iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000008098.3	ENSMMUT00000071159.1	ENSMMUP00000045606.1
ENSMMUG00000008098.3	ENSMMUT00000011318.3	ENSMMUP00000010606.3
ENSMMUG00000008098.3	ENSMMUT00000060176.1	ENSMMUP00000044340.1
ENSMMUG00000008098.3	ENSMMUT00000059447.1	ENSMMUP00000054700.1
ENSMMUG00000008098.3	ENSMMUT00000073418.1	ENSMMUP00000044084.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.20e-61	207.6	1892	2210

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           +Gl+Nlg+tCY+ S++Q+L++ipe r+++++ k++e++       ++++ l +lqk+f+ l++s+ ka++pr + k+  + ++ +++
   Q: 1892 VGLTNLGATCYLASTIQQLYMIPEARQAVFTaKYSEDM-------KHKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNT 1971
           6******************************3444444.......4568899*********************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            eq+D  Ef++ l+ ++ee                               + k++++ lF+g ++++++ l+c++vs++ e+f+++ 
   Q: 1972 GEQKDMTEFFTDLITKIEEMS----------------------------PELKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVR 2030
           *****************9977............................567899******************************** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLd 260
           ++v + +     ++ ++L++ t +++leg+n+y c++c kk++aek+  +kklP++L+++ +R++f+  ++++ek+n++++fpl+Ld
   Q: 2031 CQVADMK-----NIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLD 2112
           *******.....9************************************************************************** PP
   S: 261  lspfcts................peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdD.skVtevkeeevleetg... 327
           ++p++++                + +k++e+++Y+Li+v vH+G++++GHY++++++  +   + +     ++   +++  ++    
   Q: 2113 MTPYTEDflmgkserkegfkevnDHSKDSESYEYDLIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNkCFLKTFYRNKFMDFSFekt 2199
           *******99999999999999986666667***************************777754444404455556666666555677 PP
   S: 328  staYvlfYkrr 338
           ++aY+lfYkr+
   Q: 2200 HSAYMLFYKRM 2210
           99*******96 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

PCEGSYDFKE GVLSDVEGGD GLQLRKEHTL KIFTYINSWT QRQCLCCFKE YKHLEIFNQV 60
VCALINLVIA QVQVLRDQLC KHCTTINIDS TWQDESNQAE EPLNIDRECN EGSSERQKSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTGTGAAG GAAGCTATGA CTTCAAGGAA GGTGTATGCT CTGTGGCTAC TGCTGATACA 60
CCTGAGAGGA GTGCCATGAG ACTGGTTCTT GGAATACTAA GCTGGAGGCT AGAATCAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002257	Ailuropoda melanoleuca	97.48	0.00e+00	6741.00
IUUC-Apl-003284	Anas platyrhynchos	93.80	0.00e+00	6202.00
IUUC-Aca-004415	Anolis carolinensis	91.58	0.00e+00	6338.00
IUUC-Ani-009257	Aspergillus nidulans	26.53	6.00e-46	181.00
IUUC-Ame-011219	Astyanax mexicanus	63.22	0.00e+00	2390.00
IUUC-Bgr-012195	Blumeria graminis	25.46	2.00e-56	216.00
IUUC-Bta-012989	Bos taurus	97.18	0.00e+00	6697.00
IUUC-Bci-013798	Botrytis cinerea	31.17	9.00e-51	197.00
IUUC-Cja-018974	Callithrix jacchus	97.88	0.00e+00	830.00
IUUC-Cfa-021214	Canis familiaris	97.65	0.00e+00	6756.00
IUUC-Cpo-021912	Cavia porcellus	96.96	0.00e+00	4663.00
IUUC-Csa-023658	Chlorocebus sabaeus	98.70	0.00e+00	6823.00
IUUC-Cho-024971	Choloepus hoffmanni	83.06	0.00e+00	3130.00
IUUC-Cgl-026466	Colletotrichum gloeosporioides	26.89	4.00e-56	214.00
IUUC-Dre-027428	Danio rerio	83.65	0.00e+00	4536.00
IUUC-Dno-029690	Dasypus novemcinctus	96.70	0.00e+00	6554.00
IUUC-Dor-030817	Dipodomys ordii	88.85	0.00e+00	2155.00
IUUC-Dme-032102	Drosophila melanogaster	54.00	0.00e+00	848.00
IUUC-Ete-032552	Echinops telfairi	91.86	0.00e+00	2913.00
IUUC-Eca-033457	Equus caballus	97.44	0.00e+00	6440.00
IUUC-Eeu-035118	Erinaceus europaeus	93.70	0.00e+00	3051.00
IUUC-Fca-036213	Felis catus	95.07	0.00e+00	4979.00
IUUC-Fal-037643	Ficedula albicollis	91.25	0.00e+00	6295.00
IUUC-Fox-037971	Fusarium oxysporum	25.81	2.00e-53	205.00
IUUC-Ggr-040075	Gaeumannomyces graminis	31.03	6.00e-54	207.00
IUUC-Gga-040511	Gallus gallus	91.12	0.00e+00	6342.00
IUUC-Gac-042024	Gasterosteus aculeatus	86.82	0.00e+00	4928.00
IUUC-Ggo-044924	Gorilla gorilla	94.45	0.00e+00	6227.00
IUUC-Hsa-046913	Homo sapiens	98.39	0.00e+00	6815.00
IUUC-Itr-048626	Ictidomys tridecemlineatus	97.49	0.00e+00	6747.00
IUUC-Lch-049675	Latimeria chalumnae	85.21	0.00e+00	4800.00
IUUC-Loc-052832	Lepisosteus oculatus	85.51	0.00e+00	5863.00
IUUC-Lma-053130	Leptosphaeria maculans	26.07	4.00e-51	198.00
IUUC-Laf-054169	Loxodonta africana	95.75	0.00e+00	6675.00
IUUC-Meu-056327	Macropus eugenii	85.38	0.00e+00	1565.00
IUUC-Mor-057152	Magnaporthe oryzae	33.52	6.00e-54	207.00
IUUC-Mpo-057310	Magnaporthe poae	25.96	7.00e-52	201.00
IUUC-Mmr-060780	Microcebus murinus	97.66	0.00e+00	6771.00
IUUC-Mdo-062308	Monodelphis domestica	91.55	0.00e+00	6055.00
IUUC-Mmu-063457	Mus musculus	95.25	0.00e+00	6638.00
IUUC-Mpu-066917	Mustela putorius furo	95.30	0.00e+00	6536.00
IUUC-Mlu-067696	Myotis lucifugus	97.20	0.00e+00	6708.00
IUUC-Ncr-068911	Neurospora crassa	24.56	6.00e-52	201.00
IUUC-Nle-069586	Nomascus leucogenys	98.53	0.00e+00	6833.00
IUUC-Opr-070447	Ochotona princeps	91.77	0.00e+00	2797.00
IUUC-Ont-072396	Oreochromis niloticus	83.79	0.00e+00	5392.00
IUUC-Oan-073147	Ornithorhynchus anatinus	93.71	0.00e+00	6491.00
IUUC-Ocu-074324	Oryctolagus cuniculus	97.25	0.00e+00	6711.00
IUUC-Ola-086312	Oryzias latipes	81.29	0.00e+00	5204.00
IUUC-Oga-088878	Otolemur garnettii	97.71	0.00e+00	6762.00
IUUC-Oar-089919	Ovis aries	97.23	0.00e+00	6693.00
IUUC-Ptr-090713	Pan troglodytes	98.40	0.00e+00	6232.00
IUUC-Pan-091957	Papio anubis	98.65	0.00e+00	5090.00
IUUC-Psi-093240	Pelodiscus sinensis	92.68	0.00e+00	6405.00
IUUC-Pma-094469	Petromyzon marinus	71.89	0.00e+00	4005.00
IUUC-Pno-095059	Phaeosphaeria nodorum	28.01	9.00e-49	190.00
IUUC-Pfo-097159	Poecilia formosa	80.62	0.00e+00	5428.00
IUUC-Pab-098003	Pongo abelii	97.93	0.00e+00	6459.00
IUUC-Pca-100799	Procavia capensis	88.08	0.00e+00	1854.00
IUUC-Pva-103226	Pteropus vampyrus	91.93	0.00e+00	6287.00
IUUC-Pyt-104803	Pyrenophora triticirepentis	25.81	6.00e-51	196.00
IUUC-Rno-105389	Rattus norvegicus	95.30	0.00e+00	5457.00
IUUC-Sha-106979	Sarcophilus harrisii	93.54	0.00e+00	6465.00
IUUC-Sar-113444	Sorex araneus	90.20	0.00e+00	5867.00
IUUC-Ssc-115815	Sus scrofa	96.67	0.00e+00	5571.00
IUUC-Tgu-117470	Taeniopygia guttata	93.05	0.00e+00	6124.00
IUUC-Tru-118543	Takifugu rubripes	81.34	0.00e+00	5294.00
IUUC-Tsy-119081	Tarsius syrichta	96.69	0.00e+00	2571.00
IUUC-Tni-120294	Tetraodon nigroviridis	81.67	2.00e-164	572.00
IUUC-Tre-122057	Trichoderma reesei	28.57	1.00e-54	209.00
IUUC-Tvi-122570	Trichoderma virens	34.08	6.00e-52	201.00
IUUC-Tme-127154	Tuber melanosporum	26.17	2.00e-50	194.00
IUUC-Tbe-127801	Tupaia belangeri	85.18	0.00e+00	3233.00
IUUC-Ttr-129262	Tursiops truncatus	92.75	0.00e+00	6362.00
IUUC-Vda-129686	Verticillium dahliae	26.96	3.00e-52	201.00
IUUC-Vpa-130484	Vicugna pacos	94.83	0.00e+00	5206.00
IUUC-Xtr-131769	Xenopus tropicalis	85.29	0.00e+00	5952.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence