iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063592

UUCD1 version

UUC-MuM-01072

Ensembl Protein ID

ENSMUSP00000041299.3

UniProt Accession

P56399; UBP5_MOUSE

Genbank Protein ID

AAC36015.1; AAH66993.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 5; Deubiquitinating enzyme 5; Isopeptidase T; Ubiquitin thioesterase 5; Ubiquitin-specific-processing protease 5

Genbank Nucleotide ID

AC002397; BC066993

Gene Name

Usp5; Isot

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000038429.10	ENSMUST00000047510.9	ENSMUSP00000041299.3
ENSMUSG00000038429.10	ENSMUST00000122110.7	ENSMUSP00000114000.1
ENSMUSG00000038429.10	ENSMUST00000142058.7	ENSMUSP00000117439.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
circBase	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	7578059

Classification

Family	E-value	Score	Start	End
DUB/USP	1.70e-63	216.0	326	855
UBD/Alpha-Helix/UBA	2.30e-22	79.5	725	762

Active Site

Position(s)	Description	Evidence
335	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
818	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 326  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpalesgdgeqvpeQKEVQDGIA 413
           7******************************.99999999********************66666666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 414  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 473
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            +++cLe++ ++e++++   ++++  ++k+ a+k+
   Q: 474  TEKVKYTQRVDYIMQLPVPMDAALNKEelleyeekkrqaeeekvplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVKT 559
           **********************999989*****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                          
   Q: 560  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsphf 647
           *******************997.*******************98888788888888888888888888888888888888888888777 PP
   S: 268  .................................................................................peekqke. 274
                                                                                            +     + 
   Q: 648  ssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvT-----Ti 731
           7777777777777777777777777777777777766666666666666666666666666666666555555555555550.....05 PP
   S: 275  ..................................................................kkkYeLiavvvHsG.slssGHYv 296
                                                                             + kY+L+a ++H+G s+ +GHYv
   Q: 732  vsmgfsrdqalkalratnnsleravdwifshiddldaeaamdisegrsaaesisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYV 820
           555555555555555666666666677777777777777777777777777888888888888888*********************** PP
   S: 297  ayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 821  CHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 855
           *****.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 725  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 762
           889999******************************97 PP

Organism

Mus musculus

Functional Description
(View)

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity).

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRPK EEDTSAGTGD PPRKKPTRLA IGVEGGFDLT EDKFEFDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTCGCGCT CATTGGATGC GAGAGACGGA GGGGGGCGGT ACTAGGTACA GTGGGAGCTG 60
CTGTGTGAGG AGGAGCTGCT GCCGGTGTCA TGGCGGAGCT GAGTGAAGAG GCGCTGCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:22225

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.43	0.00e+00	649.00
IUUC-Aml-002104	Ailuropoda melanoleuca	97.76	0.00e+00	1640.00
IUUC-Atr-002580	Amborella trichopoda	46.09	0.00e+00	740.00
IUUC-Apl-003774	Anas platyrhynchos	91.43	0.00e+00	1529.00
IUUC-Aca-005368	Anolis carolinensis	86.36	0.00e+00	1511.00
IUUC-Aly-005727	Arabidopsis lyrata	47.05	0.00e+00	731.00
IUUC-Ath-006974	Arabidopsis thaliana	47.26	0.00e+00	731.00
IUUC-Ago-007890	Ashbya gossypii	28.95	3.00e-82	299.00
IUUC-Acl-008057	Aspergillus clavatus	33.61	1.00e-124	441.00
IUUC-Afl-008547	Aspergillus flavus	36.31	4.00e-118	419.00
IUUC-Afu-008805	Aspergillus fumigatus	34.36	3.00e-115	409.00
IUUC-Ani-009441	Aspergillus nidulans	32.53	2.00e-98	353.00
IUUC-Ang-009720	Aspergillus niger	33.91	4.00e-119	422.00
IUUC-Aor-010111	Aspergillus oryzae	33.99	7.00e-128	451.00
IUUC-Ate-010531	Aspergillus terreus	31.80	2.00e-104	373.00
IUUC-Ame-011893	Astyanax mexicanus	65.36	0.00e+00	994.00
IUUC-Bgr-012183	Blumeria graminis	33.99	2.00e-122	433.00
IUUC-Bta-013179	Bos taurus	98.11	0.00e+00	1648.00
IUUC-Bci-013858	Botrytis cinerea	34.84	9.00e-131	461.00
IUUC-Bdi-014904	Brachypodium distachyon	47.09	0.00e+00	712.00
IUUC-Bol-015296	Brassica oleracea	47.55	0.00e+00	743.00
IUUC-Bra-017939	Brassica rapa	47.55	0.00e+00	748.00
IUUC-Cel-018625	Caenorhabditis elegans	34.93	2.00e-136	479.00
IUUC-Cja-019063	Callithrix jacchus	97.06	0.00e+00	1621.00
IUUC-Cfa-020976	Canis familiaris	95.63	0.00e+00	1593.00
IUUC-Cpo-022265	Cavia porcellus	95.99	0.00e+00	1593.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.22	7.00e-112	397.00
IUUC-Csa-024177	Chlorocebus sabaeus	95.18	0.00e+00	1455.00
IUUC-Cho-024702	Choloepus hoffmanni	89.30	0.00e+00	991.00
IUUC-Cin-025411	Ciona intestinalis	50.29	0.00e+00	830.00
IUUC-Csv-026347	Ciona savignyi	46.53	0.00e+00	795.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.56	2.00e-114	406.00
IUUC-Cne-026831	Cryptococcus neoformans	35.53	2.00e-129	456.00
IUUC-Dre-027982	Danio rerio	67.36	0.00e+00	1105.00
IUUC-Dno-029034	Dasypus novemcinctus	98.11	0.00e+00	1662.00
IUUC-Dor-030479	Dipodomys ordii	94.92	0.00e+00	722.00
IUUC-Dse-031467	Dothistroma septosporum	36.42	2.00e-133	469.00
IUUC-Dme-032075	Drosophila melanogaster	49.37	0.00e+00	803.00
IUUC-Ete-032865	Echinops telfairi	87.06	0.00e+00	1469.00
IUUC-Eca-034059	Equus caballus	98.36	0.00e+00	1664.00
IUUC-Eeu-035304	Erinaceus europaeus	92.21	0.00e+00	1496.00
IUUC-Fca-035515	Felis catus	98.35	0.00e+00	1652.00
IUUC-Fal-037271	Ficedula albicollis	88.30	0.00e+00	1434.00
IUUC-Fox-037745	Fusarium oxysporum	35.24	1.00e-128	454.00
IUUC-Fso-038158	Fusarium solani	35.81	3.00e-128	452.00
IUUC-Gmo-039071	Gadus morhua	65.30	0.00e+00	1080.00
IUUC-Ggr-040098	Gaeumannomyces graminis	33.79	2.00e-119	423.00
IUUC-Gga-040635	Gallus gallus	91.38	0.00e+00	1603.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.38	0.00e+00	1090.00
IUUC-Gma-043614	Glycine max	46.74	0.00e+00	707.00
IUUC-Ggo-044602	Gorilla gorilla	98.35	0.00e+00	1648.00
IUUC-Hsa-045959	Homo sapiens	98.35	0.00e+00	1648.00
IUUC-Hvu-047563	Hordeum vulgare	47.38	2.00e-168	585.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	98.70	0.00e+00	1655.00
IUUC-Kpa-049156	Komagataella pastoris	33.18	2.00e-115	410.00
IUUC-Lch-049648	Latimeria chalumnae	82.25	0.00e+00	1378.00
IUUC-Lpe-051523	Leersia perrieri	46.89	0.00e+00	719.00
IUUC-Loc-052520	Lepisosteus oculatus	62.50	0.00e+00	1013.00
IUUC-Lma-053216	Leptosphaeria maculans	34.44	4.00e-114	407.00
IUUC-Laf-054327	Loxodonta africana	97.76	0.00e+00	1644.00
IUUC-Mcc-055443	Macaca mulatta	98.23	0.00e+00	1646.00
IUUC-Meu-056298	Macropus eugenii	93.75	0.00e+00	1067.00
IUUC-Mor-057106	Magnaporthe oryzae	35.05	6.00e-131	461.00
IUUC-Mpo-057589	Magnaporthe poae	34.67	1.00e-123	437.00
IUUC-Mtr-058680	Medicago truncatula	48.43	0.00e+00	739.00
IUUC-Mla-058903	Melampsora laricipopulina	32.43	2.00e-120	426.00
IUUC-Mga-059669	Meleagris gallopavo	90.30	0.00e+00	1516.00
IUUC-Mvi-060476	Microbotryum violaceum	34.58	9.00e-121	427.00
IUUC-Mmr-060575	Microcebus murinus	98.58	0.00e+00	1655.00
IUUC-Mdo-062183	Monodelphis domestica	91.97	0.00e+00	1538.00
IUUC-Mac-065634	Musa acuminata	43.01	0.00e+00	689.00
IUUC-Mpu-066082	Mustela putorius furo	95.04	0.00e+00	1580.00
IUUC-Mlu-067345	Myotis lucifugus	96.12	0.00e+00	1613.00
IUUC-Nfi-068558	Neosartorya fischeri	35.13	1.00e-123	437.00
IUUC-Ncr-068960	Neurospora crassa	34.88	2.00e-116	413.00
IUUC-Nle-070173	Nomascus leucogenys	95.51	0.00e+00	1585.00
IUUC-Opr-070556	Ochotona princeps	97.52	0.00e+00	1644.00
IUUC-Ont-071502	Oreochromis niloticus	64.81	0.00e+00	1085.00
IUUC-Ocu-074861	Oryctolagus cuniculus	95.51	0.00e+00	1591.00
IUUC-Oba-075109	Oryza barthii	46.72	0.00e+00	723.00
IUUC-Obr-076292	Oryza brachyantha	47.78	0.00e+00	713.00
IUUC-Ogl-077065	Oryza glaberrima	48.01	0.00e+00	752.00
IUUC-Ogu-078776	Oryza glumaepatula	46.96	0.00e+00	734.00
IUUC-Oin-080048	Oryza indica	47.78	0.00e+00	746.00
IUUC-Olo-080711	Oryza longistaminata	45.14	0.00e+00	665.00
IUUC-Ome-081506	Oryza meridionalis	46.20	0.00e+00	677.00
IUUC-Oni-082320	Oryza nivara	46.16	0.00e+00	721.00
IUUC-Opu-083801	Oryza punctata	46.67	0.00e+00	712.00
IUUC-Oru-085139	Oryza rufipogon	46.16	0.00e+00	723.00
IUUC-Osa-085713	Oryza sativa	48.13	0.00e+00	755.00
IUUC-Ola-086951	Oryzias latipes	65.77	0.00e+00	1087.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.27	2.00e-179	622.00
IUUC-Oga-088625	Otolemur garnettii	97.64	0.00e+00	1634.00
IUUC-Oar-089995	Ovis aries	95.41	0.00e+00	1614.00
IUUC-Ptr-090640	Pan troglodytes	95.75	0.00e+00	1627.00
IUUC-Pan-091974	Papio anubis	97.29	0.00e+00	1627.00
IUUC-Psi-093957	Pelodiscus sinensis	90.23	0.00e+00	1603.00
IUUC-Pma-094242	Petromyzon marinus	72.18	3.00e-166	577.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.78	9.00e-108	384.00
IUUC-Ppa-095901	Physcomitrella patens	49.37	0.00e+00	781.00
IUUC-Pfo-097148	Poecilia formosa	66.28	0.00e+00	1098.00
IUUC-Pab-098068	Pongo abelii	90.55	0.00e+00	1468.00
IUUC-Pop-098943	Populus trichocarpa	47.09	0.00e+00	717.00
IUUC-Pca-100738	Procavia capensis	98.17	0.00e+00	1139.00
IUUC-Ppe-101315	Prunus persica	47.21	0.00e+00	725.00
IUUC-Pva-102154	Pteropus vampyrus	96.69	0.00e+00	1622.00
IUUC-Pgr-103343	Puccinia graminis	33.80	3.00e-111	395.00
IUUC-Ptt-103928	Puccinia triticina	30.65	1.00e-107	384.00
IUUC-Pte-104306	Pyrenophora teres	32.04	6.00e-104	372.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.14	9.00e-107	381.00
IUUC-Rno-105801	Rattus norvegicus	99.17	0.00e+00	1664.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.46	9.00e-74	271.00
IUUC-Sha-107635	Sarcophilus harrisii	92.09	0.00e+00	1546.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.48	3.00e-110	393.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.69	3.00e-114	405.00
IUUC-Smo-108848	Selaginella moellendorffii	48.07	0.00e+00	739.00
IUUC-Sit-110728	Setaria italica	48.25	0.00e+00	771.00
IUUC-Sly-111523	Solanum lycopersicum	47.27	0.00e+00	761.00
IUUC-Sbi-114419	Sorghum bicolor	47.49	0.00e+00	754.00
IUUC-Sre-115225	Sporisorium reilianum	35.06	1.00e-126	447.00
IUUC-Ssc-115686	Sus scrofa	97.41	0.00e+00	1639.00
IUUC-Tgu-117346	Taeniopygia guttata	91.04	0.00e+00	1573.00
IUUC-Tru-118350	Takifugu rubripes	65.39	0.00e+00	1117.00
IUUC-Tni-120658	Tetraodon nigroviridis	66.13	0.00e+00	1097.00
IUUC-Tca-121585	Theobroma cacao	47.62	0.00e+00	723.00
IUUC-Tre-122043	Trichoderma reesei	34.18	7.00e-120	424.00
IUUC-Tvi-122303	Trichoderma virens	34.61	5.00e-126	445.00
IUUC-Tae-125686	Triticum aestivum	47.31	0.00e+00	732.00
IUUC-Tur-126732	Triticum urartu	44.84	0.00e+00	686.00
IUUC-Tme-126909	Tuber melanosporum	34.49	1.00e-118	420.00
IUUC-Tbe-127261	Tupaia belangeri	91.01	0.00e+00	1035.00
IUUC-Uma-129599	Ustilago maydis	34.16	2.00e-131	463.00
IUUC-Vda-129688	Verticillium dahliae	33.37	4.00e-119	422.00
IUUC-Vvi-131116	Vitis vinifera	47.39	0.00e+00	702.00
IUUC-Xtr-131953	Xenopus tropicalis	79.39	0.00e+00	1357.00
IUUC-Xma-133837	Xiphophorus maculatus	66.51	0.00e+00	1102.00
IUUC-Yli-134510	Yarrowia lipolytica	35.70	2.00e-130	459.00
IUUC-Zma-135786	Zea mays	47.61	0.00e+00	721.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence