iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bgr-011972

Ensembl Protein ID

CCU75230

UniProt Accession

N1J5R4; N1J5R4_BLUG1

Genbank Protein ID

CCU75230.1

Protein Name

Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog

Genbank Nucleotide ID

CAUH01001096

Gene Name

PAC1; LIS1; BGHDH14_bgh05663

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
BGHDH14_bgh05663	CCU75230	CCU75230

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-50	165.2	114	149
UBD/Beta-Prp	1.20e-68	229.9	112	459

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           H d+vtc+af +    l+sGs D+tik+WD+  g l
   Q: 114  HRDPVTCVAFhPVfSSLASGSEDNTIKIWDWELGEL 149
           9*********955568**************876665 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfs 103
           + +h +++tcv+f+p  s la+gs+d+tik+wd++ g l r+++gh+++v +++f   +   +l+++s+D tik+wd++  +k ++tl gh++s+ +++f 
   Q: 112  Q-SHRDPVTCVAFHPVFSSLASGSEDNTIKIWDWELGELERTVKGHTKAVLDLDFGGPKGgtLLASCSSDLTIKLWDPNdEYKNIRTLPGHDHSISAVRFI 211
           4.56669999*********************************************8655456**************998689******************* PP
   S: 104  p........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng.... 192
           p        s+++lvs+s+d+ +r+wd++tg+c++ t +gh ++v+ v+ + dg+ lvs+++D+t r+Wd +tg+l  tl g h++ +++  f + +    
   Q: 212  PsgatgmtsSSNFLVSASRDKSLRIWDVSTGYCVK-TVRGHVDWVRDVCPSHDGRFLVSAGNDQTARIWDTATGELKATLLG-HEHVIECCVFAPPSsyry 310
           999999986669***********************.*********************************************9.*********888888889 PP
   S: 193  .................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlqlhnssvisvavlsf 275
                            +++++gs+d+ +++wd+ +g+ ++tl+gh+++v+ + f+p++++l+s+s+D+++r+Wdl + g+l+ktl+  + ++is+  + +
   Q: 311  lsslgnskkppplsssaEFVATGSRDKIIRIWDV-RGTLIYTLKGHDNWVRGLVFHPDGKYLLSVSDDKTLRCWDLtQEGKLVKTLEDAHGHFISCIRWAP 410
           99999999999999999*****************.7889************************************83579**********66666655444 PP
   S: 276  g.dnvl...............................vlgsedskvniw 292
           g  +++                               ++gs d +v+++
   Q: 411  GvVKEVptlngndrsglangpsrkeqsteivttrcviATGSVDLNVRVF 459
           3322222333333333344444444444444444433666667777766 PP

Organism

Blumeria graminis

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MSQVLTPRQA EELHKSIIAY LSSKNLFNSA TALQQELNLG DSFDSATSKK YEGIIEKKWT 60
GIVRLQKKIM ELEVVNAGLQ AELDSVTPVS LSRRNQDPSK WLPRSPARYT LQSHRDPVTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCAGG TCTTAACGCC GCGGCAGGCC GAGGAACTGT ATGTTAATGC GATATTACTT 60
AAATTTAGTT TACTAATCTC GTTGTAGTCA CAAGTCAATC ATAGCTTACC TATCATCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0378--Hydrolase
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0016787--F:hydrolase activity
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	47.43	1.00e-102	364.00
IUUC-Apl-004024	Anas platyrhynchos	47.49	6.00e-106	375.00
IUUC-Aca-004564	Anolis carolinensis	47.02	1.00e-103	367.00
IUUC-Ago-007862	Ashbya gossypii	26.86	1.00e-35	142.00
IUUC-Acl-008360	Aspergillus clavatus	67.88	0.00e+00	634.00
IUUC-Afl-008502	Aspergillus flavus	61.16	2.00e-160	556.00
IUUC-Afu-008848	Aspergillus fumigatus	68.52	0.00e+00	664.00
IUUC-Ani-009173	Aspergillus nidulans	60.09	2.00e-165	573.00
IUUC-Ang-009873	Aspergillus niger	59.69	6.00e-162	561.00
IUUC-Aor-009973	Aspergillus oryzae	58.84	1.00e-155	540.00
IUUC-Ate-010523	Aspergillus terreus	61.66	9.00e-170	587.00
IUUC-Ame-011154	Astyanax mexicanus	46.78	3.00e-106	376.00
IUUC-Bta-013106	Bos taurus	47.73	3.00e-106	376.00
IUUC-Bci-013615	Botrytis cinerea	74.41	0.00e+00	714.00
IUUC-Bra-017390	Brassica rapa	32.34	3.00e-29	122.00
IUUC-Cel-018459	Caenorhabditis elegans	42.93	5.00e-93	332.00
IUUC-Cja-018755	Callithrix jacchus	46.54	6.00e-103	365.00
IUUC-Cfa-020749	Canis familiaris	47.73	3.00e-106	376.00
IUUC-Cpo-022371	Cavia porcellus	47.73	3.00e-106	376.00
IUUC-Csa-023524	Chlorocebus sabaeus	49.29	3.00e-90	323.00
IUUC-Cho-024764	Choloepus hoffmanni	45.65	4.00e-88	316.00
IUUC-Cin-025753	Ciona intestinalis	45.48	1.00e-96	344.00
IUUC-Csv-025817	Ciona savignyi	44.80	7.00e-100	355.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	73.65	0.00e+00	696.00
IUUC-Cne-027087	Cryptococcus neoformans	51.21	1.00e-110	391.00
IUUC-Dre-028314	Danio rerio	47.20	2.00e-104	370.00
IUUC-Dno-029050	Dasypus novemcinctus	47.49	4.00e-106	375.00
IUUC-Dor-030222	Dipodomys ordii	44.55	8.00e-97	345.00
IUUC-Dse-031164	Dothistroma septosporum	65.31	0.00e+00	624.00
IUUC-Dme-031745	Drosophila melanogaster	44.47	2.00e-95	340.00
IUUC-Ete-032508	Echinops telfairi	49.29	4.00e-72	263.00
IUUC-Eca-034288	Equus caballus	46.94	2.00e-101	360.00
IUUC-Eeu-034984	Erinaceus europaeus	44.31	1.00e-95	341.00
IUUC-Fca-036498	Felis catus	47.73	3.00e-106	376.00
IUUC-Fal-036920	Ficedula albicollis	47.49	6.00e-106	375.00
IUUC-Fox-037996	Fusarium oxysporum	66.81	0.00e+00	655.00
IUUC-Fso-038160	Fusarium solani	64.79	0.00e+00	627.00
IUUC-Gmo-038983	Gadus morhua	47.02	7.00e-105	372.00
IUUC-Ggr-040051	Gaeumannomyces graminis	63.30	4.00e-179	619.00
IUUC-Gga-040623	Gallus gallus	47.49	6.00e-106	375.00
IUUC-Gac-041613	Gasterosteus aculeatus	46.62	3.00e-104	370.00
IUUC-Ggo-045410	Gorilla gorilla	43.36	2.00e-87	314.00
IUUC-Hsa-046358	Homo sapiens	47.73	4.00e-106	375.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	47.73	3.00e-106	376.00
IUUC-Kpa-049351	Komagataella pastoris	29.82	1.00e-46	179.00
IUUC-Lch-049936	Latimeria chalumnae	47.49	1.00e-105	374.00
IUUC-Loc-052476	Lepisosteus oculatus	46.94	2.00e-101	360.00
IUUC-Lma-053170	Leptosphaeria maculans	75.05	0.00e+00	691.00
IUUC-Laf-053713	Loxodonta africana	47.57	1.00e-103	367.00
IUUC-Mcc-054628	Macaca mulatta	47.73	5.00e-106	375.00
IUUC-Meu-055927	Macropus eugenii	42.55	3.00e-53	199.00
IUUC-Mor-056962	Magnaporthe oryzae	65.16	0.00e+00	639.00
IUUC-Mpo-057583	Magnaporthe poae	62.88	2.00e-172	597.00
IUUC-Mtr-058053	Medicago truncatula	28.37	6.00e-30	124.00
IUUC-Mla-058819	Melampsora laricipopulina	47.11	2.00e-113	400.00
IUUC-Mga-059945	Meleagris gallopavo	47.26	1.00e-105	374.00
IUUC-Mvi-060403	Microbotryum violaceum	50.75	3.00e-127	446.00
IUUC-Mmr-061289	Microcebus murinus	47.00	9.00e-103	364.00
IUUC-Mdo-061912	Monodelphis domestica	47.49	1.00e-105	374.00
IUUC-Mmu-063253	Mus musculus	47.73	3.00e-106	376.00
IUUC-Mpu-066638	Mustela putorius furo	47.73	3.00e-106	376.00
IUUC-Mlu-067267	Myotis lucifugus	46.75	6.00e-103	365.00
IUUC-Nfi-068571	Neosartorya fischeri	63.94	2.00e-178	616.00
IUUC-Ncr-068895	Neurospora crassa	68.88	0.00e+00	637.00
IUUC-Nle-069087	Nomascus leucogenys	47.06	2.00e-88	317.00
IUUC-Opr-070579	Ochotona princeps	47.49	4.00e-106	375.00
IUUC-Ont-072432	Oreochromis niloticus	47.26	3.00e-105	373.00
IUUC-Oan-073072	Ornithorhynchus anatinus	47.73	3.00e-106	376.00
IUUC-Ocu-074180	Oryctolagus cuniculus	47.49	4.00e-106	375.00
IUUC-Obr-076385	Oryza brachyantha	31.60	7.00e-29	120.00
IUUC-Ola-086772	Oryzias latipes	47.26	1.00e-104	371.00
IUUC-Oga-088219	Otolemur garnettii	46.43	2.00e-103	366.00
IUUC-Oar-090394	Ovis aries	47.73	3.00e-106	376.00
IUUC-Ptr-091517	Pan troglodytes	47.73	3.00e-106	376.00
IUUC-Pan-092421	Papio anubis	47.73	5.00e-106	375.00
IUUC-Psi-093370	Pelodiscus sinensis	47.49	1.00e-105	374.00
IUUC-Pma-094319	Petromyzon marinus	46.72	6.00e-88	315.00
IUUC-Pno-094815	Phaeosphaeria nodorum	73.65	0.00e+00	693.00
IUUC-Pfo-097089	Poecilia formosa	47.97	2.00e-106	377.00
IUUC-Pab-098421	Pongo abelii	47.73	3.00e-106	376.00
IUUC-Pca-100120	Procavia capensis	39.71	3.00e-64	237.00
IUUC-Pva-102960	Pteropus vampyrus	47.49	6.00e-105	372.00
IUUC-Pgr-103538	Puccinia graminis	48.40	8.00e-119	418.00
IUUC-Ptt-103990	Puccinia triticina	40.00	3.00e-40	157.00
IUUC-Pte-104261	Pyrenophora teres	72.94	0.00e+00	695.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	73.16	0.00e+00	696.00
IUUC-Rno-105123	Rattus norvegicus	47.73	3.00e-106	376.00
IUUC-Sce-106208	Saccharomyces cerevisiae	26.34	3.00e-34	137.00
IUUC-Sha-107010	Sarcophilus harrisii	47.49	7.00e-106	375.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	37.10	5.00e-70	256.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	74.60	0.00e+00	689.00
IUUC-Sar-113309	Sorex araneus	46.70	4.00e-100	356.00
IUUC-Sre-115003	Sporisorium reilianum	50.33	4.00e-127	446.00
IUUC-Ssc-116148	Sus scrofa	47.73	3.00e-106	376.00
IUUC-Tgu-117299	Taeniopygia guttata	47.49	7.00e-106	375.00
IUUC-Tru-117721	Takifugu rubripes	47.02	6.00e-104	369.00
IUUC-Tsy-119493	Tarsius syrichta	47.73	1.00e-104	371.00
IUUC-Tni-120355	Tetraodon nigroviridis	46.62	4.00e-103	366.00
IUUC-Tre-121977	Trichoderma reesei	62.34	2.00e-170	590.00
IUUC-Tvi-122661	Trichoderma virens	63.38	6.00e-171	591.00
IUUC-Tme-127031	Tuber melanosporum	67.03	0.00e+00	636.00
IUUC-Tbe-127492	Tupaia belangeri	43.54	1.00e-49	188.00
IUUC-Ttr-128929	Tursiops truncatus	47.73	4.00e-106	376.00
IUUC-Uma-129347	Ustilago maydis	50.54	2.00e-127	446.00
IUUC-Vda-129837	Verticillium dahliae	68.97	0.00e+00	647.00
IUUC-Vpa-130532	Vicugna pacos	41.69	2.00e-85	306.00
IUUC-Xtr-131985	Xenopus tropicalis	47.26	4.00e-106	376.00
IUUC-Xma-133314	Xiphophorus maculatus	47.73	3.00e-106	376.00
IUUC-Yli-134403	Yarrowia lipolytica	41.82	1.00e-99	354.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence