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Tag Content
iUUCD ID IUUC-Bta-013432
Ensembl Protein ID ENSBTAP00000010324.5
UniProt Accession Q3SZ25; EED_BOVIN
Genbank Protein ID AAI03218.1
Protein Name Polycomb protein EED
Genbank Nucleotide ID BC103217
Gene Name EED
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000007847.5 ENSBTAT00000010324.5 ENSBTAP00000010324.5
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.00e-15 54.5 188 225
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           gH + ++ l+f   d +ll+s s D+ +++W++ t++l
   Q: 188  GHGNAINELKFhpRDpNLLLSVSKDHALRLWNIQTDTL 225
           899*********9888****************999876 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity).
 Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity).
Protein Sequence
(Fasta)
MSEREVSTVP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP 60
NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR 120
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Protein Fasta Sequence


>IUUC-Bta-013432|E3,WD_repeat|Bos taurus
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Nucleotide Sequence
(Fasta)
GGAGGAATAT GTCCGAGAGG GAAGTGTCGA CAGTGCCGGC GGGAACAGAC ATGCCTGCGG 60
CCAAGAAGCA GAAGCTGAGC AGCGACGAGA ATAGCAACCC GGACCTCTCT GGAGACGAGA 120
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Nucleotide Fasta Sequence


>IUUC-Bta-013432|E3,WD_repeat|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0045120--C:pronucleus
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0042054--F:histone methyltransferase activity
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:2000011--P:regulation of adaxial/abaxial pattern formation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0006351--P:transcription, DNA-templated
KEGG bta:404183
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000689 Aegilops tauschii 41.01 9.00e-76 277.00
IUUC-Aml-001510 Ailuropoda melanoleuca 99.10 0.00e+00 862.00
IUUC-Atr-002496 Amborella trichopoda 40.40 3.00e-69 255.00
IUUC-Apl-003768 Anas platyrhynchos 96.36 0.00e+00 829.00
IUUC-Aca-004382 Anolis carolinensis 98.35 0.00e+00 823.00
IUUC-Aly-005980 Arabidopsis lyrata 40.71 1.00e-76 279.00
IUUC-Ath-006579 Arabidopsis thaliana 40.71 1.00e-76 279.00
IUUC-Ame-010987 Astyanax mexicanus 93.97 0.00e+00 801.00
IUUC-Bci-013970 Botrytis cinerea 33.47 2.00e-30 127.00
IUUC-Bdi-014553 Brachypodium distachyon 43.14 8.00e-78 283.00
IUUC-Bol-016522 Brassica oleracea 40.22 7.00e-76 277.00
IUUC-Bra-017137 Brassica rapa 40.22 6.00e-76 277.00
IUUC-Cel-018494 Caenorhabditis elegans 24.36 1.00e-29 124.00
IUUC-Cja-019066 Callithrix jacchus 99.77 0.00e+00 877.00
IUUC-Cfa-021261 Canis familiaris 99.77 0.00e+00 875.00
IUUC-Cpo-022375 Cavia porcellus 94.10 0.00e+00 810.00
IUUC-Csa-024005 Chlorocebus sabaeus 99.77 0.00e+00 875.00
IUUC-Cho-024881 Choloepus hoffmanni 86.38 3.00e-158 551.00
IUUC-Cin-025697 Ciona intestinalis 61.06 7.00e-142 496.00
IUUC-Csv-026221 Ciona savignyi 63.31 3.00e-145 508.00
IUUC-Cgl-026519 Colletotrichum gloeosporioides 26.24 1.00e-24 107.00
IUUC-Cne-026877 Cryptococcus neoformans 30.20 8.00e-28 118.00
IUUC-Cme-027353 Cyanidioschyzon merolae 44.83 4.00e-33 135.00
IUUC-Dre-028346 Danio rerio 91.42 0.00e+00 785.00
IUUC-Dno-029319 Dasypus novemcinctus 98.87 0.00e+00 868.00
IUUC-Dor-030746 Dipodomys ordii 71.46 0.00e+00 645.00
IUUC-Dse-031324 Dothistroma septosporum 26.55 7.00e-27 115.00
IUUC-Dme-032029 Drosophila melanogaster 60.82 8.00e-138 483.00
IUUC-Ete-032880 Echinops telfairi 80.19 2.00e-133 468.00
IUUC-Eca-034272 Equus caballus 100.00 0.00e+00 800.00
IUUC-Eeu-035303 Erinaceus europaeus 91.85 0.00e+00 828.00
IUUC-Fca-036008 Felis catus 100.00 0.00e+00 848.00
IUUC-Fal-037577 Ficedula albicollis 98.01 0.00e+00 785.00
IUUC-Fso-038294 Fusarium solani 24.66 3.00e-27 116.00
IUUC-Gmo-039008 Gadus morhua 89.66 0.00e+00 759.00
IUUC-Ggr-039894 Gaeumannomyces graminis 30.83 5.00e-25 108.00
IUUC-Gga-040859 Gallus gallus 98.35 0.00e+00 821.00
IUUC-Gac-041667 Gasterosteus aculeatus 87.56 0.00e+00 755.00
IUUC-Gma-043832 Glycine max 39.89 3.00e-75 275.00
IUUC-Ggo-045624 Gorilla gorilla 94.42 0.00e+00 862.00
IUUC-Hsa-046505 Homo sapiens 99.77 0.00e+00 875.00
IUUC-Hvu-047228 Hordeum vulgare 37.77 6.00e-33 133.00
IUUC-Itr-048381 Ictidomys tridecemlineatus 99.55 0.00e+00 874.00
IUUC-Lch-050492 Latimeria chalumnae 96.52 0.00e+00 822.00
IUUC-Lpe-050807 Leersia perrieri 37.78 1.00e-72 266.00
IUUC-Loc-052361 Lepisosteus oculatus 92.55 0.00e+00 805.00
IUUC-Lma-053058 Leptosphaeria maculans 28.15 2.00e-21 97.10
IUUC-Laf-053941 Loxodonta africana 92.29 0.00e+00 825.00
IUUC-Mcc-055518 Macaca mulatta 94.42 0.00e+00 862.00
IUUC-Mor-056944 Magnaporthe oryzae 26.87 1.00e-27 117.00
IUUC-Mtr-058716 Medicago truncatula 42.51 1.00e-71 263.00
IUUC-Mga-059469 Meleagris gallopavo 98.35 0.00e+00 821.00
IUUC-Mmr-061026 Microcebus murinus 94.21 0.00e+00 860.00
IUUC-Mdo-062346 Monodelphis domestica 97.96 0.00e+00 860.00
IUUC-Mmu-063785 Mus musculus 99.77 0.00e+00 875.00
IUUC-Mac-064681 Musa acuminata 41.03 9.00e-80 290.00
IUUC-Mpu-066862 Mustela putorius furo 99.77 0.00e+00 875.00
IUUC-Mlu-067103 Myotis lucifugus 92.56 0.00e+00 728.00
IUUC-Ncr-068782 Neurospora crassa 30.89 5.00e-26 112.00
IUUC-Nle-069472 Nomascus leucogenys 99.77 0.00e+00 875.00
IUUC-Opr-070376 Ochotona princeps 96.94 4.00e-126 444.00
IUUC-Ont-071513 Oreochromis niloticus 91.84 0.00e+00 817.00
IUUC-Oan-073202 Ornithorhynchus anatinus 98.76 0.00e+00 791.00
IUUC-Ocu-074012 Oryctolagus cuniculus 99.55 0.00e+00 875.00
IUUC-Oba-075030 Oryza barthii 42.51 2.00e-80 292.00
IUUC-Obr-076895 Oryza brachyantha 41.98 2.00e-78 285.00
IUUC-Ogl-077522 Oryza glaberrima 42.78 1.00e-79 290.00
IUUC-Ogu-078250 Oryza glumaepatula 38.84 3.00e-68 252.00
IUUC-Oin-079886 Oryza indica 42.23 9.00e-80 290.00
IUUC-Olo-080238 Oryza longistaminata 42.51 2.00e-80 292.00
IUUC-Ome-081204 Oryza meridionalis 39.37 3.00e-67 248.00
IUUC-Oni-082388 Oryza nivara 38.63 2.00e-70 259.00
IUUC-Opu-083537 Oryza punctata 42.09 8.00e-79 287.00
IUUC-Oru-084863 Oryza rufipogon 39.12 4.00e-69 255.00
IUUC-Osa-085622 Oryza sativa 42.43 2.00e-80 292.00
IUUC-Ola-087426 Oryzias latipes 90.87 0.00e+00 801.00
IUUC-Olu-087788 Ostreococcus lucimarinus 29.89 3.00e-44 172.00
IUUC-Oga-088228 Otolemur garnettii 99.55 0.00e+00 874.00
IUUC-Oar-090139 Ovis aries 99.75 0.00e+00 798.00
IUUC-Pan-092874 Papio anubis 100.00 7.00e-159 552.00
IUUC-Psi-093927 Pelodiscus sinensis 98.51 0.00e+00 789.00
IUUC-Pma-094740 Petromyzon marinus 84.29 3.00e-138 484.00
IUUC-Pno-095072 Phaeosphaeria nodorum 28.32 2.00e-20 93.60
IUUC-Ppa-095871 Physcomitrella patens 39.02 1.00e-72 266.00
IUUC-Pfo-097208 Poecilia formosa 93.27 0.00e+00 820.00
IUUC-Pab-097658 Pongo abelii 99.77 0.00e+00 875.00
IUUC-Pop-098930 Populus trichocarpa 41.30 2.00e-78 285.00
IUUC-Ppe-101807 Prunus persica 40.65 3.00e-76 278.00
IUUC-Pva-103191 Pteropus vampyrus 84.98 0.00e+00 754.00
IUUC-Pgr-103619 Puccinia graminis 25.87 8.00e-19 88.20
IUUC-Pte-104406 Pyrenophora teres 29.19 1.00e-28 120.00
IUUC-Pyt-104821 Pyrenophora triticirepentis 26.53 7.00e-23 101.00
IUUC-Rno-105854 Rattus norvegicus 99.77 0.00e+00 875.00
IUUC-Sha-107426 Sarcophilus harrisii 97.73 0.00e+00 858.00
IUUC-Smo-109638 Selaginella moellendorffii 40.17 1.00e-75 276.00
IUUC-Sit-110481 Setaria italica 41.85 8.00e-79 286.00
IUUC-Sly-111464 Solanum lycopersicum 39.89 2.00e-75 276.00
IUUC-Stu-112910 Solanum tuberosum 39.89 2.00e-75 276.00
IUUC-Sar-113754 Sorex araneus 92.20 0.00e+00 660.00
IUUC-Sbi-114023 Sorghum bicolor 42.13 8.00e-80 290.00
IUUC-Ssc-115386 Sus scrofa 99.77 0.00e+00 875.00
IUUC-Tgu-117123 Taeniopygia guttata 97.44 0.00e+00 823.00
IUUC-Tru-117720 Takifugu rubripes 88.13 0.00e+00 803.00
IUUC-Tsy-119584 Tarsius syrichta 94.42 0.00e+00 862.00
IUUC-Tni-119695 Tetraodon nigroviridis 91.20 0.00e+00 819.00
IUUC-Tca-121787 Theobroma cacao 41.58 5.00e-78 284.00
IUUC-Tvi-122409 Trichoderma virens 24.81 9.00e-23 101.00
IUUC-Tae-124454 Triticum aestivum 41.01 9.00e-76 277.00
IUUC-Tme-126906 Tuber melanosporum 29.38 2.00e-34 139.00
IUUC-Tbe-127557 Tupaia belangeri 79.83 0.00e+00 734.00
IUUC-Vda-129774 Verticillium dahliae 25.15 5.00e-21 95.50
IUUC-Vpa-130256 Vicugna pacos 85.55 0.00e+00 717.00
IUUC-Vvi-131201 Vitis vinifera 41.58 1.00e-76 280.00
IUUC-Xtr-132206 Xenopus tropicalis 94.05 0.00e+00 817.00
IUUC-Xma-134102 Xiphophorus maculatus 93.27 0.00e+00 820.00
IUUC-Zma-135593 Zea mays 42.70 2.00e-80 292.00
Created Date 25-Jun-2017

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