e-40 157.00
IUUC-Cja-019624 Callithrix jacchus 73.14 0.00e+00 647.00
IUUC-Cpo-022319 Cavia porcellus 73.05 0.00e+00 648.00
IUUC-Csa-023791 Chlorocebus sabaeus 73.36 0.00e+00 649.00
IUUC-Cho-024850 Choloepus hoffmanni 75.86 8.00e-159 553.00
IUUC-Csv-025832 Ciona savignyi 44.78 1.00e-90 327.00
IUUC-Dre-028071 Danio rerio 66.15 3.00e-170 590.00
IUUC-Dno-029431 Dasypus novemcinctus 73.42 0.00e+00 648.00
IUUC-Dor-030571 Dipodomys ordii 65.77 9.00e-162 562.00
IUUC-Dme-031920 Drosophila melanogaster 28.13 6.00e-38 152.00
IUUC-Eca-033462 Equus caballus 73.42 0.00e+00 648.00
IUUC-Fca-036279 Felis catus 72.94 0.00e+00 639.00
IUUC-Fal-037498 Ficedula albicollis 74.39 0.00e+00 662.00
IUUC-Gmo-038734 Gadus morhua 70.57 7.00e-173 599.00
IUUC-Gga-040615 Gallus gallus 76.39 0.00e+00 687.00
IUUC-Gac-041426 Gasterosteus aculeatus 68.57 2.00e-177 615.00
IUUC-Gma-043891 Glycine max 37.90 2.00e-39 157.00
IUUC-Ggo-045108 Gorilla gorilla 73.36 0.00e+00 650.00
IUUC-Hsa-046888 Homo sapiens 73.36 0.00e+00 650.00
IUUC-Itr-047937 Ictidomys tridecemlineatus 75.55 0.00e+00 650.00
IUUC-Lch-050189 Latimeria chalumnae 71.18 2.00e-160 558.00
IUUC-Lpe-050808 Leersia perrieri 37.19 2.00e-39 157.00
IUUC-Loc-051762 Lepisosteus oculatus 69.98 0.00e+00 627.00
IUUC-Laf-053882 Loxodonta africana 73.50 0.00e+00 652.00
IUUC-Mcc-054883 Macaca mulatta 73.36 0.00e+00 649.00
IUUC-Mtr-058216 Medicago truncatula 37.56 1.00e-38 154.00
IUUC-Mdo-062260 Monodelphis domestica 76.29 0.00e+00 680.00
IUUC-Mmu-063438 Mus musculus 72.65 0.00e+00 648.00
IUUC-Mac-064610 Musa acuminata 41.84 6.00e-41 162.00
IUUC-Mpu-066362 Mustela putorius furo 73.32 0.00e+00 647.00
IUUC-Nle-069908 Nomascus leucogenys 73.59 0.00e+00 652.00
IUUC-Ont-072223 Oreochromis niloticus 73.50 1.00e-179 622.00
IUUC-Ocu-074151 Oryctolagus cuniculus 74.50 0.00e+00 631.00
IUUC-Oba-075882 Oryza barthii 36.76 5.00e-39 155.00
IUUC-Obr-076670 Oryza brachyantha 35.68 1.00e-37 150.00
IUUC-Ogl-077753 Oryza glaberrima 36.76 5.00e-39 155.00
IUUC-Ogu-078786 Oryza glumaepatula 36.76 5.00e-39 155.00
IUUC-Oin-079191 Oryza indica 36.76 5.00e-39 155.00
IUUC-Olo-080357 Oryza longistaminata 36.76 5.00e-39 155.00
IUUC-Ome-081227 Oryza meridionalis 27.27 6.00e-19 88.60
IUUC-Oni-082557 Oryza nivara 36.76 4.00e-39 155.00
IUUC-Opu-083920 Oryza punctata 35.78 2.00e-38 153.00
IUUC-Oru-085227 Oryza rufipogon 36.76 5.00e-39 155.00
IUUC-Ola-087321 Oryzias latipes 71.08 5.00e-173 600.00
IUUC-Oga-088413 Otolemur garnettii 73.09 0.00e+00 646.00
IUUC-Oar-089512 Ovis aries 70.64 0.00e+00 629.00
IUUC-Ptr-090764 Pan troglodytes 73.36 0.00e+00 650.00
IUUC-Pan-091942 Papio anubis 73.36 0.00e+00 649.00
IUUC-Psi-092985 Pelodiscus sinensis 78.64 0.00e+00 676.00
IUUC-Ppa-095670 Physcomitrella patens 43.09 6.00e-46 178.00
IUUC-Pfo-097251 Poecilia formosa 72.91 8.00e-176 609.00
IUUC-Pab-097842 Pongo abelii 73.36 0.00e+00 650.00
IUUC-Pop-099118 Populus trichocarpa 40.98 1.00e-39 157.00
IUUC-Pca-101077 Procavia capensis 64.72 5.00e-157 547.00
IUUC-Ppe-101706 Prunus persica 38.86 5.00e-39 155.00
IUUC-Pva-102245 Pteropus vampyrus 62.46 3.00e-110 391.00
IUUC-Rno-105788 Rattus norvegicus 72.65 0.00e+00 649.00
IUUC-Smo-109165 Selaginella moellendorffii 39.81 8.00e-43 168.00
IUUC-Sit-109818 Setaria italica 37.77 1.00e-37 151.00
IUUC-Sly-111062 Solanum lycopersicum 37.44 1.00e-41 164.00
IUUC-Sbi-114298 Sorghum bicolor 37.77 1.00e-38 154.00
IUUC-Ssc-115779 Sus scrofa 72.75 7.00e-159 553.00
IUUC-Tgu-117378 Taeniopygia guttata 74.55 0.00e+00 669.00
IUUC-Tru-118515 Takifugu rubripes 71.40 3.00e-171 594.00
IUUC-Tsy-119555 Tarsius syrichta 72.94 4.00e-164 570.00
IUUC-Tni-119679 Tetraodon nigroviridis 71.53 7.00e-167 579.00
IUUC-Tca-121374 Theobroma cacao 37.64 1.00e-31 131.00
IUUC-Tae-123098 Triticum aestivum 32.93 7.00e-51 194.00
IUUC-Tur-126689 Triticum urartu 29.11 1.00e-13 71.20
IUUC-Vpa-130719 Vicugna pacos 63.33 7.00e-155 540.00
IUUC-Vvi-131014 Vitis vinifera 36.40 8.00e-41 161.00
IUUC-Xma-133238 Xiphophorus maculatus 73.15 2.00e-177 614.00
Created Date 25-Jun-2017

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