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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063528
UUCD1 version UUC-MuM-00762
Ensembl Protein ID ENSMUSP00000048244.7
UniProt Accession Q8K2H6; Q9CW24; APC10_MOUSE
Genbank Protein ID BAB23942.1; BAC30921.1; AAH31460.1
Protein Name Anaphase-promoting complex subunit 10; Cyclosome subunit 10
Genbank Nucleotide ID AK005303; AK041373; BC031460
Gene Name Anapc10; Apc10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000036977.8 ENSMUST00000048147.8 ENSMUSP00000048244.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
CPLMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 99.46 1.00e-108 389.00 IUUC-Hsa-046971
E3 adaptor/Cullin RING/APC_C/APC_C 34.46 1.00e-23 103.00 IUUC-Sce-106448
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MTTPNKTPPG ADPKQLERTA TVREIGSQAV WSLSSCKPGF GVDQLRDDNL ETYWQSDGSQ 60
PHLVNIQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN NFHNLQEIRQ LELVEPSGWI 120
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Protein Fasta Sequence


>IUUC-Mmu-063528|E3,APC_C|Mus musculus
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Nucleotide Sequence
(Fasta)
GAGAACCGGA ATTGTGGCGA ATCAGGTGTG TAAGACAGCG GCTCTCCCTC GGTTTAGAGA 60
ACTGTGTGCT AGCGGGCGCA GGTAGAGCCC TTCTCCCTAG TCTCGGCGGC GTTAGGCTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063528|E3,APC_C|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR016901--APC10
IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
PROSITE

PS51284--DOC
Pfam

PF03256--ANAPC10
SMART

SM01337--APC10
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
KEGG mmu:68999
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000560 Aegilops tauschii 54.29 8.00e-28 116.00
IUUC-Aml-001522 Ailuropoda melanoleuca 99.46 5.00e-110 389.00
IUUC-Atr-002797 Amborella trichopoda 57.83 9.00e-54 202.00
IUUC-Apl-004185 Anas platyrhynchos 97.84 2.00e-108 384.00
IUUC-Aca-004900 Anolis carolinensis 96.76 1.00e-106 378.00
IUUC-Aly-005760 Arabidopsis lyrata 55.42 2.00e-49 188.00
IUUC-Ath-007516 Arabidopsis thaliana 55.42 2.00e-49 187.00
IUUC-Ago-007889 Ashbya gossypii 32.35 4.00e-24 105.00
IUUC-Acl-008130 Aspergillus clavatus 40.95 2.00e-20 94.00
IUUC-Afl-008640 Aspergillus flavus 41.90 5.00e-20 92.00
IUUC-Afu-009101 Aspergillus fumigatus 40.95 4.00e-20 92.40
IUUC-Ani-009484 Aspergillus nidulans 42.72 3.00e-20 93.20
IUUC-Ang-009847 Aspergillus niger 40.95 2.00e-19 90.90
IUUC-Aor-010077 Aspergillus oryzae 41.90 5.00e-20 92.00
IUUC-Ate-010544 Aspergillus terreus 40.95 3.00e-20 92.80
IUUC-Ame-011330 Astyanax mexicanus 91.16 1.00e-80 291.00
IUUC-Bgr-011978 Blumeria graminis 42.24 4.00e-37 147.00
IUUC-Bta-013351 Bos taurus 99.46 5.00e-110 389.00
IUUC-Bci-013611 Botrytis cinerea 44.87 2.00e-36 146.00
IUUC-Bdi-014443 Brachypodium distachyon 53.18 1.00e-49 189.00
IUUC-Bol-015534 Brassica oleracea 56.29 4.00e-54 204.00
IUUC-Bra-017298 Brassica rapa 56.89 2.00e-54 204.00
IUUC-Cel-018170 Caenorhabditis elegans 48.55 3.00e-40 157.00
IUUC-Cja-019877 Callithrix jacchus 99.46 5.00e-110 389.00
IUUC-Cfa-020698 Canis familiaris 99.46 5.00e-110 389.00
IUUC-Cpo-022007 Cavia porcellus 98.92 3.00e-109 386.00
IUUC-Cre-023013 Chlamydomonas reinhardtii 51.52 1.00e-48 185.00
IUUC-Csa-023980 Chlorocebus sabaeus 99.46 5.00e-110 389.00
IUUC-Cho-024703 Choloepus hoffmanni 100.00 1.00e-84 305.00
IUUC-Cin-025346 Ciona intestinalis 52.46 1.00e-57 215.00
IUUC-Csv-026225 Ciona savignyi 53.41 3.00e-53 200.00
IUUC-Cgl-026544 Colletotrichum gloeosporioides 42.47 1.00e-32 133.00
IUUC-Cne-027042 Cryptococcus neoformans 40.82 4.00e-34 137.00
IUUC-Cme-027223 Cyanidioschyzon merolae 49.09 2.00e-28 120.00
IUUC-Dre-027804 Danio rerio 90.27 5.00e-101 359.00
IUUC-Dno-029995 Dasypus novemcinctus 99.46 5.00e-110 389.00
IUUC-Dor-030429 Dipodomys ordii 98.92 7.00e-109 385.00
IUUC-Dse-031499 Dothistroma septosporum 37.50 3.00e-32 131.00
IUUC-Dme-031675 Drosophila melanogaster 57.14 8.00e-62 229.00
IUUC-Ete-032499 Echinops telfairi 99.37 5.00e-94 336.00
IUUC-Eca-034281 Equus caballus 99.46 5.00e-110 389.00
IUUC-Eeu-034913 Erinaceus europaeus 98.37 5.00e-71 258.00
IUUC-Fca-036364 Felis catus 99.46 6.00e-110 389.00
IUUC-Fal-037041 Ficedula albicollis 97.84 2.00e-108 384.00
IUUC-Fox-037777 Fusarium oxysporum 40.26 2.00e-33 136.00
IUUC-Fso-038311 Fusarium solani 41.83 1.00e-33 137.00
IUUC-Gmo-039318 Gadus morhua 87.93 2.00e-59 219.00
IUUC-Ggr-039935 Gaeumannomyces graminis 41.10 2.00e-29 123.00
IUUC-Gga-041006 Gallus gallus 97.30 2.00e-108 384.00
IUUC-Gac-042367 Gasterosteus aculeatus 89.25 9.00e-100 355.00
IUUC-Gma-043650 Glycine max 56.71 1.00e-53 202.00
IUUC-Ggo-045044 Gorilla gorilla 99.46 5.00e-110 389.00
IUUC-Hsa-046971 Homo sapiens 99.46 5.00e-110 389.00
IUUC-Hvu-047485 Hordeum vulgare 57.69 4.00e-11 58.90
IUUC-Itr-048324 Ictidomys tridecemlineatus 99.08 3.00e-62 229.00
IUUC-Kpa-049293 Komagataella pastoris 43.17 3.00e-31 127.00
IUUC-Lch-049462 Latimeria chalumnae 91.84 5.00e-81 292.00
IUUC-Lpe-050846 Leersia perrieri 55.42 4.00e-48 184.00
IUUC-Loc-052857 Lepisosteus oculatus 92.43 6.00e-103 365.00
IUUC-Lma-052974 Leptosphaeria maculans 43.43 7.00e-18 85.10
IUUC-Laf-053536 Loxodonta africana 99.46 5.00e-110 389.00
IUUC-Mcc-054806 Macaca mulatta 99.46 5.00e-110 389.00
IUUC-Meu-056282 Macropus eugenii 96.05 6.00e-41 159.00
IUUC-Mor-057080 Magnaporthe oryzae 42.66 1.00e-29 124.00
IUUC-Mpo-057503 Magnaporthe poae 40.49 5.00e-29 121.00
IUUC-Mtr-057837 Medicago truncatula 56.29 2.00e-53 201.00
IUUC-Mla-059010 Melampsora laricipopulina 49.28 1.00e-32 131.00
IUUC-Mga-059728 Meleagris gallopavo 97.84 2.00e-108 384.00
IUUC-Mvi-060224 Microbotryum violaceum 40.83 3.00e-39 154.00
IUUC-Mdo-062602 Monodelphis domestica 97.84 1.00e-108 384.00
IUUC-Mac-065629 Musa acuminata 60.40 1.00e-49 189.00
IUUC-Mpu-066046 Mustela putorius furo 99.46 5.00e-110 389.00
IUUC-Mlu-068107 Myotis lucifugus 99.46 5.00e-110 389.00
IUUC-Nfi-068426 Neosartorya fischeri 40.95 5.00e-20 92.40
IUUC-Ncr-068810 Neurospora crassa 41.96 5.00e-30 125.00
IUUC-Nle-069550 Nomascus leucogenys 99.46 5.00e-110 389.00
IUUC-Opr-071205 Ochotona princeps 100.00 2.00e-92 330.00
IUUC-Ont-071625 Oreochromis niloticus 90.27 5.00e-101 359.00
IUUC-Oan-073396 Ornithorhynchus anatinus 97.30 4.00e-108 383.00
IUUC-Ocu-074136 Oryctolagus cuniculus 98.92 1.00e-109 388.00
IUUC-Oba-075504 Oryza barthii 55.42 3.00e-48 184.00
IUUC-Obr-076300 Oryza brachyantha 56.02 3.00e-50 191.00
IUUC-Ogl-077163 Oryza glaberrima 55.42 3.00e-48 184.00
IUUC-Ogu-078459 Oryza glumaepatula 55.42 3.00e-48 184.00
IUUC-Oin-079095 Oryza indica 48.94 3.00e-44 171.00
IUUC-Olo-080226 Oryza longistaminata 48.65 3.00e-43 171.00
IUUC-Ome-081690 Oryza meridionalis 55.42 3.00e-48 184.00
IUUC-Oni-082984 Oryza nivara 55.42 3.00e-48 184.00
IUUC-Opu-083753 Oryza punctata 56.02 8.00e-53 199.00
IUUC-Oru-084459 Oryza rufipogon 55.42 3.00e-48 184.00
IUUC-Osa-085969 Oryza sativa 55.42 3.00e-48 184.00
IUUC-Ola-087291 Oryzias latipes 88.71 4.00e-99 353.00
IUUC-Olu-087704 Ostreococcus lucimarinus 51.92 2.00e-44 172.00
IUUC-Oga-088086 Otolemur garnettii 99.46 5.00e-110 389.00
IUUC-Oar-089191 Ovis aries 99.46 5.00e-110 389.00
IUUC-Ptr-091583 Pan troglodytes 99.46 5.00e-110 389.00
IUUC-Pan-092440 Papio anubis 99.46 5.00e-110 389.00
IUUC-Psi-093158 Pelodiscus sinensis 97.84 1.00e-108 384.00
IUUC-Pma-094382 Petromyzon marinus 69.74 3.00e-31 125.00
IUUC-Pno-094776 Phaeosphaeria nodorum 42.86 6.00e-21 95.10
IUUC-Ppa-095243 Physcomitrella patens 54.20 8.00e-39 153.00
IUUC-Pfo-096853 Poecilia formosa 89.25 9.00e-100 355.00
IUUC-Pab-098464 Pongo abelii 87.03 1.00e-91 328.00
IUUC-Pop-099055 Populus trichocarpa 56.47 7.00e-52 196.00
IUUC-Pca-100402 Procavia capensis 99.32 2.00e-85 307.00
IUUC-Ppe-101826 Prunus persica 54.22 1.00e-48 185.00
IUUC-Pva-102272 Pteropus vampyrus 99.46 5.00e-110 389.00
IUUC-Pgr-103519 Puccinia graminis 40.51 1.00e-34 139.00
IUUC-Ptt-103904 Puccinia triticina 35.79 2.00e-14 72.00
IUUC-Pte-104017 Pyrenophora teres 44.44 6.00e-22 98.60
IUUC-Pyt-104453 Pyrenophora triticirepentis 43.43 2.00e-21 96.30
IUUC-Rno-105561 Rattus norvegicus 100.00 2.00e-110 391.00
IUUC-Sce-106448 Saccharomyces cerevisiae 34.46 7.00e-24 103.00
IUUC-Sha-106901 Sarcophilus harrisii 97.84 1.00e-108 384.00
IUUC-Sja-107924 Schizosaccharomyces japonicus 43.56 4.00e-39 154.00
IUUC-Spo-108082 Schizosaccharomyces pombe 44.90 3.00e-37 147.00
IUUC-Ssl-108422 Sclerotinia sclerotiorum 46.15 2.00e-36 146.00
IUUC-Smo-109182 Selaginella moellendorffii 59.77 1.00e-56 211.00
IUUC-Sit-110292 Setaria italica 59.06 3.00e-49 187.00
IUUC-Sly-111772 Solanum lycopersicum 53.45 3.00e-46 177.00
IUUC-Stu-112789 Solanum tuberosum 54.02 2.00e-46 178.00
IUUC-Sar-113731 Sorex araneus 69.19 1.00e-67 248.00
IUUC-Sbi-114468 Sorghum bicolor 54.34 2.00e-53 201.00
IUUC-Sre-115201 Sporisorium reilianum 38.38 2.00e-33 135.00
IUUC-Ssc-115318 Sus scrofa 99.46 5.00e-110 389.00
IUUC-Tgu-116782 Taeniopygia guttata 97.30 2.00e-108 384.00
IUUC-Tru-117918 Takifugu rubripes 89.78 4.00e-100 356.00
IUUC-Tni-120731 Tetraodon nigroviridis 89.78 3.00e-100 357.00
IUUC-Tca-121546 Theobroma cacao 55.42 2.00e-49 188.00
IUUC-Tre-122092 Trichoderma reesei 42.96 3.00e-32 130.00
IUUC-Tvi-122416 Trichoderma virens 42.66 3.00e-32 132.00
IUUC-Tae-123195 Triticum aestivum 54.91 4.00e-51 193.00
IUUC-Tur-126519 Triticum urartu 53.76 3.00e-49 187.00
IUUC-Tme-127131 Tuber melanosporum 47.55 7.00e-41 160.00
IUUC-Tbe-128098 Tupaia belangeri 99.08 3.00e-62 229.00
IUUC-Ttr-128765 Tursiops truncatus 88.11 1.00e-94 338.00
IUUC-Uma-129533 Ustilago maydis 36.51 6.00e-32 130.00
IUUC-Vda-129741 Verticillium dahliae 41.96 7.00e-33 134.00
IUUC-Vpa-130667 Vicugna pacos 99.46 5.00e-110 389.00
IUUC-Vvi-131400 Vitis vinifera 55.42 6.00e-54 203.00
IUUC-Xtr-132526 Xenopus tropicalis 94.05 9.00e-105 372.00
IUUC-Xma-133326 Xiphophorus maculatus 89.25 1.00e-99 355.00
IUUC-Yli-134645 Yarrowia lipolytica 44.12 9.00e-35 139.00
IUUC-Zma-134968 Zea mays 54.91 1.00e-50 192.00
Created Date 25-Jun-2017

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