iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059669

UUCD1 version

UUC-MeG-00868

Ensembl Protein ID

ENSMGAP00000014943.2

UniProt Accession

G1NMV7; G1NMV7_MELGA

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000014124.2	ENSMGAT00000015887.2	ENSMGAP00000014943.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.30e-62	208.9	296	826
UBD/Alpha-Helix/UBA	6.10e-23	80.0	694	732

Active Site

Position(s)	Description	Evidence
305	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
789	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel..................wkskkkavspr 71
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                  +k+ ++ ++pr
   Q: 296  TGIRNLGNSCYLNSVMQVLFSIPDFQRKYVD-KLEKIFQSAPSDPTQDFSTQVAKLGHGLlsgeyskpasaegeqqpdQKGVQNGIAPR 383
           7******************************.99999999********************666666666555554333355566***** PP
   S: 72   ellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecd 160
           ++++ ++k ++efs+++qqDaqEf+ ++++ +e+++                             ++++  +++F++ +++++kcl+ +
   Q: 384  MFKSLIGKGHPEFSTNRQQDAQEFFLHFINMVERNC-----------------------------RSSENPNEVFRFLVEEKLKCLATE 443
           ************************************.............................6788899***************** PP
   S: 161  nvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekklk 222
           +v+ ++   + ++lpvp++   +k                             +++cLe++ ++e++++   ++++  ++k+ a k+++
   Q: 444  KVKYTQRVDYIMQLPVPMDAALNKDelleyeekkrqaeeekqplpelvrakvPFSSCLEAYGAPEQVDD---FWSTALQAKSVALKTTR 529
           ******************998877799****************************************97...***************** PP
   S: 223  lkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............................................ 267
           + ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s                                                 
   Q: 530  FASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISALQGMglqdgeeempdiapplvtpdepkgslgfygnedddsfcsphfss 617
           *****************997.*******************6555567777777777777777777777777777777777777777777 PP
   S: 268  ...............................................................................peekqke... 274
                                                                                          +     +   
   Q: 618  ptspmldesviiqlvemgfpmdacrkavyytgnsgveaamnwvmshmddpaadfanplvlpgssgpgstiacpdppsedS-----Vati 701
           77777777777777777776666666666666666666666666666666666666666666666666666655555550.....0555 PP
   S: 275  ...................................................................kkkYeLiavvvHsG.slssGHY 295
                                                                               k+Y+L+a ++H+G s+ +GHY
   Q: 702  vsmgfsrdqamkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpigpkvrngpGKEYQLFAFISHMGtSTMCGHY 790
           5555555555556666666666666777777777777777777777777777777888888888888********************** PP
   S: 296  vayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           v+++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 791  VCHIKK-DGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 826
           ******.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +ed ++ +v+MGF+r++a +aLra+nn+le+Av++++++
   Q: 694  SEDSVATIVSMGFSRDQAMKALRATNNSLERAVDWIFSH 732
           699**********************************97 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

LSPSFQESDG GLYICMNTFL GFGKQYVEKH YQKTGQRVYL HLKRTRKPKE EDANSSAGDP 60
PRKKPTRLAI VGVEGGFDIT EEKFEYDEDV KIVILPEHLD IPRDGLEGLP DMVRDRIANA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCCCCTT CCTTCCAGGA GTCTGATGGC GGCTTATATA TCTGCATGAA CACGTTCCTG 60
GGTTTTGGAA AACAGTATGT GGAAAAGCAC TACCAGAAAA CAGGCCAGCG GGTCTATCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.34	0.00e+00	649.00
IUUC-Aml-002104	Ailuropoda melanoleuca	90.21	0.00e+00	1477.00
IUUC-Atr-002580	Amborella trichopoda	45.80	0.00e+00	697.00
IUUC-Apl-003774	Anas platyrhynchos	98.41	0.00e+00	1645.00
IUUC-Aca-005368	Anolis carolinensis	90.89	0.00e+00	1522.00
IUUC-Aly-005727	Arabidopsis lyrata	47.41	0.00e+00	710.00
IUUC-Ath-006974	Arabidopsis thaliana	47.53	0.00e+00	711.00
IUUC-Ago-007890	Ashbya gossypii	28.77	4.00e-76	278.00
IUUC-Acl-008057	Aspergillus clavatus	34.12	2.00e-120	426.00
IUUC-Afl-008547	Aspergillus flavus	35.73	1.00e-113	403.00
IUUC-Afu-008805	Aspergillus fumigatus	34.48	2.00e-114	405.00
IUUC-Ani-009441	Aspergillus nidulans	33.15	6.00e-96	344.00
IUUC-Ang-009720	Aspergillus niger	34.28	2.00e-109	389.00
IUUC-Aor-010111	Aspergillus oryzae	33.89	4.00e-119	422.00
IUUC-Ate-010531	Aspergillus terreus	32.07	3.00e-98	352.00
IUUC-Ame-011893	Astyanax mexicanus	63.79	0.00e+00	934.00
IUUC-Bgr-012183	Blumeria graminis	33.81	7.00e-117	414.00
IUUC-Bta-013179	Bos taurus	90.42	0.00e+00	1483.00
IUUC-Bci-013858	Botrytis cinerea	33.85	7.00e-123	434.00
IUUC-Bdi-014904	Brachypodium distachyon	47.35	0.00e+00	686.00
IUUC-Bol-015296	Brassica oleracea	47.83	0.00e+00	719.00
IUUC-Bra-017619	Brassica rapa	47.89	0.00e+00	725.00
IUUC-Cel-018625	Caenorhabditis elegans	35.13	4.00e-127	448.00
IUUC-Cja-019063	Callithrix jacchus	88.65	0.00e+00	1449.00
IUUC-Cfa-020976	Canis familiaris	87.76	0.00e+00	1427.00
IUUC-Cpo-022265	Cavia porcellus	87.41	0.00e+00	1417.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	38.93	2.00e-113	402.00
IUUC-Csa-024177	Chlorocebus sabaeus	84.38	0.00e+00	1295.00
IUUC-Cho-024702	Choloepus hoffmanni	84.64	0.00e+00	937.00
IUUC-Cin-025411	Ciona intestinalis	50.12	0.00e+00	805.00
IUUC-Csv-026347	Ciona savignyi	45.66	0.00e+00	748.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.61	1.00e-107	383.00
IUUC-Cne-026831	Cryptococcus neoformans	35.05	8.00e-123	434.00
IUUC-Dre-027982	Danio rerio	66.15	0.00e+00	1045.00
IUUC-Dno-029034	Dasypus novemcinctus	90.42	0.00e+00	1493.00
IUUC-Dor-030479	Dipodomys ordii	88.32	0.00e+00	676.00
IUUC-Dse-031467	Dothistroma septosporum	34.49	9.00e-125	440.00
IUUC-Dme-032075	Drosophila melanogaster	50.18	0.00e+00	781.00
IUUC-Ete-032865	Echinops telfairi	80.61	0.00e+00	1305.00
IUUC-Eca-034059	Equus caballus	90.55	0.00e+00	1484.00
IUUC-Eeu-035304	Erinaceus europaeus	89.78	0.00e+00	1367.00
IUUC-Fca-035515	Felis catus	90.30	0.00e+00	1483.00
IUUC-Fal-037271	Ficedula albicollis	94.84	0.00e+00	1538.00
IUUC-Fox-037745	Fusarium oxysporum	34.88	9.00e-122	430.00
IUUC-Fso-038158	Fusarium solani	34.80	5.00e-120	424.00
IUUC-Gmo-039071	Gadus morhua	63.54	0.00e+00	1019.00
IUUC-Ggr-040098	Gaeumannomyces graminis	33.25	6.00e-112	398.00
IUUC-Gga-040635	Gallus gallus	98.78	0.00e+00	1658.00
IUUC-Gac-042528	Gasterosteus aculeatus	63.10	0.00e+00	1023.00
IUUC-Gma-043614	Glycine max	46.39	0.00e+00	682.00
IUUC-Ggo-044602	Gorilla gorilla	90.18	0.00e+00	1478.00
IUUC-Hsa-045959	Homo sapiens	90.18	0.00e+00	1478.00
IUUC-Hvu-047563	Hordeum vulgare	47.74	1.00e-169	589.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	89.35	0.00e+00	1479.00
IUUC-Kpa-049156	Komagataella pastoris	33.21	4.00e-109	388.00
IUUC-Lch-049648	Latimeria chalumnae	80.68	0.00e+00	1323.00
IUUC-Lpe-051523	Leersia perrieri	46.55	0.00e+00	684.00
IUUC-Loc-052520	Lepisosteus oculatus	61.81	0.00e+00	961.00
IUUC-Lma-053216	Leptosphaeria maculans	34.63	9.00e-110	392.00
IUUC-Laf-054327	Loxodonta africana	89.82	0.00e+00	1475.00
IUUC-Mcc-055443	Macaca mulatta	90.06	0.00e+00	1475.00
IUUC-Meu-056298	Macropus eugenii	90.56	0.00e+00	980.00
IUUC-Mor-057106	Magnaporthe oryzae	35.41	6.00e-125	441.00
IUUC-Mpo-057589	Magnaporthe poae	34.05	4.00e-116	411.00
IUUC-Mtr-058680	Medicago truncatula	47.02	0.00e+00	693.00
IUUC-Mla-058903	Melampsora laricipopulina	32.28	1.00e-115	410.00
IUUC-Mvi-060476	Microbotryum violaceum	35.03	8.00e-117	414.00
IUUC-Mmr-060575	Microcebus murinus	90.42	0.00e+00	1485.00
IUUC-Mdo-062183	Monodelphis domestica	88.61	0.00e+00	1424.00
IUUC-Mmu-063592	Mus musculus	90.30	0.00e+00	1483.00
IUUC-Mac-065634	Musa acuminata	43.23	0.00e+00	660.00
IUUC-Mpu-066082	Mustela putorius furo	87.39	0.00e+00	1418.00
IUUC-Mlu-067345	Myotis lucifugus	87.68	0.00e+00	1451.00
IUUC-Nfi-068558	Neosartorya fischeri	35.14	9.00e-123	434.00
IUUC-Ncr-068960	Neurospora crassa	34.32	3.00e-108	385.00
IUUC-Nle-070173	Nomascus leucogenys	87.39	0.00e+00	1419.00
IUUC-Opr-070556	Ochotona princeps	89.82	0.00e+00	1488.00
IUUC-Ont-071502	Oreochromis niloticus	63.39	0.00e+00	1029.00
IUUC-Ocu-074861	Oryctolagus cuniculus	87.39	0.00e+00	1435.00
IUUC-Oba-075109	Oryza barthii	46.61	0.00e+00	690.00
IUUC-Obr-076292	Oryza brachyantha	47.95	0.00e+00	693.00
IUUC-Ogl-077065	Oryza glaberrima	47.95	0.00e+00	719.00
IUUC-Ogu-078776	Oryza glumaepatula	46.49	0.00e+00	699.00
IUUC-Oin-080048	Oryza indica	47.46	0.00e+00	713.00
IUUC-Olo-080711	Oryza longistaminata	45.15	0.00e+00	668.00
IUUC-Ome-081506	Oryza meridionalis	46.21	0.00e+00	680.00
IUUC-Oni-082320	Oryza nivara	46.04	0.00e+00	685.00
IUUC-Opu-083801	Oryza punctata	46.85	0.00e+00	684.00
IUUC-Oru-085139	Oryza rufipogon	45.92	0.00e+00	689.00
IUUC-Osa-085713	Oryza sativa	48.07	0.00e+00	722.00
IUUC-Ola-086951	Oryzias latipes	63.87	0.00e+00	1021.00
IUUC-Olu-087822	Ostreococcus lucimarinus	40.55	2.00e-170	592.00
IUUC-Oga-088625	Otolemur garnettii	89.23	0.00e+00	1462.00
IUUC-Oar-089995	Ovis aries	87.80	0.00e+00	1457.00
IUUC-Ptr-090640	Pan troglodytes	87.88	0.00e+00	1473.00
IUUC-Pan-091974	Papio anubis	89.13	0.00e+00	1458.00
IUUC-Psi-093957	Pelodiscus sinensis	94.55	0.00e+00	1624.00
IUUC-Pma-094242	Petromyzon marinus	71.77	2.00e-170	591.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.19	2.00e-105	376.00
IUUC-Ppa-095901	Physcomitrella patens	48.94	0.00e+00	755.00
IUUC-Pfo-097148	Poecilia formosa	63.94	0.00e+00	1035.00
IUUC-Pab-098068	Pongo abelii	83.29	0.00e+00	1313.00
IUUC-Pop-098943	Populus trichocarpa	46.87	0.00e+00	691.00
IUUC-Pca-100738	Procavia capensis	82.79	0.00e+00	1327.00
IUUC-Pva-102154	Pteropus vampyrus	89.31	0.00e+00	1457.00
IUUC-Pgr-103343	Puccinia graminis	33.62	2.00e-102	365.00
IUUC-Ptt-103928	Puccinia triticina	29.83	2.00e-98	352.00
IUUC-Pte-104306	Pyrenophora teres	32.16	2.00e-97	349.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.49	5.00e-101	361.00
IUUC-Rno-105801	Rattus norvegicus	90.30	0.00e+00	1484.00
IUUC-Sce-106304	Saccharomyces cerevisiae	29.63	3.00e-72	266.00
IUUC-Sha-107635	Sarcophilus harrisii	88.36	0.00e+00	1429.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	30.49	2.00e-98	353.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.74	2.00e-109	389.00
IUUC-Smo-108848	Selaginella moellendorffii	47.40	0.00e+00	715.00
IUUC-Sit-110728	Setaria italica	47.71	0.00e+00	731.00
IUUC-Sly-111523	Solanum lycopersicum	47.49	0.00e+00	740.00
IUUC-Sbi-114419	Sorghum bicolor	47.34	0.00e+00	718.00
IUUC-Sre-115225	Sporisorium reilianum	33.75	1.00e-115	410.00
IUUC-Ssc-115686	Sus scrofa	88.26	0.00e+00	1469.00
IUUC-Tgu-117346	Taeniopygia guttata	97.57	0.00e+00	1615.00
IUUC-Tru-118350	Takifugu rubripes	64.24	0.00e+00	1056.00
IUUC-Tni-120658	Tetraodon nigroviridis	65.23	0.00e+00	1042.00
IUUC-Tca-121585	Theobroma cacao	47.60	0.00e+00	699.00
IUUC-Tre-122043	Trichoderma reesei	33.45	4.00e-113	401.00
IUUC-Tvi-122303	Trichoderma virens	33.97	4.00e-115	408.00
IUUC-Tae-123798	Triticum aestivum	47.12	0.00e+00	699.00
IUUC-Tur-126732	Triticum urartu	44.57	0.00e+00	652.00
IUUC-Tme-126909	Tuber melanosporum	34.56	2.00e-112	399.00
IUUC-Tbe-127261	Tupaia belangeri	85.43	0.00e+00	978.00
IUUC-Uma-129599	Ustilago maydis	33.04	2.00e-122	432.00
IUUC-Vda-129688	Verticillium dahliae	33.09	3.00e-112	399.00
IUUC-Vvi-131116	Vitis vinifera	47.54	0.00e+00	681.00
IUUC-Xtr-131953	Xenopus tropicalis	79.52	0.00e+00	1314.00
IUUC-Xma-133837	Xiphophorus maculatus	64.06	0.00e+00	1037.00
IUUC-Yli-134510	Yarrowia lipolytica	34.62	2.00e-119	422.00
IUUC-Zma-135786	Zea mays	47.22	0.00e+00	686.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence