iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067084

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAPE02031654

Gene Name

USP51

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000015717.2	ENSMLUT00000015717.2	ENSMLUP00000014316.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-88	297.5	360	702

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 360  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCIMT---SPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 444
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k        +         s  +e ++ +  +++i+++F g l+s+++c++c++vs++ +p +d+sl++p++
   Q: 445  DAHEFLIAILDVLHRHSKD-------D---------SVGQEANNFNCCNCIIDQIFTGGLQSDVTCQTCHSVSTTIDPCWDISLDLPSS 517
           *****************22.......2.........2234467889999**************************************98 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t ++                    sl+dcL+ ft++e+l +  k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 518  CATFNSqsteradgavsrndhipgipSLTDCLQWFTRPEHLGSGSKIKCSSCQSYQESTKQLTMKKLPIVACFHLKRF--EHLGKQRRK 604
           877766889999******************************************************************..66778999* PP
   S: 249  inkkvefpleLdlspfctspeekqke...........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           in+ ++fpleLd++pf++s++e+  +           ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l   
   Q: 605  INTFISFPLELDMTPFLASTKESRMKdgqpptdcapnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAVITKATIEDLLY-- 691
           ******************9666655578888888888**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 692  -SEGYLLFYHKQ 702
           .********985 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MAQVREASLP SASVVRWSSG GRGGASPVEA AVKAGEMEEE AAAARAMKAC AGREAAEVKL 60
QPLQERQPAP ENLPWRSSSR GEEKVLPSTP PRWLSSSSPL CPRRKPRPRP QPWARARGPP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCCAAG TTCGAGAAGC TTCCTTGCCC TCCGCCTCTG TGGTCCGCTG GAGCTCCGGA 60
GGTAGGGGAG GAGCCTCACC CGTGGAGGCG GCTGTGAAGG CTGGGGAGAT GGAGGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.15	4.00e-62	233.00
IUUC-Aml-001480	Ailuropoda melanoleuca	93.17	0.00e+00	991.00
IUUC-Acl-008124	Aspergillus clavatus	30.22	3.00e-54	206.00
IUUC-Afl-008464	Aspergillus flavus	33.57	2.00e-54	206.00
IUUC-Ani-009168	Aspergillus nidulans	30.49	3.00e-54	206.00
IUUC-Ang-009694	Aspergillus niger	32.74	2.00e-58	219.00
IUUC-Aor-010035	Aspergillus oryzae	35.71	1.00e-39	156.00
IUUC-Ate-010382	Aspergillus terreus	31.93	4.00e-52	198.00
IUUC-Bol-016509	Brassica oleracea	38.57	5.00e-74	272.00
IUUC-Csa-023824	Chlorocebus sabaeus	93.17	0.00e+00	993.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	29.92	1.00e-54	207.00
IUUC-Dse-031415	Dothistroma septosporum	29.35	2.00e-58	220.00
IUUC-Eca-033872	Equus caballus	87.05	0.00e+00	1027.00
IUUC-Fca-035534	Felis catus	88.36	0.00e+00	1013.00
IUUC-Gma-043933	Glycine max	35.27	9.00e-88	317.00
IUUC-Ggo-045109	Gorilla gorilla	91.76	0.00e+00	964.00
IUUC-Hsa-045765	Homo sapiens	92.56	0.00e+00	1004.00
IUUC-Hvu-047739	Hordeum vulgare	38.12	5.00e-68	251.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	93.56	0.00e+00	943.00
IUUC-Lpe-050969	Leersia perrieri	38.38	3.00e-70	259.00
IUUC-Lma-053105	Leptosphaeria maculans	31.69	1.00e-61	231.00
IUUC-Mcc-055420	Macaca mulatta	92.31	0.00e+00	1019.00
IUUC-Mor-057103	Magnaporthe oryzae	30.33	9.00e-55	207.00
IUUC-Mtr-057894	Medicago truncatula	36.36	2.00e-82	300.00
IUUC-Mla-059185	Melampsora laricipopulina	33.52	1.00e-42	167.00
IUUC-Mmr-061690	Microcebus murinus	93.03	0.00e+00	1013.00
IUUC-Mmu-063435	Mus musculus	79.43	0.00e+00	825.00
IUUC-Mac-065419	Musa acuminata	33.47	1.00e-73	270.00
IUUC-Mpu-065679	Mustela putorius furo	93.55	0.00e+00	978.00
IUUC-Nle-069859	Nomascus leucogenys	93.55	0.00e+00	1002.00
IUUC-Ocu-074365	Oryctolagus cuniculus	91.89	0.00e+00	960.00
IUUC-Ptr-091479	Pan troglodytes	92.74	0.00e+00	1009.00
IUUC-Pan-091707	Papio anubis	92.98	0.00e+00	989.00
IUUC-Pno-095141	Phaeosphaeria nodorum	30.96	1.00e-53	204.00
IUUC-Pab-097894	Pongo abelii	93.58	0.00e+00	1008.00
IUUC-Pgr-103657	Puccinia graminis	29.47	1.00e-38	154.00
IUUC-Pte-104340	Pyrenophora teres	31.59	7.00e-55	207.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	34.53	6.00e-63	234.00
IUUC-Rno-105644	Rattus norvegicus	80.15	0.00e+00	845.00
IUUC-Sar-113426	Sorex araneus	71.71	0.00e+00	833.00
IUUC-Ssc-115500	Sus scrofa	91.86	0.00e+00	977.00
IUUC-Tsy-119413	Tarsius syrichta	90.02	0.00e+00	976.00
IUUC-Tre-122139	Trichoderma reesei	31.05	5.00e-52	198.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence