iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055591

Ensembl Protein ID

ENSMMUP00000008896.3

UniProt Accession

H9EN45; F7HCZ9; H9EN45_MACMU

Genbank Protein ID

AFE63804.1; AFE63805.1; AFH28142.1; AFH28143.1; AFI35525.1

Protein Name

Regulatory-associated protein of mTOR isoform 1

Genbank Nucleotide ID

JSUE03017609; JU320049; JU471338; JU471339; JV045454

Gene Name

RPTOR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000006761.3	ENSMMUT00000009463.3	ENSMMUP00000008896.3
ENSMMUG00000006761.3	ENSMMUT00000017948.3	ENSMMUP00000016807.3
ENSMMUG00000006761.3	ENSMMUT00000017943.3	ENSMMUP00000016802.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-14	54.6	1302	1330

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf.sd.tllvsGsdDgtikvWDl 30
           + ++claf +  ++l++Gs+D  i v+++
   Q: 1302 GAISCLAFhPHwPHLAVGSNDYYISVYSV 1330
           679******888**************997 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MESEMLQSPL LGLGEEDEAD LTDWNLPLAF MKKRHCEKIE GSKSLAQSWR MKDRMKTVSV 60
ALVLCLNVGV DPPDVVKTTP CARLECWIDP LSMGPQKALE TIGANLQKQY ENWQPRARYK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGTGCATTC TGGGTCCTGG CAATATGGCG TCCTCCTTGA TGTGCTGATG AGATGAGTTT 60
CCCTGTAGCT CCAAACCAGA GGGCAAAGCT CCCCTGACCC AGTAAGCCCT CATTGTCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR029030--Caspase-like_dom
IPR000357--HEAT
IPR004083--Raptor
IPR029347--Raptor_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50294--WD_REPEATS_REGION

Pfam

PF02985--HEAT
PF14538--Raptor_N
PF00400--WD40

SMART

SM01302--Raptor_N
SM00320--WD40

Gene Ontology

GO:0010494--C:cytoplasmic stress granule
GO:0005829--C:cytosol
GO:0005765--C:lysosomal membrane
GO:0005654--C:nucleoplasm
GO:0031931--C:TORC1 complex
GO:0030295--F:protein kinase activator activity
GO:0030291--F:protein serine/threonine kinase inhibitor activity
GO:0001030--F:RNA polymerase III type 1 promoter DNA binding
GO:0001031--F:RNA polymerase III type 2 promoter DNA binding
GO:0001032--F:RNA polymerase III type 3 promoter DNA binding
GO:0016049--P:cell growth
GO:0071230--P:cellular response to amino acid stimulus
GO:0031669--P:cellular response to nutrient levels
GO:0030307--P:positive regulation of cell growth
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0032008--P:positive regulation of TOR signaling
GO:0045945--P:positive regulation of transcription from RNA polymerase III promoter
GO:0008361--P:regulation of cell size
GO:0038202--P:TORC1 signaling

KEGG

mcc:712848

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000354	Aegilops tauschii	57.30	0.00e+00	673.00
IUUC-Aml-001499	Ailuropoda melanoleuca	96.10	0.00e+00	2544.00
IUUC-Atr-002704	Amborella trichopoda	59.91	0.00e+00	734.00
IUUC-Apl-003540	Anas platyrhynchos	93.77	0.00e+00	2500.00
IUUC-Aca-004449	Anolis carolinensis	95.31	0.00e+00	1363.00
IUUC-Aly-006524	Arabidopsis lyrata	59.02	0.00e+00	761.00
IUUC-Ath-007688	Arabidopsis thaliana	40.84	0.00e+00	882.00
IUUC-Ago-007709	Ashbya gossypii	56.47	7.00e-118	419.00
IUUC-Acl-008215	Aspergillus clavatus	55.98	0.00e+00	769.00
IUUC-Afl-008401	Aspergillus flavus	54.65	0.00e+00	769.00
IUUC-Afu-008797	Aspergillus fumigatus	56.27	0.00e+00	772.00
IUUC-Ani-009268	Aspergillus nidulans	57.19	0.00e+00	762.00
IUUC-Ang-009608	Aspergillus niger	56.20	0.00e+00	762.00
IUUC-Aor-009894	Aspergillus oryzae	54.65	0.00e+00	769.00
IUUC-Ate-010357	Aspergillus terreus	56.27	0.00e+00	770.00
IUUC-Ame-011186	Astyanax mexicanus	85.96	0.00e+00	2111.00
IUUC-Bgr-012085	Blumeria graminis	52.51	0.00e+00	674.00
IUUC-Bta-013422	Bos taurus	96.63	0.00e+00	2581.00
IUUC-Bci-013736	Botrytis cinerea	54.53	0.00e+00	712.00
IUUC-Bdi-015042	Brachypodium distachyon	49.62	0.00e+00	706.00
IUUC-Bol-016048	Brassica oleracea	59.11	0.00e+00	763.00
IUUC-Bra-016961	Brassica rapa	57.16	0.00e+00	777.00
IUUC-Cel-018321	Caenorhabditis elegans	45.31	2.00e-100	361.00
IUUC-Cja-018939	Callithrix jacchus	98.58	0.00e+00	2607.00
IUUC-Cfa-020898	Canis familiaris	96.18	0.00e+00	2551.00
IUUC-Cpo-021514	Cavia porcellus	97.08	0.00e+00	2569.00
IUUC-Cre-022818	Chlamydomonas reinhardtii	63.64	8.00e-111	392.00
IUUC-Csa-023314	Chlorocebus sabaeus	100.00	0.00e+00	2651.00
IUUC-Cin-025701	Ciona intestinalis	71.35	0.00e+00	1002.00
IUUC-Csv-026362	Ciona savignyi	72.09	0.00e+00	995.00
IUUC-Cgl-026561	Colletotrichum gloeosporioides	54.23	0.00e+00	679.00
IUUC-Cne-027009	Cryptococcus neoformans	47.87	0.00e+00	668.00
IUUC-Cme-027253	Cyanidioschyzon merolae	56.36	2.00e-137	484.00
IUUC-Dre-028485	Danio rerio	85.71	0.00e+00	2364.00
IUUC-Dno-029901	Dasypus novemcinctus	93.85	0.00e+00	2307.00
IUUC-Dor-030140	Dipodomys ordii	92.54	0.00e+00	2268.00
IUUC-Dse-031462	Dothistroma septosporum	50.00	0.00e+00	692.00
IUUC-Dme-031670	Drosophila melanogaster	64.23	0.00e+00	867.00
IUUC-Ete-032578	Echinops telfairi	73.78	0.00e+00	771.00
IUUC-Eca-034076	Equus caballus	96.70	0.00e+00	2578.00
IUUC-Eeu-035140	Erinaceus europaeus	92.75	0.00e+00	1167.00
IUUC-Fca-035651	Felis catus	96.33	0.00e+00	2561.00
IUUC-Fal-037244	Ficedula albicollis	93.86	0.00e+00	2461.00
IUUC-Fox-037742	Fusarium oxysporum	54.17	0.00e+00	683.00
IUUC-Fso-038369	Fusarium solani	55.50	0.00e+00	633.00
IUUC-Gmo-039007	Gadus morhua	79.62	0.00e+00	1810.00
IUUC-Ggr-039836	Gaeumannomyces graminis	53.56	0.00e+00	692.00
IUUC-Gga-041121	Gallus gallus	92.58	0.00e+00	2507.00
IUUC-Gac-041430	Gasterosteus aculeatus	87.46	0.00e+00	2329.00
IUUC-Gma-043160	Glycine max	42.15	0.00e+00	899.00
IUUC-Ggo-044934	Gorilla gorilla	99.86	0.00e+00	1434.00
IUUC-Hsa-045887	Homo sapiens	99.70	0.00e+00	2642.00
IUUC-Hvu-047823	Hordeum vulgare	42.44	0.00e+00	805.00
IUUC-Itr-048274	Ictidomys tridecemlineatus	96.66	0.00e+00	789.00
IUUC-Kpa-049399	Komagataella pastoris	59.26	7.00e-125	442.00
IUUC-Lch-050405	Latimeria chalumnae	90.87	0.00e+00	2469.00
IUUC-Lpe-050864	Leersia perrieri	64.39	2.00e-151	529.00
IUUC-Loc-051868	Lepisosteus oculatus	83.58	0.00e+00	2269.00
IUUC-Lma-052993	Leptosphaeria maculans	52.54	0.00e+00	756.00
IUUC-Laf-053339	Loxodonta africana	96.51	0.00e+00	1852.00
IUUC-Meu-056642	Macropus eugenii	85.30	0.00e+00	1202.00
IUUC-Mor-057204	Magnaporthe oryzae	53.38	0.00e+00	704.00
IUUC-Mpo-057532	Magnaporthe poae	53.39	0.00e+00	690.00
IUUC-Mtr-058553	Medicago truncatula	42.29	0.00e+00	915.00
IUUC-Mla-058907	Melampsora laricipopulina	44.64	1.00e-150	528.00
IUUC-Mga-059256	Meleagris gallopavo	94.17	0.00e+00	2519.00
IUUC-Mvi-060457	Microbotryum violaceum	49.66	0.00e+00	665.00
IUUC-Mmr-060874	Microcebus murinus	94.21	0.00e+00	2482.00
IUUC-Mdo-062436	Monodelphis domestica	93.79	0.00e+00	2504.00
IUUC-Mmu-063264	Mus musculus	96.78	0.00e+00	2620.00
IUUC-Mac-065524	Musa acuminata	41.96	0.00e+00	838.00
IUUC-Mpu-065899	Mustela putorius furo	94.94	0.00e+00	2332.00
IUUC-Mlu-067344	Myotis lucifugus	94.37	0.00e+00	1915.00
IUUC-Nfi-068615	Neosartorya fischeri	56.27	0.00e+00	771.00
IUUC-Ncr-068744	Neurospora crassa	53.67	0.00e+00	679.00
IUUC-Nle-069014	Nomascus leucogenys	99.10	0.00e+00	2619.00
IUUC-Opr-070548	Ochotona princeps	84.74	0.00e+00	1337.00
IUUC-Ont-072485	Oreochromis niloticus	88.32	0.00e+00	2357.00
IUUC-Oan-073253	Ornithorhynchus anatinus	91.64	0.00e+00	689.00
IUUC-Ocu-074290	Oryctolagus cuniculus	93.98	0.00e+00	813.00
IUUC-Oba-075130	Oryza barthii	48.79	0.00e+00	712.00
IUUC-Obr-076161	Oryza brachyantha	49.94	0.00e+00	756.00
IUUC-Ogl-077800	Oryza glaberrima	51.88	0.00e+00	752.00
IUUC-Ogu-078292	Oryza glumaepatula	64.66	4.00e-47	181.00
IUUC-Oin-080126	Oryza indica	47.45	0.00e+00	648.00
IUUC-Olo-080598	Oryza longistaminata	33.92	8.00e-36	145.00
IUUC-Ome-081293	Oryza meridionalis	48.35	7.00e-141	495.00
IUUC-Oni-082236	Oryza nivara	58.63	3.00e-83	303.00
IUUC-Opu-083423	Oryza punctata	51.33	0.00e+00	741.00
IUUC-Oru-085086	Oryza rufipogon	49.13	0.00e+00	686.00
IUUC-Osa-086012	Oryza sativa	51.12	0.00e+00	720.00
IUUC-Ola-086662	Oryzias latipes	86.57	0.00e+00	2024.00
IUUC-Olu-087760	Ostreococcus lucimarinus	39.11	0.00e+00	808.00
IUUC-Oga-088053	Otolemur garnettii	96.94	0.00e+00	2439.00
IUUC-Oar-089466	Ovis aries	92.72	0.00e+00	2552.00
IUUC-Ptr-090868	Pan troglodytes	98.95	0.00e+00	2631.00
IUUC-Pan-092259	Papio anubis	100.00	0.00e+00	2651.00
IUUC-Psi-093641	Pelodiscus sinensis	93.18	0.00e+00	2331.00
IUUC-Pno-094789	Phaeosphaeria nodorum	52.24	0.00e+00	717.00
IUUC-Ppa-095979	Physcomitrella patens	58.43	0.00e+00	757.00
IUUC-Pfo-096837	Poecilia formosa	86.55	0.00e+00	2354.00
IUUC-Pab-097545	Pongo abelii	99.57	0.00e+00	1308.00
IUUC-Pop-099059	Populus trichocarpa	62.18	0.00e+00	753.00
IUUC-Pca-100579	Procavia capensis	70.07	1.00e-178	620.00
IUUC-Ppe-101494	Prunus persica	58.40	0.00e+00	784.00
IUUC-Pva-103245	Pteropus vampyrus	85.32	0.00e+00	1808.00
IUUC-Pgr-103460	Puccinia graminis	47.12	5.00e-49	190.00
IUUC-Ptt-103797	Puccinia triticina	35.21	6.00e-65	243.00
IUUC-Pte-104367	Pyrenophora teres	53.09	0.00e+00	747.00
IUUC-Pyt-104771	Pyrenophora triticirepentis	50.36	0.00e+00	696.00
IUUC-Rno-104965	Rattus norvegicus	96.93	0.00e+00	2622.00
IUUC-Sce-106156	Saccharomyces cerevisiae	55.61	2.00e-119	424.00
IUUC-Sha-106474	Sarcophilus harrisii	93.47	0.00e+00	1992.00
IUUC-Sja-107888	Schizosaccharomyces japonicus	57.83	0.00e+00	771.00
IUUC-Spo-108057	Schizosaccharomyces pombe	56.94	0.00e+00	755.00
IUUC-Ssl-108423	Sclerotinia sclerotiorum	54.53	0.00e+00	717.00
IUUC-Smo-109363	Selaginella moellendorffii	57.70	0.00e+00	778.00
IUUC-Sit-109884	Setaria italica	41.40	0.00e+00	863.00
IUUC-Sly-110910	Solanum lycopersicum	56.29	0.00e+00	771.00
IUUC-Stu-112814	Solanum tuberosum	55.87	0.00e+00	761.00
IUUC-Sbi-114349	Sorghum bicolor	58.45	0.00e+00	743.00
IUUC-Sre-115168	Sporisorium reilianum	42.83	0.00e+00	683.00
IUUC-Ssc-115398	Sus scrofa	93.25	0.00e+00	1909.00
IUUC-Tgu-117361	Taeniopygia guttata	93.22	0.00e+00	2407.00
IUUC-Tsy-119587	Tarsius syrichta	99.46	0.00e+00	1161.00
IUUC-Tni-119757	Tetraodon nigroviridis	86.16	0.00e+00	2300.00
IUUC-Tca-121570	Theobroma cacao	62.61	0.00e+00	762.00
IUUC-Tre-122024	Trichoderma reesei	56.32	0.00e+00	641.00
IUUC-Tvi-122502	Trichoderma virens	55.83	0.00e+00	645.00
IUUC-Tae-125799	Triticum aestivum	58.18	0.00e+00	754.00
IUUC-Tme-127001	Tuber melanosporum	55.67	1.00e-154	540.00
IUUC-Ttr-129128	Tursiops truncatus	87.49	0.00e+00	2254.00
IUUC-Uma-129588	Ustilago maydis	45.05	0.00e+00	685.00
IUUC-Vda-129990	Verticillium dahliae	53.58	1.00e-179	624.00
IUUC-Vvi-131611	Vitis vinifera	42.15	0.00e+00	914.00
IUUC-Xtr-132727	Xenopus tropicalis	91.14	0.00e+00	2443.00
IUUC-Xma-133492	Xiphophorus maculatus	87.96	0.00e+00	2377.00
IUUC-Yli-134358	Yarrowia lipolytica	55.64	0.00e+00	697.00
IUUC-Zma-135723	Zea mays	57.62	0.00e+00	677.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence