iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042528

UUCD1 version

UUC-GaA-01263

Ensembl Protein ID

ENSGACP00000013007.1

UniProt Accession

G3P5Y4; G3P5Y4_GASAC

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000009840.1	ENSGACT00000013032.1	ENSGACP00000013007.1
ENSGACG00000009840.1	ENSGACT00000013040.1	ENSGACP00000013015.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.70e-59	200.7	341	851
UBD/Alpha-Helix/UBA	9.00e-19	67.4	721	758

Active Site

Position(s)	Description	Evidence
350	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
814	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk....................avs 69
           tG+kNlgN+CY+NSv+Q+L+ +p++++ + + +  k+ +e+p++p++++ ++++kl   l++++ +                     ++
   Q: 341  TGMKNLGNSCYLNSVMQVLFTVPDFQNKYVS-NIDKIIDEAPSDPTQDFKTQVAKLGYGLLSGEYSkpapdpadengaseprgdqiGIA 428
           7******************************.888888999*******************63333333455666666666666777*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ +++ + efs+++qqDaqEfl ++++ +e+++                             ++ s  s+ F++ ++++i+c++
   Q: 429  PRMFKALVGRGHAEFSTNRQQDAQEFLLHFINMVERNC-----------------------------RSGSNPSEAFRFLVEERIVCQQ 488
           **************************************.............................6778899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke.......................slqdcLesftkeeelegenkyycekckkkqeaekklklk 224
            ++ + ++   + ++lpvp+++ t++e                        ++ c+++ +++e l++   ++++  ++k++a+k++++ 
   Q: 489  SQKAKYTQRVDYIVQLPVPMDQATNTEelqeaerrreegdssaptvraqiPFTACMAALSEPEILTD---FWSSAVQSKTTATKTTRFA 574
           **********************99999***************************************7...******************* PP
   S: 225  klPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.............................................. 267
           ++P+ L++++k+f+f  + ++++k++ ++++p++Ldls   ++                                              
   Q: 575  SFPDHLVIQIKKFTFGLD-WVPKKLDVSIDVPDTLDLSALRATgqqpgeellpevappplmtpdvekafvswdlsysilddstvsqlce 662
           ***************997.*******************988885666666666666666666666666666666666666666666666 PP
   S: 268  ....................................................peekqke.............................. 274
                                                               p     +                              
   Q: 663  mgfpleacrkavyytgntgidaamnwimshmddpdfaaplvlpgcssgpgttP-----Teslseehlativsmgfsrdqatkalratsn 746
           66666666666666655555555555555555555555555555555555551.....0555556666666666666666666677777 PP
   S: 275  ...............................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVt 315
                                                            kYeL+a v+H+G s+ +GHYv+++k+ +++W+ f+D+kV 
   Q: 747  vleravdwifshlddlesmdvseggrsaaeseggrdppppgprvkdgAGKYELFAFVSHMGtSTMCGHYVCHIKK-DQQWVIFNDQKVC 834
           777777777777777777777777778888888888888888888889***************************.999*********9 PP
   S: 316  evkeeevleetgstaYvlfYkr 337
           ++  e+  +   + +Y++fY+r
   Q: 835  AS--EKPPK---DLGYLYFYRR 851
           99..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ l+ +v+MGF+r++a +aLra++n le+Av++++++
   Q: 721  EEHLATIVSMGFSRDQATKALRATSNVLERAVDWIFSH 758
           7889********************************97 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

LEPRGGGDGA DGGERGGTKL VMAEVGEVLM SVLSTIRVPK PGDRVHKDEC ALSFSSPESE 60
GGLYVCMNTF LGFGSQYVDR YHARTGQRAY LHITRIRKAK KEDDNSSGSG HPPKKKPTRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGAACCCC GCGGAGGGGG AGACGGAGCA GATGGGGGGG AGAGAGGTGG GACTAAAGGA 60
AATAGTTGGG GAGTGAAGGA GAGTGCAATG AAGAAAGTAT ACAGTATGAT GTAATGGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	40.94	2.00e-172	598.00
IUUC-Aml-002104	Ailuropoda melanoleuca	65.06	0.00e+00	1125.00
IUUC-Atr-002580	Amborella trichopoda	43.98	0.00e+00	686.00
IUUC-Apl-003774	Anas platyrhynchos	65.16	0.00e+00	1095.00
IUUC-Aca-005368	Anolis carolinensis	66.19	0.00e+00	1159.00
IUUC-Aly-005727	Arabidopsis lyrata	45.05	0.00e+00	696.00
IUUC-Ath-006974	Arabidopsis thaliana	45.29	0.00e+00	699.00
IUUC-Ago-007890	Ashbya gossypii	26.60	4.00e-72	266.00
IUUC-Acl-008057	Aspergillus clavatus	35.42	1.00e-125	443.00
IUUC-Afl-008547	Aspergillus flavus	36.82	3.00e-114	405.00
IUUC-Afu-008805	Aspergillus fumigatus	33.54	7.00e-111	394.00
IUUC-Ani-009441	Aspergillus nidulans	33.07	6.00e-97	348.00
IUUC-Ang-009720	Aspergillus niger	33.97	7.00e-113	401.00
IUUC-Aor-010111	Aspergillus oryzae	35.40	6.00e-124	438.00
IUUC-Ate-010531	Aspergillus terreus	32.18	9.00e-104	371.00
IUUC-Ame-011893	Astyanax mexicanus	85.77	0.00e+00	1290.00
IUUC-Bgr-012183	Blumeria graminis	32.78	2.00e-114	406.00
IUUC-Bta-013179	Bos taurus	65.45	0.00e+00	1132.00
IUUC-Bci-013858	Botrytis cinerea	35.21	7.00e-125	441.00
IUUC-Bdi-014904	Brachypodium distachyon	43.76	0.00e+00	653.00
IUUC-Bol-015296	Brassica oleracea	46.03	0.00e+00	703.00
IUUC-Bra-017939	Brassica rapa	45.58	0.00e+00	709.00
IUUC-Cel-018625	Caenorhabditis elegans	32.33	1.00e-119	424.00
IUUC-Cja-019063	Callithrix jacchus	64.05	0.00e+00	1113.00
IUUC-Cfa-020976	Canis familiaris	66.39	0.00e+00	1141.00
IUUC-Cpo-022265	Cavia porcellus	66.27	0.00e+00	1144.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.92	6.00e-114	404.00
IUUC-Csa-024177	Chlorocebus sabaeus	65.39	0.00e+00	1019.00
IUUC-Cin-025411	Ciona intestinalis	48.91	0.00e+00	787.00
IUUC-Csv-026347	Ciona savignyi	47.11	0.00e+00	780.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.24	8.00e-115	407.00
IUUC-Cne-026831	Cryptococcus neoformans	35.29	2.00e-121	429.00
IUUC-Dre-027982	Danio rerio	85.36	0.00e+00	1357.00
IUUC-Dno-029034	Dasypus novemcinctus	65.57	0.00e+00	1134.00
IUUC-Dse-031467	Dothistroma septosporum	34.45	8.00e-122	431.00
IUUC-Dme-032075	Drosophila melanogaster	47.47	0.00e+00	776.00
IUUC-Ete-032865	Echinops telfairi	59.19	0.00e+00	988.00
IUUC-Eca-034059	Equus caballus	65.07	0.00e+00	1130.00
IUUC-Eeu-035304	Erinaceus europaeus	61.69	0.00e+00	1028.00
IUUC-Fca-035515	Felis catus	65.33	0.00e+00	1134.00
IUUC-Fal-037271	Ficedula albicollis	66.42	0.00e+00	1081.00
IUUC-Fox-037745	Fusarium oxysporum	36.22	6.00e-127	448.00
IUUC-Fso-038158	Fusarium solani	35.41	3.00e-123	436.00
IUUC-Gmo-039071	Gadus morhua	88.54	0.00e+00	1435.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.33	3.00e-118	419.00
IUUC-Gga-040635	Gallus gallus	65.47	0.00e+00	1159.00
IUUC-Gma-043614	Glycine max	43.82	0.00e+00	670.00
IUUC-Ggo-044602	Gorilla gorilla	65.33	0.00e+00	1132.00
IUUC-Hsa-045959	Homo sapiens	65.33	0.00e+00	1132.00
IUUC-Hvu-047563	Hordeum vulgare	45.60	2.00e-159	556.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	65.22	0.00e+00	1131.00
IUUC-Kpa-049156	Komagataella pastoris	31.45	1.00e-100	361.00
IUUC-Lch-049648	Latimeria chalumnae	67.31	0.00e+00	1139.00
IUUC-Lpe-051523	Leersia perrieri	43.65	0.00e+00	664.00
IUUC-Loc-052520	Lepisosteus oculatus	67.96	0.00e+00	1091.00
IUUC-Lma-053216	Leptosphaeria maculans	33.61	5.00e-105	377.00
IUUC-Laf-054327	Loxodonta africana	65.10	0.00e+00	1124.00
IUUC-Mcc-055443	Macaca mulatta	65.33	0.00e+00	1131.00
IUUC-Meu-056298	Macropus eugenii	65.80	0.00e+00	799.00
IUUC-Mor-057106	Magnaporthe oryzae	37.19	5.00e-129	455.00
IUUC-Mpo-057589	Magnaporthe poae	34.96	2.00e-121	429.00
IUUC-Mtr-058680	Medicago truncatula	45.54	0.00e+00	700.00
IUUC-Mla-058903	Melampsora laricipopulina	33.22	5.00e-115	409.00
IUUC-Mga-059669	Meleagris gallopavo	64.55	0.00e+00	1088.00
IUUC-Mvi-060476	Microbotryum violaceum	34.62	6.00e-116	411.00
IUUC-Mmr-060575	Microcebus murinus	65.10	0.00e+00	1126.00
IUUC-Mdo-062183	Monodelphis domestica	66.19	0.00e+00	1140.00
IUUC-Mmu-063592	Mus musculus	65.33	0.00e+00	1131.00
IUUC-Mac-065634	Musa acuminata	41.69	0.00e+00	645.00
IUUC-Mpu-066082	Mustela putorius furo	65.91	0.00e+00	1131.00
IUUC-Mlu-067345	Myotis lucifugus	65.22	0.00e+00	1128.00
IUUC-Nfi-068558	Neosartorya fischeri	35.19	3.00e-120	425.00
IUUC-Ncr-068960	Neurospora crassa	34.72	1.00e-114	407.00
IUUC-Nle-070173	Nomascus leucogenys	66.27	0.00e+00	1138.00
IUUC-Opr-070556	Ochotona princeps	66.51	0.00e+00	1153.00
IUUC-Ont-071502	Oreochromis niloticus	92.35	0.00e+00	1478.00
IUUC-Ocu-074861	Oryctolagus cuniculus	66.39	0.00e+00	1144.00
IUUC-Oba-075109	Oryza barthii	43.74	0.00e+00	673.00
IUUC-Obr-076292	Oryza brachyantha	44.17	0.00e+00	658.00
IUUC-Ogl-077065	Oryza glaberrima	44.71	0.00e+00	697.00
IUUC-Ogu-078776	Oryza glumaepatula	43.74	0.00e+00	687.00
IUUC-Oin-080048	Oryza indica	44.83	0.00e+00	694.00
IUUC-Olo-080711	Oryza longistaminata	42.28	7.00e-177	614.00
IUUC-Ome-081506	Oryza meridionalis	43.18	5.00e-179	621.00
IUUC-Oni-082320	Oryza nivara	42.96	0.00e+00	667.00
IUUC-Opu-083801	Oryza punctata	43.86	0.00e+00	659.00
IUUC-Oru-085139	Oryza rufipogon	42.96	0.00e+00	667.00
IUUC-Osa-085713	Oryza sativa	44.83	0.00e+00	702.00
IUUC-Ola-086951	Oryzias latipes	89.21	0.00e+00	1401.00
IUUC-Olu-087822	Ostreococcus lucimarinus	40.43	5.00e-167	581.00
IUUC-Oga-088625	Otolemur garnettii	64.67	0.00e+00	1124.00
IUUC-Oar-089995	Ovis aries	64.52	0.00e+00	1117.00
IUUC-Ptr-090640	Pan troglodytes	64.82	0.00e+00	1132.00
IUUC-Pan-091974	Papio anubis	65.11	0.00e+00	1126.00
IUUC-Psi-093957	Pelodiscus sinensis	66.20	0.00e+00	1174.00
IUUC-Pma-094242	Petromyzon marinus	68.77	9.00e-157	546.00
IUUC-Pno-094835	Phaeosphaeria nodorum	35.54	1.00e-103	370.00
IUUC-Ppa-095901	Physcomitrella patens	46.40	0.00e+00	748.00
IUUC-Pfo-097148	Poecilia formosa	92.23	0.00e+00	1468.00
IUUC-Pab-098068	Pongo abelii	60.75	0.00e+00	989.00
IUUC-Pop-098943	Populus trichocarpa	45.82	0.00e+00	689.00
IUUC-Pca-100738	Procavia capensis	65.89	0.00e+00	790.00
IUUC-Ppe-101315	Prunus persica	43.36	0.00e+00	679.00
IUUC-Pva-102154	Pteropus vampyrus	65.10	0.00e+00	1122.00
IUUC-Pgr-103343	Puccinia graminis	33.57	3.00e-100	359.00
IUUC-Ptt-103928	Puccinia triticina	30.53	9.00e-101	361.00
IUUC-Pte-104306	Pyrenophora teres	33.33	1.00e-103	371.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.33	1.00e-104	374.00
IUUC-Rno-105801	Rattus norvegicus	65.57	0.00e+00	1134.00
IUUC-Sce-106304	Saccharomyces cerevisiae	26.94	1.00e-67	251.00
IUUC-Sha-107635	Sarcophilus harrisii	65.63	0.00e+00	1129.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.85	3.00e-96	346.00
IUUC-Spo-108144	Schizosaccharomyces pombe	31.64	2.00e-108	386.00
IUUC-Smo-108848	Selaginella moellendorffii	45.11	0.00e+00	690.00
IUUC-Sit-110728	Setaria italica	44.82	0.00e+00	723.00
IUUC-Sly-111523	Solanum lycopersicum	44.35	0.00e+00	717.00
IUUC-Sbi-114419	Sorghum bicolor	44.70	0.00e+00	712.00
IUUC-Sre-115225	Sporisorium reilianum	32.92	6.00e-116	411.00
IUUC-Ssc-115686	Sus scrofa	65.14	0.00e+00	1129.00
IUUC-Tgu-117346	Taeniopygia guttata	65.78	0.00e+00	1145.00
IUUC-Tru-118350	Takifugu rubripes	85.56	0.00e+00	1408.00
IUUC-Tni-120658	Tetraodon nigroviridis	86.90	0.00e+00	1384.00
IUUC-Tca-121585	Theobroma cacao	45.66	0.00e+00	682.00
IUUC-Tre-122043	Trichoderma reesei	33.61	2.00e-112	399.00
IUUC-Tvi-122303	Trichoderma virens	33.97	1.00e-112	400.00
IUUC-Tae-125686	Triticum aestivum	43.88	0.00e+00	671.00
IUUC-Tur-126732	Triticum urartu	41.42	0.00e+00	636.00
IUUC-Tme-126909	Tuber melanosporum	35.11	5.00e-115	408.00
IUUC-Tbe-127261	Tupaia belangeri	60.93	0.00e+00	700.00
IUUC-Uma-129599	Ustilago maydis	34.54	5.00e-120	425.00
IUUC-Vda-129688	Verticillium dahliae	35.20	8.00e-118	417.00
IUUC-Vvi-131116	Vitis vinifera	44.04	0.00e+00	664.00
IUUC-Xtr-131953	Xenopus tropicalis	65.08	0.00e+00	1073.00
IUUC-Xma-133837	Xiphophorus maculatus	92.11	0.00e+00	1467.00
IUUC-Yli-134510	Yarrowia lipolytica	35.12	7.00e-119	421.00
IUUC-Zma-135786	Zea mays	43.57	0.00e+00	664.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence