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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Ath-006667
UUCD1 version UUC-ArT-01476
Ensembl Protein ID AT1G57820.3
UniProt Accession Q8VYZ0; Q3ECM8; Q9FVS3; ORTH2_ARATH
Genbank Protein ID AAG29238.1; AEE33469.1; AEE33470.1; ANM59484.1; AAL38879.1; AAM51310.1
Protein Name E3 ubiquitin-protein ligase ORTHRUS 2; Protein VARIANT IN METHYLATION 1; RING-type E3 ubiquitin transferase ORTHRUS 2
Genbank Nucleotide ID AC079732; CP002684; CP002684; CP002684; AY065438; AY117235
Gene Name ORTH2; VIM1; At1g57820; F12K22.14
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT1G57820 AT1G57820.2 AT1G57820.2
AT1G57820 AT1G57820.3 AT1G57820.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18643997
Classification
Family E-value Score Start End
E3 activity/RING/U-box 5.10e-07 30.5 143 191
E3 activity/RING/RING 2.20e-08 35.4 146 185
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqpltee 53
            ++C+  ++l++ Pv+ p+G+    ++ ekw+ +g++tc ++r+ + e+
   Q: 143  NLMCSFCMQLPERPVTKPCGHNACLKCFEKWMGQGKRTCGKCRSIIPEK 191
           689************************************9999877655 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C++ +++ p++ pCgH  +++C++kw     + +++ +C  Cr
   Q: 146  CSFCMQLPER-PVTKPCGHNACLKCFEKW-----MGQGKRTCGKCR 185
           **********.9*9***************.....7999999*9997 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Associates with methylated DNA, and can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate. Probably acts at the DNA methylation?histone interface to maintain centromeric heterochromatin.
 E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Associates with methylated DNA, and can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate. Probably acts at the DNA methylation?histone interface to maintain centromeric heterochromatin.
Protein Sequence
(Fasta)
MARDIQLPCD GDGVCMRCKS NPPPEESLTC GTCVTPWHVS CLSSPPKTLA STLQWHCPDC 60
SGEIDPLPVS GGATGFESAG SDLVAAIRAI EADESLSTEE KAKMRQRLLS GKGVEEDDEE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-006667|E3,RING;E3,U-box|Arabidopsis thaliana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACAAGACAAC ACATAGCCAA AAAAATCTTT TGGGTATCGT TTTGAATTTC AAAGACGCTC 60
TCGTCCTTTC CCAAAATATT TCAAACACCC GCCTCTTCAG TATTTCGTTT CCCACTCTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-006667|E3,RING;E3,U-box|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015947--PUA-like_domain
IPR003105--SRA_YDG
IPR019786--Zinc_finger_PHD-type_CS
IPR027370--Znf-RING_LisH
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51015--YDG
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF02182--SAD_SRA
PF13445--zf-RING_UBOX
SMART

SM00249--PHD
SM00184--RING
SM00466--SRA
Gene Ontology

GO:0010369--C:chromocenter
GO:0005720--C:nuclear heterochromatin
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0010385--F:double-stranded methylated DNA binding
GO:0042393--F:histone binding
GO:0008327--F:methyl-CpG binding
GO:0010428--F:methyl-CpNpG binding
GO:0010429--F:methyl-CpNpN binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016569--P:covalent chromatin modification
GO:0032776--P:DNA methylation on cytosine
GO:0010424--P:DNA methylation on cytosine within a CG sequence
GO:0010216--P:maintenance of DNA methylation
GO:0031508--P:pericentric heterochromatin assembly
GO:0090309--P:positive regulation of methylation-dependent chromatin silencing
GO:0016567--P:protein ubiquitination
KEGG ath:AT1G57820
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000242 Aegilops tauschii 72.06 1.00e-166 578.00
IUUC-Atr-002603 Amborella trichopoda 63.14 0.00e+00 784.00
IUUC-Aca-005287 Anolis carolinensis 33.09 5.00e-49 188.00
IUUC-Aly-006276 Arabidopsis lyrata 89.54 0.00e+00 1143.00
IUUC-Ame-011845 Astyanax mexicanus 34.31 1.00e-47 184.00
IUUC-Bta-012600 Bos taurus 35.57 1.00e-48 187.00
IUUC-Bdi-014586 Brachypodium distachyon 64.33 0.00e+00 753.00
IUUC-Bol-015519 Brassica oleracea 82.38 0.00e+00 1019.00
IUUC-Bra-017110 Brassica rapa 77.54 0.00e+00 1028.00
IUUC-Cfa-020558 Canis familiaris 47.22 2.00e-43 170.00
IUUC-Cpo-022125 Cavia porcellus 35.48 7.00e-52 198.00
IUUC-Cin-025454 Ciona intestinalis 35.12 3.00e-45 176.00
IUUC-Cgl-026498 Colletotrichum gloeosporioides 33.60 4.00e-10 58.90
IUUC-Cne-026942 Cryptococcus neoformans 46.71 2.00e-31 127.00
IUUC-Dre-028200 Danio rerio 34.23 1.00e-48 187.00
IUUC-Dno-029523 Dasypus novemcinctus 48.11 9.00e-44 171.00
IUUC-Dor-031084 Dipodomys ordii 33.82 6.00e-50 191.00
IUUC-Eeu-035077 Erinaceus europaeus 48.55 3.00e-37 148.00
IUUC-Fca-035685 Felis catus 48.76 3.00e-43 169.00
IUUC-Gmo-039452 Gadus morhua 36.22 4.00e-49 189.00
IUUC-Gga-040484 Gallus gallus 34.91 6.00e-51 195.00
IUUC-Gac-042196 Gasterosteus aculeatus 35.77 5.00e-49 188.00
IUUC-Gma-044194 Glycine max 64.44 0.00e+00 781.00
IUUC-Hvu-047471 Hordeum vulgare 71.33 0.00e+00 666.00
IUUC-Itr-047867 Ictidomys tridecemlineatus 35.92 1.00e-50 194.00
IUUC-Lpe-050756 Leersia perrieri 64.51 0.00e+00 786.00
IUUC-Lma-052953 Leptosphaeria maculans 29.86 1.00e-10 60.80
IUUC-Mcc-055513 Macaca mulatta 47.22 1.00e-43 170.00
IUUC-Meu-056189 Macropus eugenii 52.46 6.00e-28 119.00
IUUC-Mtr-058805 Medicago truncatula 63.88 0.00e+00 763.00
IUUC-Mla-058836 Melampsora laricipopulina 50.64 5.00e-40 158.00
IUUC-Mga-059759 Meleagris gallopavo 34.23 2.00e-50 193.00
IUUC-Mdo-062659 Monodelphis domestica 34.24 2.00e-49 190.00
IUUC-Mmu-063738 Mus musculus 35.56 4.00e-50 192.00
IUUC-Mac-064697 Musa acuminata 63.13 0.00e+00 783.00
IUUC-Mlu-067538 Myotis lucifugus 48.78 1.00e-43 171.00
IUUC-Oan-073109 Ornithorhynchus anatinus 33.67 5.00e-49 187.00
IUUC-Oba-075108 Oryza barthii 64.72 0.00e+00 785.00
IUUC-Obr-076572 Oryza brachyantha 62.90 0.00e+00 766.00
IUUC-Ogl-077177 Oryza glaberrima 64.72 0.00e+00 785.00
IUUC-Ogu-078298 Oryza glumaepatula 64.72 0.00e+00 785.00
IUUC-Oin-079911 Oryza indica 64.72 0.00e+00 786.00
IUUC-Olo-080527 Oryza longistaminata 56.74 0.00e+00 695.00
IUUC-Ome-081137 Oryza meridionalis 61.97 0.00e+00 739.00
IUUC-Oni-082620 Oryza nivara 64.72 0.00e+00 786.00
IUUC-Opu-083974 Oryza punctata 64.24 0.00e+00 780.00
IUUC-Oru-084976 Oryza rufipogon 64.72 0.00e+00 786.00
IUUC-Osa-085339 Oryza sativa 64.72 0.00e+00 786.00
IUUC-Ola-086706 Oryzias latipes 46.01 1.00e-43 171.00
IUUC-Oga-088221 Otolemur garnettii 35.32 3.00e-50 192.00
IUUC-Pan-092855 Papio anubis 47.22 2.00e-43 170.00
IUUC-Pma-094339 Petromyzon marinus 49.30 7.00e-45 175.00
IUUC-Ppa-095940 Physcomitrella patens 58.36 0.00e+00 727.00
IUUC-Pfo-096243 Poecilia formosa 48.31 6.00e-42 165.00
IUUC-Pab-098211 Pongo abelii 32.90 7.00e-45 175.00
IUUC-Pop-099561 Populus trichocarpa 66.39 0.00e+00 814.00
IUUC-Ppe-101961 Prunus persica 71.91 0.00e+00 863.00
IUUC-Pyt-104740 Pyrenophora triticirepentis 28.23 5.00e-15 75.90
IUUC-Rno-105345 Rattus norvegicus 35.48 1.00e-50 194.00
IUUC-Sce-106362 Saccharomyces cerevisiae 25.74 1.00e-08 53.90
IUUC-Sha-106687 Sarcophilus harrisii 34.60 6.00e-49 188.00
IUUC-Smo-109319 Selaginella moellendorffii 54.21 0.00e+00 631.00
IUUC-Sit-110588 Setaria italica 60.80 0.00e+00 768.00
IUUC-Sly-111415 Solanum lycopersicum 63.96 0.00e+00 800.00
IUUC-Stu-112842 Solanum tuberosum 63.69 0.00e+00 790.00
IUUC-Sbi-114726 Sorghum bicolor 62.90 0.00e+00 759.00
IUUC-Sre-115182 Sporisorium reilianum 42.70 2.00e-32 132.00
IUUC-Ssc-116081 Sus scrofa 46.76 8.00e-43 168.00
IUUC-Tgu-116945 Taeniopygia guttata 46.51 2.00e-44 173.00
IUUC-Tru-117599 Takifugu rubripes 48.79 8.00e-44 171.00
IUUC-Tca-121614 Theobroma cacao 70.81 0.00e+00 866.00
IUUC-Tae-125473 Triticum aestivum 65.38 0.00e+00 713.00
IUUC-Tme-127149 Tuber melanosporum 46.51 1.00e-23 103.00
IUUC-Ttr-128215 Tursiops truncatus 33.33 8.00e-47 181.00
IUUC-Vvi-131413 Vitis vinifera 64.66 0.00e+00 820.00
IUUC-Xtr-132432 Xenopus tropicalis 34.40 1.00e-49 191.00
IUUC-Xma-133516 Xiphophorus maculatus 34.34 2.00e-47 183.00
Created Date 25-Jun-2017

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