iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052072

Ensembl Protein ID

ENSLOCP00000001521.1

UniProt Accession

W5LZG4; W5LZG4_LEPOC

Genbank Protein ID

ENSLOCP00000001521

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHAT01022416

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000001321.1	ENSLOCT00000001526.1	ENSLOCP00000001521.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.80e-52	178.1	326	851
UBD/Alpha-Helix/UBA	3.00e-18	65.5	718	755

Active Site

Position(s)	Description	Evidence
335	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
814	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................w..kskkka 67
           tG+kNlg +CY+  ++Q+L++ipe+++++   + +++ + +p +p+++++++++kl + l                       k +++ 
   Q: 326  TGIKNLGSSCYLSTTMQVLFSIPEFQRAFVG-NIQRIFDYSPLDPTQDFSTQMAKLGHGLlsgqyskppvkselieqvmkEerKPQQRG 413
           7******************************.7777777789******************8888888888888777765414578888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ +++ ++efs+++qqDaqEf+ ++++q+e++                              ++++  sd+F++ ++++++c
   Q: 414  ISPRMFKALVSRGHVEFSSSRQQDAQEFFLHVINQVERNS-----------------------------EGSENPSDVFRFLVEERVQC 473
           **************************************99.............................5788899************* PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  ++   + ++lp p +  t+ke                            ++ cL++ft++e++ +   ++++  ++k+   
   Q: 474  CQTRKVRYTQRVDYLMQLPAPLEAATNKEelisyesrrqeaeegrrpppervrariPFSACLQAFTEPENVAD---FWSSALQAKSAGI 559
           99999987777766666666666666666789***************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++P +L++++k+f+f  + ++++k++ ++++p+ Ld+s+  +                                         
   Q: 560  KTSRFASFPLYLVVQIKKFTFGVD-WVPKKVDLSIDVPDLLDISHLRAAglrpgeeelpdlappivipddprdhsmshlmdspeidess 647
           *********************776.*******************988888999999999999999999999999999999999888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 648  vmqlaemgfpleacrkavyytgnmgpemafnwiiahmeepdfaeplalpsfgdpgtggssltsgmdsqppeesiailtsmgfsrrqtvq 736
           88888888888888888888888888888888888888888888888888888888777777777777777777777777777666666 PP
   S: 268  ...................peekqke....................................kkkYeLiavvvHsG.slssGHYvayvk 300
                              p     e                                    + +YeL+a ++H+G s+ +GHYv+++k
   Q: 737  algatnnnleraldwifthP-----EseeesepvsgvadaegnsaaeassgaepagprvrdgPGRYELFAFISHMGtSTMCGHYVCHIK 820
           66666666666666666551.....0444556777788888888888899999999999999*************************** PP
   S: 301  nekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           + +g+W+ ++D+kV+ +  e+  +   + +Y++fY+r
   Q: 821  K-EGRWVIYNDHKVSLS--ERPPK---DLGYIYFYQR 851
           *.9************99..67888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ ++ l++MGF+r + +qaL a+nnnle+A+++++++
   Q: 718  EESIAILTSMGFSRRQTVQALGATNNNLERALDWIFTH 755
           789*********************************98 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

GAGGRNAKMA ADLGELLVPY MPTIRVPRTG DRVFKSECAF SYDSPESEGG LYVCMNTFLG 60
FGREHVERHY RKTGQCVYMH LKRTIKEKDP GASGGAVPRR QNGKVFLEDV DLSCDFNGDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCTGGAG GCAGGAATGC GAAGATGGCT GCAGACTTGG GAGAGCTGCT GGTCCCGTAC 60
ATGCCCACCA TCCGAGTCCC CAGGACCGGG GACCGGGTTT TCAAGAGCGA GTGCGCCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	41.30	3.00e-173	602.00
IUUC-Aml-001356	Ailuropoda melanoleuca	76.96	0.00e+00	1296.00
IUUC-Atr-002580	Amborella trichopoda	42.94	0.00e+00	658.00
IUUC-Apl-003712	Anas platyrhynchos	76.45	0.00e+00	1264.00
IUUC-Aca-004634	Anolis carolinensis	76.00	0.00e+00	1303.00
IUUC-Aly-005727	Arabidopsis lyrata	44.37	0.00e+00	674.00
IUUC-Ath-006974	Arabidopsis thaliana	43.76	0.00e+00	671.00
IUUC-Ago-007890	Ashbya gossypii	26.38	4.00e-68	252.00
IUUC-Acl-008057	Aspergillus clavatus	33.09	2.00e-115	409.00
IUUC-Afl-008547	Aspergillus flavus	34.59	2.00e-106	380.00
IUUC-Afu-008805	Aspergillus fumigatus	32.09	6.00e-100	358.00
IUUC-Ani-009441	Aspergillus nidulans	32.73	4.00e-91	329.00
IUUC-Ang-009720	Aspergillus niger	32.12	2.00e-107	383.00
IUUC-Aor-010111	Aspergillus oryzae	31.96	5.00e-114	405.00
IUUC-Ate-010531	Aspergillus terreus	30.67	1.00e-94	341.00
IUUC-Ame-011470	Astyanax mexicanus	78.81	0.00e+00	1352.00
IUUC-Bgr-012183	Blumeria graminis	30.49	1.00e-106	380.00
IUUC-Bta-013349	Bos taurus	77.01	0.00e+00	1314.00
IUUC-Bci-013858	Botrytis cinerea	31.77	2.00e-113	403.00
IUUC-Bdi-014904	Brachypodium distachyon	42.46	0.00e+00	629.00
IUUC-Bol-015296	Brassica oleracea	43.93	0.00e+00	680.00
IUUC-Bra-017939	Brassica rapa	44.52	0.00e+00	689.00
IUUC-Cel-018625	Caenorhabditis elegans	31.48	3.00e-113	402.00
IUUC-Cja-019021	Callithrix jacchus	76.73	0.00e+00	1288.00
IUUC-Cfa-020614	Canis familiaris	76.96	0.00e+00	1295.00
IUUC-Cpo-022484	Cavia porcellus	76.28	0.00e+00	1228.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	38.61	1.00e-105	377.00
IUUC-Csa-024078	Chlorocebus sabaeus	76.90	0.00e+00	1298.00
IUUC-Cho-024522	Choloepus hoffmanni	64.20	0.00e+00	965.00
IUUC-Cin-025411	Ciona intestinalis	44.84	0.00e+00	710.00
IUUC-Csv-026347	Ciona savignyi	43.11	0.00e+00	698.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	30.86	1.00e-94	340.00
IUUC-Cne-026831	Cryptococcus neoformans	33.57	8.00e-117	414.00
IUUC-Cme-027335	Cyanidioschyzon merolae	27.41	8.00e-35	142.00
IUUC-Dre-027651	Danio rerio	79.65	0.00e+00	1432.00
IUUC-Dno-028975	Dasypus novemcinctus	76.60	0.00e+00	1289.00
IUUC-Dor-030130	Dipodomys ordii	57.20	0.00e+00	847.00
IUUC-Dse-031467	Dothistroma septosporum	32.86	1.00e-109	390.00
IUUC-Dme-032075	Drosophila melanogaster	45.08	0.00e+00	687.00
IUUC-Ete-032251	Echinops telfairi	64.69	0.00e+00	1012.00
IUUC-Eca-033568	Equus caballus	76.79	0.00e+00	1227.00
IUUC-Fca-036280	Felis catus	76.86	0.00e+00	1226.00
IUUC-Fal-036610	Ficedula albicollis	76.43	0.00e+00	1242.00
IUUC-Fox-037745	Fusarium oxysporum	31.41	3.00e-106	379.00
IUUC-Fso-038158	Fusarium solani	31.62	4.00e-107	382.00
IUUC-Gmo-038906	Gadus morhua	75.87	0.00e+00	1337.00
IUUC-Ggr-040098	Gaeumannomyces graminis	31.76	9.00e-106	377.00
IUUC-Gga-041215	Gallus gallus	75.70	0.00e+00	1312.00
IUUC-Gac-042441	Gasterosteus aculeatus	77.84	0.00e+00	1377.00
IUUC-Gma-043614	Glycine max	42.29	0.00e+00	647.00
IUUC-Ggo-044446	Gorilla gorilla	77.13	0.00e+00	1302.00
IUUC-Hsa-046546	Homo sapiens	77.01	0.00e+00	1299.00
IUUC-Hvu-047563	Hordeum vulgare	45.15	2.00e-160	559.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	70.56	0.00e+00	1175.00
IUUC-Kpa-049156	Komagataella pastoris	30.13	8.00e-104	371.00
IUUC-Lch-050425	Latimeria chalumnae	77.34	0.00e+00	1381.00
IUUC-Lpe-051523	Leersia perrieri	41.91	0.00e+00	627.00
IUUC-Lma-053216	Leptosphaeria maculans	32.55	2.00e-101	364.00
IUUC-Laf-053909	Loxodonta africana	76.25	0.00e+00	1283.00
IUUC-Mcc-054686	Macaca mulatta	76.90	0.00e+00	1298.00
IUUC-Meu-056361	Macropus eugenii	70.40	0.00e+00	1173.00
IUUC-Mor-057106	Magnaporthe oryzae	33.41	6.00e-119	421.00
IUUC-Mpo-057589	Magnaporthe poae	32.51	1.00e-106	380.00
IUUC-Mtr-058680	Medicago truncatula	43.82	0.00e+00	660.00
IUUC-Mla-058903	Melampsora laricipopulina	31.05	6.00e-103	368.00
IUUC-Mga-059972	Meleagris gallopavo	70.76	0.00e+00	1186.00
IUUC-Mvi-060476	Microbotryum violaceum	32.99	2.00e-107	383.00
IUUC-Mmr-060916	Microcebus murinus	77.43	0.00e+00	1302.00
IUUC-Mdo-062302	Monodelphis domestica	78.47	0.00e+00	1369.00
IUUC-Mmu-063639	Mus musculus	77.76	0.00e+00	1303.00
IUUC-Mac-065634	Musa acuminata	40.37	4.00e-179	621.00
IUUC-Mpu-066533	Mustela putorius furo	76.96	0.00e+00	1295.00
IUUC-Mlu-067786	Myotis lucifugus	72.66	0.00e+00	1207.00
IUUC-Nfi-068558	Neosartorya fischeri	33.54	1.00e-112	400.00
IUUC-Ncr-068960	Neurospora crassa	30.31	1.00e-100	360.00
IUUC-Nle-069997	Nomascus leucogenys	76.56	0.00e+00	1216.00
IUUC-Ont-071859	Oreochromis niloticus	77.53	0.00e+00	1365.00
IUUC-Oan-072959	Ornithorhynchus anatinus	79.92	3.00e-117	413.00
IUUC-Ocu-074265	Oryctolagus cuniculus	76.78	0.00e+00	1294.00
IUUC-Oba-075109	Oryza barthii	43.09	0.00e+00	649.00
IUUC-Obr-076292	Oryza brachyantha	43.70	0.00e+00	635.00
IUUC-Ogl-077065	Oryza glaberrima	44.05	0.00e+00	671.00
IUUC-Ogu-078776	Oryza glumaepatula	43.09	0.00e+00	665.00
IUUC-Oin-080048	Oryza indica	43.82	0.00e+00	664.00
IUUC-Olo-080711	Oryza longistaminata	41.99	3.00e-172	598.00
IUUC-Ome-081506	Oryza meridionalis	42.87	3.00e-175	608.00
IUUC-Oni-082320	Oryza nivara	42.18	0.00e+00	642.00
IUUC-Opu-083801	Oryza punctata	42.86	0.00e+00	635.00
IUUC-Oru-085139	Oryza rufipogon	42.18	0.00e+00	637.00
IUUC-Osa-085713	Oryza sativa	44.17	0.00e+00	674.00
IUUC-Ola-087344	Oryzias latipes	77.52	0.00e+00	1386.00
IUUC-Olu-087822	Ostreococcus lucimarinus	37.73	4.00e-155	541.00
IUUC-Oga-088734	Otolemur garnettii	76.91	0.00e+00	1274.00
IUUC-Oar-089636	Ovis aries	76.91	0.00e+00	1276.00
IUUC-Ptr-090982	Pan troglodytes	77.13	0.00e+00	1301.00
IUUC-Pan-091991	Papio anubis	77.01	0.00e+00	1299.00
IUUC-Psi-093509	Pelodiscus sinensis	77.75	0.00e+00	1347.00
IUUC-Pma-094242	Petromyzon marinus	62.92	8.00e-149	519.00
IUUC-Pno-094835	Phaeosphaeria nodorum	32.50	3.00e-92	332.00
IUUC-Ppa-095901	Physcomitrella patens	43.07	0.00e+00	677.00
IUUC-Pfo-096029	Poecilia formosa	79.45	0.00e+00	1414.00
IUUC-Pab-098672	Pongo abelii	73.63	0.00e+00	1214.00
IUUC-Pop-098943	Populus trichocarpa	43.13	0.00e+00	652.00
IUUC-Pca-100860	Procavia capensis	61.07	0.00e+00	868.00
IUUC-Ppe-101315	Prunus persica	43.60	0.00e+00	666.00
IUUC-Pva-102545	Pteropus vampyrus	71.65	0.00e+00	1187.00
IUUC-Pgr-103343	Puccinia graminis	31.40	4.00e-94	338.00
IUUC-Ptt-103928	Puccinia triticina	29.21	4.00e-97	349.00
IUUC-Pte-104306	Pyrenophora teres	30.55	1.00e-91	330.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	31.38	5.00e-93	335.00
IUUC-Rno-105210	Rattus norvegicus	77.14	0.00e+00	1284.00
IUUC-Sce-106304	Saccharomyces cerevisiae	26.41	7.00e-63	235.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	28.98	4.00e-90	325.00
IUUC-Spo-108144	Schizosaccharomyces pombe	30.70	6.00e-102	365.00
IUUC-Smo-108848	Selaginella moellendorffii	43.04	0.00e+00	657.00
IUUC-Sit-110728	Setaria italica	43.76	0.00e+00	689.00
IUUC-Sly-111523	Solanum lycopersicum	43.41	0.00e+00	694.00
IUUC-Sar-113733	Sorex araneus	77.72	0.00e+00	642.00
IUUC-Sbi-114419	Sorghum bicolor	43.33	0.00e+00	668.00
IUUC-Sre-115225	Sporisorium reilianum	31.50	6.00e-105	375.00
IUUC-Tgu-116591	Taeniopygia guttata	77.11	0.00e+00	1327.00
IUUC-Tru-118627	Takifugu rubripes	75.94	0.00e+00	1372.00
IUUC-Tsy-119278	Tarsius syrichta	69.88	0.00e+00	1107.00
IUUC-Tni-120804	Tetraodon nigroviridis	77.66	0.00e+00	1400.00
IUUC-Tca-121585	Theobroma cacao	44.07	0.00e+00	647.00
IUUC-Tre-122043	Trichoderma reesei	32.44	5.00e-103	369.00
IUUC-Tvi-122303	Trichoderma virens	32.75	6.00e-108	385.00
IUUC-Tae-125686	Triticum aestivum	43.52	0.00e+00	659.00
IUUC-Tur-126732	Triticum urartu	41.12	1.00e-180	626.00
IUUC-Tbe-127699	Tupaia belangeri	64.15	0.00e+00	711.00
IUUC-Ttr-128295	Tursiops truncatus	70.64	0.00e+00	1178.00
IUUC-Uma-129599	Ustilago maydis	31.17	5.00e-108	385.00
IUUC-Vda-129688	Verticillium dahliae	30.38	9.00e-99	354.00
IUUC-Vpa-130170	Vicugna pacos	68.73	0.00e+00	1057.00
IUUC-Vvi-131116	Vitis vinifera	42.42	8.00e-180	624.00
IUUC-Xtr-132809	Xenopus tropicalis	71.09	0.00e+00	1230.00
IUUC-Xma-134273	Xiphophorus maculatus	79.68	0.00e+00	1417.00
IUUC-Yli-134510	Yarrowia lipolytica	33.13	3.00e-111	395.00
IUUC-Zma-135786	Zea mays	42.71	0.00e+00	638.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence