iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004930

UUCD1 version

UUC-AnC-01024

Ensembl Protein ID

ENSACAP00000006964.2

UniProt Accession

G1KG63; G1KG63_ANOCA

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000007067.3	ENSACAT00000007115.3	ENSACAP00000006964.2
ENSACAG00000007067.3	ENSACAT00000030653.1	ENSACAP00000023234.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.90e-20	72.7	521	909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 521  NAYCNCMIQVLYFLEPVRCLVQN---HLCQK------EFCLSCELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEAAAlGLILADSDEAT 600
           56*********************...55654......57*********************************99955599999***998 PP
   S: 97   afl.ldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetk 183
             + l +l ++ ++   ++  +e++e++  ++ +   ++  ++ +s+i +lF  ++++  +c +c+++++r ++ l ++l+ p+++++ 
   Q: 601  GKVnLGRLIQSWNRfILTQLHQETQEQEGPQAYRGIGSSFGSSWDSVIGQLFSCEVENCSMC-RCGKETVRVSSTLLFTLSYPESNDNI 688
           65549999999988744455555555555566777889999*****************9999.8*******************988642 PP
   S: 184  ke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.... 267
           k  ++ ++L+       le++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e      k++ +++f+ +L +++   +    
   Q: 689  KDyDFAQILKRSIC---LEQNTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSSKE--AEFWKMQAEYSFK-KLMMKKGGLElpts 771
           22255555544444...5666679****************************9995544..4556999999996.78888744444555 PP
   S: 268  ............................................peekqke............................kkkYeLiavv 284
                                                             e                            ++ Y+L+a v
   Q: 772  retslgewnelggaegghsytsieelkniwipysikmklsknkeL-----EvynwdesaedlgqlttksklsiledqesTYVYDLMATV 855
           556666666666666666666666666666666666655555550.....055555555555556666666666666669********* PP
   S: 285  vHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleet 326
           vH   s  +G  v ++k            ++++W+lf+D  +++v++ e +++ 
   Q: 856  VHILdSRTGGSLVGHIKVgetyhqrkegvTHQQWYLFNDFLIEPVDKCEAVQFD 909
           ****9*************999988877777888******999999986666654 PP

Organism

Anolis carolinensis

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFETLDPAL AEYVPALHPA LDPHLNPSLL QNVELDPEGV PLEGIPVPDS VHIMEGMYSE 60
LHTVVSEVGV PVSFSHFDLH EEMLWVGNHG GHATSFFGPA LERYSSFQVH SSDDIRQIQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAAACCTCC ACCATGAATT TTGAAACCCT TGACCCAGCT CTTGCAGAGT ACGTGCCTGC 60
CCTCCATCCT GCCTTGGATC CTCACCTCAA CCCTAGCCTT CTCCAGAATG TGGAGCTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	84.12	0.00e+00	2027.00
IUUC-Apl-003500	Anas platyrhynchos	89.73	0.00e+00	1979.00
IUUC-Acl-008214	Aspergillus clavatus	31.32	8.00e-156	544.00
IUUC-Afu-009112	Aspergillus fumigatus	31.30	3.00e-146	512.00
IUUC-Ang-009531	Aspergillus niger	30.96	4.00e-149	522.00
IUUC-Ame-011259	Astyanax mexicanus	76.40	0.00e+00	1873.00
IUUC-Bta-012371	Bos taurus	84.33	0.00e+00	2027.00
IUUC-Bci-013684	Botrytis cinerea	31.61	7.00e-132	465.00
IUUC-Cja-019297	Callithrix jacchus	81.83	0.00e+00	1970.00
IUUC-Cfa-020489	Canis familiaris	83.91	0.00e+00	2013.00
IUUC-Cpo-022392	Cavia porcellus	83.29	0.00e+00	2033.00
IUUC-Csa-023220	Chlorocebus sabaeus	83.87	0.00e+00	2025.00
IUUC-Csv-025841	Ciona savignyi	45.93	0.00e+00	929.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	30.40	3.00e-91	330.00
IUUC-Cne-026932	Cryptococcus neoformans	43.52	2.00e-72	268.00
IUUC-Dre-028482	Danio rerio	73.83	0.00e+00	1814.00
IUUC-Dno-029398	Dasypus novemcinctus	84.16	0.00e+00	2026.00
IUUC-Dor-030307	Dipodomys ordii	76.82	0.00e+00	1112.00
IUUC-Dme-032111	Drosophila melanogaster	43.16	0.00e+00	917.00
IUUC-Eca-033985	Equus caballus	84.33	0.00e+00	2026.00
IUUC-Eeu-034928	Erinaceus europaeus	74.44	0.00e+00	697.00
IUUC-Fca-035587	Felis catus	83.95	0.00e+00	2041.00
IUUC-Fal-037587	Ficedula albicollis	89.32	0.00e+00	2112.00
IUUC-Fso-038133	Fusarium solani	31.92	3.00e-96	346.00
IUUC-Gmo-039076	Gadus morhua	73.90	0.00e+00	1798.00
IUUC-Ggr-039957	Gaeumannomyces graminis	31.79	4.00e-142	498.00
IUUC-Gga-040948	Gallus gallus	90.14	0.00e+00	2161.00
IUUC-Gac-042396	Gasterosteus aculeatus	74.77	0.00e+00	1858.00
IUUC-Ggo-045412	Gorilla gorilla	83.79	0.00e+00	2021.00
IUUC-Hsa-046076	Homo sapiens	83.95	0.00e+00	2026.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	78.55	0.00e+00	1840.00
IUUC-Kpa-049178	Komagataella pastoris	38.99	2.00e-64	241.00
IUUC-Lch-050279	Latimeria chalumnae	75.89	0.00e+00	1806.00
IUUC-Loc-052872	Lepisosteus oculatus	77.91	0.00e+00	1893.00
IUUC-Lma-052986	Leptosphaeria maculans	32.67	3.00e-159	555.00
IUUC-Laf-054181	Loxodonta africana	82.59	0.00e+00	2004.00
IUUC-Mcc-054812	Macaca mulatta	84.00	0.00e+00	2020.00
IUUC-Meu-056325	Macropus eugenii	86.35	0.00e+00	2081.00
IUUC-Mor-057246	Magnaporthe oryzae	28.88	1.00e-121	430.00
IUUC-Mpo-057464	Magnaporthe poae	31.90	5.00e-146	512.00
IUUC-Mla-058911	Melampsora laricipopulina	32.92	1.00e-100	361.00
IUUC-Mga-059335	Meleagris gallopavo	90.05	0.00e+00	2099.00
IUUC-Mvi-060461	Microbotryum violaceum	32.58	8.00e-149	521.00
IUUC-Mmr-060636	Microcebus murinus	84.08	0.00e+00	2018.00
IUUC-Mmu-063503	Mus musculus	83.43	0.00e+00	2012.00
IUUC-Mpu-066670	Mustela putorius furo	84.33	0.00e+00	2025.00
IUUC-Mlu-068119	Myotis lucifugus	83.42	0.00e+00	2065.00
IUUC-Nfi-068398	Neosartorya fischeri	32.08	3.00e-156	546.00
IUUC-Ncr-068927	Neurospora crassa	29.70	4.00e-128	452.00
IUUC-Nle-069651	Nomascus leucogenys	80.17	0.00e+00	1927.00
IUUC-Opr-070614	Ochotona princeps	83.25	0.00e+00	1981.00
IUUC-Ont-072433	Oreochromis niloticus	76.31	0.00e+00	1891.00
IUUC-Oan-073283	Ornithorhynchus anatinus	72.79	0.00e+00	1405.00
IUUC-Ocu-074401	Oryctolagus cuniculus	83.84	0.00e+00	2027.00
IUUC-Ola-087522	Oryzias latipes	75.00	0.00e+00	1823.00
IUUC-Oga-088226	Otolemur garnettii	83.62	0.00e+00	2044.00
IUUC-Oar-089241	Ovis aries	83.95	0.00e+00	2048.00
IUUC-Pan-092297	Papio anubis	84.24	0.00e+00	1810.00
IUUC-Psi-094043	Pelodiscus sinensis	87.06	0.00e+00	2042.00
IUUC-Pma-094394	Petromyzon marinus	69.03	0.00e+00	1589.00
IUUC-Pno-095053	Phaeosphaeria nodorum	32.30	6.00e-149	521.00
IUUC-Ppa-095188	Physcomitrella patens	31.88	5.00e-165	575.00
IUUC-Pfo-097517	Poecilia formosa	75.33	0.00e+00	1881.00
IUUC-Pca-100471	Procavia capensis	83.99	0.00e+00	1911.00
IUUC-Pva-102805	Pteropus vampyrus	79.54	0.00e+00	1571.00
IUUC-Pte-104021	Pyrenophora teres	30.92	9.00e-97	348.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	30.78	3.00e-96	347.00
IUUC-Rno-105471	Rattus norvegicus	83.32	0.00e+00	2012.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.66	4.00e-62	233.00
IUUC-Sha-106883	Sarcophilus harrisii	86.11	0.00e+00	1937.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.22	2.00e-145	509.00
IUUC-Sar-113323	Sorex araneus	82.98	0.00e+00	1496.00
IUUC-Sre-115075	Sporisorium reilianum	30.17	2.00e-70	261.00
IUUC-Ssc-116363	Sus scrofa	84.01	0.00e+00	2056.00
IUUC-Tru-118427	Takifugu rubripes	76.27	0.00e+00	1934.00
IUUC-Tni-120218	Tetraodon nigroviridis	75.78	0.00e+00	1919.00
IUUC-Tre-122177	Trichoderma reesei	31.09	2.00e-153	536.00
IUUC-Tme-127176	Tuber melanosporum	31.72	5.00e-142	498.00
IUUC-Tbe-127641	Tupaia belangeri	76.67	0.00e+00	713.00
IUUC-Ttr-128888	Tursiops truncatus	82.28	0.00e+00	1255.00
IUUC-Uma-129361	Ustilago maydis	38.62	1.00e-62	235.00
IUUC-Xtr-132811	Xenopus tropicalis	82.28	0.00e+00	1966.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence