iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059754

UUCD1 version

UUC-MeG-00360

Ensembl Protein ID

ENSMGAP00000007746.2

UniProt Accession

G1N6L9; G1N6L9_MELGA

Protein Name

Uncharacterized protein

Gene Name

CUL4B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000007563.2	ENSMGAT00000008527.2	ENSMGAP00000007746.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.80e-220	733.5	187	783

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkif 87
           kl+eav++i++++s+k+++eely+av+nlc++k++a+lYk+l++++e++i +q+++ +e+s d+  +Lk++ ++W+++++q+ ++r+if
   Q: 187  KLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIkAQIHQFREDSLDSVlFLKKIDKCWQDHCRQMIMIRSIF 275
           589***********************************************99************************************* PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++++ ++++++l+l+r++i++d  +++++++ +l lie+eR+gea+dr+ll+++ ++l++L     +iy++sFE +fle
   Q: 276  LFLDRTYVLQNSMLPSIWDMGLELFRTHIISDqkVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDL-----QIYQDSFEHRFLE 359
           ********************************9**********************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
           +t+++y+ae ++++qe+ev eYl++v++rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++ +dls++y+L+
   Q: 360  ETNRLYAAEGQRLMQEREVPEYLHHVNKRLEEEADRIITYLDQSTQKPLIATVEKQLLGEHLTAILqKGLNHLLDENRIQDLSLLYQLF 448
           ****************************************************************9989********************* PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           srv+ g++ ll+++ ++ik  g+++++++ek+k+   +V++ll++k+k++++++ +F +++kF++a+++afetf+nk+     +++p E
   Q: 449  SRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDKT---MVQELLDFKDKVDHIIDVCFLKNEKFVNAMKEAFETFINKR-----PNKPaE 529
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           l+A+y+D++Lr+++k++t+eele++ldk++++f++i +kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+
   Q: 530  LIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 618
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFk.eekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelk 527
           d+++S+d+++qFk + ++n++   ++el+v++L++g+Wpt+  +e v+LP+e+ k++e+f++fYl khsgRkLqWq tlg++ lkae+k
   Q: 619  DMELSKDIMIQFKqQYMQNQNVPGNIELTVNILTMGYWPTYVPME-VHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFK 706
           *************5568999999********************99.******************************************* PP
   S: 528  kgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           +gk+elqVs fQ++vLL+fn+ e++s+ee+k+at++++ eLrrtlqsL+++k++vl+k+p++k++e++d+f++N++f
   Q: 707  EGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLTKSPKGKDVEDGDKFTCNDDF 783
           ***************************************************************************98 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

TGFSSPNPSA AAQEVRPATD GSSGSSSSCK KRKLNNSNSE REEFDSISSC SSSPSKNNSS 60
SSSLVITASS CSSSGVASSN HHLQKKLRFE DSLDFIGLDV KMAEESSSSS SPAASSQQQH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGGTTTCT CTTCCCCCAA CCCCTCCGCT GCAGCTCAGG AGGTCAGGCC TGCCACTGAT 60
GGTAGTAGCG GCAGCAGCTC CTCCTGCAAG AAGAGAAAGT TAAATAACAG CAACTCCGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0003684--F:damaged DNA binding
GO:0035518--P:histone H2A monoubiquitination
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0045732--P:positive regulation of protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0070914--P:UV-damage excision repair

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000285	Aegilops tauschii	57.46	0.00e+00	833.00
IUUC-Aml-002062	Ailuropoda melanoleuca	89.60	0.00e+00	1513.00
IUUC-Atr-002727	Amborella trichopoda	58.40	0.00e+00	816.00
IUUC-Apl-004157	Anas platyrhynchos	94.12	0.00e+00	1589.00
IUUC-Aca-004430	Anolis carolinensis	90.49	0.00e+00	1496.00
IUUC-Aly-006547	Arabidopsis lyrata	57.97	0.00e+00	822.00
IUUC-Ath-006748	Arabidopsis thaliana	57.49	0.00e+00	815.00
IUUC-Acl-008359	Aspergillus clavatus	36.18	1.00e-125	443.00
IUUC-Afl-008567	Aspergillus flavus	38.27	4.00e-135	475.00
IUUC-Afu-008833	Aspergillus fumigatus	38.18	2.00e-131	463.00
IUUC-Ani-009373	Aspergillus nidulans	39.06	7.00e-137	481.00
IUUC-Ang-009622	Aspergillus niger	39.74	3.00e-134	472.00
IUUC-Aor-010241	Aspergillus oryzae	38.12	1.00e-131	463.00
IUUC-Ate-010251	Aspergillus terreus	39.45	7.00e-139	487.00
IUUC-Ame-011580	Astyanax mexicanus	89.88	0.00e+00	1439.00
IUUC-Bgr-012219	Blumeria graminis	37.01	1.00e-115	410.00
IUUC-Bta-013244	Bos taurus	89.61	0.00e+00	1512.00
IUUC-Bci-013744	Botrytis cinerea	39.12	2.00e-127	449.00
IUUC-Bdi-014223	Brachypodium distachyon	55.66	0.00e+00	831.00
IUUC-Bol-016036	Brassica oleracea	58.62	0.00e+00	842.00
IUUC-Bra-016615	Brassica rapa	57.92	0.00e+00	844.00
IUUC-Cja-019180	Callithrix jacchus	90.23	0.00e+00	1507.00
IUUC-Cfa-021189	Canis familiaris	90.03	0.00e+00	1520.00
IUUC-Cpo-021928	Cavia porcellus	89.60	0.00e+00	1510.00
IUUC-Cre-022739	Chlamydomonas reinhardtii	47.10	9.00e-179	620.00
IUUC-Csa-023831	Chlorocebus sabaeus	90.23	0.00e+00	1505.00
IUUC-Cin-025727	Ciona intestinalis	63.90	0.00e+00	776.00
IUUC-Csv-026117	Ciona savignyi	53.93	0.00e+00	860.00
IUUC-Cgl-026761	Colletotrichum gloeosporioides	39.72	4.00e-125	441.00
IUUC-Cme-027355	Cyanidioschyzon merolae	31.75	9.00e-110	390.00
IUUC-Dre-027916	Danio rerio	90.05	0.00e+00	1428.00
IUUC-Dno-029483	Dasypus novemcinctus	81.29	0.00e+00	1364.00
IUUC-Dse-031159	Dothistroma septosporum	37.45	3.00e-123	435.00
IUUC-Dme-031652	Drosophila melanogaster	66.05	0.00e+00	950.00
IUUC-Ete-032775	Echinops telfairi	80.38	0.00e+00	1234.00
IUUC-Eca-033952	Equus caballus	88.96	0.00e+00	1477.00
IUUC-Eeu-034767	Erinaceus europaeus	84.93	0.00e+00	1370.00
IUUC-Fca-036211	Felis catus	95.26	0.00e+00	1453.00
IUUC-Fal-037248	Ficedula albicollis	97.18	0.00e+00	1573.00
IUUC-Fox-037854	Fusarium oxysporum	39.03	1.00e-122	433.00
IUUC-Fso-038138	Fusarium solani	39.12	2.00e-125	442.00
IUUC-Gmo-038754	Gadus morhua	83.39	0.00e+00	1432.00
IUUC-Ggr-040003	Gaeumannomyces graminis	36.82	5.00e-106	378.00
IUUC-Gga-041002	Gallus gallus	99.43	0.00e+00	1619.00
IUUC-Gac-041555	Gasterosteus aculeatus	89.29	0.00e+00	1420.00
IUUC-Gma-043960	Glycine max	59.94	0.00e+00	852.00
IUUC-Ggo-045468	Gorilla gorilla	89.87	0.00e+00	1442.00
IUUC-Hsa-046848	Homo sapiens	90.23	0.00e+00	1508.00
IUUC-Itr-048365	Ictidomys tridecemlineatus	89.40	0.00e+00	1506.00
IUUC-Lch-049858	Latimeria chalumnae	88.44	0.00e+00	1517.00
IUUC-Lpe-051446	Leersia perrieri	56.75	0.00e+00	828.00
IUUC-Loc-052415	Lepisosteus oculatus	86.36	0.00e+00	1456.00
IUUC-Lma-053080	Leptosphaeria maculans	37.26	1.00e-134	473.00
IUUC-Laf-053701	Loxodonta africana	88.84	0.00e+00	1495.00
IUUC-Mcc-055538	Macaca mulatta	88.18	0.00e+00	1460.00
IUUC-Mor-057102	Magnaporthe oryzae	36.28	2.00e-118	419.00
IUUC-Mpo-057342	Magnaporthe poae	37.91	2.00e-105	376.00
IUUC-Mtr-058660	Medicago truncatula	58.65	0.00e+00	843.00
IUUC-Mla-058936	Melampsora laricipopulina	39.76	7.00e-114	404.00
IUUC-Mvi-060455	Microbotryum violaceum	41.77	1.00e-145	509.00
IUUC-Mmr-060870	Microcebus murinus	89.04	0.00e+00	1496.00
IUUC-Mdo-062015	Monodelphis domestica	93.40	0.00e+00	1477.00
IUUC-Mmu-063751	Mus musculus	93.41	0.00e+00	1483.00
IUUC-Mac-064443	Musa acuminata	56.72	0.00e+00	847.00
IUUC-Mpu-065903	Mustela putorius furo	89.82	0.00e+00	1519.00
IUUC-Mlu-068213	Myotis lucifugus	89.61	0.00e+00	1519.00
IUUC-Nfi-068363	Neosartorya fischeri	38.55	1.00e-133	470.00
IUUC-Ncr-068950	Neurospora crassa	36.46	1.00e-117	417.00
IUUC-Nle-069480	Nomascus leucogenys	90.23	0.00e+00	1505.00
IUUC-Opr-071164	Ochotona princeps	75.36	8.00e-141	493.00
IUUC-Ont-071562	Oreochromis niloticus	81.88	0.00e+00	1259.00
IUUC-Oan-073607	Ornithorhynchus anatinus	97.63	0.00e+00	1520.00
IUUC-Ocu-074446	Oryctolagus cuniculus	89.93	0.00e+00	1520.00
IUUC-Oba-075198	Oryza barthii	57.02	0.00e+00	831.00
IUUC-Obr-076095	Oryza brachyantha	57.02	0.00e+00	832.00
IUUC-Ogl-077032	Oryza glaberrima	57.02	0.00e+00	832.00
IUUC-Ogu-078051	Oryza glumaepatula	57.46	0.00e+00	832.00
IUUC-Oin-079399	Oryza indica	52.62	0.00e+00	731.00
IUUC-Olo-080988	Oryza longistaminata	56.19	0.00e+00	823.00
IUUC-Ome-081600	Oryza meridionalis	56.19	0.00e+00	823.00
IUUC-Oni-082623	Oryza nivara	56.33	0.00e+00	823.00
IUUC-Opu-083762	Oryza punctata	56.06	0.00e+00	823.00
IUUC-Oru-084499	Oryza rufipogon	57.02	0.00e+00	831.00
IUUC-Ola-087157	Oryzias latipes	84.91	0.00e+00	1442.00
IUUC-Olu-087650	Ostreococcus lucimarinus	48.36	3.00e-180	624.00
IUUC-Oga-088416	Otolemur garnettii	88.35	0.00e+00	1466.00
IUUC-Oar-090230	Ovis aries	89.72	0.00e+00	1514.00
IUUC-Ptr-091153	Pan troglodytes	94.88	0.00e+00	1501.00
IUUC-Pan-091729	Papio anubis	90.23	0.00e+00	1505.00
IUUC-Psi-093773	Pelodiscus sinensis	95.57	0.00e+00	1559.00
IUUC-Pma-094678	Petromyzon marinus	85.76	0.00e+00	1058.00
IUUC-Pno-094946	Phaeosphaeria nodorum	36.17	1.00e-111	397.00
IUUC-Ppa-095688	Physcomitrella patens	59.79	0.00e+00	893.00
IUUC-Pfo-096828	Poecilia formosa	90.65	0.00e+00	1441.00
IUUC-Pab-097816	Pongo abelii	82.27	0.00e+00	1326.00
IUUC-Pca-100858	Procavia capensis	69.80	0.00e+00	1065.00
IUUC-Ppe-101142	Prunus persica	59.27	0.00e+00	860.00
IUUC-Pva-102995	Pteropus vampyrus	83.16	0.00e+00	1390.00
IUUC-Pgr-103334	Puccinia graminis	37.84	6.00e-106	378.00
IUUC-Ptt-103903	Puccinia triticina	41.16	1.00e-95	343.00
IUUC-Pte-104167	Pyrenophora teres	36.84	3.00e-133	468.00
IUUC-Pyt-104736	Pyrenophora triticirepentis	36.79	1.00e-132	466.00
IUUC-Rno-106119	Rattus norvegicus	94.27	0.00e+00	1498.00
IUUC-Sha-106958	Sarcophilus harrisii	90.14	0.00e+00	1504.00
IUUC-Sja-107940	Schizosaccharomyces japonicus	33.11	1.00e-110	394.00
IUUC-Spo-108109	Schizosaccharomyces pombe	33.80	1.00e-110	394.00
IUUC-Ssl-108537	Sclerotinia sclerotiorum	38.87	3.00e-128	452.00
IUUC-Smo-108872	Selaginella moellendorffii	60.00	0.00e+00	910.00
IUUC-Sit-110626	Setaria italica	56.97	0.00e+00	833.00
IUUC-Sly-111497	Solanum lycopersicum	59.52	0.00e+00	860.00
IUUC-Sar-113581	Sorex araneus	83.23	0.00e+00	1020.00
IUUC-Sbi-113931	Sorghum bicolor	56.97	0.00e+00	835.00
IUUC-Sre-114943	Sporisorium reilianum	39.64	2.00e-129	456.00
IUUC-Tgu-116462	Taeniopygia guttata	96.73	0.00e+00	1565.00
IUUC-Tru-118299	Takifugu rubripes	90.14	0.00e+00	1440.00
IUUC-Tsy-119517	Tarsius syrichta	98.29	0.00e+00	712.00
IUUC-Tni-120811	Tetraodon nigroviridis	88.61	0.00e+00	1408.00
IUUC-Tca-121626	Theobroma cacao	59.69	0.00e+00	848.00
IUUC-Tre-121907	Trichoderma reesei	39.23	3.00e-125	442.00
IUUC-Tae-123442	Triticum aestivum	57.46	0.00e+00	832.00
IUUC-Tur-126032	Triticum urartu	57.46	0.00e+00	832.00
IUUC-Tme-127162	Tuber melanosporum	41.40	1.00e-139	490.00
IUUC-Tbe-127658	Tupaia belangeri	87.15	0.00e+00	1416.00
IUUC-Ttr-129112	Tursiops truncatus	81.88	0.00e+00	1339.00
IUUC-Uma-129531	Ustilago maydis	37.86	2.00e-110	392.00
IUUC-Vda-129701	Verticillium dahliae	39.48	4.00e-134	471.00
IUUC-Vpa-130217	Vicugna pacos	86.77	0.00e+00	1338.00
IUUC-Vvi-131133	Vitis vinifera	59.89	0.00e+00	860.00
IUUC-Xtr-132724	Xenopus tropicalis	93.52	0.00e+00	1479.00
IUUC-Xma-134149	Xiphophorus maculatus	90.76	0.00e+00	1452.00
IUUC-Zma-135529	Zea mays	57.10	0.00e+00	835.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence