iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045227

UUCD1 version

UUC-GoG-00460

Ensembl Protein ID

ENSGGOP00000011190.2

UniProt Accession

G3R761; G3R761_GORGO

Protein Name

Uncharacterized protein

Gene Name

WDR61

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000011473.2	ENSGGOT00000011518.2	ENSGGOP00000011190.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.20e-45	149.1	230	269
UBD/Beta-Prp	7.90e-75	252.2	12	303

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+++v  +af +d t++vs+s D+++kvWD+ t +++++
   Q: 230  GHASWVLNVAFcPDdTHFVSSSSDKSVKVWDVGTRTCVHT 269
           8***********777*****************99999875 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkf....spdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvh 88
           +++h++ i +v++    +++++ ++tgs d+ +kvw+++++ l   +sl+gh+ +v +v++s++ +i +++s D++i++wdl++gk++ 
   Q: 12   EQAHDDAIWSVAWgtnkKENSETVVTGSLDDLVKVWKWRDERLdlQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIK 100
           567788888899998888999********************99999******************************************* PP
   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           ++ +   ++++l+fsp++++l++G+h+  ++++ +e+g++ +  l+ + +++ +++++pdg++l+sG+ D++++++d++tgkll+tl+g
   Q: 101  SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY-SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEG 188
           ******************************************.*********************************************9 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnss 266
            h  +++sl+f+++++ lv++s+dg++k++d+q+ +   tl gh ++v+ v+f+p+d+++vs ssD+s+++Wd+ ++++++t+  h+++
   Q: 189  -HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQ 276
           .**************************************************************************************** PP
   S: 267  visvavlsfgdnvlvlgsedskvniwkl 294
           v+ v++ + +++++v++++d++++i+++
   Q: 277  VWGVKY-NGNGSKIVSVGDDQEIHIYDC 303
           ******.999****************98 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MTNQYGILFK QEQAHDDAIW SVAWGTNKKE NSETVVTGSL DDLVKVWKWR DERLDLQWSL 60
EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQIK SIDAGPVDAW TLAFSPDSQY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGCGCGTCA CAGTCGCGCG GAGCCCGGCT TCCGACGTGC AGCCTGGCGG TGCAGTGGTG 60
AGTTGGAGCG CAGGGCCGTT GGGGATGGTG GTCATTAGGG CCGTTGACGG TCCAGGCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0016593--C:Cdc73/Paf1 complex
GO:0005829--C:cytosol
GO:0055087--C:Ski complex
GO:0035327--C:transcriptionally active chromatin
GO:0080182--P:histone H3-K4 trimethylation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2001162--P:positive regulation of histone H3-K79 methylation
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter

KEGG

ggo:101136604

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000774	Aegilops tauschii	33.93	1.00e-47	183.00
IUUC-Aml-002245	Ailuropoda melanoleuca	98.69	4.00e-168	583.00
IUUC-Atr-003142	Amborella trichopoda	51.55	2.00e-38	152.00
IUUC-Apl-003179	Anas platyrhynchos	91.15	2.00e-157	548.00
IUUC-Aca-004880	Anolis carolinensis	88.20	2.00e-157	547.00
IUUC-Aly-005956	Arabidopsis lyrata	37.82	1.00e-55	209.00
IUUC-Ath-007230	Arabidopsis thaliana	37.50	1.00e-51	196.00
IUUC-Acl-008297	Aspergillus clavatus	28.88	5.00e-25	108.00
IUUC-Ang-009702	Aspergillus niger	29.90	7.00e-30	124.00
IUUC-Ame-011511	Astyanax mexicanus	83.71	7.00e-149	519.00
IUUC-Bgr-012189	Blumeria graminis	30.82	1.00e-28	120.00
IUUC-Bta-012936	Bos taurus	99.02	2.00e-168	584.00
IUUC-Bdi-015020	Brachypodium distachyon	37.59	4.00e-47	181.00
IUUC-Bol-016345	Brassica oleracea	38.46	9.00e-57	213.00
IUUC-Bra-017323	Brassica rapa	38.46	6.00e-57	214.00
IUUC-Cja-019961	Callithrix jacchus	100.00	7.00e-170	589.00
IUUC-Cfa-020862	Canis familiaris	98.36	3.00e-167	580.00
IUUC-Cpo-021356	Cavia porcellus	99.01	6.00e-166	576.00
IUUC-Cre-022602	Chlamydomonas reinhardtii	41.58	1.00e-57	216.00
IUUC-Csa-024067	Chlorocebus sabaeus	99.67	3.00e-169	587.00
IUUC-Cho-024421	Choloepus hoffmanni	83.84	8.00e-83	299.00
IUUC-Cin-025261	Ciona intestinalis	64.59	5.00e-116	410.00
IUUC-Cgl-026446	Colletotrichum gloeosporioides	28.30	9.00e-29	120.00
IUUC-Cne-026846	Cryptococcus neoformans	29.45	6.00e-25	108.00
IUUC-Dre-027706	Danio rerio	65.57	6.00e-110	390.00
IUUC-Dno-029084	Dasypus novemcinctus	99.02	9.00e-168	582.00
IUUC-Dor-030353	Dipodomys ordii	83.33	1.00e-123	435.00
IUUC-Dse-031348	Dothistroma septosporum	29.08	2.00e-26	112.00
IUUC-Dme-031836	Drosophila melanogaster	52.31	7.00e-88	317.00
IUUC-Ete-032261	Echinops telfairi	96.39	2.00e-162	564.00
IUUC-Eca-034231	Equus caballus	91.48	3.00e-153	534.00
IUUC-Eeu-034828	Erinaceus europaeus	97.94	3.00e-157	547.00
IUUC-Fca-036569	Felis catus	99.02	6.00e-168	582.00
IUUC-Fal-037469	Ficedula albicollis	93.11	2.00e-161	561.00
IUUC-Fox-038047	Fusarium oxysporum	33.00	4.00e-29	122.00
IUUC-Gmo-039579	Gadus morhua	83.61	7.00e-146	509.00
IUUC-Gga-040808	Gallus gallus	93.49	5.00e-154	536.00
IUUC-Gac-042100	Gasterosteus aculeatus	83.93	4.00e-147	513.00
IUUC-Gma-044408	Glycine max	40.94	7.00e-60	223.00
IUUC-Hsa-045839	Homo sapiens	100.00	7.00e-170	589.00
IUUC-Hvu-047591	Hordeum vulgare	37.97	1.00e-49	190.00
IUUC-Itr-048741	Ictidomys tridecemlineatus	99.67	3.00e-169	587.00
IUUC-Lch-049549	Latimeria chalumnae	83.61	7.00e-147	512.00
IUUC-Lpe-050746	Leersia perrieri	38.59	4.00e-48	184.00
IUUC-Loc-052540	Lepisosteus oculatus	86.56	1.00e-148	518.00
IUUC-Lma-052992	Leptosphaeria maculans	28.14	4.00e-27	115.00
IUUC-Laf-053907	Loxodonta africana	99.67	3.00e-169	587.00
IUUC-Mcc-055828	Macaca mulatta	93.54	1.00e-165	575.00
IUUC-Meu-056075	Macropus eugenii	94.51	3.00e-135	473.00
IUUC-Mtr-057728	Medicago truncatula	40.71	2.00e-56	213.00
IUUC-Mga-059872	Meleagris gallopavo	93.44	5.00e-162	563.00
IUUC-Mvi-060564	Microbotryum violaceum	32.11	1.00e-29	124.00
IUUC-Mmr-060985	Microcebus murinus	99.66	4.00e-161	560.00
IUUC-Mdo-062758	Monodelphis domestica	90.46	1.00e-158	551.00
IUUC-Mmu-063580	Mus musculus	97.38	1.00e-166	578.00
IUUC-Mac-064880	Musa acuminata	40.19	6.00e-58	217.00
IUUC-Mpu-066577	Mustela putorius furo	98.03	2.00e-166	578.00
IUUC-Nle-069573	Nomascus leucogenys	100.00	7.00e-170	589.00
IUUC-Opr-070216	Ochotona princeps	97.67	2.00e-164	571.00
IUUC-Ont-071981	Oreochromis niloticus	85.25	8.00e-150	522.00
IUUC-Oan-073223	Ornithorhynchus anatinus	93.94	1.00e-107	381.00
IUUC-Ocu-074199	Oryctolagus cuniculus	84.92	2.00e-139	488.00
IUUC-Oba-075255	Oryza barthii	40.00	1.00e-41	163.00
IUUC-Obr-076168	Oryza brachyantha	47.20	1.00e-35	143.00
IUUC-Ogl-077777	Oryza glaberrima	38.39	7.00e-49	187.00
IUUC-Ogu-078780	Oryza glumaepatula	38.39	7.00e-49	187.00
IUUC-Oin-079228	Oryza indica	38.39	1.00e-51	196.00
IUUC-Olo-080617	Oryza longistaminata	45.77	2.00e-29	120.00
IUUC-Ome-081421	Oryza meridionalis	38.39	4.00e-48	184.00
IUUC-Oni-082997	Oryza nivara	38.39	1.00e-51	196.00
IUUC-Opu-083931	Oryza punctata	38.71	7.00e-49	187.00
IUUC-Oru-084645	Oryza rufipogon	38.39	7.00e-49	187.00
IUUC-Osa-085842	Oryza sativa	38.39	1.00e-51	196.00
IUUC-Ola-086696	Oryzias latipes	84.92	1.00e-145	508.00
IUUC-Olu-087643	Ostreococcus lucimarinus	39.91	1.00e-41	162.00
IUUC-Oga-088272	Otolemur garnettii	97.70	3.00e-165	573.00
IUUC-Oar-089416	Ovis aries	99.02	2.00e-168	584.00
IUUC-Ptr-090944	Pan troglodytes	100.00	7.00e-170	589.00
IUUC-Pan-091861	Papio anubis	100.00	7.00e-170	589.00
IUUC-Psi-093750	Pelodiscus sinensis	93.77	3.00e-161	560.00
IUUC-Pma-094608	Petromyzon marinus	79.68	4.00e-135	473.00
IUUC-Pno-094832	Phaeosphaeria nodorum	32.59	3.00e-26	112.00
IUUC-Ppa-095737	Physcomitrella patens	40.38	1.00e-56	213.00
IUUC-Pfo-096479	Poecilia formosa	85.90	7.00e-144	503.00
IUUC-Pab-098179	Pongo abelii	100.00	7.00e-170	589.00
IUUC-Pop-099532	Populus trichocarpa	40.91	3.00e-56	211.00
IUUC-Pca-100664	Procavia capensis	76.45	7.00e-106	376.00
IUUC-Ppe-102056	Prunus persica	40.26	5.00e-58	218.00
IUUC-Pva-102859	Pteropus vampyrus	99.02	5.00e-168	583.00
IUUC-Pte-104236	Pyrenophora teres	35.56	2.00e-25	109.00
IUUC-Rno-105826	Rattus norvegicus	97.05	7.00e-166	575.00
IUUC-Sha-106660	Sarcophilus harrisii	92.03	8.00e-153	532.00
IUUC-Sja-107800	Schizosaccharomyces japonicus	33.22	5.00e-36	144.00
IUUC-Spo-108244	Schizosaccharomyces pombe	31.39	3.00e-35	141.00
IUUC-Smo-109234	Selaginella moellendorffii	42.81	4.00e-61	228.00
IUUC-Sit-110048	Setaria italica	36.86	1.00e-40	160.00
IUUC-Sly-111618	Solanum lycopersicum	38.46	4.00e-52	198.00
IUUC-Stu-112543	Solanum tuberosum	38.78	2.00e-55	209.00
IUUC-Sar-113743	Sorex araneus	78.36	4.00e-130	457.00
IUUC-Sbi-114309	Sorghum bicolor	38.57	7.00e-42	164.00
IUUC-Ssc-115560	Sus scrofa	93.44	3.00e-155	540.00
IUUC-Tgu-117300	Taeniopygia guttata	93.44	7.00e-162	562.00
IUUC-Tru-117933	Takifugu rubripes	84.59	4.00e-149	520.00
IUUC-Tsy-119574	Tarsius syrichta	88.85	3.00e-145	507.00
IUUC-Tni-120191	Tetraodon nigroviridis	87.34	6.00e-113	399.00
IUUC-Tca-120983	Theobroma cacao	40.13	2.00e-57	216.00
IUUC-Tae-124056	Triticum aestivum	36.16	1.00e-49	190.00
IUUC-Tur-126711	Triticum urartu	36.05	1.00e-48	186.00
IUUC-Tme-127066	Tuber melanosporum	33.83	5.00e-34	138.00
IUUC-Tbe-127802	Tupaia belangeri	99.02	6.00e-168	582.00
IUUC-Ttr-128861	Tursiops truncatus	98.11	1.00e-56	212.00
IUUC-Vda-129720	Verticillium dahliae	29.27	6.00e-23	101.00
IUUC-Vpa-130618	Vicugna pacos	95.55	8.00e-136	475.00
IUUC-Vvi-130981	Vitis vinifera	40.38	7.00e-56	210.00
IUUC-Xtr-132460	Xenopus tropicalis	85.90	6.00e-146	509.00
IUUC-Xma-134154	Xiphophorus maculatus	85.90	5.00e-144	503.00
IUUC-Yli-134554	Yarrowia lipolytica	27.90	3.00e-20	92.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence